3-Dimethylaminopropylamine supplier

Name
3-Dimethylaminopropylamine
EINECS 203-680-9
CAS No. 109-55-7
Article Data55
CAS DataBase
Density 0.803 g/cm³
Solubility Soluble in water
Melting Point -60 °C
Formula C₅H₁₄N₂
Boiling Point 107.8 °C at 760 mmHg
Molecular Weight 102.18
Flash Point 9.1 °C
Transport Information UN 2733 3/PG 3
Appearance Colorless liquid
Safety 26-36/37/39-45
Risk Codes 10-22-34-43
Molecular Structure
Hazard Symbols C
Synonyms 1,3-Propanediamine,N,N-dimethyl- (6CI,8CI,9CI);(3-Aminopropyl)dimethylamine;(3-Dimethylaminopropan-1-yl)amine;1,1-Dimethyl-1,3-propylenediamine;1-(Dimethylamino)-3-aminopropane;1-Amino-3-(dimethylamino)propane;3-(Dimethylamino)-1-aminopropane;3-(Dimethylamino)-1-propanamine;3-(Dimethylamino)-1-propylamine;3-(Dimethylamino)propanamine;3-(Dimethylamino)propylamine;3-Amino-1-(dimethylamino)propane;3-N,N-Dimethylaminopropylamine;N,N-Dimethyl-1,3-diaminopropane;N,N-Dimethyl-1,3-propanediamine;N,N-Dimethyl-1,3-propylenediamine;N,N-Dimethyl-3-aminopropylamine;N,N-Dimethyl-N-(3-aminopropyl)amine;
PSA 29.26000
LogP 0.59710

Synthetic route

: 1738-25-6
3-dimethylaminopropiononitrile

: 109-55-7
1-amino-3-(dimethylamino)propane

Conditions

Conditions	Yield
With potassium hydroxide; sodium hydroxide; hydrogen; Ni-MC502 In water at 90℃; under 5932.2 Torr;	99.98%
With ethanol; sodium
With sodium-potassium alloy; butan-1-ol

: 5350-67-4
α-(dimethylamino)-propionitrile

A: 107-10-8
propylamine

B: 110-95-2
N,N,N'N'-tetramethyl-1,3-propanediamine

C: 109-55-7
1-amino-3-(dimethylamino)propane

D: 6711-48-4
N,N-bis-(3-dimethylaminopropyl)amine

Conditions

Conditions	Yield
With caustic; hydrogen; nickel catalyst Degussa MC502 In water at 90℃; under 5932.2 Torr; for 0.45h; Product distribution / selectivity;	A n/a B n/a C 99.98% D n/a

...Expand

: 1071-29-0
3-aminopropyl hydrogen sulfate

: 124-40-3
dimethyl amine

: 109-55-7
1-amino-3-(dimethylamino)propane

Conditions

Conditions	Yield
With water at 170℃;

: 13474-65-2
N,N-dimethyl-N-(3-phthalimidopropyl)amine

: 109-55-7
1-amino-3-(dimethylamino)propane

Conditions

Conditions	Yield
With hydrazine
With diazene In ethanol for 3h;

: 20916-47-6
N,N-Dimethylisobutenylamin

: 61507-91-3
C5H14N2*H(1+)

A: C6H13N*H(1+)

B: 109-55-7
1-amino-3-(dimethylamino)propane

Conditions

Conditions	Yield
ICR double resonance, proton affinity;

...Expand

: 7664-41-7
ammonia

: 1738-25-6
3-dimethylaminopropiononitrile

Raney nickel: Raney nickel

: 109-55-7
1-amino-3-(dimethylamino)propane

Conditions

Conditions	Yield
at 90 - 100℃; under 66195.7 - 73550.8 Torr; Hydrogenation;

...Expand

: 1738-25-6
3-dimethylaminopropiononitrile

: 71-36-3
butan-1-ol

sodium-potassium-alloy: sodium-potassium-alloy

: 109-55-7
1-amino-3-(dimethylamino)propane

...Expand

: 64-17-5
ethanol

: 1738-25-6
3-dimethylaminopropiononitrile

sodium: sodium

: 109-55-7
1-amino-3-(dimethylamino)propane

...Expand

: 1738-25-6
3-dimethylaminopropiononitrile

: 71-36-3
butan-1-ol

sodium: sodium

A: 109-55-7
1-amino-3-(dimethylamino)propane

B: 6711-48-4
N,N-bis-(3-dimethylaminopropyl)amine

...Expand

: 1-[4-(4-dimethylamino-phenylazo)-phenyl]-1-(3-dimethylamino-propylamino)-2,2,2-trifluoro-ethanol

A: 109-55-7
1-amino-3-(dimethylamino)propane

B: 4-dimethylamino-4'-(trifluoroacetyl)azobenzene

Conditions

Conditions	Yield
In tetrahydrofuran Equilibrium constant;

: 67-56-1
methanol

: 109-76-2
Trimethylenediamine

A: 109-55-7
1-amino-3-(dimethylamino)propane

B: 111-33-1
1,3-bis(methylamino)propane

C: 6291-84-5
N-Methyl-1,3-propanediamine

Conditions

Conditions	Yield
With Cs-P-Si at 300℃; under 61504.9 Torr;

...Expand

: 124-40-3
dimethyl amine

: 107-13-1
acrylonitrile

: 109-55-7
1-amino-3-(dimethylamino)propane

Conditions

Conditions	Yield
Stage #1: dimethyl amine; acrylonitrile for 48h; Stage #2: With sodium In ethanol

: 5350-67-4
α-(dimethylamino)-propionitrile

A: 109-55-7
1-amino-3-(dimethylamino)propane

B: 6711-48-4
N,N-bis-(3-dimethylaminopropyl)amine

Conditions

Conditions	Yield
With sodium hydroxide; hydrogen; nickel catalyst Degussa MC502 In water at 90℃; under 5688.78 Torr; Product distribution / selectivity;
With lithium hydroxide; hydrogen; nickel catalyst Degussa MC502 In water at 90℃; under 25858.1 Torr; Product distribution / selectivity;
With potassium hydroxide; hydrogen; nickel catalyst Degussa MC502 In water at 90℃; under 5171.62 Torr; Product distribution / selectivity;

: 124-40-3
dimethyl amine

: 107-02-8
acrolein

: 109-55-7
1-amino-3-(dimethylamino)propane

Conditions

Conditions	Yield
Stage #1: dimethyl amine; acrolein at 4℃; for 1.25h; autoclave; Stage #2: With ammonia; hydrogen; Raney cobalt In water at 100℃; under 45004.5 Torr; for 2h; Product distribution / selectivity; autoclave;	91.4 %Chromat.
Stage #1: dimethyl amine; acrolein at 4℃; for 1.25h; Stage #2: With ammonia; hydrogen; Ra-Co In water at 100℃; under 45004.5 Torr; for 3h; Autoclave;

: 124-40-3
dimethyl amine

: 107-02-8
acrolein

A: 3179-63-3
3-Dimethylamino-1-propanol

B: 109-55-7
1-amino-3-(dimethylamino)propane

Conditions

Conditions	Yield
Stage #1: dimethyl amine; acrolein at 4℃; for 1.25h; autoclave; Stage #2: With ammonia; hydrogen; Raney cobalt In water at 80℃; under 45004.5 Torr; for 2h; Product distribution / selectivity; autoclave;	A 13.9 %Chromat. B 80.3 %Chromat.
Stage #1: dimethyl amine; acrolein at 4℃; for 1.25h; Autoclave; Stage #2: With ammonia; hydrogen; Ra-Co In tetrahydrofuran; water at 40℃; under 45004.5 Torr; for 2h; Product distribution / selectivity; Autoclave;
Stage #1: dimethyl amine; acrolein at 4℃; for 1.25h; Autoclave; Stage #2: With ammonia; hydrogen; Ra-Co In tetrahydrofuran; water at 40℃; under 45004.5 Torr; for 3h; Product distribution / selectivity; Autoclave;

...Expand

: 3845-76-9
N-[3-(dimethylamino)propyl]acrylamide

A: 109-55-7
1-amino-3-(dimethylamino)propane

B: 79-10-7
acrylic acid

Conditions

Conditions	Yield
With Rhodococcus erythropolis TA37 acylamidase at 37℃; for 0.333333h; pH=7.5; Kinetics; aq. buffer; Enzymatic reaction;

: 111-26-2
hexan-1-amine

: N'-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-N,N-dimethyl-propane-1,3-diamine

A: 53054-00-5
N-hexyl-1-(4-methoxyphenyl)methanimine

B: 109-55-7
1-amino-3-(dimethylamino)propane

Conditions

Conditions	Yield
In [D3]acetonitrile at 24.84℃; Equilibrium constant;

...Expand

: 2407-68-3
3-dimethylaminoacrylonitrile

: 109-55-7
1-amino-3-(dimethylamino)propane

Conditions

Conditions	Yield
With hydrogen In ammonia at 80℃; under 18751.9 Torr; Temperature; Pressure; Autoclave; liquid NH3;

: 307-79-9
perfluorodecanoic acid methyl ester

: 109-55-7
1-amino-3-(dimethylamino)propane

: N-(3-N,N-dimethylamidopropyl)perfluorodecylamide

Conditions

Conditions	Yield
In methanol at 65℃; for 24h;	100%

: 104-88-1
4-chlorobenzaldehyde

: 109-55-7
1-amino-3-(dimethylamino)propane

: N-(4-chlorobenzylidene)-N',N'-dimethyl-1,3-propanediamine

Conditions

Conditions	Yield
In ethanol for 2h; Heating;	100%
In benzene Heating;
In benzene Reflux; Dean-Stark;

: 555-16-8
4-nitrobenzaldehdye

: 109-55-7
1-amino-3-(dimethylamino)propane

: 867313-08-4
N-(4-nitrobenzylidene)-N',N'-dimethyl-1,3-propanediamine

Conditions

Conditions	Yield
In ethanol Heating;	100%
In benzene Heating;

: 100-52-7
benzaldehyde

: 109-55-7
1-amino-3-(dimethylamino)propane

: 62203-90-1
3-(benzylideneamino)-N,N-dimethylpropan-1-amine

Conditions

Conditions	Yield
In ethanol Heating;	100%
In benzene Heating;
In methanol at 20℃; Inert atmosphere;
In benzene Reflux; Dean-Stark;

: 587-04-2
3-Chlorobenzaldehyde

: 109-55-7
1-amino-3-(dimethylamino)propane

: N-(3-chlorobenzylidene)-N',N'-dimethyl-1,3-propanediamine

Conditions

Conditions	Yield
In ethanol Heating;	100%
In benzene Heating;

: 53391-42-7
5-nitro-2-(trichloroacetyl)-1-methylpyrrole

: 109-55-7
1-amino-3-(dimethylamino)propane

: 128484-07-1
1-Methyl-5-nitro-1H-pyrrole-2-carboxylic acid (3-dimethylamino-propyl)-amide

Conditions

Conditions	Yield
	100%

: 120095-64-9
2,2,2-trichloro-1-(1-methyl-4-nitro-1H-imidazol-2-yl)ethan-1-one

: 109-55-7
1-amino-3-(dimethylamino)propane

: 128484-08-2
N-[3-(dimethylamino)propyl]-1-methyl-4-nitroimidazole-2-carboxamide

Conditions

Conditions	Yield
	100%
In tetrahydrofuran at 20℃; for 2h; Condensation;	98%
In tetrahydrofuran	90%

: 120095-65-0
2,2,2-Trichloro-1-(1-methyl-5-nitro-1H-imidazol-2-yl)-ethanone

: 109-55-7
1-amino-3-(dimethylamino)propane

: 128484-09-3
1-Methyl-5-nitro-1H-imidazole-2-carboxylic acid (3-dimethylamino-propyl)-amide

Conditions

Conditions	Yield
	100%

: 123018-64-4
4,4-dipropyl-1-carboxycyclohexane-1-acetic acid anhydride

: 109-55-7
1-amino-3-(dimethylamino)propane

: 130065-95-1
2-<3-(dimethylamino)propyl>-8,8-dipropyl-2-azaspiro<4.5>decane-1,3-dione

Conditions

Conditions	Yield
Heating;	100%

: 109-55-7
1-amino-3-(dimethylamino)propane

: 620-23-5
m-tolyl aldehyde

: N-(3-methylbenzylidene)-N',N'-dimethyl-1,3-propanediamine

Conditions

Conditions	Yield
In ethanol Heating;	100%
In benzene Heating;

: 109-55-7
1-amino-3-(dimethylamino)propane

: 456-48-4
3-Fluorobenzaldehyde

: N-(3-fluorobenzylidene)-N',N'-dimethyl-1,3-propanediamine

Conditions

Conditions	Yield
In ethanol Heating;	100%
In benzene Heating;

: 109-55-7
1-amino-3-(dimethylamino)propane

: 95-92-1
oxalic acid diethyl ester

: 25148-90-7
N,N'-bis(3-dimethylaminopropyl)oxalamide

Conditions

Conditions	Yield
In ethanol Inert atmosphere; Flow reactor;	100%
In tetrahydrofuran at 65℃; for 24h;	90%

: 80271-19-8
11-chloro-10H-indolo-[3,2-b]quinoline

: 109-55-7
1-amino-3-(dimethylamino)propane

: N'-(10H-indolo[3,2-b]-quinolin-11-yl)-N,N-dimethyl-ethane-1,2-diamine

Conditions

Conditions	Yield
for 24h; Heating;	100%
With phenol at 120℃; for 4h;

: 109-55-7
1-amino-3-(dimethylamino)propane

: 108962-82-9
2-chlorobenzo[h]quinoline-3-carboxaldehyde

: 2-Chloro-3-[3-(N,N-dimethylamino)propyliminomethyl]benzo[h]quinoline

Conditions

Conditions	Yield
In ethanol for 4h; Condensation; Heating;	100%

: 109-55-7
1-amino-3-(dimethylamino)propane

: {3-[5-(3-dithiocarboxyamino-propyl)-9,9-dimethyl-9H-xanthen-4-yl]-propyl}-dithiocarbamic acid

: 1-(3-dimethylamino-propyl)-3-[3-(5-{3-[3-(3-dimethylamino-propyl)-thioureido]-propyl}-9,9-dimethyl-9H-xanthen-4-yl)-propyl]-thiourea

Conditions

Conditions	Yield
In dichloromethane at 25℃; for 18h; Condensation;	100%

: 89-98-5
2-chloro-benzaldehyde

: 109-55-7
1-amino-3-(dimethylamino)propane

: 647824-13-3
N-(2-chlorobenzylidene)-N',N'-dimethyl-1,3-propanediamine

Conditions

Conditions	Yield
In ethanol Heating;	100%
In chloroform Heating;

: 7539-12-0
allylsuccinic anhydride

: 109-55-7
1-amino-3-(dimethylamino)propane

: 3-(3-dimethylamino-propylcarbamoyl)-hex-5-enoic acid

Conditions

Conditions	Yield
In dichloromethane at 25℃; for 18h;	100%

: 400-94-2
4-fluoro-3-nitrobenzoyl chloride

: 109-55-7
1-amino-3-(dimethylamino)propane

: N-(3-(dimethylamino)propyl)-4-fluoro-3-nitrobenzamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 18h;	100%
With triethylamine In dichloromethane at 23℃; for 1h;	97%

: 109-55-7
1-amino-3-(dimethylamino)propane

: 639519-58-7
1,5,10-trimethoxy-1H-benzo[g]isochromene-3-carbaldehyde

: 639519-60-1
1,5,10-trimethoxy-1H-benzo[g]isochromene-3-carboxylic acid (3-dimethylaminopropyl)-amide

Conditions

Conditions	Yield
With manganese(IV) oxide; sodium cyanide In isopropyl alcohol at 0℃; for 5h;	100%

: 1121-60-4
pyridine-2-carbaldehyde

: 109-55-7
1-amino-3-(dimethylamino)propane

: (E)-N1,N1-dimethyl-N3-(pyridin-2-ylmethylene)propane-1,3-diamine

Conditions

Conditions	Yield
With sodium carbonate In ethanol for 72h;	100%
In methanol

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 109-55-7
1-amino-3-(dimethylamino)propane

: 867313-09-5
N1-(3,4-dimethoxybenzylidene)-N3,N3-dimethylpropan-1,3-diamine

Conditions

Conditions	Yield
In ethanol Heating;	100%
In ethanol for 6h; Reflux;

: 2729-36-4
4,5-dichloro-2-fluoro-phenylamine

: 109-55-7
1-amino-3-(dimethylamino)propane

: 91214-86-7
4,5-dichloro-N-(3-dimethylaminopropyl)-benzene-1,2-diamine

Conditions

Conditions	Yield
	100%

: 1185281-45-1
C50H56N16O11

: 109-55-7
1-amino-3-(dimethylamino)propane

: C55H68N18O10*H(1+)

Conditions

Conditions	Yield
With pentafluorophenyl diphenyl-phosphinate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide	100%

: 56554-52-0
perfluorododecanoic acid methyl ester

: 109-55-7
1-amino-3-(dimethylamino)propane

: N-(3-N,N-dimethylamidopropyl)perfluorododecylamide

Conditions

Conditions	Yield
In methanol at 65℃; for 24h;	100%

: 75-21-8
oxirane

ricinus oil: ricinus oil

: 109-55-7
1-amino-3-(dimethylamino)propane

: 77-78-1
dimethyl sulfate

Dehyquart AU 39: Dehyquart AU 39

Conditions

Conditions	Yield
Stage #1: oxirane; ricinus oil; 1-amino-3-(dimethylamino)propane With sodium tetrahydroborate; sodium methylate In methanol at 130℃; for 2h; Stage #2: dimethyl sulfate at 65℃; for 4h;	100%

...Expand

: 1450742-88-7
ethyl 7-(4-fluorophenyl)-4-oxo-4H-thieno[3,4-c]pyran-6-carboxylate

: 109-55-7
1-amino-3-(dimethylamino)propane

: 1450742-96-7
ethyl 3-(4-((3-(dimethylamino)propyl)carbamoyl)-3-thienyl)-3-(4-fluorophenyl)-2-hydroxyacrylate

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 2h;	100%

: 1829-34-1
2-hydroxy-3-bromobenzaldehyde

: 109-55-7
1-amino-3-(dimethylamino)propane

: 1582815-37-9
2-bromo-6-[(3-dimethylaminopropylimino)methyl]phenol

Conditions

Conditions	Yield
In methanol at 20℃; for 1h;	100%
In methanol at 20℃;	79%

: 474018-94-5
N,N-diethyl-4-fluoro-3-nitrobenzamide

: 109-55-7
1-amino-3-(dimethylamino)propane

: 4-((3-(dimethylamino)propyl)amino)-N,N-diethyl-3-nitrobenzamide

Conditions

Conditions	Yield
Stage #1: 1-amino-3-(dimethylamino)propane With triethylamine In ethanol for 0.5h; Stage #2: N,N-diethyl-4-fluoro-3-nitrobenzamide In ethanol at 50 - 75℃; for 18h;	100%
With triethylamine In ethanol at 50℃;	99%

: C14H13N3O3

: 109-55-7
1-amino-3-(dimethylamino)propane

: C19H25N5O2

Conditions

Conditions	Yield
Stage #1: C14H13N3O3 With triethylamine In acetonitrile at 20℃; for 0.0833333h; Stage #2: With bis(pentafluorophenyl)carbonate In acetonitrile at 20℃; for 0.75h; Stage #3: 1-amino-3-(dimethylamino)propane With triethylamine In acetonitrile at 20℃; for 18h;	100%

: 98-01-1
furfural

: 109-55-7
1-amino-3-(dimethylamino)propane

: 71326-13-1
N1-(furan-2-ylmethylene)-N3,N3-dimethylpropan-1,3-diamine

Conditions

Conditions	Yield
With magnesium sulfate In dichloromethane at 20℃; Inert atmosphere; Darkness;	100%
for 20h;

3-Dimethylaminopropylamine Chemical Properties

Molecular Structure of 3-Dimethylaminopropylamine (CAS NO.109-55-7):

IUPAC Name: N,N-dimethylpropane-1,3-diamine
Empirical Formula: C₅H₁₄N₂
Molecular Weight: 102.1781
H bond acceptors: 2
H bond donors: 1
Freely Rotating Bonds: 3
Polar Surface Area: 6.48 Å²
Index of Refraction: 1.425
Molar Refractivity: 32.52 cm³
Molar Volume: 127.1 cm³
Surface Tension: 25.1 dyne/cm
Density: 0.803 g/cm³
Flash Point: 9.1 °C
Enthalpy of Vaporization: 34.66 kJ/mol
Boiling Point: 107.8 °C at 760 mmHg
Vapour Pressure: 26.7 mmHg at 25°C
Melting point: -60 °C
storage temp: Flammables area
Water Solubility: Soluble
FreezingPoint: -70°C
BRN: 605293
EINECS: 203-680-9
InChI
InChI=1/C5H14N2/c1-7(2)5-3-4-6/h3-6H2,1-2H3
Smiles
C(N(C)C)CCN
Classification Code: Skin / Eye Irritant

3-Dimethylaminopropylamine Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rabbit	LD50	skin	600uL/kg (0.6mL/kg)		Union Carbide Data Sheet. Vol. 12/15/1971,
rat	LD50	oral	1870mg/kg (1870mg/kg)		American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962.

3-Dimethylaminopropylamine Safety Profile

Hazard Codes: Corrosive C
Risk Statements: 10-22-34-43
R10:Flammable.
R22:Harmful if swallowed.
R34:Causes burns.
R43:May cause sensitization by skin contact.
Safety Statements: 26-36/37/39-45
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2733 3/PG 3
WGK Germany: 2
RTECS: T7525000
HazardClass: 8
PackingGroup: II
HS Code: 29212900

3-Dimethylaminopropylamine Specification

3-Dimethylaminopropylamine , with CAS number of 109-55-7, can be called 1,3-Propanediamine,N,N-dimethyl- (6CI,8CI,9CI) ; (3-Aminopropyl)dimethylamine ; (3-Dimethylaminopropan-1-yl)amine ; 3-(Dimethylamino)propylamine ; N,N-Dimethyl-3-aminopropylamine ; N,N-Dimethyl-N-(3-aminopropyl)amine ; N',N'-Dimethylpropane-1,3-diamine ; g-Dimethylaminopropylamine . It is a clear liquid, 3-Dimethylaminopropylamine (CAS NO.109-55-7) is incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Product Name

3-Dimethylaminopropylamine

Synthetic route

3-Dimethylaminopropylamine Chemical Properties

3-Dimethylaminopropylamine Toxicity Data With Reference

3-Dimethylaminopropylamine Safety Profile

3-Dimethylaminopropylamine Specification

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