101219-73-2

Basic information

• Product Name: (S)-1-(4-FLUOROPHENYL)ETHANOL
• Synonyms: (S)-(-)-4-FLUORO-ALPHA-METHYLBENZYL ALCOHOL;(S)-(-)-1-(4-FLUOROPHENYL)ETHANOL;(S)-1-(4-FLUOROPHENYL)ETHANOL;S-PF-PEL;(S)-1-(4-Fluorophenyl)ethanol 98%;(S)-1-(4-Fluorophenyl)ethanol98%;(S)-4-Fluoro-α-methylbenzyl alcohol;(S)-(-)-4-Fluoro-alpha-methylbenzyl alcohol,95% (98% E.E.)%
• CAS NO: 101219-73-2
• Molecular Formula: C₈H₉FO
• Molecular Weight: 140.15
• Product Categories: Alcohols, Hydroxy Esters and Derivatives;Chiral Compounds;API intermediates;Alcohols;Aryl Fluorinated Building Blocks;Asymmetric Synthesis;Building Blocks;C8-C12;Chemical Synthesis;Chiral Building Blocks;Fluorinated Building Blocks;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks
• Mol File: 101219-73-2.mol
• Article Data: 337

Chemical Properties

• Boiling Point: 216.2 °C at 760 mmHg
• Flash Point: 90.6 °C
• Appearance: clear colorless liquid
• Density: 1.111 g/mL at 25 °C
• Refractive Index: n20/D 1.502
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.36±0.20(Predicted)
• CAS DataBase Reference: (S)-1-(4-FLUOROPHENYL)ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-(4-FLUOROPHENYL)ETHANOL(101219-73-2)
• EPA Substance Registry System: (S)-1-(4-FLUOROPHENYL)ETHANOL(101219-73-2)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 36/37/38-20/21/22-22
• Safety Statements: 36/37/39-26
• WGK Germany: 3
• Hazardous Substances Data: 101219-73-2(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless liquid

Uses

(S)-4-Fluoro-α-methylbenzyl alcohol can be used as a starting material to synthesize a CCR5 antagonist named MLN1251.Along with its ortho- and non-fluorine substituted analogs, it can be used to study the role of fluorine substitution in chiral discrimination in molecular complexes.

InChI:InChI=1/C4H3F4I/c5-3(2-9)1-4(6,7)8/h1H,2H2/b3-1-

Upstream product

• 403-42-9 1-(4-fluorophenyl)ethanone 
• 18511-62-1 R-(-)-2-(4-fluorophenyl)oxirane 
• 126534-43-8 [R]-1-chloro-2-(4-fluorophenyl)-2-ethanol 
• 170876-34-3 C₁₄H₂₃FO₃Si 
• 403-41-8 1-(4-Fluorophenyl)ethanol 
• 108-24-7 acetic anhydride 
• 459-47-2 1-ethyl-4-fluorobenzene 
• 405-99-2 para-fluorostyrene 
• 67-63-0 isopropyl alcohol 
• 108-22-5 Isopropenyl acetate 
• 101109-90-4 diphenylacetic acid vinyl ester 
• 75-24-1 trimethylaluminum 
• 459-57-4 4-fluorobenzaldehyde 
• 108-05-4 vinyl acetate 

Downstream Products

• 1097209-11-4 C₂₆H₂₇ClF₂N₂O₂ 
• 1128105-68-9 C₁₃H₁₁FN₂O₃ 
• 1128105-86-1 C₁₅H₁₃BrFNO₃ 
• 172585-57-8 (R)-acetic acid 1-(4-fluoro-phenyl)-ethyl ester 
• 403-41-8 1-(4-Fluorophenyl)ethanol 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 1240815-55-7 (S)-(-)-1-(4-fluorophenyl)ethyl N,N-diisopropylcarbamate 
• 1128105-87-2 C₁₄H₁₃BrFNO₂ 
• 1128105-72-5 C₁₄H₁₁BrF₃NO 
• 1128103-63-8 C₂₅H₂₃ClFN₃O₃ 
• 1282036-04-7 C₁₄H₁₀BrF₂NO₂ 
• 1160358-21-3 (S)-7-(1-(4-fluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-5-methyl-7H-pyrazolo[3,4-b]pyridine 
• 1160359-85-2 C₂₂H₂₁BrFNO₃ 
• 1128103-55-8 C₃₄H₃₄FN₃O₅ 

Relevant articles and documents

Nickel-Catalyzed Enantioselective Hydroboration of Vinylarenes

The enantioselective hydroboration of vinylarenes catalyzed by a chiral, nonracemic nickel catalyst is presented as a facile method for generating chiral benzylic boronate esters. Various vinylarenes react with bis(pinacolato)diboron (B2pin2) in the presence of MeOH as a hydride source to form chiral boronate esters in up to 92% yield with up to 94% ee. The use of anhydrous Me4NF to activate B2pin2 is crucial for ensuring fast transmetalation to achieve high enantioselectivities.

One-Pot Chemoenzymatic Conversion of Alkynes to Chiral Amines

A one-pot chemoenzymatic sequential cascade for the synthesis of chiral amines from alkynes was developed. In this integrated approach, just ppm amounts of gold catalysts enabled the conversion of alkynes to ketones (>99%) after which a transaminase was used to catalyze the production of biologically valuable chiral amines in a good yield (up to 99%) and enantiomeric excess (>99%). A preparative scale synthesis of (S)-methylbenzylamine and (S)-4-methoxy-methylbenzylamine from its alkyne form gave a yield of 59 and 92%, respectively, withee> 99%.

Chiral Yolk-Shell MOF as an Efficient Nanoreactor for Asymmetric Catalysis in Organic-Aqueous Two-Phase System

It remains a great challenge to introduce large and efficient homogeneous asymmetric catalysts into MOFs and other microporous materials as well as retain their degrees of freedom. Herein, a new heterogeneous strategy of homogeneous chiral catalysts is proposed, that is, to construct a yolk-shell MOFs-confined, large-size, and highly efficient homogeneous chiral catalyst, which can be used as a nanoreactor for asymmetric catalytic reactions.