56020-70-3Relevant articles and documents
Wakamatsu et al.
, p. 2755 (1977)
A Polyketide Cyclase That Forms Medium-Ring Lactones
Gao, De-Wei,Jamieson, Cooper S.,Wang, Gaoqian,Yan, Yan,Zhou, Jiahai,Houk,Tang, Yi
, p. 80 - 84 (2021/01/13)
Medium-ring lactones are synthetically challenging due to unfavorable energetics involved in cyclization. We have discovered a thioesterase enzyme DcsB, from the decarestrictine C1 (1) biosynthetic pathway, that efficiently performs medium-ring lactonizations. DcsB shows broad substrate promiscuity toward linear substrates that vary in lengths and substituents, and is a potential biocatalyst for lactonization. X-ray crystal structure and computational analyses provide insights into the molecular basis of catalysis.
A concise stereoselective total synthesis of diplodialide C
Pratapareddy, Bommareddy,Sreenivasulu, Reddymasu,Hatti, Islavathu,Venkata Basaveswara Rao, Mandava,Raju, Rudraraju Ramesh
, p. 1921 - 1926 (2015/10/29)
An asymmetric total synthesis of diplodialide C has been achieved starting from commercially available homoallylic alcohol. Regioselective opening of the chiral epoxide, cross-metathesis reaction, and Yamaguchi macrolactonization were used as the key step