Glycolic acid supplier | CasNO.79-14-1

Name
Glycolic acid
EINECS 201-180-5
CAS No. 79-14-1
Article Data660
CAS DataBase
Density 1.416 g/cm³
Solubility H₂O: 0.1 g/mL, clear
Melting Point 75-80 °C(lit.)
Formula C₂H₄O₃
Boiling Point 265.6 °C at 760 mmHg
Molecular Weight 76.052
Flash Point 128.7 °C
Transport Information
Appearance Light yellow to amber liquid
Safety 26-36/37/39-45-23
Risk Codes 34-22
Molecular Structure
Hazard Symbols C
Synonyms Aceticacid, hydroxy- (9CI);Glycolic acid (7CI,8CI);2-Hydroxyacetic acid;2-Hydroxyethanoic acid;GlyPure;GlyPure 70;GlyPure 99;Glycocide;Hydroxyaceticacid;Hydroxyethanoic acid;NSC 166;a-Hydroxyacetic acid;
PSA 57.53000
LogP -0.93670

Synthetic route

: 141-46-8
Glycolaldehyde

: 79-14-1
glycolic Acid

Conditions

Conditions	Yield
With sodium chlorite; dimethyl sulfoxide In aq. phosphate buffer at 0 - 20℃; pH=4;	100%
With 5 % platinum on carbon In water at 80℃; under 7500.75 Torr; for 6h; Temperature; Time; Reagent/catalyst; Autoclave;	78%
With oxygen In water at 180℃; under 3750.38 Torr; for 1h; Autoclave;	50%

: N-acetyl-N-nitrosoglycine

A: 79-14-1
glycolic Acid

B: 64-19-7
acetic acid

Conditions

Conditions	Yield
With water at 25℃;	A 100% B 100%
With water-d2 at 25℃; Rate constant; Kinetics; half life; reactions of derivatives under var. conditions;	A 100% B 100%

: 96-35-5
glycolic acid methyl ester

: 79-14-1
glycolic Acid

Conditions

Conditions	Yield
With water at 95 - 97℃; under 760.051 Torr; for 2h; Reactive distillation;	100%
With water; Candida rugosa lipase In aq. phosphate buffer at 45℃; for 30h; pH=7.2; Enzymatic reaction;
With water In methanol at 100℃;

: 50-00-0
formaldehyd

: 201230-82-2
carbon monoxide

: 79-14-1
glycolic Acid

Conditions

Conditions	Yield
With trifluorormethanesulfonic acid; acetic acid at 140℃; under 13689.1 - 52476.2 Torr; for 4h; Catalytic behavior; Pressure; Temperature; Time; Reagent/catalyst; Concentration; Autoclave;	99.9%
With trifluorormethanesulfonic acid; acetic acid at 140℃; under 13689.1 - 52476.2 Torr; for 4h; Catalytic behavior; Pressure; Temperature; Time; Reagent/catalyst; Concentration; Autoclave;	99.9%
With trifluorormethanesulfonic acid; acetic acid at 140℃; under 13689.1 - 52476.2 Torr; for 4h; Catalytic behavior; Pressure; Temperature; Time; Reagent/catalyst; Concentration; Autoclave;	99.9%

: 107-21-1
ethylene glycol

: 79-14-1
glycolic Acid

Conditions

Conditions	Yield
Stage #1: ethylene glycol With Rh(OTf)(trop2NH)(PPh3); water; cyclohexanone; sodium hydroxide at 20℃; for 2h; Inert atmosphere; Stage #2: With hydrogenchloride In water Inert atmosphere;	99%
Wird durch verschiedene Essigbakterien;
With ruthenium trichloride; N-Bromosuccinimide; perchloric acid; mercury(II) diacetate; acetic acid In water Thermodynamic data; Mechanism; Kinetics; ΔE(excit.), ΔS(excit.), ΔH(excit.), and ΔF(excit.);

: 35249-89-9
glycolic acid ammonium salt

: 79-14-1
glycolic Acid

Conditions

Conditions	Yield
With water	98%
With sulfuric acid In water; 4-methyl-2-pentanone; kerosene at 25 - 75℃; for 0.5 - 1h; pH=2 - 3; Purification / work up;
With sulfuric acid In water; toluene at 25 - 75℃; for 0.5h; pH=2 - 3; Purification / work up;

: 131543-46-9
Glyoxal

: 79-14-1
glycolic Acid

Conditions

Conditions	Yield
With aluminum trihydroxide; water at 165℃; for 3h; Mechanism;	92%
With water at 99.84℃; for 18h; Catalytic behavior; Reagent/catalyst; Temperature; Time; Sealed tube; Green chemistry;	91%
With alkali

: 107-16-4
glycolonitrile

: 79-14-1
glycolic Acid

Conditions

Conditions	Yield
With sulfuric acid; water at 105 - 110℃; for 6h; Temperature;	92%
With water; microbial enzyme at 40℃; for 12h; Product distribution / selectivity;	10 - 99 %Chromat.
Stage #1: glycolonitrile With sulfuric acid In water for 2191.5h; pH=3; Stage #2: With sodium hydroxide pH=7; Stage #3: With water; microbial enzyme at 40℃; for 12h; Product distribution / selectivity;	99 %Chromat.
With nitrilase from Hoeflea phototrophica DFL-43; water In aq. phosphate buffer; dimethyl sulfoxide at 30℃; for 0.166667h; pH=8; Enzymatic reaction;

: 56-81-5
glycerol

A: 79-14-1
glycolic Acid

B: 473-81-4
glyceric acid

C: 96-26-4
dihydroxyacetone

Conditions

Conditions	Yield
With oxygen In water at 60℃; Catalytic behavior; Reagent/catalyst; Autoclave; chemoselective reaction;	A 8.9% B 89.9% C 6.8%
With oxygen In water at 80℃; under 7500.75 Torr; for 2h; pH=6.7; Reagent/catalyst; Autoclave;
With oxygen In water at 60℃; under 3750.38 Torr; for 24h; Catalytic behavior; Kinetics; Reagent/catalyst; Time; High pressure;	A 7.8 %Chromat. B 55.4 %Chromat. C 7.7 %Chromat.

...Expand

: 30379-58-9
benzyl glycolate

: 79-14-1
glycolic Acid

Conditions

Conditions	Yield
With hydrogen Hydrogenolysis;	88%

: 68210-96-8
3-(α,α,α-trifluoro-m-tolyl)-4-isothiazolecarboxylic acid

: 105-39-5
chloroacetic acid ethyl ester

: 79-14-1
glycolic Acid

Conditions

Conditions	Yield
With sodium hydroxide In N,N,N,N,N,N-hexamethylphosphoric triamide; chloroform; benzene	87%
With sodium hydroxide In N,N,N,N,N,N-hexamethylphosphoric triamide; chloroform; benzene	87%

: 7044-96-4
POMP

: 201230-82-2
carbon monoxide

: 79-14-1
glycolic Acid

Conditions

Conditions	Yield
With water; propionic acid at 140℃; under 52476.2 Torr; for 2h; Autoclave;	86%
With water; propionic acid at 140℃; under 52476.2 Torr; for 2h; Autoclave;	86%
With water; propionic acid at 140℃; under 52476.2 Torr; for 2h; Autoclave;	86%
With water; propionic acid at 140℃; under 52476.2 Torr; for 2h; Reagent/catalyst; Concentration; Autoclave;	86 %Chromat.

: 96-26-4
dihydroxyacetone

A: 64-18-6
formic acid

B: 79-14-1
glycolic Acid

Conditions

Conditions	Yield
With dihydrogen peroxide In neat (no solvent) at 25℃; for 24h; Catalytic behavior; Reagent/catalyst;	A n/a B 86%
With oxygen; vanadia In water at 79.84℃; under 2250.23 Torr; for 1h; Autoclave;	A 14 %Chromat. B 13 %Chromat.

: 7748-25-6
potassium chloroacetate

: 79-14-1
glycolic Acid

Conditions

Conditions	Yield
With water at 150℃; for 5h;	85%

: 13831-30-6
acetoxyacetic acid

: 79-14-1
glycolic Acid

Conditions

Conditions	Yield
With copper dichloride In methanol; water for 3h; Heating;	85%

: 76757-85-2
N-nitrosoglycocholic acid

A: 79-14-1
glycolic Acid

B: 81-25-4
cholic acid

Conditions

Conditions	Yield
With water at 37℃; Rate constant; Mechanism; pH 7.0 - 9.0;	A 85% B 50%

: 13360-52-6
Cellobiose

A: 79-14-1
glycolic Acid

B: 57-48-7
D-Fructose

C: 642-99-9
mannonic acid

Conditions

Conditions	Yield
With copper(II) oxide In water at 199.84℃; for 0.5h; Temperature; Inert atmosphere;	A n/a B n/a C 85%

...Expand

: 141-46-8
Glycolaldehyde

A: 64-18-6
formic acid

B: 79-14-1
glycolic Acid

C: 131543-46-9
Glyoxal

D: 124-38-9
carbon dioxide

E: 64-19-7
acetic acid

Conditions

Conditions	Yield
With water; oxygen at 90℃; under 7500.75 Torr; for 8h; Catalytic behavior; Mechanism; Temperature; Pressure; Time; Reagent/catalyst;	A 80.5% B 4.2% C 6.2% D 2.6% E 0.3%

...Expand

: 85515-90-8
C11H14N2O5S

: 79-14-1
glycolic Acid

Conditions

Conditions	Yield
With copper dichloride In methanol; water for 24h; Heating;	80%

: 56-81-5
glycerol

: 79-14-1
glycolic Acid

Conditions

Conditions	Yield
With dihydrogen peroxide; zinc(II) oxide In water for 3h; Reagent/catalyst; UV-irradiation;	77%
With dihydrogen peroxide; yttrium(III) trifluoromethanesulfonate In acetonitrile at 70℃; for 12h;	16%
With dihydrogen peroxide

: 50-99-7
D-glucose

A: 79-14-1
glycolic Acid

B: 849585-22-4
LACTIC ACID

Conditions

Conditions	Yield
With oxygen In water at 180℃; under 13680.9 Torr; for 20h; Green chemistry;	A 23.3% B 76.7%

: 87-69-4
tartaric acid

A: 79-14-1
glycolic Acid

B: 110-17-8
(2E)-but-2-enedioic acid

Conditions

Conditions	Yield
With oxygen In water at 160℃; under 13680.9 Torr; for 10h; Reagent/catalyst;	A 27% B 73%

: 56-81-5
glycerol

A: 64-18-6
formic acid

B: 79-14-1
glycolic Acid

C: 64-19-7
acetic acid

Conditions

Conditions	Yield
With aluminium(III) triflate; dihydrogen peroxide In acetonitrile at 70℃; for 12h; Reagent/catalyst;	A 72% B 20% C 8%

...Expand

: 50-99-7
D-glucose

A: 79-14-1
glycolic Acid

B: 849585-22-4
LACTIC ACID

C: 110-15-6
succinic acid

Conditions

Conditions	Yield
With oxygen In water at 180℃; under 7600.51 Torr; for 20h; Temperature; Pressure; Reagent/catalyst; Green chemistry;	A 15.5% B 71% C 13.5%

...Expand

: 13360-52-6
Cellobiose

A: 79-14-1
glycolic Acid

B: 526-95-4
gluconic acid

C: 110-15-6
succinic acid

D: 144-62-7
oxalic acid

E: 64-19-7
acetic acid

Conditions

Conditions	Yield
With carbon nanotube supported gold nanoparticles (0.5 wt%); water; oxygen at 145℃; under 7500.75 Torr; for 3h;	A n/a B 70% C n/a D n/a E n/a

...Expand

: 56-81-5
glycerol

A: 64-18-6
formic acid

B: 79-14-1
glycolic Acid

C: 56-82-6
Glyceraldehyde

Conditions

Conditions	Yield
With potassium hydroxide for 4h; Reagent/catalyst; Electrochemical reaction;	A 70% B 13% C 17%
With dihydrogen peroxide In water at 60℃; for 4h;

...Expand

: 87-69-4
tartaric acid

A: 79-14-1
glycolic Acid

B: 849585-22-4
LACTIC ACID

C: 110-17-8
(2E)-but-2-enedioic acid

Conditions

Conditions	Yield
With oxygen In water at 160℃; under 13680.9 Torr; for 10h;	A 69% B 7% C 24%

...Expand

: 13360-52-6
Cellobiose

A: 79-14-1
glycolic Acid

B: 50-99-7
D-glucose

C: 526-95-4
gluconic acid

D: 110-15-6
succinic acid

E: 144-62-7
oxalic acid

F: 64-19-7
acetic acid

Conditions

Conditions	Yield
With carbon nanotube supported gold nanoparticles (0.5 wt%); water; oxygen at 145℃; under 3750.38 Torr; for 3h;	A n/a B n/a C 68% D n/a E n/a F n/a

...Expand

: 58-86-6
D-xylose

A: 79-14-1
glycolic Acid

B: 849585-22-4
LACTIC ACID

Conditions

Conditions	Yield
With water; Amberlite IRA400 at 50℃; for 2h; Product distribution / selectivity;	A n/a B 64%

: 56-81-5
glycerol

A: 5464-28-8
1,3-dioxolane-4-methanol

B: 4740-78-7
glycerol formal

C: 79-14-1
glycolic Acid

D: 623-50-7
ethyl 2-hydroxyacetate

E: 627-82-7
diglycerol

F: 556-52-5
oxiranyl-methanol

G: 116-09-6
hydroxy-2-propanone

H: 107-02-8
acrolein

Conditions

Conditions	Yield
With pretreated aluminium vanadium phosphate In water at 280℃; under 760.051 Torr; Catalytic behavior; Activation energy; Reagent/catalyst; Temperature;	A n/a B n/a C n/a D n/a E n/a F n/a G n/a H 62%

...Expand

: 79-14-1
glycolic Acid

: 496-72-0
4-methyl-1,2-diaminobenzene

: 20034-02-0
(5-methyl-1H-benzimidazole-2-yl)methanol

Conditions

Conditions	Yield
With hydrogenchloride In water for 3h; Reflux;	100%
With hydrogenchloride In water for 6h; Reflux;	83%
With phosphoric acid at 130℃; for 3h;	72%

: 79-14-1
glycolic Acid

: 18162-48-6
tert-butyldimethylsilyl chloride

: 67226-76-0
(tert-butyldimethylsiloxy) acetic acid tert-butyldimethylsilyl ester

Conditions

Conditions	Yield
With pyridine for 2h; Ambient temperature;	100%
With 1H-imidazole In N,N-dimethyl-formamide for 10h; Ambient temperature;	97%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 16h;	95%

: 79-14-1
glycolic Acid

: 222851-56-1
N-phenylsulfinylamine

: 4746-61-6
glycolanilide

Conditions

Conditions	Yield
at 25℃; for 8h;	100%
In acetonitrile at 20℃; Inert atmosphere;	53.6%

: 79-14-1
glycolic Acid

: 13165-68-9, 52867-11-5
N-(4-chloro-phenyl)-sulfur imide oxide

: 21919-09-5
glycolic acid-(4-chloro-anilide)

Conditions

Conditions	Yield
at 25℃; for 6h;	100%

: 79-14-1
glycolic Acid

: FR901469 hydrochloride

: C73H118N14O25

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;	100%

: 2,2′-bis(pyrazolyl)-ethylamine

: 79-14-1
glycolic Acid

: C10H13N5O2

Conditions

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 20℃;	100%

: 79-14-1
glycolic Acid

: 102-51-2
4-methoxy-1,2-phenylenediamine

: 20033-99-2
(5-methoxy-1H-benzimidazole-2-yl)-methanol

Conditions

Conditions	Yield
With hydrogenchloride In water Reflux;	100%
With hydrogenchloride In water for 6h; Reflux;	51%
Stage #1: glycolic Acid; 4-methoxy-1,2-phenylenediamine With hydrogenchloride In water for 16h; Heating / reflux; Stage #2: With sodium hydroxide In water
With hydrogenchloride In water for 6h; Reflux;
With hydrogenchloride In water at 100℃; for 6h;

: 79-14-1
glycolic Acid

: piperidine-4-carboxylic acid benzyl ester hydrochloride

: 945955-09-9
benzyl 1-glycoloylpiperidine-4-carboxylate

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In acetonitrile at 20℃; for 12h;	100%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In acetonitrile at 20℃; for 48h;	57%

: 79-14-1
glycolic Acid

: 71125-38-7
meloxicam

: 1174325-97-3
meloxicam glycolic acid

Conditions

Conditions	Yield
In chloroform for 0.5h;	100%
In tetrahydrofuran Product distribution / selectivity;

: 79-14-1
glycolic Acid

: 78583-81-0
3-(4-chlorophenyl)-1H-pyrazol-5-amine

: 1160285-30-2
N-(3-(4-chlorophenyl)-1H-pyrazol-5-yl)-2-hydroxyacetamide

Conditions

Conditions	Yield
In toluene at 110℃; for 48h; Inert atmosphere;	100%

: 79-14-1
glycolic Acid

: 36394-85-1
4,6,4',6'-tetrachloro-2,2'-(3,6-dioxa-octane-1,8-diyldioxy)-bis-[1,3,5]triazine

: C16H16Cl2N6O10(2-)*2Na(1+)

Conditions

Conditions	Yield
Stage #1: glycolic Acid With sodium hydride In DMF (N,N-dimethyl-formamide) at 0 - 20℃; for 2h; Stage #2: 4,6,4',6'-tetrachloro-2,2'-(3,6-dioxa-octane-1,8-diyldioxy)-bis-[1,3,5]triazine In DMF (N,N-dimethyl-formamide) at 0 - 20℃;	100%

: 79-14-1
glycolic Acid

: (R)-6-chloro-5-fluoro-2-(6-fluoroimidazo[1,2-a]pyridin-3-yl)-N-(piperidin-3-yl)pyrimidin-4-amine

: 2-((3R)-3-{[6-chloro-5-fluoro-2-(6-fluoroimidazo[1,2-a]pyridin-3-yl)pyrimidin-4-yl]amino} piperidin-1-yl)-2-oxoethanol

Conditions

Conditions	Yield
Stage #1: (R)-6-chloro-5-fluoro-2-(6-fluoroimidazo[1,2-a]pyridin-3-yl)-N-(piperidin-3-yl)pyrimidin-4-amine With triethylamine In N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: glycolic Acid With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 4.5h;	100%

: 79-14-1
glycolic Acid

: C25H33NO9

: C23H31NO9

Conditions

Conditions	Yield
Stage #1: C25H33NO9 With tetrakis(triphenylphosphine) palladium(0); N,N-Dimethyltrimethylsilylamine In chloroform at 20℃; for 2h; Inert atmosphere; Stage #2: glycolic Acid With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride In tetrahydrofuran at 20℃; for 2h;	100%

: 79-14-1
glycolic Acid

: C47H58N2O14

: 1-allyl-2-glycolylamino-6-O-benzyl-4-O-(3’-O-benzyl-4’,6’-O-benzylidene-2’-deoxy-2’-ethylamino-β-D-glucopyranosyl)-2-deoxy-3-O-[(R)-1-(ethoxycarbonyl)ethyl]-α-D-glucopyranoside

Conditions

Conditions	Yield
Stage #1: C47H58N2O14 With tetrakis(triphenylphosphine) palladium(0); N,N-Dimethyltrimethylsilylamine In chloroform at 20℃; for 2h; Inert atmosphere; Stage #2: glycolic Acid With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride In tetrahydrofuran at 20℃; for 2h;	100%

: 79-14-1
glycolic Acid

: 4-(benzyloxy)-5-chlorobenzene-1,2-diamine

: N-(2-amino-4-(benzyloxy)-5-chlorophenyl)-2-hydroxyacetamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane at 20℃; for 2h;	100%

: 79-14-1
glycolic Acid

: 214360-73-3
4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline

: C14H20BNO4

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 36h;	100%

: 79-14-1
glycolic Acid

: tris(4-aza-2-hydroxydecyl)amine

: tris(4-aza-2,6-dihydroxy-4-hexyl-5-oxohexyl)amine

Conditions

Conditions	Yield
In 5,5-dimethyl-1,3-cyclohexadiene	99.7%

: 79-14-1
glycolic Acid

: 60142-96-3
H-Gpn-OH

: C9H17NO2*C2H4O3

Conditions

Conditions	Yield
In neat (no solvent) for 0.25h; Green chemistry;	99.3%

: 108-01-0
2-(N,N-dimethylamino)ethanol

: 79-14-1
glycolic Acid

: 176158-74-0
N,N-dimethylethanolammonium glycolate

Conditions

Conditions	Yield
In ethanol	99%

: 79-14-1
glycolic Acid

: 141-43-5
ethanolamine

: 22375-00-4
(4,5-dihydrooxazol-2-yl)methanol

Conditions

Conditions	Yield
In xylene for 6h; Heating / reflux;	99%

: 79-14-1
glycolic Acid

: 939965-82-9
N-[4-(4-amino-7-piperidin-4-ylpyrrolo[2,1-f][1,2,4]triazin-5-yl)-2-fluorophenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]urea

: 939965-86-3
N-4-[4-amino-7-(1-glycoloylpiperidin-4-yl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]-2-fluorophenyl-N'-[2-fluoro-5-(trifluoromethyl)phenyl]urea

Conditions

Conditions	Yield
With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 17h;	99%

: 79-14-1
glycolic Acid

: 108-42-9
3-chloro-aniline

: N-(3-chlorophenyl)-2-hydroxyacetamide

Conditions

Conditions	Yield
at 130℃; for 5h; Inert atmosphere;	99%

: 5625-96-7
(morpholinomethyl)hydrosilane

: 79-14-1
glycolic Acid

: 1138348-24-9
5-(morpholin-4-iomethyl)-2,7-dioxo-1,4,6,9-tetraoxa-5-silaspiro[4,4]nonan-5-uide

Conditions

Conditions	Yield
In dichloromethane at 20℃; for 0.25h; Solvent;	99%

: 79-14-1
glycolic Acid

: (R)-5-bromo-2-(3-methylpiperazin-1-yl)pyrimidine dihydrochloride

: (R)-1-(4-(5-bromopyrimidin-2-yl)-2-methylpiperazin-1-yl)-2-hydroxyethanone

Conditions

Conditions	Yield
With triethylamine; HATU In N,N-dimethyl-formamide for 1.5h;	99%
With triethylamine; HATU In N,N-dimethyl-formamide for 4h;	87%

: 79-14-1
glycolic Acid

: 64-19-7
acetic acid

Conditions

Conditions	Yield
With hydrogen; propionic acid; sodium iodide at 220℃; under 20686.5 Torr; for 1h;	99%

Glycolic acid Chemical Properties

Product Name: Glycolic acid (CAS NO.79-14-1)

Molecular Formula: C₂H₄O₃
Molecular Weight: 76.05g/mol
Mol File: 79-14-1.mol
EINECS: 201-180-5
Appearance: colourless crystalline solid
Melting Point: 75-80 °C(lit.)
Boiling point: 265.6 °C at 760 mmHg
Flash Point: 128.7 °C
Density: 1.416 g/cm³
Refractive index: n20/D 1.424
Water Solubility: SOLUBLE
Sensitive: Hygroscopic
Stability: Stable. Incompatible with bases, oxidizing agents and reducing agents
Index of Refraction: 1.449
Molar Refractivity: 14.41 cm³
Molar Volume: 53.6 cm³
Surface Tension: 61.3 dyne/cm
Enthalpy of Vaporization: 58.47 kJ/mol
Vapour Pressure: 0.00125 mmHg at 25°C
XLogP3-AA: -1.1
H-Bond Donor: 2
H-Bond Acceptor: 3
Structure Descriptors of Glycolic acid (CAS NO.79-14-1):
IUPAC Name: 2-hydroxyacetic acid
Canonical SMILES: C(C(=O)O)O
InChI: InChI=1S/C2H4O3/c3-1-2(4)5/h3H,1H2,(H,4,5)
InChIKey: AEMRFAOFKBGASW-UHFFFAOYSA-N
Product Categories: Pharmaceutical Intermediates; Roxatidine Acetate; omega-Hydroxycarboxylic Acids; omega-Functional Alkanols, Carboxylic Acids, Amines & Halides; Hydroxycarboxylic Acids (for High-Performance Polymer Research); Functional Materials; Reagent for High-Performance Polymer Research; Cosmetic Ingredients & Chemicals

Glycolic acid Uses

Glycolic acid (CAS NO.79-14-1) can be used in various skin-care products.Due to its excellent capability to penetrate skin.
Glycolic acid is also a useful intermediate for organic synthesis, in a range of reactions including: oxidation-reduction, esterification and long chain polymerization. It is also used as a monomer in the preparation of polyglycolic acid and other biocompatible copolymers. Glycolic acid is often included into emulsion polymers, solvents and additives for ink and paint in order to improve flow properties and impart gloss.Other uses :in the textile industry as a dyeing and tanning agent, in food processing as a flavoring agent and as a preservative.

Glycolic acid Production

Glycolic acid (CAS NO.79-14-1) is prepared by the reaction of chloroacetic acid with sodium hydroxide followed by re-acidification as follows:
ClCH₂CO₂H + NaOH → HOCH₂CO₂H + NaCl
In this way, a few million kilograms are produced annually. Other methods, include hydrogenation of oxalic acid and the hydrolysis of the cyanohydrin derived from formaldehyde.but not apparently in use. Glycolic acid can be isolated from natural sources, such as sugar beets, sugarcane, canteloupe, pineapple, and unripe grapes.
Glycolic acid,we can also using an enzymatic biochemical process,compared to traditional chemical synthesis,it produces fewer impurities , requires less energy in production and produces less co-product.

Glycolic acid Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LD50	intravenous	1gm/kg (1000mg/kg)		"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 656, 1986.
guinea pig	LD50	oral	1920mg/kg (1920mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES	Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941.
rat	LC50	inhalation	7100ug/m3/4H (7.1mg/m3)	SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Inhalation Toxicology. Vol. 9, Pg. 435, 1997.
rat	LD50	oral	1950mg/kg (1950mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES	Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941.

Glycolic acid Consensus Reports

Reported in EPA TSCA Inventory.

Glycolic acid Safety Profile

Moderately toxic by ingestion. A severe eye irritant. A skin and mucous membrane irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
Safety Information of Glycolic acid (CAS NO.79-14-1):
Hazard Codes: C Corrosive
Risk Statements: 34-22
R34: Causes burns.
R22: Harmful if swallowed.
Safety Statements: 26-36/37/39-45-23
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S23: Do not breathe vapour.
RIDADR: UN 3265 8/PG 3
WGK Germany: 1
RTECS: MC5250000
HazardClass: 8
PackingGroup: II

Glycolic acid Specification

Glycolic acid , its CAS NO. is 79-14-1, the synonyms are 2-Hydroxyacetic acid ; Acetic acid, hydroxy- ; EPA Pesticide Chemical Code 000101 ; Glycollic acid ; Hydroxyacetic acid ; Hydroxyethanoic acid ; Kyselina glykolova ; Kyselina hydroxyoctova .

Product Name

Glycolic acid

Synthetic route

Glycolic acid Chemical Properties

Glycolic acid Uses

Glycolic acid Production

Glycolic acid Toxicity Data With Reference

Glycolic acid Consensus Reports

Glycolic acid Safety Profile

Glycolic acid Specification

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