Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi
Cas:960203-27-4
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inquiryItems Standard Result Assay (Ursolic acid) 98%min -------------------------------------------------------------------------------
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inquiryWe can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO
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inquiryUnique advantages for Vortioxetine hydrobromide Cas 960203-27-4 High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:N/A Package:10g,100g,1kg/foil bag Application:Nervous System
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inquiryVortioxetine Hydrobromide[CAS:960203-27-4] 1-[2-[(2,4-Dimethylphenyl)thio]phenyl]piperazine Hydrobromide HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. W
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inquiry1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s
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inquiryCangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap
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inquiryWith our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin
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inquiryOur company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O
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inquiryName: Vortioxetine Hydrobromide CAS: 960203-27-4 MF: C18H22N2S.HBr Appearance:White Powder Storage:Store in cool and dry place, away from sun light. Package:25KG Application: APIs Transportation:By sea or by air Port:Qingdao Powder
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inquiryAppearance:White powder Storage:Room temperature Package:1kg/bag, 25kg/drum Application:API Transportation:Express/Sea/Air Port:Any port in china
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inquiryProduct Name: Vortioxetine hydrobromide Synonyms: 1-[2-[(2,4-Dimethylphenyl)thio]phenyl]piperazine hydrobromide;Lu AA21004 (HBr);Lu AA 21004 hydrobromide;Vortioxetine hydrobromide;Vortioxetine (Lu AA21004) hydrobroMide;Vortioxetine (Lu AA21004)
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inquiryVortioxetine hydrobromide CAS:960203-27-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organi
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inquiryHello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai
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inquiryHubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other
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inquiryLorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin h
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inquiryVortioxetine hydrobromide cas 960203-27-4 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quali
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inquiryWe are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to provide excellence in researching, manufacturing and drug discovery process. Our research team of scienti
Cas:960203-27-4
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inquiryvortioxetine
Vortioxetine hydrobromide
Conditions | Yield |
---|---|
With hydrogen bromide In water; isopropyl alcohol for 0.166667h; Concentration; Solvent; Sonication; | 96% |
With hydrogen bromide In ethyl acetate at 20℃; for 1h; | 96% |
With hydrogen bromide In Isopropyl acetate at 30 - 40℃; for 0.666667h; Time; Temperature; Solvent; Sealed tube; | 96.6% |
piperazine
(2′-bromophenyl)(2,4-dimethylphenyl)sulfane
Vortioxetine hydrobromide
Conditions | Yield |
---|---|
Stage #1: piperazine; 1-((2-bromophenyl)sulfanyl)-2,4-dimethylbenzene With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene at 105 - 115℃; Inert atmosphere; Stage #2: With hydrogen bromide at 20 - 40℃; Concentration; | 90.2% |
With copper(l) iodide; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 80℃; for 10h; | 84.6% |
bis(2-bromoethyl)amine hydrobromide
2-(2,4-dimethylphenylsulphanyl)benzeneamine
Vortioxetine hydrobromide
Conditions | Yield |
---|---|
at 100 - 180℃; for 9h; Temperature; | 89.6% |
Vortioxetine hydrochloride
Vortioxetine hydrobromide
Conditions | Yield |
---|---|
Stage #1: Vortioxetine hydrochloride With sodium hydroxide In dichloromethane; water at 25 - 30℃; Stage #2: With hydrogen bromide In Isopropyl acetate; water | 88% |
With hydrogen bromide In water; ethyl acetate pH=1 - 3; Solvent; | 79.3% |
Stage #1: Vortioxetine hydrochloride With sodium hydroxide In dichloromethane; water at 25 - 30℃; Stage #2: With hydrogen bromide; acetic acid In acetonitrile at 50℃; for 1h; Solvent; | 75% |
piperazine
1-iodo-2,4-dimethylbenzene
2-bromothiophenol
Vortioxetine hydrobromide
Conditions | Yield |
---|---|
Stage #1: piperazine; 1-iodo-2,4-dimethylbenzene; o-bromothiophenol With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate In toluene at 100℃; for 1h; Inert atmosphere; Stage #2: With hydrogen bromide In toluene at 60℃; Time; | 84.3% |
Vortioxetine hydrobromide
Conditions | Yield |
---|---|
With p-cresol; hydrogen bromide; acetic acid at 70 - 75℃; for 2h; | 84.2% |
4-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine-1-carboxylic acid tert-butyl ester
Vortioxetine hydrobromide
Conditions | Yield |
---|---|
With hydrogen bromide In methanol; water at 20 - 60℃; for 1h; | 83.5% |
With water; hydrogen bromide In methanol for 2h; Reflux; | 81% |
With hydrogen bromide In isopropyl alcohol at 50℃; for 1.5h; Temperature; | 79% |
piperazine
1-Bromo-2-iodobenzene
2,4-dimethyl-thiophenol
Vortioxetine hydrobromide
Conditions | Yield |
---|---|
Stage #1: piperazine; 1-Bromo-2-iodobenzene; 2,4-dimethyl-thiophenol With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate for 6h; Reflux; Inert atmosphere; Stage #2: With hydrogen bromide In toluene at 60℃; | 81.5% |
Stage #1: 1-Bromo-2-iodobenzene; 2,4-dimethyl-thiophenol With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate In toluene for 5h; Inert atmosphere; Reflux; Stage #2: piperazine With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate for 2h; Reflux; Stage #3: With hydrogen bromide In water at 70℃; for 0.5h; | 75% |
Stage #1: piperazine With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene for 0.833333h; Inert atmosphere; Stage #2: 1-Bromo-2-iodobenzene In toluene for 0.5h; Inert atmosphere; Stage #3: 2,4-dimethyl-thiophenol Further stages; | 46.3% |
Stage #1: piperazine With sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; bis(dibenzylideneacetone)-palladium(0) In toluene at 20℃; for 0.5h; Inert atmosphere; Stage #2: 1-Bromo-2-iodobenzene; 2,4-dimethyl-thiophenol at 20℃; for 6h; Reflux; Stage #3: With hydrogen bromide In toluene Product distribution / selectivity; | |
Stage #1: 1-Bromo-2-iodobenzene; 2,4-dimethyl-thiophenol With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate In toluene for 5h; Inert atmosphere; Reflux; Stage #2: piperazine for 2h; Solvent; Inert atmosphere; Reflux; |
Vortioxetine hydrobromide
Conditions | Yield |
---|---|
Stage #1: 1-[2-(2,4-dimethyl-phenylsulfanyl)phenyl]piperazin-2-one hydrochloride With dimethylsulfide borane complex In dichloromethane at 35 - 45℃; Stage #2: With hydrogen bromide In water; iso-butanol at 25 - 70℃; | 80% |
Multi-step reaction with 2 steps 1: dimethylsulfide borane complex / tetrahydrofuran / -10 - 60 °C 2: hydrogen bromide / water; ethyl acetate / 25 - 35 °C View Scheme |
bis-(2-chloroethyl)amine hydrochloride
2-(2,4-dimethylphenylsulphanyl)benzeneamine
Vortioxetine hydrobromide
Conditions | Yield |
---|---|
Stage #1: bis-(2-chloroethyl)amine hydrochloride; 2-(2,4-dimethylphenylsulphanyl)benzeneamine In toluene Reflux; Inert atmosphere; Stage #2: With hydrogen bromide In water pH=1 - 2; Solvent; | 78.3% |
2-(2,4-dimethylphenylsulphanyl)benzeneamine
Vortioxetine hydrobromide
Conditions | Yield |
---|---|
Stage #1: 2-(2,4-dimethylphenylsulphanyl)benzeneamine With bis-(2-chloroethyl)amine hydrochloride In dichloromethane at 25 - 180℃; Stage #2: With hydrogen bromide In water; iso-butanol | 75% |
Multi-step reaction with 3 steps 1: diethylene glycol dimethyl ether / 72 h / 130 °C 2: sodium hydroxide / 1 h / 20 °C 3: hydrogen bromide / water; Isopropyl acetate / 1 h / 20 °C View Scheme | |
Multi-step reaction with 2 steps 1: 1,3-dimethyl-2-imidazolidinone; potassium carbonate / toluene / 12 h / 170 - 180 °C 2: hydrogen bromide / acetone; water / 3 h / 20 °C / Reflux View Scheme |
Conditions | Yield |
---|---|
Stage #1: piperazine; (η6-1,2-dichlorobenzene)(η5-cyclopentadienyl)iron(II) hexafluorophosphate With potassium carbonate In tetrahydrofuran; water at 20℃; for 1h; Stage #2: 2,4-dimethyl-thiophenol In tetrahydrofuran; water at 20℃; Further stages; | 64.1% |
1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine hydrobromide ethyl acetate solvate
Vortioxetine hydrobromide
Conditions | Yield |
---|---|
at 75℃; Product distribution / selectivity; |
A
Vortioxetine hydrobromide
B
4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazin-1-ol
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium cyanoborohydride; acetic acid / tetrahydrofuran / 21 h / 45 °C 2: sodium methylate / methanol / 1 h / Inert atmosphere 3: water; sodium hydroxide / acetone / 0.08 h 4: β-glucuronidase solution / 0.5 h / 37 °C / pH 6.8 / Phosphate buffer View Scheme |
A
Vortioxetine hydrobromide
B
4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazin-1-ol
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere 1.2: 1 h / -78 - 20 °C / Inert atmosphere 2.1: sodium cyanoborohydride; acetic acid / tetrahydrofuran / 21 h / 45 °C 3.1: sodium methylate / methanol / 1 h / Inert atmosphere 4.1: water; sodium hydroxide / acetone / 0.08 h 5.1: β-glucuronidase solution / 0.5 h / 37 °C / pH 6.8 / Phosphate buffer View Scheme |
(2S,3S,4S,5R,6S)-6-{4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazin-1-yloxy}-3,4,5-trihydroxy-tetrahydro-pyran-2-carboxylic acid
A
Vortioxetine hydrobromide
B
4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazin-1-ol
Conditions | Yield |
---|---|
With β-glucuronidase solution at 37℃; for 0.5h; pH=6.8; Phosphate buffer; |
A
Vortioxetine hydrobromide
B
4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazin-1-ol
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: water; sodium hydroxide / acetone / 0.08 h 2: β-glucuronidase solution / 0.5 h / 37 °C / pH 6.8 / Phosphate buffer View Scheme |
4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-1-β-D-glucuronic acid-piperazine-1-oxide
A
Vortioxetine hydrobromide
B
4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazin-1-ol
Conditions | Yield |
---|---|
With β-glucuronidase solution at 37℃; for 0.5h; pH=6.8; Phosphate buffer; |
A
Vortioxetine hydrobromide
B
4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazin-1-ol
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium methylate / methanol / 1 h / Inert atmosphere 2: water; sodium hydroxide / acetone / 0.08 h 3: β-glucuronidase solution / 0.5 h / 37 °C / pH 6.8 / Phosphate buffer View Scheme |
A
Vortioxetine hydrobromide
B
4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazin-1-ol
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1.1: lithium borohydride / tetrahydrofuran / 18 h / 0 °C 1.2: 1 h 2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere 2.2: 1 h / -78 - 20 °C / Inert atmosphere 3.1: sodium cyanoborohydride; acetic acid / tetrahydrofuran / 21 h / 45 °C 4.1: sodium methylate / methanol / 1 h / Inert atmosphere 5.1: water; sodium hydroxide / acetone / 0.08 h 6.1: β-glucuronidase solution / 0.5 h / 37 °C / pH 6.8 / Phosphate buffer View Scheme |
2-(2,4-dimethylphenylsulphanyl)benzeneamine
A
Vortioxetine hydrobromide
B
4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazin-1-ol
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1.1: potassium iodide / 1-methyl-pyrrolidin-2-one / 26 h / 120 °C 2.1: lithium borohydride / tetrahydrofuran / 18 h / 0 °C 2.2: 1 h 3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere 3.2: 1 h / -78 - 20 °C / Inert atmosphere 4.1: sodium cyanoborohydride; acetic acid / tetrahydrofuran / 21 h / 45 °C 5.1: sodium methylate / methanol / 1 h / Inert atmosphere 6.1: water; sodium hydroxide / acetone / 0.08 h 7.1: β-glucuronidase solution / 0.5 h / 37 °C / pH 6.8 / Phosphate buffer View Scheme |
piperazine
2,4-dimethyl-thiophenol
1,2-dichloro-benzene
Vortioxetine hydrobromide
Conditions | Yield |
---|---|
Stage #1: 1,2-dichloro-benzene With aluminum (III) chloride; ferrocene; aluminium at 110℃; for 6h; Stage #2: piperazine With potassium carbonate In tetrahydrofuran; water at 20℃; for 3h; Stage #3: 2,4-dimethyl-thiophenol Further stages; | 7.3 g |
Vortioxetine hydrobromide
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: iron; acetic acid / 16 h / 30 °C 2: diethylene glycol dimethyl ether / 72 h / 130 °C 3: sodium hydroxide / 1 h / 20 °C 4: hydrogen bromide / water; Isopropyl acetate / 1 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: hydrogen; palladium 10% on activated carbon / ethanol / 6 h / 80 °C / Autoclave 2: 1,3-dimethyl-2-imidazolidinone; potassium carbonate / toluene / 12 h / 170 - 180 °C 3: hydrogen bromide / acetone; water / 3 h / 20 °C / Reflux View Scheme | |
Multi-step reaction with 4 steps 1.1: iron; acetic acid / 16 h / 30 °C 2.1: sulfuric acid; sodium nitrite / water; acetonitrile / 0 °C 2.2: 16 h / 0 - 25 °C 3.1: copper(l) iodide; potassium phosphate; 2-Phenylphenol / dimethyl sulfoxide / 20 h / 120 °C / Inert atmosphere 4.1: hydrogen bromide / water; Isopropyl acetate / 1 h / 20 °C View Scheme |
ortho-nitrofluorobenzene
Vortioxetine hydrobromide
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 25 °C 2: iron; acetic acid / 16 h / 30 °C 3: diethylene glycol dimethyl ether / 72 h / 130 °C 4: sodium hydroxide / 1 h / 20 °C 5: hydrogen bromide / water; Isopropyl acetate / 1 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 17 h / 50 °C 2.1: 5%-palladium/activated carbon; hydrogen / methanol / 18 h / 3750.38 Torr 3.1: acetic acid; sodium nitrite / water / 0.5 h / 0 °C 3.2: 16.08 h / 5 - 70 °C 4.1: potassium hydroxide / water; methanol / 24 h / Reflux 5.1: hydrogen bromide / Isopropyl acetate / 1 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 25 °C 1.2: 2.5 h / 25 °C 2.1: iron; acetic acid / 16 h / 30 °C 3.1: sulfuric acid; sodium nitrite / water; acetonitrile / 0 °C 3.2: 16 h / 0 - 25 °C 4.1: copper(l) iodide; potassium phosphate; 2-Phenylphenol / dimethyl sulfoxide / 20 h / 120 °C / Inert atmosphere 5.1: hydrogen bromide / water; Isopropyl acetate / 1 h / 20 °C View Scheme |
2,4-dimethyl-thiophenol
Vortioxetine hydrobromide
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 25 °C 2: iron; acetic acid / 16 h / 30 °C 3: diethylene glycol dimethyl ether / 72 h / 130 °C 4: sodium hydroxide / 1 h / 20 °C 5: hydrogen bromide / water; Isopropyl acetate / 1 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 25 °C 2: iron; acetic acid / 16 h / 30 °C 3: diethylene glycol dimethyl ether / 72 h / 130 °C 4: sodium hydroxide / 1 h / 20 °C 5: hydrogen bromide / water; Isopropyl acetate / 1 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: potassium carbonate / N,N-dimethyl-formamide / 96 h / 90 °C / Inert atmosphere 2: caesium carbonate / N,N-dimethyl-formamide / 140 °C 3: hydrogen bromide / Isopropyl acetate / 1 h / 20 °C View Scheme |
2-Chloronitrobenzene
Vortioxetine hydrobromide
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 25 °C 2: iron; acetic acid / 16 h / 30 °C 3: diethylene glycol dimethyl ether / 72 h / 130 °C 4: sodium hydroxide / 1 h / 20 °C 5: hydrogen bromide / water; Isopropyl acetate / 1 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 100 °C / Inert atmosphere 2: hydrogen; palladium 10% on activated carbon / ethanol / 6 h / 80 °C / Autoclave 3: 1,3-dimethyl-2-imidazolidinone; potassium carbonate / toluene / 12 h / 170 - 180 °C 4: hydrogen bromide / acetone; water / 3 h / 20 °C / Reflux View Scheme | |
Multi-step reaction with 5 steps 1.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 25 °C 2.1: iron; acetic acid / 16 h / 30 °C 3.1: sulfuric acid; sodium nitrite / water; acetonitrile / 0 °C 3.2: 16 h / 0 - 25 °C 4.1: copper(l) iodide; potassium phosphate; 2-Phenylphenol / dimethyl sulfoxide / 20 h / 120 °C / Inert atmosphere 5.1: hydrogen bromide / water; Isopropyl acetate / 1 h / 20 °C View Scheme |
Vortioxetine hydrobromide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: potassium carbonate / dimethyl sulfoxide / 48 h / 100 °C 2: Lawessons reagent / tetrahydrofuran / 18 h / 20 °C 3: hydrogen bromide / Isopropyl acetate / 1 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: potassium carbonate / dimethyl sulfoxide / 48 h / 100 °C 2.1: iodine; magnesium / methanol / 19 h / 20 °C 2.2: 1 h / 20 °C 3.1: sodium hydroxide / ethyl acetate / 1 h / 20 °C 4.1: hydrogen bromide / Isopropyl acetate / 1 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: potassium carbonate / dimethyl sulfoxide / 168 h / 140 °C 2.1: hydrogenchloride / methanol; water / 16 h / 60 °C 2.2: 20 °C / pH 12 3.1: Lawessons reagent / tetrahydrofuran / 18 h / 20 °C 4.1: hydrogen bromide / Isopropyl acetate / 1 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: potassium carbonate / dimethyl sulfoxide / 168 h / 140 °C 2.1: hydrogenchloride / methanol; water / 16 h / 60 °C 2.2: 20 °C / pH 12 3.1: iodine; magnesium / methanol / 19 h / 20 °C 3.2: 1 h / 20 °C 4.1: sodium hydroxide / ethyl acetate / 1 h / 20 °C 5.1: hydrogen bromide / Isopropyl acetate / 1 h / 20 °C View Scheme |
Vortioxetine hydrobromide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: Lawessons reagent / tetrahydrofuran / 18 h / 20 °C 2: hydrogen bromide / Isopropyl acetate / 1 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1.1: iodine; magnesium / methanol / 19 h / 20 °C 1.2: 1 h / 20 °C 2.1: sodium hydroxide / ethyl acetate / 1 h / 20 °C 3.1: hydrogen bromide / Isopropyl acetate / 1 h / 20 °C View Scheme |
Vortioxetine hydrobromide
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: hydrogenchloride / methanol; water / 16 h / 60 °C 1.2: 20 °C / pH 12 2.1: Lawessons reagent / tetrahydrofuran / 18 h / 20 °C 3.1: hydrogen bromide / Isopropyl acetate / 1 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1.1: hydrogenchloride / methanol; water / 16 h / 60 °C 1.2: 20 °C / pH 12 2.1: iodine; magnesium / methanol / 19 h / 20 °C 2.2: 1 h / 20 °C 3.1: sodium hydroxide / ethyl acetate / 1 h / 20 °C 4.1: hydrogen bromide / Isopropyl acetate / 1 h / 20 °C View Scheme | |
Multi-step reaction with 3 steps 1: hydrogenchloride / water; methanol / 2 h / 15 - 25 °C / Inert atmosphere 2: iodine; magnesium / methanol / 18 h / 15 - 25 °C / Inert atmosphere 3: hydrogen bromide / water; toluene / 2 h / 0 - 60 °C / Inert atmosphere View Scheme |
Vortioxetine hydrobromide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: caesium carbonate / N,N-dimethyl-formamide / 140 °C 2: hydrogen bromide / Isopropyl acetate / 1 h / 20 °C View Scheme | |
Multi-step reaction with 4 steps 1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 0.5 h / 0 °C 2: potassium carbonate / dimethyl sulfoxide / 48 h / 100 °C 3: Lawessons reagent / tetrahydrofuran / 18 h / 20 °C 4: hydrogen bromide / Isopropyl acetate / 1 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 0.5 h / 0 °C 2.1: potassium carbonate / dimethyl sulfoxide / 168 h / 140 °C 3.1: hydrogenchloride / methanol; water / 16 h / 60 °C 3.2: 20 °C / pH 12 4.1: Lawessons reagent / tetrahydrofuran / 18 h / 20 °C 5.1: hydrogen bromide / Isopropyl acetate / 1 h / 20 °C View Scheme | |
Multi-step reaction with 5 steps 1.1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 0.5 h / 0 °C 2.1: potassium carbonate / dimethyl sulfoxide / 48 h / 100 °C 3.1: iodine; magnesium / methanol / 19 h / 20 °C 3.2: 1 h / 20 °C 4.1: sodium hydroxide / ethyl acetate / 1 h / 20 °C 5.1: hydrogen bromide / Isopropyl acetate / 1 h / 20 °C View Scheme | |
Multi-step reaction with 6 steps 1.1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 0.5 h / 0 °C 2.1: potassium carbonate / dimethyl sulfoxide / 168 h / 140 °C 3.1: hydrogenchloride / methanol; water / 16 h / 60 °C 3.2: 20 °C / pH 12 4.1: iodine; magnesium / methanol / 19 h / 20 °C 4.2: 1 h / 20 °C 5.1: sodium hydroxide / ethyl acetate / 1 h / 20 °C 6.1: hydrogen bromide / Isopropyl acetate / 1 h / 20 °C View Scheme |
Vortioxetine hydrobromide
vortioxetine
Conditions | Yield |
---|---|
With sodium hydroxide; water In ethyl acetate for 0.166667h; | 98% |
With sodium hydroxide In dichloromethane; water for 0.5h; pH=9 - 10; | 94% |
With sodium hydroxide In water; toluene pH=13 - 14; | 90.6% |
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