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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

High purity Vortioxetine hydrobromide

Cas:960203-27-4

Min.Order:10 Gram

FOB Price: $100.0

Type:Lab/Research institutions

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SEASONS BIOTECHNOLOGY CO., LTD

1. High-quality products, cost-effective prices, best reputation and professional services. 2. Strong technology team and service team, Professional data management system. 3. Professional synthesis and formulations laboratory and production

1-[2-(2,4-Dimethylphenyl)sulfanylphenyl]piperazine hydrobromide

Cas:960203-27-4

Min.Order:1 Gram

Negotiable

Type:

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Dayang Chem (Hangzhou) Co.,Ltd.

Dayangchem's R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. DayangChem can provide different quantities

Vortioxetine hydrobromide

Cas:960203-27-4

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

inquiry

Hangzhou Dingyan Chem Co., Ltd

Items Standard Result Assay (Ursolic acid) 98%min -------------------------------------------------------------------------------

High purity Vortioxetine hydrobromide CAS:960203-27-4

Cas:960203-27-4

Min.Order:1 Gram

FOB Price: $100.0 / 500.0

Type:Manufacturers

inquiry

Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need CMO

Vortioxetine hydrobromide manufacturer/supplier

Cas:960203-27-4

Min.Order:1 Gram

Negotiable

Type:Manufacturers

inquiry

Wuhan Fortuna Chemical Co.,Ltd

Unique advantages for Vortioxetine hydrobromide Cas 960203-27-4 High quality & competitive price Quality control Fast feedback Prompt shipment Appearance:White powder Storage:N/A Package:10g,100g,1kg/foil bag Application:Nervous System

Factory supply high quality Vortioxetine hydrobromide Cas 960203-27-4 with best price

Cas:960203-27-4

Min.Order:10 Gram

Negotiable

Type:Trading Company

inquiry

Hangzhou Think Chemical Co. Ltd

Vortioxetine Hydrobromide[CAS:960203-27-4] 1-[2-[(2,4-Dimethylphenyl)thio]phenyl]piperazine Hydrobromide HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture. W

competitive price Vortioxetine Hydrobromide

Cas:960203-27-4

Min.Order:1 Kilogram

Negotiable

Type:Other

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Vortioxetine hydrobromide 960203-27-4 GMP Manufacturer

Cas:960203-27-4

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

inquiry

Enke Pharma-tech Co.,Ltd. (Cangzhou, China )

Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

1-[2-[(2,4-Dimethylphenyl)thio]phenyl]piperazine hydrobromide

Cas:960203-27-4

Min.Order:1 Kilogram

FOB Price: $5.0 / 10.0

Type:Manufacturers

inquiry

Chemwill Asia Co., Ltd.

Our main production base is located in Xuzhou industry park. We are certified both to the ISO 9001 and ISO 14001 Standards, have a safety management system in place.Our R&D team masters core technology for process-design of target building block

Vortioxetine hydrobromide

Cas:960203-27-4

Min.Order:5 Kiloliter

FOB Price: $1.2 / 5.0

Type:Manufacturers

inquiry

Sinoway Industrial Co., Ltd.

Why is SINOWAY: 1) Specialized in pharmaceutical and healthcare industrial for 34 years. 2) ISO 9001:2015 & SGS audited supplier . 3) Accept various payment terms : T.T 30-60 days. 4) We have warehouse in USA with quickly shipment . 5) We c

Factory Supply Vortioxetine hydrobromide CAS:960203-27-4

Cas:960203-27-4

Min.Order:1 Kilogram

FOB Price: $20.0

Type:Trading Company

inquiry

Hebei Nengqian Chemical Import and Export Co., LTD

With our good experience, we offer detailed technical support and advice to assist customers. We communicate closely with customers to establish their quality requirements. Consistent Quality Our plant has strict quality control in each manufacturin

Vortioxetine Hydrobromide 960203-27-4

Cas:960203-27-4

Min.Order:1 Kilogram

FOB Price: $3.0 / 10.0

Type:Trading Company

inquiry

Henan Tianfu Chemical Co., Ltd.

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.O

C18H22N2S.HBr Vortioxetine hydrobromide 960203-27-4

Cas:960203-27-4

Min.Order:1 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 960203-27-4 with best quality

Cas:960203-27-4

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

inquiry

Henan Sinotech Import&Export Corporation

Name: Vortioxetine Hydrobromide CAS: 960203-27-4 MF: C18H22N2S.HBr Appearance:White Powder Storage:Store in cool and dry place, away from sun light. Package:25KG Application: APIs Transportation:By sea or by air Port:Qingdao Powder

Vortioxetine Hydrobromide CAS: 960203-27-4

Cas:960203-27-4

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Other

inquiry

Hangzhou Sartort Biopharma Co., Ltd

Appearance:White powder Storage:Room temperature Package:1kg/bag, 25kg/drum Application:API Transportation:Express/Sea/Air Port:Any port in china

Factory Price Vortioxetine hydrobromide CAS:960203-27-4

Cas:960203-27-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Langyou International Trading Co., Ltd

1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White Crystalline Powder Storage:Store in sealed conta

high quality 960203-27-4 Vortioxetine hydrobromide with best price

Cas:960203-27-4

Min.Order:10 Gram

Negotiable

Type:Other

inquiry

Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Vortioxetine hydrobromide 960203-27-4

Cas:960203-27-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Xi'an Faithful Biotech Co., Ltd.

We are the manufacturers and suppliers of API in China, and warehouse in Germany and USA of California, which can quickly and safely deliver to your address 1.High quality and competitive price. 2.Free sample for your evaluation. 3.Promptly delivery

Shanghai Minstar Chemical Co., Ltd

Product Name: Vortioxetine hydrobromide Synonyms: 1-[2-[(2,4-Dimethylphenyl)thio]phenyl]piperazine hydrobromide;Lu AA21004 (HBr);Lu AA 21004 hydrobromide;Vortioxetine hydrobromide;Vortioxetine (Lu AA21004) hydrobroMide;Vortioxetine (Lu AA21004)

Vortioxetine hydrobromide

Cas:960203-27-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Qingdao Beluga Import and Export Co., LTD

Vortioxetine hydrobromide CAS:960203-27-4 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organi

Vortioxetine hydrobromide CAS:960203-27-4

Cas:960203-27-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Vortioxetine hydrobromide

Cas:960203-27-4

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Vortioxetine hydrobromide/ LIDE PHARMA- Factory supply / Best price

Cas:960203-27-4

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wuhan Wonda Pharm Limited

1.high quality: quality is life. quality is the most important element for all goods. we have a lab doing research in wuhan china. hplc and nmr is available if needed. 2.reasonable price: we provide high quality products with competi

Vortioxetine Hydrobromide factory bulk supply

Cas:960203-27-4

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Hubei Yuanmeng Biological Technology Co., Ltd.

Hubei Yuanmeng Biological Technology Co., Ltd., which is located in Wuhan, China. We are specializing in the exportation of APIs, and plant extracts ect. Our products has been exported to America, Australia, Brazil, the Europe, Middle East and other

High Purity Vortioxetine Hydrobromide CAS 960203-27-4 with Fast Shipment

Cas:960203-27-4

Min.Order:1 Kilogram

FOB Price: $3.0 / 5.0

Type:Trading Company

inquiry

Triumph International Development Limilted

Lorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin h

1-[2-[(2,4-Dimethylphenyl)thio]phenyl]piperazine hydrobromide

Cas:960203-27-4

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

Vortioxetine hydrobromide 960203-27-4

Cas:960203-27-4

Min.Order:100 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Hefei Zhaobo Technology Co., Ltd.

Vortioxetine hydrobromide cas 960203-27-4 Purity: 99% Min Application: Intermediates Appearance: Powder Package: Bag Delivery: 3-5days Our Advantage & Service 1.Top quality: Using high quality material and establishing a strict quali

Vortioxetine hydrobromide cas 960203-27-4

Cas:960203-27-4

Min.Order:1 Kilogram

FOB Price: $10.0 / 50.0

Type:Trading Company

inquiry

Afine Chemicals Limited

Company Introduction 1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division. 2. Main product: Optical brightener Textile auxiliary Dye stuff Pigments

VORTIOXETINE HYDROBROMIDE;

Cas:960203-27-4

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

ACHIEVER SYSTEAM BIOCHEM CO., LTD.

We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to provide excellence in researching, manufacturing and drug discovery process. Our research team of scienti

Vortioxetine hydrobromide

Cas:960203-27-4

Min.Order:100 Gram

FOB Price: $1.0

Type:Lab/Research institutions

inquiry

Synthetic route

vortioxetine
508233-74-7

vortioxetine

Vortioxetine hydrobromide
960203-27-4

Vortioxetine hydrobromide

Conditions
ConditionsYield
With hydrogen bromide In water; isopropyl alcohol for 0.166667h; Concentration; Solvent; Sonication;96%
With hydrogen bromide In ethyl acetate at 20℃; for 1h;96%
With hydrogen bromide In Isopropyl acetate at 30 - 40℃; for 0.666667h; Time; Temperature; Solvent; Sealed tube;96.6%
piperazine
110-85-0

piperazine

(2′-bromophenyl)(2,4-dimethylphenyl)sulfane
960203-41-2

(2′-bromophenyl)(2,4-dimethylphenyl)sulfane

Vortioxetine hydrobromide
960203-27-4

Vortioxetine hydrobromide

Conditions
ConditionsYield
Stage #1: piperazine; 1-((2-bromophenyl)sulfanyl)-2,4-dimethylbenzene With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene at 105 - 115℃; Inert atmosphere;
Stage #2: With hydrogen bromide at 20 - 40℃; Concentration;
90.2%
With copper(l) iodide; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 80℃; for 10h;84.6%
bis(2-bromoethyl)amine hydrobromide
43204-63-3

bis(2-bromoethyl)amine hydrobromide

2-(2,4-dimethylphenylsulphanyl)benzeneamine
1019453-85-0

2-(2,4-dimethylphenylsulphanyl)benzeneamine

Vortioxetine hydrobromide
960203-27-4

Vortioxetine hydrobromide

Conditions
ConditionsYield
at 100 - 180℃; for 9h; Temperature;89.6%
Vortioxetine hydrochloride
960203-28-5

Vortioxetine hydrochloride

Vortioxetine hydrobromide
960203-27-4

Vortioxetine hydrobromide

Conditions
ConditionsYield
Stage #1: Vortioxetine hydrochloride With sodium hydroxide In dichloromethane; water at 25 - 30℃;
Stage #2: With hydrogen bromide In Isopropyl acetate; water
88%
With hydrogen bromide In water; ethyl acetate pH=1 - 3; Solvent;79.3%
Stage #1: Vortioxetine hydrochloride With sodium hydroxide In dichloromethane; water at 25 - 30℃;
Stage #2: With hydrogen bromide; acetic acid In acetonitrile at 50℃; for 1h; Solvent;
75%
piperazine
110-85-0

piperazine

1-iodo-2,4-dimethylbenzene
4214-28-2

1-iodo-2,4-dimethylbenzene

2-bromothiophenol
6320-02-1

2-bromothiophenol

Vortioxetine hydrobromide
960203-27-4

Vortioxetine hydrobromide

Conditions
ConditionsYield
Stage #1: piperazine; 1-iodo-2,4-dimethylbenzene; o-bromothiophenol With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate In toluene at 100℃; for 1h; Inert atmosphere;
Stage #2: With hydrogen bromide In toluene at 60℃; Time;
84.3%
C24H26N2O2S2

C24H26N2O2S2

Vortioxetine hydrobromide
960203-27-4

Vortioxetine hydrobromide

Conditions
ConditionsYield
With p-cresol; hydrogen bromide; acetic acid at 70 - 75℃; for 2h;84.2%
4-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine-1-carboxylic acid tert-butyl ester
960203-42-3

4-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine-1-carboxylic acid tert-butyl ester

Vortioxetine hydrobromide
960203-27-4

Vortioxetine hydrobromide

Conditions
ConditionsYield
With hydrogen bromide In methanol; water at 20 - 60℃; for 1h;83.5%
With water; hydrogen bromide In methanol for 2h; Reflux;81%
With hydrogen bromide In isopropyl alcohol at 50℃; for 1.5h; Temperature;79%
piperazine
110-85-0

piperazine

1-Bromo-2-iodobenzene
583-55-1

1-Bromo-2-iodobenzene

2,4-dimethyl-thiophenol
13616-82-5

2,4-dimethyl-thiophenol

Vortioxetine hydrobromide
960203-27-4

Vortioxetine hydrobromide

Conditions
ConditionsYield
Stage #1: piperazine; 1-Bromo-2-iodobenzene; 2,4-dimethyl-thiophenol With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate for 6h; Reflux; Inert atmosphere;
Stage #2: With hydrogen bromide In toluene at 60℃;
81.5%
Stage #1: 1-Bromo-2-iodobenzene; 2,4-dimethyl-thiophenol With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate In toluene for 5h; Inert atmosphere; Reflux;
Stage #2: piperazine With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate for 2h; Reflux;
Stage #3: With hydrogen bromide In water at 70℃; for 0.5h;
75%
Stage #1: piperazine With tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate In toluene for 0.833333h; Inert atmosphere;
Stage #2: 1-Bromo-2-iodobenzene In toluene for 0.5h; Inert atmosphere;
Stage #3: 2,4-dimethyl-thiophenol Further stages;
46.3%
Stage #1: piperazine With sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; bis(dibenzylideneacetone)-palladium(0) In toluene at 20℃; for 0.5h; Inert atmosphere;
Stage #2: 1-Bromo-2-iodobenzene; 2,4-dimethyl-thiophenol at 20℃; for 6h; Reflux;
Stage #3: With hydrogen bromide In toluene Product distribution / selectivity;
Stage #1: 1-Bromo-2-iodobenzene; 2,4-dimethyl-thiophenol With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate In toluene for 5h; Inert atmosphere; Reflux;
Stage #2: piperazine for 2h; Solvent; Inert atmosphere; Reflux;
1-[2-(2,4-dimethyl-phenylsulfanyl)phenyl]piperazin-2-one hydrochloride

1-[2-(2,4-dimethyl-phenylsulfanyl)phenyl]piperazin-2-one hydrochloride

Vortioxetine hydrobromide
960203-27-4

Vortioxetine hydrobromide

Conditions
ConditionsYield
Stage #1: 1-[2-(2,4-dimethyl-phenylsulfanyl)phenyl]piperazin-2-one hydrochloride With dimethylsulfide borane complex In dichloromethane at 35 - 45℃;
Stage #2: With hydrogen bromide In water; iso-butanol at 25 - 70℃;
80%
Multi-step reaction with 2 steps
1: dimethylsulfide borane complex / tetrahydrofuran / -10 - 60 °C
2: hydrogen bromide / water; ethyl acetate / 25 - 35 °C
View Scheme
bis-(2-chloroethyl)amine hydrochloride
821-48-7

bis-(2-chloroethyl)amine hydrochloride

2-(2,4-dimethylphenylsulphanyl)benzeneamine
1019453-85-0

2-(2,4-dimethylphenylsulphanyl)benzeneamine

Vortioxetine hydrobromide
960203-27-4

Vortioxetine hydrobromide

Conditions
ConditionsYield
Stage #1: bis-(2-chloroethyl)amine hydrochloride; 2-(2,4-dimethylphenylsulphanyl)benzeneamine In toluene Reflux; Inert atmosphere;
Stage #2: With hydrogen bromide In water pH=1 - 2; Solvent;
78.3%
2-(2,4-dimethylphenylsulphanyl)benzeneamine
1019453-85-0

2-(2,4-dimethylphenylsulphanyl)benzeneamine

Vortioxetine hydrobromide
960203-27-4

Vortioxetine hydrobromide

Conditions
ConditionsYield
Stage #1: 2-(2,4-dimethylphenylsulphanyl)benzeneamine With bis-(2-chloroethyl)amine hydrochloride In dichloromethane at 25 - 180℃;
Stage #2: With hydrogen bromide In water; iso-butanol
75%
Multi-step reaction with 3 steps
1: diethylene glycol dimethyl ether / 72 h / 130 °C
2: sodium hydroxide / 1 h / 20 °C
3: hydrogen bromide / water; Isopropyl acetate / 1 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: 1,3-dimethyl-2-imidazolidinone; potassium carbonate / toluene / 12 h / 170 - 180 °C
2: hydrogen bromide / acetone; water / 3 h / 20 °C / Reflux
View Scheme
piperazine
110-85-0

piperazine

(η6-1,2-dichlorobenzene)(η5-cyclopentadienyl)iron(II) hexafluorophosphate

(η6-1,2-dichlorobenzene)(η5-cyclopentadienyl)iron(II) hexafluorophosphate

2,4-dimethyl-thiophenol
13616-82-5

2,4-dimethyl-thiophenol

Vortioxetine hydrobromide
960203-27-4

Vortioxetine hydrobromide

Conditions
ConditionsYield
Stage #1: piperazine; (η6-1,2-dichlorobenzene)(η5-cyclopentadienyl)iron(II) hexafluorophosphate With potassium carbonate In tetrahydrofuran; water at 20℃; for 1h;
Stage #2: 2,4-dimethyl-thiophenol In tetrahydrofuran; water at 20℃; Further stages;
64.1%
1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine hydrobromide ethyl acetate solvate
960203-39-8

1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine hydrobromide ethyl acetate solvate

Vortioxetine hydrobromide
960203-27-4

Vortioxetine hydrobromide

Conditions
ConditionsYield
at 75℃; Product distribution / selectivity;
C18H19NO2S

C18H19NO2S

A

Vortioxetine hydrobromide
960203-27-4

Vortioxetine hydrobromide

B

4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazin-1-ol
1393644-67-1

4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazin-1-ol

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium cyanoborohydride; acetic acid / tetrahydrofuran / 21 h / 45 °C
2: sodium methylate / methanol / 1 h / Inert atmosphere
3: water; sodium hydroxide / acetone / 0.08 h
4: β-glucuronidase solution / 0.5 h / 37 °C / pH 6.8 / Phosphate buffer
View Scheme
{[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-(2-hydroxy-ethyl)-amino}-ethanol

{[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-(2-hydroxy-ethyl)-amino}-ethanol

A

Vortioxetine hydrobromide
960203-27-4

Vortioxetine hydrobromide

B

4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazin-1-ol
1393644-67-1

4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazin-1-ol

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere
1.2: 1 h / -78 - 20 °C / Inert atmosphere
2.1: sodium cyanoborohydride; acetic acid / tetrahydrofuran / 21 h / 45 °C
3.1: sodium methylate / methanol / 1 h / Inert atmosphere
4.1: water; sodium hydroxide / acetone / 0.08 h
5.1: β-glucuronidase solution / 0.5 h / 37 °C / pH 6.8 / Phosphate buffer
View Scheme
(2S,3S,4S,5R,6S)-6-{4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazin-1-yloxy}-3,4,5-trihydroxy-tetrahydro-pyran-2-carboxylic acid
1393733-77-1

(2S,3S,4S,5R,6S)-6-{4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazin-1-yloxy}-3,4,5-trihydroxy-tetrahydro-pyran-2-carboxylic acid

A

Vortioxetine hydrobromide
960203-27-4

Vortioxetine hydrobromide

B

4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazin-1-ol
1393644-67-1

4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazin-1-ol

Conditions
ConditionsYield
With β-glucuronidase solution at 37℃; for 0.5h; pH=6.8; Phosphate buffer;
C25H32N2O7S

C25H32N2O7S

A

Vortioxetine hydrobromide
960203-27-4

Vortioxetine hydrobromide

B

4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazin-1-ol
1393644-67-1

4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazin-1-ol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: water; sodium hydroxide / acetone / 0.08 h
2: β-glucuronidase solution / 0.5 h / 37 °C / pH 6.8 / Phosphate buffer
View Scheme
4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-1-β-D-glucuronic acid-piperazine-1-oxide
1393733-76-0

4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-1-β-D-glucuronic acid-piperazine-1-oxide

A

Vortioxetine hydrobromide
960203-27-4

Vortioxetine hydrobromide

B

4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazin-1-ol
1393644-67-1

4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazin-1-ol

Conditions
ConditionsYield
With β-glucuronidase solution at 37℃; for 0.5h; pH=6.8; Phosphate buffer;
(2S,3S,4S,5R,6S)-3,4,5-triacetoxy-6-{4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazin-1-yloxy}-tetrahydro-pyran-2-carboxylic acid methyl ester

(2S,3S,4S,5R,6S)-3,4,5-triacetoxy-6-{4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazin-1-yloxy}-tetrahydro-pyran-2-carboxylic acid methyl ester

A

Vortioxetine hydrobromide
960203-27-4

Vortioxetine hydrobromide

B

4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazin-1-ol
1393644-67-1

4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazin-1-ol

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium methylate / methanol / 1 h / Inert atmosphere
2: water; sodium hydroxide / acetone / 0.08 h
3: β-glucuronidase solution / 0.5 h / 37 °C / pH 6.8 / Phosphate buffer
View Scheme
C22H27NO4S

C22H27NO4S

A

Vortioxetine hydrobromide
960203-27-4

Vortioxetine hydrobromide

B

4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazin-1-ol
1393644-67-1

4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazin-1-ol

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: lithium borohydride / tetrahydrofuran / 18 h / 0 °C
1.2: 1 h
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere
2.2: 1 h / -78 - 20 °C / Inert atmosphere
3.1: sodium cyanoborohydride; acetic acid / tetrahydrofuran / 21 h / 45 °C
4.1: sodium methylate / methanol / 1 h / Inert atmosphere
5.1: water; sodium hydroxide / acetone / 0.08 h
6.1: β-glucuronidase solution / 0.5 h / 37 °C / pH 6.8 / Phosphate buffer
View Scheme
2-(2,4-dimethylphenylsulphanyl)benzeneamine
1019453-85-0

2-(2,4-dimethylphenylsulphanyl)benzeneamine

A

Vortioxetine hydrobromide
960203-27-4

Vortioxetine hydrobromide

B

4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazin-1-ol
1393644-67-1

4-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazin-1-ol

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: potassium iodide / 1-methyl-pyrrolidin-2-one / 26 h / 120 °C
2.1: lithium borohydride / tetrahydrofuran / 18 h / 0 °C
2.2: 1 h
3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere
3.2: 1 h / -78 - 20 °C / Inert atmosphere
4.1: sodium cyanoborohydride; acetic acid / tetrahydrofuran / 21 h / 45 °C
5.1: sodium methylate / methanol / 1 h / Inert atmosphere
6.1: water; sodium hydroxide / acetone / 0.08 h
7.1: β-glucuronidase solution / 0.5 h / 37 °C / pH 6.8 / Phosphate buffer
View Scheme
piperazine
110-85-0

piperazine

2,4-dimethyl-thiophenol
13616-82-5

2,4-dimethyl-thiophenol

1,2-dichloro-benzene
95-50-1

1,2-dichloro-benzene

Vortioxetine hydrobromide
960203-27-4

Vortioxetine hydrobromide

Conditions
ConditionsYield
Stage #1: 1,2-dichloro-benzene With aluminum (III) chloride; ferrocene; aluminium at 110℃; for 6h;
Stage #2: piperazine With potassium carbonate In tetrahydrofuran; water at 20℃; for 3h;
Stage #3: 2,4-dimethyl-thiophenol Further stages;
7.3 g
2,4-dimethyl-1-[(2-nitro-phenyl)-sulfanyl]-benzene

2,4-dimethyl-1-[(2-nitro-phenyl)-sulfanyl]-benzene

Vortioxetine hydrobromide
960203-27-4

Vortioxetine hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: iron; acetic acid / 16 h / 30 °C
2: diethylene glycol dimethyl ether / 72 h / 130 °C
3: sodium hydroxide / 1 h / 20 °C
4: hydrogen bromide / water; Isopropyl acetate / 1 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: hydrogen; palladium 10% on activated carbon / ethanol / 6 h / 80 °C / Autoclave
2: 1,3-dimethyl-2-imidazolidinone; potassium carbonate / toluene / 12 h / 170 - 180 °C
3: hydrogen bromide / acetone; water / 3 h / 20 °C / Reflux
View Scheme
Multi-step reaction with 4 steps
1.1: iron; acetic acid / 16 h / 30 °C
2.1: sulfuric acid; sodium nitrite / water; acetonitrile / 0 °C
2.2: 16 h / 0 - 25 °C
3.1: copper(l) iodide; potassium phosphate; 2-Phenylphenol / dimethyl sulfoxide / 20 h / 120 °C / Inert atmosphere
4.1: hydrogen bromide / water; Isopropyl acetate / 1 h / 20 °C
View Scheme
ortho-nitrofluorobenzene
1493-27-2

ortho-nitrofluorobenzene

Vortioxetine hydrobromide
960203-27-4

Vortioxetine hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 25 °C
2: iron; acetic acid / 16 h / 30 °C
3: diethylene glycol dimethyl ether / 72 h / 130 °C
4: sodium hydroxide / 1 h / 20 °C
5: hydrogen bromide / water; Isopropyl acetate / 1 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 17 h / 50 °C
2.1: 5%-palladium/activated carbon; hydrogen / methanol / 18 h / 3750.38 Torr
3.1: acetic acid; sodium nitrite / water / 0.5 h / 0 °C
3.2: 16.08 h / 5 - 70 °C
4.1: potassium hydroxide / water; methanol / 24 h / Reflux
5.1: hydrogen bromide / Isopropyl acetate / 1 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 25 °C
1.2: 2.5 h / 25 °C
2.1: iron; acetic acid / 16 h / 30 °C
3.1: sulfuric acid; sodium nitrite / water; acetonitrile / 0 °C
3.2: 16 h / 0 - 25 °C
4.1: copper(l) iodide; potassium phosphate; 2-Phenylphenol / dimethyl sulfoxide / 20 h / 120 °C / Inert atmosphere
5.1: hydrogen bromide / water; Isopropyl acetate / 1 h / 20 °C
View Scheme
2,4-dimethyl-thiophenol
13616-82-5

2,4-dimethyl-thiophenol

Vortioxetine hydrobromide
960203-27-4

Vortioxetine hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 25 °C
2: iron; acetic acid / 16 h / 30 °C
3: diethylene glycol dimethyl ether / 72 h / 130 °C
4: sodium hydroxide / 1 h / 20 °C
5: hydrogen bromide / water; Isopropyl acetate / 1 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 25 °C
2: iron; acetic acid / 16 h / 30 °C
3: diethylene glycol dimethyl ether / 72 h / 130 °C
4: sodium hydroxide / 1 h / 20 °C
5: hydrogen bromide / water; Isopropyl acetate / 1 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 96 h / 90 °C / Inert atmosphere
2: caesium carbonate / N,N-dimethyl-formamide / 140 °C
3: hydrogen bromide / Isopropyl acetate / 1 h / 20 °C
View Scheme
2-Chloronitrobenzene
88-73-3

2-Chloronitrobenzene

Vortioxetine hydrobromide
960203-27-4

Vortioxetine hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 25 °C
2: iron; acetic acid / 16 h / 30 °C
3: diethylene glycol dimethyl ether / 72 h / 130 °C
4: sodium hydroxide / 1 h / 20 °C
5: hydrogen bromide / water; Isopropyl acetate / 1 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 100 °C / Inert atmosphere
2: hydrogen; palladium 10% on activated carbon / ethanol / 6 h / 80 °C / Autoclave
3: 1,3-dimethyl-2-imidazolidinone; potassium carbonate / toluene / 12 h / 170 - 180 °C
4: hydrogen bromide / acetone; water / 3 h / 20 °C / Reflux
View Scheme
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 25 °C
2.1: iron; acetic acid / 16 h / 30 °C
3.1: sulfuric acid; sodium nitrite / water; acetonitrile / 0 °C
3.2: 16 h / 0 - 25 °C
4.1: copper(l) iodide; potassium phosphate; 2-Phenylphenol / dimethyl sulfoxide / 20 h / 120 °C / Inert atmosphere
5.1: hydrogen bromide / water; Isopropyl acetate / 1 h / 20 °C
View Scheme
1-((2-fluorophenyl)sulfinyl)-2,4-dimethylbenzene

1-((2-fluorophenyl)sulfinyl)-2,4-dimethylbenzene

Vortioxetine hydrobromide
960203-27-4

Vortioxetine hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate / dimethyl sulfoxide / 48 h / 100 °C
2: Lawessons reagent / tetrahydrofuran / 18 h / 20 °C
3: hydrogen bromide / Isopropyl acetate / 1 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: potassium carbonate / dimethyl sulfoxide / 48 h / 100 °C
2.1: iodine; magnesium / methanol / 19 h / 20 °C
2.2: 1 h / 20 °C
3.1: sodium hydroxide / ethyl acetate / 1 h / 20 °C
4.1: hydrogen bromide / Isopropyl acetate / 1 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: potassium carbonate / dimethyl sulfoxide / 168 h / 140 °C
2.1: hydrogenchloride / methanol; water / 16 h / 60 °C
2.2: 20 °C / pH 12
3.1: Lawessons reagent / tetrahydrofuran / 18 h / 20 °C
4.1: hydrogen bromide / Isopropyl acetate / 1 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: potassium carbonate / dimethyl sulfoxide / 168 h / 140 °C
2.1: hydrogenchloride / methanol; water / 16 h / 60 °C
2.2: 20 °C / pH 12
3.1: iodine; magnesium / methanol / 19 h / 20 °C
3.2: 1 h / 20 °C
4.1: sodium hydroxide / ethyl acetate / 1 h / 20 °C
5.1: hydrogen bromide / Isopropyl acetate / 1 h / 20 °C
View Scheme
1-(2-((2,4-dimethylphenyl)sulfinyl)phenyl)piperazine

1-(2-((2,4-dimethylphenyl)sulfinyl)phenyl)piperazine

Vortioxetine hydrobromide
960203-27-4

Vortioxetine hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Lawessons reagent / tetrahydrofuran / 18 h / 20 °C
2: hydrogen bromide / Isopropyl acetate / 1 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: iodine; magnesium / methanol / 19 h / 20 °C
1.2: 1 h / 20 °C
2.1: sodium hydroxide / ethyl acetate / 1 h / 20 °C
3.1: hydrogen bromide / Isopropyl acetate / 1 h / 20 °C
View Scheme
4-[2-(2,4-dimethylphenylsulfinyl)phenyl]piperazine-1-carboxylic acid tert-butyl ester

4-[2-(2,4-dimethylphenylsulfinyl)phenyl]piperazine-1-carboxylic acid tert-butyl ester

Vortioxetine hydrobromide
960203-27-4

Vortioxetine hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: hydrogenchloride / methanol; water / 16 h / 60 °C
1.2: 20 °C / pH 12
2.1: Lawessons reagent / tetrahydrofuran / 18 h / 20 °C
3.1: hydrogen bromide / Isopropyl acetate / 1 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1.1: hydrogenchloride / methanol; water / 16 h / 60 °C
1.2: 20 °C / pH 12
2.1: iodine; magnesium / methanol / 19 h / 20 °C
2.2: 1 h / 20 °C
3.1: sodium hydroxide / ethyl acetate / 1 h / 20 °C
4.1: hydrogen bromide / Isopropyl acetate / 1 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1: hydrogenchloride / water; methanol / 2 h / 15 - 25 °C / Inert atmosphere
2: iodine; magnesium / methanol / 18 h / 15 - 25 °C / Inert atmosphere
3: hydrogen bromide / water; toluene / 2 h / 0 - 60 °C / Inert atmosphere
View Scheme
(2,4-dimethylphenyl)(2-fluorophenyl)sulfane

(2,4-dimethylphenyl)(2-fluorophenyl)sulfane

Vortioxetine hydrobromide
960203-27-4

Vortioxetine hydrobromide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: caesium carbonate / N,N-dimethyl-formamide / 140 °C
2: hydrogen bromide / Isopropyl acetate / 1 h / 20 °C
View Scheme
Multi-step reaction with 4 steps
1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 0.5 h / 0 °C
2: potassium carbonate / dimethyl sulfoxide / 48 h / 100 °C
3: Lawessons reagent / tetrahydrofuran / 18 h / 20 °C
4: hydrogen bromide / Isopropyl acetate / 1 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 0.5 h / 0 °C
2.1: potassium carbonate / dimethyl sulfoxide / 168 h / 140 °C
3.1: hydrogenchloride / methanol; water / 16 h / 60 °C
3.2: 20 °C / pH 12
4.1: Lawessons reagent / tetrahydrofuran / 18 h / 20 °C
5.1: hydrogen bromide / Isopropyl acetate / 1 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 0.5 h / 0 °C
2.1: potassium carbonate / dimethyl sulfoxide / 48 h / 100 °C
3.1: iodine; magnesium / methanol / 19 h / 20 °C
3.2: 1 h / 20 °C
4.1: sodium hydroxide / ethyl acetate / 1 h / 20 °C
5.1: hydrogen bromide / Isopropyl acetate / 1 h / 20 °C
View Scheme
Multi-step reaction with 6 steps
1.1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 0.5 h / 0 °C
2.1: potassium carbonate / dimethyl sulfoxide / 168 h / 140 °C
3.1: hydrogenchloride / methanol; water / 16 h / 60 °C
3.2: 20 °C / pH 12
4.1: iodine; magnesium / methanol / 19 h / 20 °C
4.2: 1 h / 20 °C
5.1: sodium hydroxide / ethyl acetate / 1 h / 20 °C
6.1: hydrogen bromide / Isopropyl acetate / 1 h / 20 °C
View Scheme
Vortioxetine hydrobromide
960203-27-4

Vortioxetine hydrobromide

vortioxetine
508233-74-7

vortioxetine

Conditions
ConditionsYield
With sodium hydroxide; water In ethyl acetate for 0.166667h;98%
With sodium hydroxide In dichloromethane; water for 0.5h; pH=9 - 10;94%
With sodium hydroxide In water; toluene pH=13 - 14;90.6%
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