64002-52-4

Basic information

• Product Name: (4-fluorophenyl)methanediyl diacetate
• Synonyms: (4-Fluorophenyl)methylene diacetate; methanediol, 1-(4-fluorophenyl)-, diacetate
• CAS NO: 64002-52-4
• Molecular Formula: C₁₁H₁₁FO₄
• Molecular Weight: 226.201
• Mol File: 64002-52-4.mol
• Article Data: 34

Chemical Properties

• Boiling Point: 290.8°C at 760 mmHg
• Flash Point: 125.6°C
• Density: 1.231g/cm³
• Vapor Pressure: 0.00203mmHg at 25°C
• Refractive Index: 1.491
• CAS DataBase Reference: (4-fluorophenyl)methanediyl diacetate(CAS DataBase Reference)
• NIST Chemistry Reference: (4-fluorophenyl)methanediyl diacetate(64002-52-4)
• EPA Substance Registry System: (4-fluorophenyl)methanediyl diacetate(64002-52-4)

Safety Data

• Hazardous Substances Data: 64002-52-4(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 459-57-4 4-fluorobenzaldehyde 
• 24524-97-8 1-(diethoxymethyl)-4-fluorobenzene 
• 540-63-6 ethane-1,2-dithiol 

Downstream Products

• 459-57-4 4-fluorobenzaldehyde 
• 1280728-92-8 10-(4-fluorophenyl)-2,3,6,7-tetramethoxy-9-(naphthalen-2-yl)anthracene 
• 83521-64-6 2-(4-fluorophenyl)-1,3-dithiolane 
• 64634-46-4 4,4'-((4-fluorophenyl)methylene)bis(methoxybenzene) 
• 64634-52-2 tris(4-fluorophenyl)methane 
• 140-11-4 Benzyl acetate 

Relevant articles and documents

Application of poly(Vinylbenzyltrimethylammonium tribromide) resin as an efficient polymeric catalyst in the acetalization and diacetylation of benzaldehydes

The applications of a new supported tribromide reagent (poly(vinylbenzyltrimethylammonium tribromide) resin) were reported. This supported tribromide resin was used as a catalyst in the acetalization and diacetylation of benzaldehydes under mild conditions with high efficiency. The effects of solvents, and amount of the supported tribromide resin on the reactions were investigated. Under the optimal conditions, most of acetal and 1,1-diacetates of benzaldehydes were selectively obtained in excellent yields.

The studies on chemoselective promiscuous activity of hydrolases on acylals transformations

Chemoselective, mild and convenient protocol for the hydrolysis of the synthetically relevant acylals via promiscuous enzyme-catalyzed hydrolysis has been developed. It has been shown that promiscuous activity of the used hydrolases dominates their native activity related with carboxylic esters hydrolysis. The main advantage of the present methodology is that it can be conducted under neutral conditions at room temperature. Moreover, complete deprotection of acylals takes place within 10–20 min. Developed protocol can be used with compounds having a variety of hydrolytic labile groups since the cleavage is proceeded under neutral conditions and occurs exclusively on acylal moiety. Further this protocol was extended by the tandem Passerini multicomponent reaction leading to the α-acetoxy amides using acylals as the surrogates of the carbonyl components to P-MCR.

Supported N-propylsulfamic acid onto Fe3O4 magnetic nanoparticles as a reusable and efficient nanocatalyst for the protection/deprotection of hydroxyl groups and protection of aldehydes

N-propylsulfamic acid supported onto Fe3O4 magnetic nanoparticles (MNPs-PSA) as an efficient and magnetically reusable nanocatalyst has been reported for the tetrahydropyranylation/depyranylation of a wide variety of alcohols and phenols by changing the solvent medium. Also, the protection of aldehydes as acylals using Ac2O in the presence of catalytic amount MNPs-PSA in good to high yields at room temperature under solvent-free conditions is described. After completing the reaction, the catalyst was easily separated from the reaction mixture with the assistance of an external magnetic field and reused for several consecutive runs without significant loss of their catalytic efficiency.