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1. Posaconazole: a broad-spectrum triazole antifungal
Posaconazole (CAS No. 171228-49-2) is a lipophilic triazole antifungal agent with broad-spectrum antifungal activity in vitro and in vivo against most Candida spp., Cryptococcus neoformans, Aspergillus spp. and several zygomycetes. In-vitro research and in-vivo research showed that posaconazole has broad-spectrum activity. Posaconazole is the first antifungal drug that has demonstrated superior overall survival when used for antifungal prophylaxis in patients with acute myeloid leukemia or myelodysplastic syndrome undergoing intensive remission induction chemotherapy. Aslo Voriconazole is a second-generation triazole with broad spectrum of antifungal activity. It is considered the first-line drug for the treatment of invasive aspergillosis.
2. Posaconazole usage
This medicine is used to prevent or treat a variety of yeast infections. Especially in the treatment of invasive fungal infections, Posaconazole is an extended-spectrum triazole with broad activity against a variety of fungal pathogens, both yeasts and molds. For example, in vitro research Posaconazole showed potent in-vitro activity against a globally diverse collection of 1646 C neoformans isolates.
3. Posaconazole side effects
The researchers of HANGZHOU HOLYPHARM BIOTECH CO.,LTD, a professional supplier of active pharmaceutical ingredients and intermediates, agrochemicals and Veterinary products, suggest you that you should ask for doctors.
The common side effects of Posaconazole includ difficulty breathing; swelling of your face, lips, tongue, or throat.
These are serious side effects:
slow, fast, or pounding heartbeats;
feeling light-headed, fainting;
fever, chills, cough, body aches, flu symptoms;
confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling;
numbness or tingly feeling around your mouth, fast or slow heart rate, muscle tightness or contraction, overactive reflexes;
swelling of your ankles or feet.
Less serious Noxafil side effects may include:
mild headache, tired feeling;
joint or muscle pain;
sleep problems (insomnia);
mild nausea, vomiting, diarrhea, constipation, or stomach pain; or
skin rash.
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