Mandelic acid synthesis

JiangXi Keyuan Biopharma Co., LTD.

Country:China (Mainland)

Year Established: 2002Business type: Manufacturers

Integral:

This a-hydroxy acid is prepared from benzaldehyde through the cyanohydrin, which is produced by interaction of the benzaldehyde bisulfite addition compound with potassium cyanide. This interchange reaction eliminates the hazard of working with volatile, toxic hydrogen cyanide, but even potassium cyanide is dangerous if safety measures are not observed. The interchange reaction is reversible and excess cyanide is used to shift the equilibrium in favor of the cyanohydrin. Mandelonitrile, a liquid, undergoes changes on standing and hence should be processed further without delay; it is extracted with ether, the solution is carefully washed free of cyanide ion, and the nitrile is then hydrolyzed with hydrochloric acid. An intermediate ketimine hydrochloride, C6H5CH(OH)C=NH*HCl soon gives way to mandelic acid and ammonium chloride, both of which are soluble in the aqueous acid. The solution is cooled and extracted with ether, and the ether is then displaced by benzene for crystallization, since mandelic acid is much less soluble in this solvent than in ether.

Keyuan Chemical Co., Ltd. specialized in the production for pigments, pharmaceuticals and other fine chemical intermediates, is one of Medium-sized chemical enterprises which integrates research, development and production. Its main products are including L-Serine (CAS NO.: 56-45-1) and so on. It is comprised of two pars R&D center, occupied 10000m2 and is located in jintan chemical zone in jiangsu province; another production area lied in anhui guangde chemical zone, with a total area at 25000m2. The series of Mandelic acid has got a yearly total capacity at more than 1000 metric tons, and one of DL-Mandelic acid has been up to 600mt per year. It wins the biggest capacity and the greatest variety of goods in the manufacturer of the like product. The series of Mandelic acid also become the most competitive item at home and abroad of our company. Keyuan chemical possesses perfect means in quality control and analysis, with the quality testing system, and the ISO9001 for both R&D center and production area, we can guarantee the stability of product quality. In the coming days, keeping the principle of "improving ourselves, and spirit of upwards", we will try best to make the customers satisfied through constant efforts. Let us go forward hand in hand, and get development together.