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Wuhan Han Sheng New Material Technology Co.,Ltd

Our Advantage: high quality with competitive price High quality standard: BP/USP/EP Enterprise standard All purity customized Fast and safe delivery We have reliable forwarder who can help us deliver our goods more fast and safe. We

Factory Supply High Quality CAS 99059-63-9 ,1-(4-iodophenyl)-2-methyl-1-propanone

Cas:99059-63-9

Min.Order:10 Kilogram

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Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

1-(4-Iodophenyl)-2-methylpropan-1-one

Cas:99059-63-9

Min.Order:1 Gram

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Qingdao Beluga Import and Export Co., LTD

1-(4-Iodophenyl)-2-methylpropan-1-one CAS:99059-63-9 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high qua

1-(4-Iodophenyl)-2-methylpropan-1-one CAS:99059-63-9

Cas:99059-63-9

Min.Order:1 Gram

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

1-(4-Iodophenyl)-2-methylpropan-1-one

Cas:99059-63-9

Min.Order:1 Kilogram

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Saiwante (shanghai) New Material Technology Co., Ltd.

ProName: 1-(4-Iodophenyl)-2-methylpropan-1-one CasNo: 99059-63-9 Molecular Formula: C10H11IO Appearance: white crystalline powder Application: pharmaceutical raw material DeliveryTime: 3-7days PackAge: 1kg/pack,10kg/pack,,25kg/drum Port: Sh

1-(4-Iodophenyl)-2-methylpropan-1-one

Cas:99059-63-9

Min.Order:1 Gram

FOB Price: $6.0 / 9.0

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Zibo Hangyu Biotechnology Development Co., Ltd

Zibo Hangyu Biotechnology Development Co., Ltd is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemi

1-(4-Iodophenyl)-2-methylpropan-1-one

Cas:99059-63-9

Min.Order:10 Gram

FOB Price: $100.0

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SHANGHAI SYSTEAM BIOCHEM CO., LTD

We are one of a few suppliers that can offer custom synthesis service of this product We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research. We are committed to prov

1-(4-iodophenyl)-2-methyl-1-propanone

Cas:99059-63-9

Min.Order:100 Gram

FOB Price: $100.0 / 2000.0

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EAST CHEMSOURCES LIMITED

factory?direct?saleAppearance:White Powder Storage:Store In Dry, Cool And Ventilated Place Package:25kg/drum, also according to the clients requirement Application:It is widely used as a thickener, emulsifier and stabilizer Transportation:By Sea Or B

1-(4-iodophenyl)-2-methyl-1-propanone

Cas:99059-63-9

Min.Order:1 Kilogram

FOB Price: $18.0 / 20.0

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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

1-(4-Iodophenyl)-2-methylpropan-1-one

Cas:99059-63-9

Min.Order:1 Kilogram

FOB Price: $2.0

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Shandong Mopai Biotechnology Co., LTD

Shandong Mopai Biotechnology Co., LTD is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED intermediates and other fine chemicals. W

1-(4-iodophenyl)-2-methyl-1-propanone

Cas:99059-63-9

Min.Order:1 Gram

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

1-(4-iodophenyl)-2-methyl-1-propanone

Cas:99059-63-9

Min.Order:1 Metric Ton

FOB Price: $1.5

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Bluecrystal chem-union

We are a Union of chemistry in China, consists of chemists,engineers, laboratories,factories in China. We organize surplus capacity of R&D and production as well as custom synthesis for chemical products and chemical business project. We are supp

1-(4-iodophenyl)-2-methyl-1-propanone

Cas:99059-63-9

Min.Order:1 Metric Ton

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GIHI CHEMICALS CO.,LIMITED

Lower price, sample is available,SDS test documents are available,large stock in warehouseAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:Fine chemical intermediates, used as the main raw material for the synthe

1-(4-iodophenyl)-2-methyl-1-propanone

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Hangzhou Dingyan Chem Co., Ltd

R & D enterprises have their own stock in stock Package:1kg Application:pharmaceutical intermediates

1-(4-iodophenyl)-2-methylpropan-1-one

Cas:99059-63-9

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM is one of China's leading providers of integrated fine chemical services including offering, research and development, Custom manufacturing business, as well as other Value-added customer services, for diversified range products of chemicals

1-(4-Iodophenyl)-2-methylpropan-1-one

Cas:99059-63-9

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Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

1-(4-Iodophenyl)-2-methylpropan-1-one

Cas:99059-63-9

Min.Order:0

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Xian Changyue Biological Technology Co., Ltd.

best seller Application:API

1-(4-Iodophenyl)-2-methylpropan-1-one

Cas:99059-63-9

Min.Order:0

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Antimex Chemical Limied

Our own factory produces direct sales with absolute price advantage Application:Pharmaceutical industry Transportation:By sea Port:Shanghai/tianjin

1-(4-Iodophenyl)-2-methylpropan-1-one

Cas:99059-63-9

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Hubei Langyou International Trading Co., Ltd

1-(4-iodophenyl)-2-methyl-1-propanone Application:1-(4-iodophenyl)-2-methyl-1-propanone

1-(4-iodophenyl)-2-methyl-1-propanone

Cas:99059-63-9

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DB BIOTECH CO., LTD

best seller Application:API

1-(4-Iodophenyl)-2-methylpropan-1-one

Cas:99059-63-9

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Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

1-(4-Iodophenyl)-2-methylpropan-1-one

Cas:99059-63-9

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Hebei Quanhe Biotechnology Co. LTD

1. Timely and efficient service to ensure communication with customers2. Produce products of different specifications and sizes according to your requirements.3. Quality procedures and standards recognized by SGS. Advanced plant equipment ensures sta

1-(4-Iodophenyl)-2-methylpropan-1-one

Cas:99059-63-9

Min.Order:0

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Shanghai Chinqesen Biotechnology Co., Ltd.

Good Quality Package:1kg/bag Application:Medical or chemical Transportation:Air/Train/Sea Port:Shenzhen

99059-63-9

Cas:99059-63-9

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Hangzhou ZeErRui Chemical Co., Ltd.

Hangzhou ZeErRui Chemical Co., Ltd. is focused on customization, research and development and production of APIs and advanced intermediates, which can effectively compensate for the deficiencies of traditional CRO and CMO. Priority of high-tech barri

1-(4-iodophenyl)-2-methyl-1-propanone

Cas:99059-63-9

Min.Order:0

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Wuhan Newgreat Chemical Co., Ltd

Wuhan Xinweiye Chemical Co., Ltd. is mainly engaged in the process development and production of customized synthesis and pharmaceutical intermediates. We have professional researchers in organic synthesis, analytical chemistry and production process

1-(4-iodophenyl)-2-methyl-1-propanone

Cas:99059-63-9

Min.Order:0

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Hunan Longxianng Runhui Trading Co.,Ltd

1-(4-iodophenyl)-2-methyl-1-propanoneAppearance:white crystalline powder Storage:Shading, sealed, dry place. Package:aluminous bag Application:API Transportation:By express (Door to door) such as FEDEX, DHL, EMS for small amount. By air(airport to ai

1-(4-iodophenyl)-2-methyl-1-propanone

Cas:99059-63-9

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Chemlyte Solutions

factory?direct?sale Application:Fine chemical intermediates, used as the main raw material for the synthesis of various pesticides, medicines, surfactants, polymer monomers, and antifungal agents

1-(4-iodophenyl)-2-methyl-1-propanone

Cas:99059-63-9

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Hebei Muhuang Technology Co., Ltd

best seller Application:API

1-(4-Iodophenyl)-2-methylpropan-1-one

Cas:99059-63-9

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ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

1-(4-Iodophenyl)-2-methylpropan-1-one

Cas:99059-63-9

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Shanghai Hanhong Scientific Co.,Ltd.

factory,reasonable price Appearance:detailed see specifications Storage:Store in dry, dark and ventilated place. Package:according to the clients requirement Application:pharmaceutical intermediates Transportation:by courier,air or sea Port:S

1-(4-Iodophenyl)-2-methylpropan-1-one99059-63-9

Cas:99059-63-9

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Synthetic route

potassium (4-iodophenyl)trifluoroborate

potassium (4-iodophenyl)trifluoroborate

Isobutyronitrile
78-82-0

Isobutyronitrile

1-(4-iodophenyl)-2-methyl-1-propanone
99059-63-9

1-(4-iodophenyl)-2-methyl-1-propanone

Conditions
ConditionsYield
With [2,2]bipyridinyl; palladium(II) trifluoroacetate; water; trifluoroacetic acid In tetrahydrofuran at 80℃; for 36h; Inert atmosphere; Schlenk technique;84%
4-Iodoacetophenone
13329-40-3

4-Iodoacetophenone

methyl iodide
74-88-4

methyl iodide

1-(4-iodophenyl)-2-methyl-1-propanone
99059-63-9

1-(4-iodophenyl)-2-methyl-1-propanone

Conditions
ConditionsYield
With 18-crown-6 ether; potassium hydroxide In toluene at 70℃; for 24h;79%
methanol
67-56-1

methanol

4-Iodoacetophenone
13329-40-3

4-Iodoacetophenone

1-(4-iodophenyl)-2-methyl-1-propanone
99059-63-9

1-(4-iodophenyl)-2-methyl-1-propanone

Conditions
ConditionsYield
With bis[dichloro(pentamethylcyclopentadienyl)ruthenium(III)]; bis[2-(diphenylphosphino)phenyl] ether; lithium tert-butoxide at 110℃; for 24h; Inert atmosphere; regioselective reaction;72%
1-(4-iodophenyl)propan-1-one
31970-26-0

1-(4-iodophenyl)propan-1-one

methyl iodide
74-88-4

methyl iodide

1-(4-iodophenyl)-2-methyl-1-propanone
99059-63-9

1-(4-iodophenyl)-2-methyl-1-propanone

Conditions
ConditionsYield
With sodium amide
isopropylmagnesium chloride
1068-55-9

isopropylmagnesium chloride

4-iodobenzoic acid chloride
1711-02-0

4-iodobenzoic acid chloride

1-(4-iodophenyl)-2-methyl-1-propanone
99059-63-9

1-(4-iodophenyl)-2-methyl-1-propanone

Conditions
ConditionsYield
iron(III)-acetylacetonate In tetrahydrofuran at 20℃; for 0.166667h; Inert atmosphere;
iron(III)-acetylacetonate In tetrahydrofuran at 20℃; for 0.166667h; Inert atmosphere;
iron(III)-acetylacetonate In tetrahydrofuran at 20℃; for 0.166667h; Inert atmosphere;
With iron(III)-acetylacetonate In tetrahydrofuran at 20℃;
iodobenzene
591-50-4

iodobenzene

isobutyryl chloride
79-30-1

isobutyryl chloride

1-(4-iodophenyl)-2-methyl-1-propanone
99059-63-9

1-(4-iodophenyl)-2-methyl-1-propanone

Conditions
ConditionsYield
With aluminum (III) chloride at 45℃; for 15h; Friedel-Crafts Acylation;
(3-fluorobenzyl)manganese(II) chloride

(3-fluorobenzyl)manganese(II) chloride

1-(4-iodophenyl)-2-methyl-1-propanone
99059-63-9

1-(4-iodophenyl)-2-methyl-1-propanone

1-[4-(3-fluorobenzyl)phenyl]-2-methylpropan-1-one

1-[4-(3-fluorobenzyl)phenyl]-2-methylpropan-1-one

Conditions
ConditionsYield
With bis(acetylacetonate)nickel(II) In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere; Schlenk technique;85%
1-(4-iodophenyl)-2-methyl-1-propanone
99059-63-9

1-(4-iodophenyl)-2-methyl-1-propanone

p-methoxybenzyl chloride
824-94-2

p-methoxybenzyl chloride

1-[4-(4-methoxybenzyl)phenyl]-2-methylpropan-1-one
1155702-74-1

1-[4-(4-methoxybenzyl)phenyl]-2-methylpropan-1-one

Conditions
ConditionsYield
Stage #1: p-methoxybenzyl chloride With indium; chloro-trimethyl-silane; ethylene dibromide; lithium chloride In tetrahydrofuran at 40℃; for 15h; Inert atmosphere;
Stage #2: With TurboGrignard In tetrahydrofuran at -60 - -50℃; Inert atmosphere;
Stage #3: 1-(4-iodophenyl)-2-methyl-1-propanone With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate In tetrahydrofuran; ethanol at 40℃; for 16h; Inert atmosphere; chemoselective reaction;
82%
(2-chlorobenzyl)manganese(II) chloride

(2-chlorobenzyl)manganese(II) chloride

1-(4-iodophenyl)-2-methyl-1-propanone
99059-63-9

1-(4-iodophenyl)-2-methyl-1-propanone

1-[4-(2-chlorobenzyl)phenyl]-2-methylpropan-1-one

1-[4-(2-chlorobenzyl)phenyl]-2-methylpropan-1-one

Conditions
ConditionsYield
With bis(acetylacetonate)nickel(II) In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere; Schlenk technique;80%
3-iodobenzoic acid methyl ester
58313-23-8

3-iodobenzoic acid methyl ester

1-(4-iodophenyl)-2-methyl-1-propanone
99059-63-9

1-(4-iodophenyl)-2-methyl-1-propanone

ethyl 4'-isobutyrylbiphenyl-3-carboxylate
1227402-40-5

ethyl 4'-isobutyrylbiphenyl-3-carboxylate

Conditions
ConditionsYield
Stage #1: 3-iodobenzoic acid methyl ester With chloro-trimethyl-silane; aluminium; lithium chloride; lead(II) chloride In tetrahydrofuran at 25 - 30℃; Inert atmosphere;
Stage #2: With zinc diacetate In tetrahydrofuran at 25℃; for 0.333333h; Inert atmosphere;
Stage #3: 1-(4-iodophenyl)-2-methyl-1-propanone With [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl) palladium(II) dichloride In tetrahydrofuran at 25 - 30℃; Inert atmosphere; chemoselective reaction;
78%
bis-(3-(trimethylsilyl)phenyl)manganese

bis-(3-(trimethylsilyl)phenyl)manganese

1-(4-iodophenyl)-2-methyl-1-propanone
99059-63-9

1-(4-iodophenyl)-2-methyl-1-propanone

2-methyl-1-[3′-(trimethylsilyl)[1,1′-biphenyl]-4-yl]propan-1-one

2-methyl-1-[3′-(trimethylsilyl)[1,1′-biphenyl]-4-yl]propan-1-one

Conditions
ConditionsYield
With bis(acetylacetonate)nickel(II); para-fluorostyrene In tetrahydrofuran at 0℃; for 1h; Inert atmosphere; Schlenk technique;73%
5-iodofuran-2-carbaldehyde
2689-65-8

5-iodofuran-2-carbaldehyde

1-(4-iodophenyl)-2-methyl-1-propanone
99059-63-9

1-(4-iodophenyl)-2-methyl-1-propanone

5-(4-(isobutyryl)phenyl)furan-2-carboxaldehyde
1087349-11-8

5-(4-(isobutyryl)phenyl)furan-2-carboxaldehyde

Conditions
ConditionsYield
Stage #1: 1-(4-iodophenyl)-2-methyl-1-propanone With indium; hepatdecane; lithium chloride In tetrahydrofuran at 50℃; for 24h;
Stage #2: 5-iodofuran-2-carbaldehyde With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In tetrahydrofuran; 1-methyl-pyrrolidin-2-one at 60℃; for 12h; Inert atmosphere;
70%
1-(4-iodophenyl)-2-methyl-1-propanone
99059-63-9

1-(4-iodophenyl)-2-methyl-1-propanone

di(p-tolyl)zinc
15106-88-4

di(p-tolyl)zinc

C17H18O

C17H18O

Conditions
ConditionsYield
In tetrahydrofuran at 90℃; Inert atmosphere;64%
1-(4-iodophenyl)-2-methyl-1-propanone
99059-63-9

1-(4-iodophenyl)-2-methyl-1-propanone

dimethyl sulfoxide
67-68-5

dimethyl sulfoxide

2-methyl-1-[4-(methylsulfonyl)phenyl]propan-1-one
53207-59-3

2-methyl-1-[4-(methylsulfonyl)phenyl]propan-1-one

Conditions
ConditionsYield
With copper(I) oxide; potassium tert-butylate; oxygen; palladium diacetate In acetylacetone at 100℃; for 20h; Reagent/catalyst; Temperature;58%
1-(4-iodophenyl)-2-methyl-1-propanone
99059-63-9

1-(4-iodophenyl)-2-methyl-1-propanone

methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate
171364-80-0

methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

methyl 5'-iodo-2'-isobutyrylbiphenyl-4-carboxylate

methyl 5'-iodo-2'-isobutyrylbiphenyl-4-carboxylate

Conditions
ConditionsYield
With [Cp*Rh(MeCN)3](SbF6)2; silver(l) oxide In 1,2-dichloro-ethane at 120℃; for 6h; Schlenk technique; Inert atmosphere;50%
1-(4-iodophenyl)-2-methyl-1-propanone
99059-63-9

1-(4-iodophenyl)-2-methyl-1-propanone

5-(4-iodo-phenyl)-4-methyl-[1,2]dithiol-3-thione
114223-79-9

5-(4-iodo-phenyl)-4-methyl-[1,2]dithiol-3-thione

Conditions
ConditionsYield
With biphenyl; phosphorous (V) sulfide; sulfur at 210℃;
1-(4-iodophenyl)-2-methyl-1-propanone
99059-63-9

1-(4-iodophenyl)-2-methyl-1-propanone

Methyltriphenylphosphonium bromide
1779-49-3

Methyltriphenylphosphonium bromide

1-iodo-4-(2-methyl-1-methylene-propyl)-benzene
1311446-42-0

1-iodo-4-(2-methyl-1-methylene-propyl)-benzene

Conditions
ConditionsYield
Stage #1: Methyltriphenylphosphonium bromide With tert.-butyl lithium In tetrahydrofuran; hexane at 0℃; for 1h;
Stage #2: 1-(4-iodophenyl)-2-methyl-1-propanone In tetrahydrofuran at 20℃; for 14h;
Stage #1: Methyltriphenylphosphonium bromide With tert.-butyl lithium In tetrahydrofuran; hexane at 0℃; for 1h;
Stage #2: 1-(4-iodophenyl)-2-methyl-1-propanone In tetrahydrofuran at 20℃; for 14h;
Stage #1: Methyltriphenylphosphonium bromide With tert.-butyl lithium In tetrahydrofuran; hexane at 0℃; for 1h;
Stage #2: 1-(4-iodophenyl)-2-methyl-1-propanone In tetrahydrofuran at 20℃; for 14h;
1-(4-iodophenyl)-2-methyl-1-propanone
99059-63-9

1-(4-iodophenyl)-2-methyl-1-propanone

(1RS,2RS)-5'-fluoro-2-(4-iodophenyl)-2-isopropylspiro[cyclopropane-1,3'-indolin]-2'-one

(1RS,2RS)-5'-fluoro-2-(4-iodophenyl)-2-isopropylspiro[cyclopropane-1,3'-indolin]-2'-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: tert.-butyl lithium / hexane; tetrahydrofuran / 1 h / 0 °C
1.2: 14 h / 20 °C
2.1: dirhodium tetraacetate / benzene / 0.17 h / 80 °C / Inert atmosphere
2.2: Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1.1: tert.-butyl lithium / tetrahydrofuran; hexane / 1 h / 0 °C
1.2: 14 h / 20 °C
2.1: dirhodium tetraacetate / benzene / 0.17 h / 80 °C / Inert atmosphere
2.2: Inert atmosphere
View Scheme
1-(4-iodophenyl)-2-methyl-1-propanone
99059-63-9

1-(4-iodophenyl)-2-methyl-1-propanone

methyl (1RS,2RS)-3-((-5'-fluoro-2-(4-iodophenyl)-2-isopropyl-2'-oxospiro[cyclopropane-1,3'-indoline]-1'-yl)methyl)benzoate

methyl (1RS,2RS)-3-((-5'-fluoro-2-(4-iodophenyl)-2-isopropyl-2'-oxospiro[cyclopropane-1,3'-indoline]-1'-yl)methyl)benzoate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: tert.-butyl lithium / hexane; tetrahydrofuran / 1 h / 0 °C
1.2: 14 h / 20 °C
2.1: dirhodium tetraacetate / benzene / 0.17 h / 80 °C / Inert atmosphere
2.2: Inert atmosphere
3.1: caesium carbonate / N,N-dimethyl-formamide / 14 h / 20 °C
View Scheme
Multi-step reaction with 3 steps
1.1: tert.-butyl lithium / tetrahydrofuran; hexane / 1 h / 0 °C
1.2: 14 h / 20 °C
2.1: dirhodium tetraacetate / benzene / 0.17 h / 80 °C / Inert atmosphere
2.2: Inert atmosphere
3.1: caesium carbonate / N,N-dimethyl-formamide / 14 h / 20 °C
View Scheme
1-(4-iodophenyl)-2-methyl-1-propanone
99059-63-9

1-(4-iodophenyl)-2-methyl-1-propanone

methyl (1RS,2RS)-3-((2-(4-cyanophenyl)-5'-fluoro-2-isopropyl-2'-oxospiro[cyclopropane-1,3'-indoline]-1'-yl)methyl)benzoate

methyl (1RS,2RS)-3-((2-(4-cyanophenyl)-5'-fluoro-2-isopropyl-2'-oxospiro[cyclopropane-1,3'-indoline]-1'-yl)methyl)benzoate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: tert.-butyl lithium / hexane; tetrahydrofuran / 1 h / 0 °C
1.2: 14 h / 20 °C
2.1: dirhodium tetraacetate / benzene / 0.17 h / 80 °C / Inert atmosphere
2.2: Inert atmosphere
3.1: caesium carbonate / N,N-dimethyl-formamide / 14 h / 20 °C
4.1: tetrakis(triphenylphosphine) palladium(0); copper(l) iodide / tetrahydrofuran / 2 h / 65 °C
View Scheme
Multi-step reaction with 4 steps
1.1: tert.-butyl lithium / tetrahydrofuran; hexane / 1 h / 0 °C
1.2: 14 h / 20 °C
2.1: dirhodium tetraacetate / benzene / 0.17 h / 80 °C / Inert atmosphere
2.2: Inert atmosphere
3.1: caesium carbonate / N,N-dimethyl-formamide / 14 h / 20 °C
4.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 2 h / 65 °C
View Scheme
1-(4-iodophenyl)-2-methyl-1-propanone
99059-63-9

1-(4-iodophenyl)-2-methyl-1-propanone

(1RS,2RS)-3-((2-(4-cyanophenyl)-5'-fluoro-2-isopropyl-2'-oxospiro[cyclopropane-1,3'-indoline]-1'-yl)methyl)benzoic acid

(1RS,2RS)-3-((2-(4-cyanophenyl)-5'-fluoro-2-isopropyl-2'-oxospiro[cyclopropane-1,3'-indoline]-1'-yl)methyl)benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: tert.-butyl lithium / hexane; tetrahydrofuran / 1 h / 0 °C
1.2: 14 h / 20 °C
2.1: dirhodium tetraacetate / benzene / 0.17 h / 80 °C / Inert atmosphere
2.2: Inert atmosphere
3.1: caesium carbonate / N,N-dimethyl-formamide / 14 h / 20 °C
4.1: tetrakis(triphenylphosphine) palladium(0); copper(l) iodide / tetrahydrofuran / 2 h / 65 °C
5.1: sodium hydroxide; water / tetrahydrofuran / 16 h / 20 °C
View Scheme
Multi-step reaction with 5 steps
1.1: tert.-butyl lithium / tetrahydrofuran; hexane / 1 h / 0 °C
1.2: 14 h / 20 °C
2.1: dirhodium tetraacetate / benzene / 0.17 h / 80 °C / Inert atmosphere
2.2: Inert atmosphere
3.1: caesium carbonate / N,N-dimethyl-formamide / 14 h / 20 °C
4.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 2 h / 65 °C
5.1: water; sodium hydroxide / tetrahydrofuran / 16 h / 20 °C
View Scheme
1-(4-iodophenyl)-2-methyl-1-propanone
99059-63-9

1-(4-iodophenyl)-2-methyl-1-propanone

(+)-3-((2-(4-cyanophenyl)-5'-fluoro-2-isopropyl-2'-oxospiro[(trans)-cyclopropane-1,3'-indoline]-1'-yl)methyl)benzoic acid

(+)-3-((2-(4-cyanophenyl)-5'-fluoro-2-isopropyl-2'-oxospiro[(trans)-cyclopropane-1,3'-indoline]-1'-yl)methyl)benzoic acid

(-)-3-((2-(4-cyanophenyl)-5'-fluoro-2-isopropyl-2'-oxospiro[(trans)-cyclopropane-1,3'-indoline]-1'-yl)methyl)benzoic acid

(-)-3-((2-(4-cyanophenyl)-5'-fluoro-2-isopropyl-2'-oxospiro[(trans)-cyclopropane-1,3'-indoline]-1'-yl)methyl)benzoic acid

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: tert.-butyl lithium / hexane; tetrahydrofuran / 1 h / 0 °C
1.2: 14 h / 20 °C
2.1: dirhodium tetraacetate / benzene / 0.17 h / 80 °C / Inert atmosphere
2.2: Inert atmosphere
3.1: caesium carbonate / N,N-dimethyl-formamide / 14 h / 20 °C
4.1: tetrakis(triphenylphosphine) palladium(0); copper(l) iodide / tetrahydrofuran / 2 h / 65 °C
5.1: sodium hydroxide; water / tetrahydrofuran / 16 h / 20 °C
6.1: Chiralpak AD / isopropyl alcohol; n-heptane / Resolution of racemate
View Scheme
Multi-step reaction with 6 steps
1.1: tert.-butyl lithium / tetrahydrofuran; hexane / 1 h / 0 °C
1.2: 14 h / 20 °C
2.1: dirhodium tetraacetate / benzene / 0.17 h / 80 °C / Inert atmosphere
2.2: Inert atmosphere
3.1: caesium carbonate / N,N-dimethyl-formamide / 14 h / 20 °C
4.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 2 h / 65 °C
5.1: water; sodium hydroxide / tetrahydrofuran / 16 h / 20 °C
6.1: Chiralpak AD / n-heptane; isopropyl alcohol / Resolution of racemate
View Scheme
1-(4-iodophenyl)-2-methyl-1-propanone
99059-63-9

1-(4-iodophenyl)-2-methyl-1-propanone

C17H14BrNO
1401463-68-0

C17H14BrNO

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: toluene-4-sulfonic acid / 85 °C
2.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 20 °C
2.2: 3 h / -78 - 20 °C
View Scheme
1-(4-iodophenyl)-2-methyl-1-propanone
99059-63-9

1-(4-iodophenyl)-2-methyl-1-propanone

C29H24N2O
1401463-69-1

C29H24N2O

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: toluene-4-sulfonic acid / 85 °C
2.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 20 °C
2.2: 3 h / -78 - 20 °C
3.1: XPhos; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate / toluene / 24 h / Reflux
View Scheme
1-(4-iodophenyl)-2-methyl-1-propanone
99059-63-9

1-(4-iodophenyl)-2-methyl-1-propanone

(2E)-2-cyano-3-(4-(5-(diphenylamino)-3,3-dimethyl-3H-indol-2-yl)phenyl)acrylic acid
1401463-59-9

(2E)-2-cyano-3-(4-(5-(diphenylamino)-3,3-dimethyl-3H-indol-2-yl)phenyl)acrylic acid

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: toluene-4-sulfonic acid / 85 °C
2.1: n-butyllithium / tetrahydrofuran / 1 h / 0 - 20 °C
2.2: 3 h / -78 - 20 °C
3.1: XPhos; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate / toluene / 24 h / Reflux
4.1: sodium hydroxide / ethanol / 80 °C / Inert atmosphere
View Scheme
1-(4-iodophenyl)-2-methyl-1-propanone
99059-63-9

1-(4-iodophenyl)-2-methyl-1-propanone

(4-bromophenyl)hydrazine
589-21-9

(4-bromophenyl)hydrazine

C16H13BrIN
1401463-67-9

C16H13BrIN

Conditions
ConditionsYield
With toluene-4-sulfonic acid at 85℃; Fischer Indole Synthesis;
1-(4-iodophenyl)-2-methyl-1-propanone
99059-63-9

1-(4-iodophenyl)-2-methyl-1-propanone

4,5-diamino-6-hydroxypyrimidine
1672-50-0

4,5-diamino-6-hydroxypyrimidine

C14H13IN4O

C14H13IN4O

Conditions
ConditionsYield
Stage #1: 1-(4-iodophenyl)-2-methyl-1-propanone With bromine In tetrahydrofuran at 20℃; for 2h;
Stage #2: 4,5-diamino-6-hydroxypyrimidine With hydrogenchloride In ethanol; water for 12h; Reflux;
1-(4-iodophenyl)-2-methyl-1-propanone
99059-63-9

1-(4-iodophenyl)-2-methyl-1-propanone

C23H26N4O3

C23H26N4O3

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: bromine / tetrahydrofuran / 2 h / 20 °C
1.2: 12 h / Reflux
2.1: copper(l) iodide; Pd(PPh3)Cl2; N-ethyl-N,N-diisopropylamine; triphenylphosphine / N,N-dimethyl-formamide / 18 h / 80 °C
View Scheme
1-(4-iodophenyl)-2-methyl-1-propanone
99059-63-9

1-(4-iodophenyl)-2-methyl-1-propanone

C21H22N4O3

C21H22N4O3

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: bromine / tetrahydrofuran / 2 h / 20 °C
1.2: 12 h / Reflux
2.1: copper(l) iodide; Pd(PPh3)Cl2; N-ethyl-N,N-diisopropylamine; triphenylphosphine / N,N-dimethyl-formamide / 18 h / 80 °C
3.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 10 h / 20 °C
View Scheme
1-(4-iodophenyl)-2-methyl-1-propanone
99059-63-9

1-(4-iodophenyl)-2-methyl-1-propanone

C21H24N4O3

C21H24N4O3

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: bromine / tetrahydrofuran / 2 h / 20 °C
1.2: 12 h / Reflux
2.1: copper(l) iodide; Pd(PPh3)Cl2; N-ethyl-N,N-diisopropylamine; triphenylphosphine / N,N-dimethyl-formamide / 18 h / 80 °C
3.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 10 h / 20 °C
4.1: sodium tetrahydroborate / methanol
View Scheme

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