63416-70-6

Basic information

• Product Name: 3-(4-FLUORO-PHENYL)-PROPIONALDEHYDE
• Synonyms: 3-(4-FLUORO-PHENYL)-PROPIONALDEHYDE;3-(4-Fluorophenyl)propanal;Benzenepropanal, 4-fluoro-;3-(4-flurophenyl)propionaldehyde
• CAS NO: 63416-70-6
• Molecular Formula: C₉H₉FO
• Molecular Weight: 152.17
• Mol File: 63416-70-6.mol
• Article Data: 59

Chemical Properties

• Boiling Point: 208.695°C at 760 mmHg
• Flash Point: 85.096°C
• Appearance: /
• Density: 1.085g/cm³
• Vapor Pressure: 0.211mmHg at 25°C
• Refractive Index: 1.491
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 3-(4-FLUORO-PHENYL)-PROPIONALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-FLUORO-PHENYL)-PROPIONALDEHYDE(63416-70-6)
• EPA Substance Registry System: 3-(4-FLUORO-PHENYL)-PROPIONALDEHYDE(63416-70-6)

Safety Data

• Hazardous Substances Data: 63416-70-6(Hazardous Substances Data)

Usage

General Description

3-(4-Fluoro-phenyl)-propionaldehyde is a chemical compound with the molecular formula C9H9FO. It is a colorless to pale yellow liquid with a sweet, floral odor. This aldehyde is commonly used as a flavoring agent in the food and beverage industry, adding a pleasant floral or fruity note to various products. Additionally, it has applications in the fragrance industry, where it is used to create perfumes and other scented products. It is important to handle this chemical with care, as it can irritate the skin, eyes, and respiratory system and should be stored and used in a well-ventilated area.

InChI:InChI=1/C9H9FO/c10-9-5-3-8(4-6-9)2-1-7-11/h3-7H,1-2H2

Upstream product

• 7116-38-3 ethyl 3-(4-fluorophenyl)propanoate 
• 405-99-2 para-fluorostyrene 
• 201230-82-2 carbon monoxide 
• 702-15-8 3-(4-fluorophenyl)propan-1-ol 
• 136265-10-6 ethyl 4-fluorocinnamate 
• 459-57-4 4-fluorobenzaldehyde 
• 174485-36-0 3-(4-fluorophenyl)-N-methoxy-N-methylpropanamide 
• 352-34-1 4-fluoro-1-iodobenzene 
• 107-18-6 allyl alcohol 
• 24654-55-5 trans-4-fluorocinnamaldehyde 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 459-31-4 3-(4-fluorophenyl)propanoic acid 
• 124980-95-6 (E)-3-(4-fluorophenyl)-2-propen-1-ol 
• 50-00-0 formaldehyd 

Downstream Products

• 46464-72-6 C₁₀H₁₃FN₄ 
• 168166-37-8 3-(4-fluorophenylmethyl)-5-nitro-1H-indole 
• 849833-90-5 5-benzyloxy-3-(4-fluoro-benzyl)-1H-indole 
• 225233-79-4 rac-2-amino-4-(4-fluorophenyl)butanoic acid 
• 917247-89-3 rac-2-hydroxy-4-(4-fluorophenyl)butanoic acid 
• 114990-93-1 (R)-2-hydroxy-4-(4-fluorophenyl)butanoic acid 
• 361436-25-1 3-(4-fluoro-benzyl)-1H-indol-5-ol 
• 168166-72-1 3-[5-Amino-3-(4-fluoro-benzyl)-indol-1-yl]-propionic acid methyl ester 
• 168166-54-9 methyl 3-(4-fluorophenylmethyl)-5-nitro-1H-indole-1-propanoate 
• 168167-35-9 3-[5-Benzenesulfonylamino-3-(4-fluoro-benzyl)-indol-1-yl]-propionic acid methyl ester 
• 168167-03-1 3-[3-(4-Fluoro-benzyl)-5-(toluene-4-sulfonylamino)-indol-1-yl]-propionic acid methyl ester 
• 168166-82-3 methyl 5-((4-fluorophenylsulphonyl)amino)-3-(4-fluorophenylmethyl)-1H-indole-1-propanoate 
• 168166-83-4 methyl 5-((4-chlorophenylsulphonyl)amino)-3-(4-fluorophenylmethyl)-1H-indole-1-propanoate 

Relevant articles and documents

Ligand-controlled cobalt-catalyzed remote hydroboration and alkene isomerization of allylic siloxanes

The Co-catalyzed remote hydroboration and alkene isomerization of allylic siloxanes were realized by a ligand-controlled strategy. The remote hydroboration with dcype provided borylethers, while xantphos favored the formation of silyl enol ethers.

Transfer hydrogenations catalyzed by streptavidin-hosted secondary amine organocatalysts

Here, the streptavidin-biotin technology was applied to enable organocatalytic transfer hydrogenation. By introducing a biotin-tethered pyrrolidine (1) to the tetrameric streptavidin (T-Sav), the resulting hybrid catalyst was able to mediate hydride transfer from dihydro-benzylnicotinamide (BNAH) to α,β-unsaturated aldehydes. Hydrogenation of cinnamaldehyde and some of its aryl-substituted analogues was found to be nearly quantitative. Kinetic measurements revealed that the T-Sav:1 assembly possesses enzyme-like behavior, whereas isotope effect analysis, performed by QM/MM simulations, illustrated that the step of hydride transfer is at least partially rate-limiting. These results have proven the concept thatT-Savcan be used to host secondary amine-catalyzed transfer hydrogenations.

Insight into decomposition of formic acid to syngas required for Rh-catalyzed hydroformylation of olefins

Formic acid (FA) is one kind of important bulk chemicals, which is recognized as a sustainable and eco-friendly energy carrier to transport H2 via dehydrogenation or CO via decarbonylation. Expectantly, FA upon decomposition into H2 and CO could be used as the syngas alternative for hydroformylation. In this paper, the behaviors of FA to release H2 as well as CO following the distinct pathways were carefully investigated for the first time, and then established a new hydroformylation protocol free of syngas. It was found that the atmospheric hydroformylation of olefins with formic acid (FA) as syngas alternative was smoothly fulfilled over Xantphos (L1) modified Rh-catalyst under mild conditions (80 °C, Rh concentration 1 mol %, 14 h), resulting in >90% conversion of the olefins along with the high selectivity to the target aldehydes (>93%). By using FA as syngas source, the side-reaction of olefin-hydrogenation was greatly depressed. The in situ FT-IR and the high-pressure 1H NMR spectroscopic analyses were applied to reveal how FA behaves dually as CO surrogate and hydrogen source over L1-Rh(acac)(CO)2 catalytic system, based on which the deeply insight into the catalytic mechanism of hydroformylation of olefins with FA as syngas alternative was offered.