tekturna;aliskiren;renin inhibitor;renin inhibitors;tekturna aliskiren

HANGZHOU HOLYPHARM BIOTECH CO.,LTD

Country:China (Mainland)

Year Established: 2009Business type: Other

Integral:

1. Introduction of Tekturna

Tekturna (Aliskiren), with its cas register number 173334-57-1, can be called as (2S,4S,5S,7S)-5-Amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide. It is an orally active, synthetic nonpeptide renin inhibitor, used to be antihypertensive. The Classification Code of Aliskiren are as below: Antihypertensive; Renin Inhibitor; Treatment of essential hypertension [renin inhibitors].

2. Properties of Tekturna

Properties of Aliskiren (Tekturna) are as below: (1)ACD/LogP: 2.794; (2)# of Rule of 5 Violations: 2; (3)ACD/LogD (pH 5.5): -0.30; (4)ACD/LogD (pH 7.4): 0.12; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4): 1.69; (9)#H bond acceptors: 9; (10)#H bond donors: 6; (11)#Freely Rotating Bonds: 21; (12)Polar Surface Area: 146.13; (13)Index of Refraction: 1.514; (14)Molar Refractivity: 155.539 cm³; (15)Molar Volume: 516.977 cm³; (16)Polarizability: 61.66×10^-24 cm³; (17)Surface Tension: 40.5839996337891 dyne/cm; (18)Density: 1.067 g/cm³; (19)Flash Point: 406.402 °C; (20)Enthalpy of Vaporization: 114.478 kJ/mol; (21)Boiling Point: 748.374 °C at 760 mmHg; (22)Vapour Pressure: 0 mmHg at 25°C.

You can still convert the following datas into molecular structure:
1). SMILES:O=C(N)C(C)(C)CNC(=O)[C@H](C(C)C)C[C@H](O)[C@@H](N)C[C@@H](C(C)C)Cc1cc(OCCCOC)c(OC)cc1
2). Std. InChI:InChI=1S/C30H53N3O6/c1-19(2)22(14-21-10-11-26(38-8)27(15-21)39-13-9-12-37-7)16-24(31)25(34)17-23(20(3)4)28(35)33-18-30(5,6)29(32)36/h10-11,15,19-20,22-25,34H,9,12-14,16-18,31H2,1-8H3,(H2,32,36)(H,33,35)/t22-,23-,24-,25-/m0/s1
3). Std. InChIKey:UXOWGYHJODZGMF-QORCZRPOSA-N

3. Side effects of Tekturna

When used as one renin Inhibitor, Tekturna has many adverse effects, such as Angioedema, Hyperkalemia, Hypotension and so on. But according to the researchers in Hangzhou Holypharm biotech Co.,Ltd., a professional supplier of active pharmaceutical ingredients and intermediates, it will be no much serious matters if you do after referring to your own doctor.

HANGZHOU HOLYPHARM BIOTECH CO.,LTD is a professional supplier of active pharmaceutical ingredients and intermediates; agrochemicals and Veterinary products. We are specialized in contract R&D and custom manufacturing. we have rich experience on a wide range of chemical reactions and fermentation from multi gram scale to hundred tons scale according to customers' requirement. Moreover, we are quite strong on registration. Our products have been registered in India, Vietnam, Latin America, Turkey, etc. HANGZHOU HOLYPHARM BIOTECH CO.,LTD is mainly engaged in the importing and exporting of pharmaceutical raw materials and intermediates to the markets of Europe and North America, and B2B e-commerce platform is undoubtedly an important platform for foreign trade enterprises who are looking for domestic opportunities. Holypharm forges their products to the foreign buyers' accustomed searching mode, which is the most effective way to advertise. We have three departments, PHARM DEPT. ,VETERINARY DEPT., AGROCHMICAL DEPT. We gather most qualified staffs with years of practical experience and knowledge in each department . They have better ideas on quality control, registration data, excellent packaging & labeling and logistics. To provide clients with more technology support, we will present efficient regulatory documents to show professional abilities in this field. Professional services The enterprise armed with knowledge will always keep its vitality and development. The human resources department in HANGZHOU HOLYPHARM will train its staff at regular intervals, to help them have a in-depth understanding of business regulations, foreign trade processes, chemical knowledge, communication skills, and so on. After foreign buyers gives the order, the company will give the one-stop services with factory-auditing, inspection, order management, export declaration to freight logistics. In addition, HANGZHOU HOLYPHARM will provide free extra services for foreign buyers like investigation of domestic market and consulting services, which is highly appraised by customers. As a company in the field of chemical export industry for many years, HOLYPHARM is engaged in improving the professional competence of the business staff and their professional services, which is not only the best way to win customers, but also helps to dig out the potential value of the chemical industry chain which are negligent.

Basic Information

Company Name：HANGZHOU HOLYPHARM BIOTECH CO.,LTD
Number of Employees：11 - 50
Contact person：Leonard
Street Address：Room D808, Block 4 NO.176, Zixia Rd
City：Hangzhou
Province/State：Zhejiang
Country/Region：China (Mainland)
Zip：310007
Business type：Other
Tel：86 571 86853097
Fax：86 571 87357695
Website：
Year Established：2009

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