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HANGZHOU HOLYPHARM BIOTECH CO.,LTD

Country:China (Mainland)

Year Established: 2009Business type: Other

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1. What is ramelteon?
Ramelteon (CAS NO.196597-26-9)
is a off-white solid and is the first in a new class of sleep agents. Rozerem is the synonym of it. Some people even call it "ramelteon rozerem". Ramelteon is (S)-N-[2-(1, 6, 7, 8tetrahydro-2H-indeno-[5, 4-b]furan-8-yl)ethyl]propionamide. The compound is produced as the (S)-enantiomer, with an empirical formula of C16H21NO2, molecular weight of 259.34.

2. Other properties of ramelteon
Ramelteon structure :



Melting Point : 113-115 °C
Appearance : crystalline solid
Ramelteon solubility : Ramelteon is freely soluble in organic solvents, such as methanol, ethanol, and dimethyl sulfoxide; soluble in 1-octanol and acetonitrile; and very slightly soluble in water and in aqueous buffers from pH 3 to pH 11.

Other properties:
(1)ACD/LogP: 2.29 ; (2)# of Rule of 5 Violations: 0 ; (3)ACD/LogD (pH 5.5): 2.29 ; (4)ACD/LogD (pH 7.4): 2.29 ; (5)ACD/BCF (pH 5.5): 32.40 ; (6)ACD/BCF (pH 7.4): 32.40 ; (7)ACD/KOC (pH 5.5): 419.64 ; (8)ACD/KOC (pH 7.4): 419.64 ; (9)#H bond acceptors: 3 ; (10)#H bond donors: 1 ; (11)#Freely Rotating Bonds: 4 ; (12)Polar Surface Area: 38.33 Å2 ; (13)Index of Refraction: 1.556 ; (14)Molar Refractivity: 74.445 cm3 ; (15)Molar Volume: 231.687 cm3 ; (16)Polarizability: 29.512 10-24cm3 ; (17)Surface Tension: 45.2099990844727 dyne/cm ; (18)Density: 1.119 g/cm3 ; (19)Flash Point: 229.164 °C ; (20)Enthalpy of Vaporization: 71.505 kJ/mol ; (21)Boiling Point: 455.311 °C at 760 mmHg ; (22)Vapour Pressure: 0 mmHg at 25°C.

3. Ramelteon price
The price of ramelteon raw material ranges from $1-100 / Kilogram. High quality ramelteon 196597-26-9 can be provided. HANGZHOU HOLYPHARM BIOTECH CO.,LTD is one of the top quality ramelteon suppliers. You can send the inquiries to john@holypharm.com to know the ramelteon price directly.

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