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HANGZHOU HOLYPHARM BIOTECH CO.,LTD

Country:China (Mainland)

Year Established: 2009Business type: Other

Integral:

1.  Introduction of Aliskiren

Aliskiren, with its brand name of Tekturna and CAS registry number 173334-57-1, has its IUPAC Name of (2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2,2-dimethylethyl)-4-hydroxy-7-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-8-methyl-2-(propan-2-yl)nonanamide. Belonging to the Categories of Antihypertensive Agents, Aliskiren is being for the treatment of mild to moderate hypertension, and it may be used alone or in combination with other antihypertensive agents. As to its toxicity, the most likely manifestation of overdosage would be hypotension.

2. Aliskiren Synthesis

As a nonpeptide renin inhibitor, Aliskiren is marketed under the trade name Tekturna by Novartis. And when comes to Aliskiren synthesis, it could be done through the following way: Use the chemical resolution method to produce chiral fragment compound 1 and 2 which are needed in the synthesis of aliskiren; And then have the five-steps method to produce the final product aliskiren, with the total yield of 15.6%. And if you want to know more about the synthesis methods of Aliskiren, you could refer to many leading Chinese suppliers, such as Hangzhou Holypharm biotech Co.,Ltd., which is a professional supplier of active pharmaceutical ingredients and intermediates.

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