211245-16-8Relevant articles and documents
Pyridopyrimidinone derivatives for treatment of neurodegenerative disease
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, (2008/06/13)
This invention provides pyridopyrimidines and 4-aminopyrimidines that are useful for treating cell proliferatives disorders, such as cancer and restenosis. We have now discovered a group of 7,8-dihydro-2 (amino and thio)pyrido[2,3-d]pyrimidines and 2,4-di
Pyrido[2,3-d]pyrimidin-7-one inhibitors of cyclin-dependent kinases
Barvian,Boschelli,Cossrow,Dobrusin,Fattaey,Fritsch,Fry,Harvey,Keller,Garrett,La,Leopold,McNamara,Quin,Trumpp-Kallmeyer,Toogood,Wu,Zhang
, p. 4606 - 4616 (2007/10/03)
The identification of 8-ethyl-2-phenylamino-8H-pyrido [2,3-d]pyrimidin-7-one (1) as an inhibitor of Cdk4 led to the initiation of a program to evaluate related pyrido [2,3-d]pyrimidin-7-ones for inhibition of cyclin-dependent kinases (Cdks). Analysis of m