89524-18-5

Basic information

• Product Name: (E)-1,1,1-trifluoro-4-phenylbut-3-en-2-ol
• Synonyms: (E)-1,1,1-trifluoro-4-phenylbut-3-en-2-ol
• CAS NO: 89524-18-5
• Molecular Formula: C₁₀H₉F₃O
• Molecular Weight: 202.1730696
• Mol File: 89524-18-5.mol
• Article Data: 36

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (E)-1,1,1-trifluoro-4-phenylbut-3-en-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1,1,1-trifluoro-4-phenylbut-3-en-2-ol(89524-18-5)
• EPA Substance Registry System: (E)-1,1,1-trifluoro-4-phenylbut-3-en-2-ol(89524-18-5)

Safety Data

• Hazardous Substances Data: 89524-18-5(Hazardous Substances Data)

Usage

General Description

(E)-1,1,1-trifluoro-4-phenylbut-3-en-2-ol is a chemical compound with a molecular formula C10H9F3O. It is a colorless liquid with a high boiling point and a strong, sweet odor. (E)-1,1,1-trifluoro-4-phenylbut-3-en-2-ol is primarily used as an intermediate in the production of various pharmaceuticals and agrochemicals. It can also be used as a reagent in organic synthesis and as a building block in the production of specialty chemicals. (E)-1,1,1-trifluoro-4-phenylbut-3-en-2-ol is considered to be a potentially hazardous substance and should be handled with care, as it may cause irritation to the skin, eyes, and respiratory system upon exposure.

Upstream product

• 14371-10-9 (E)-3-phenylpropenal 
• 75-63-8 Bromotrifluoromethane 
• 2314-97-8 iodotrifluoromethane 
• 108-86-1 bromobenzene 
• 59938-06-6 (E)-4-Ethoxy-1,1,1-trifluoro-3-buten-2-one 
• 106578-69-2 1-phenyl-1-(N-phenylamino)-4,4,4-trifluoro-1-buten-3-one 
• 130240-22-1 (Z)-1,1,1-Trifluoro-4-phenyl-4-pyrrolidin-1-yl-but-3-en-2-one 
• 89524-12-9 1-phenyl-3-hydroxy-4,4,4-trifluoro-1-butyne 
• 228123-21-5 trimethyl[[(2E)-3-phenyl-1-(trifluoromethyl)-2-propenyl]oxy]silane 
• 431-35-6 3-bromo-1,1,1-trifluoroacetone 
• 100-52-7 benzaldehyde 
• 122920-70-1 (E)-1,1,1-trifluoro-4-phenylbut-3-en-2-yl acetate 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 104-55-2 3-phenyl-propenal 

Downstream Products

• 122920-70-1 (E)-1,1,1-trifluoro-4-phenylbut-3-en-2-yl acetate 
• 3108-32-5 (E)-1,1,1-trifluoro-4-phenyl-3-buten-2-one 
• 86571-26-8 1,1,1-trifluoro-4-phenylbutan-2-one 
• 595604-44-7 ethyl (E)-3-phenyl-1-(trifluoromethyl)allyl carbonate 
• 351536-31-7 2-tert-butyldimethylsilyloxy-1,1,1-trifluoro-4-phenyl-3-butene 
• 108644-85-5 (E)-(R)-1,1,1-trifluoro-4-phenyl-3-buten-2-ol 
• 111004-15-0 (E)-(S)-1,1,1-trifluoro-4-phenyl-3-buten-2-ol 
• 121194-38-5 4,4,4-trifluoro-3-hydroxy-1-phenylbutan-2-one 
• 108644-83-3 (R)-(+)-1,1,1-trifluoro-4-phenyl-2-butanol 
• 111004-16-1 (2S)-1,1,1-trifluoro-4-phenylbutan-2-ol 
• 1135311-99-7 (E)-(S)-1,1,1-trifluoro-4-phenyl-3-buten-2-yl isobutyrate 
• 1135312-35-4 (E)-1,1,1-trifluoro-4-phenyl-3-buten-2-yl isobutyrate 
• 1373211-67-6 C₁₀H₉F₃O₂ 
• 1415354-84-5 2,2,2-trichloro-N-((2E)-4,4,4-trifluoro-1-phenylbut-2-enyl)acetamide 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS AS ANTI-VIRAL AGENTS

The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV) or HMPV. The present invention further relates to pharmaceutical compositions comp

Enantioselective Palladium-Catalyzed [3+2] Cycloaddition of Trimethylenemethane and Fluorinated Ketones

A nitrile-substituted trimethylenemethane (TMM) donor undergoes palladium-catalyzed [3+2] cycloadditions with fluorinated ketones to generate tetrasubstituted trifluoromethylated centers in high enantioselectivity under mild conditions. The generation of the palladium–TMM complex was achieved by a self-deprotonation strategy, which shows remarkable improvements in regiocontrol, efficiency, and atom economy of asymmetric [3+2] cycloadditions. Moreover, the versatility of the nitrile group provides direct access to a variety of synthetically useful intermediates, including amides, aldehydes, and esters. The developed reaction conditions allow for the synthesis of a wide variety of aromatic, heteroaromatic, and aliphatic fluorinated dihydrofurans in excellent regio- and enantioselectivities.

Palladium-Catalyzed Trimethylenemethane Cycloaddition of Olefins Activated by the δ-Electron-Withdrawing Trifluoromethyl Group

α-Trifluoromethyl-styrenes, trifluoromethyl-enynes, and dienes undergo palladium-catalyzed trimethylenemethane cycloadditions under mild reaction conditions. The trifluoromethyl group serves as a unique δ-electron-withdrawing group for the activation of the olefin toward the cycloaddition. This method allows for the formation of exomethylene cyclopentanes bearing a quaternary center substituted by the trifluoromethyl group, compounds of interest for the pharmaceutical, agrochemical, and materials industries. In the diene series, the cycloaddition operates in a [3 + 4] and/or [3 + 2] manner to give rise to seven- and/or five-membered rings. This transformation greatly improves the scope of the TMM cycloaddition technology and provides invaluable insights into the reaction mechanism.