(1,1'-Biphenyl)-4-sulphonyl chloride supplier

Name
4-BIPHENYLSULFONYL CHLORIDE
EINECS 216-609-1
CAS No. 1623-93-4
Article Data23
CAS DataBase
Density 1.32 g/cm³
Solubility Reacts with water.
Melting Point 103-108 °C(lit.)
Formula C₁₂HC₉ClOC₂S
Boiling Point 375.3 °C at 760 mmHg
Molecular Weight 252.721
Flash Point 180.8 °C
Transport Information UN 3261 8
Appearance White crystalline powder
Safety S26; S36/37/39; S45
Risk Codes R14; R34
Molecular Structure
Hazard Symbols C
Synonyms 4-Biphenylsulfonylchloride (6CI,7CI,8CI);(4-Biphenylyl)sulfonyl chloride;4-(Chlorosulfonyl)biphenyl;4-Phenylbenzenesulfonic acid chloride;4-Phenylbenzenesulfonyl chloride;p-Biphenylsulfonyl chloride;p-Phenylbenzenesulfonyl chloride;
PSA 42.52000
LogP 4.36190

Synthetic route

: 2113-68-0
4-biphenylmonosulfonic acid

: 1623-93-4
4-diphenylsulfonyl chloride

Conditions

Conditions	Yield
With thionyl chloride; N,N-dimethyl-formamide at 80℃; for 2h;	80%
With P,P-dichlorophenylphosphine oxide at 90℃; for 24h;
With trichlorophosphate Yield given;

: 92-67-1
4-Aminobiphenyl

: 1623-93-4
4-diphenylsulfonyl chloride

Conditions

Conditions	Yield
Stage #1: 4-phenylalanine With hydrogenchloride; acetic acid; sodium nitrite In water; acetonitrile at 0 - 5℃; Stage #2: With sulfur dioxide; copper dichloride In water; acetonitrile at 20℃; for 16h;	80%

: biphenyl-4-sulphonic acid potassium salt

: 1623-93-4
4-diphenylsulfonyl chloride

Conditions

Conditions	Yield
With phosphorus pentachloride; trichlorophosphate at 130℃; for 3h;	77.3%

: 92-52-4
biphenyl

: 1623-93-4
4-diphenylsulfonyl chloride

Conditions

Conditions	Yield
With chlorosulfonic acid; thionyl chloride for 168h; Ambient temperature;	43%
With chlorosulfonic acid at 5 - 65℃;
With chlorosulfonic acid In chloroform at 20℃; for 0.75h;
Multi-step reaction with 2 steps 1: chlorosulfonic acid / chloroform / 1.5 h / Inert atmosphere; Cooling with ice 2: thionyl chloride; N,N-dimethyl-formamide / 2 h / 80 °C View Scheme

potassium salt of/the/ dibenzenesulfonic acid-(4): potassium salt of/the/ dibenzenesulfonic acid-(4)

: 1623-93-4
4-diphenylsulfonyl chloride

Conditions

Conditions	Yield
With phosphorus pentachloride

: 92-66-0
4-bromo-1,1'-biphenyl

: 1623-93-4
4-diphenylsulfonyl chloride

Conditions

Conditions	Yield
Stage #1: 4-bromo-1,1'-biphenyl With iodine; magnesium In tetrahydrofuran for 1h; Heating; Stage #2: With sulfur dioxide In tetrahydrofuran at -40℃; for 0.5h; Stage #3: With sulfuryl dichloride In tetrahydrofuran at -40 - 20℃;

: 92-52-4
biphenyl

C6H4Cl2, C12H9Cl, HCl: C6H4Cl2, C12H9Cl, HCl

: 1623-93-4
4-diphenylsulfonyl chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: ClSO3H / CHCl3 / 20 °C 2: SOCl2 / dimethylformamide / Heating View Scheme

: 92-52-4
biphenyl

trans-PdPh(I)(PEt2Ph)2: trans-PdPh(I)(PEt2Ph)2

: 1623-93-4
4-diphenylsulfonyl chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: concentrated sulfuric acid / 1 h / 80 °C 2: phosphorus oxychloride View Scheme

: 92-52-4
biphenyl

methyldibenzothiophene, ethyldibenzothiophene, H2S,others: methyldibenzothiophene, ethyldibenzothiophene, H2S,others

: 1623-93-4
4-diphenylsulfonyl chloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: chlorosulfonic acid / 0.5 h 2: phenylphosphonic dichloride / 24 h / 90 °C View Scheme

: 885672-69-5
1-(4-chlorophenyl)-N3,N3-dimethylpropane-1,3-diamine

: 1623-93-4
4-diphenylsulfonyl chloride

: N-[1-(4-chlorophenyl)-3-dimethylaminopropyl]-4-phenyl-benzenesulfonamide

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 18h;	100%

: 1623-93-4
4-diphenylsulfonyl chloride

: 107-11-9
1-amino-2-propene

: 1136711-00-6
N-allyl-[1,1'-biphenyl]-4-sulfonamide

Conditions

Conditions	Yield
With sodium hydroxide In diethyl ether; water at 0 - 20℃; for 3h;	100%

: 875-74-1
(R)-phenylglycine

: 1623-93-4
4-diphenylsulfonyl chloride

: 193808-16-1
N-(biphenyl-4-sulfonyl)-D-phenylglycine

Conditions

Conditions	Yield
With sodium hydroxide In diethyl ether at 20℃; for 16h;	99%

: 1623-93-4
4-diphenylsulfonyl chloride

: 2133-40-6
L-proline methyl ester monohydrochloride

: methyl (S)-1-([1,1’-biphenyl]-4-ylsulfonyl)pyrrolidine-2-carboxylate

Conditions

Conditions	Yield
With 4-methyl-morpholine In dichloromethane at 20℃; for 5h; Inert atmosphere;	98%

: 2620-50-0
1,3-benzodioxol-5-ylmethyl amine

: 1623-93-4
4-diphenylsulfonyl chloride

: N-(1,3-benzodioxol-5-ylmethyl)-4-diphenylsulfonamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 4h; Reflux;	98%

: 1623-93-4
4-diphenylsulfonyl chloride

: 19813-90-2
4-biphenylthiol

Conditions

Conditions	Yield
With tris(2-carboxyethyl)phosphine In 1,4-dioxane; water for 6h; Heating;	96%
With triphenylphosphine In 1,4-dioxane; water for 16h; Heating;	84%

: 1365699-34-8
N1-((5S,5aS,8aR,9R)-8-oxo-9-(3,4,5-trimethoxyphenyl)-5,5a,6,8,8a,9-hexahydro[1,3]dioxolo[4',5':4,5]benzo[f]isobenzofuran-5-yl)-4-aminobenzamide

: 1623-93-4
4-diphenylsulfonyl chloride

: 1365699-51-9
4β-[4'-(biphenyl-4-sulfonamido)benzamide]podophyllotoxin

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 3h;	96%

: 177198-62-8, 177198-64-0, 177202-62-9
1,2,3,4-Tetrahydro-quinoline-3-carboxylic acid methyl ester

: 1623-93-4
4-diphenylsulfonyl chloride

: (±)-methyl 1-([1,1'-biphenyl]-4-ylsulfonyl)-1,2,3,4-tetrahydroquinoline-3-carboxylate

Conditions

Conditions	Yield
With dmap; N-ethyl-N,N-diisopropylamine In chloroform for 16h; Inert atmosphere; Reflux;	96%

: 1623-93-4
4-diphenylsulfonyl chloride

: 197069-37-7
(1R,2R,3S,5S)-(5Z)-7-(2-amino-6,6-dimethylbicyclo[3.1.1]hept-3-yl)-hept-5-enoic acid methyl ester

: 120632-50-0
methyl (5Z)-7-((1R,2R,3S,5S)-2-(p-biphenyl sulfonylamino)-6,6-dimethylbicyclo<3.1.1>hept-3-yl)hept-5-enoate

Conditions

Conditions	Yield
With triethylamine In dichloromethane for 1h; Ambient temperature;	95.3%

: 578-66-5
8-amino quinoline

: 1623-93-4
4-diphenylsulfonyl chloride

: N-(quinolin-8-yl)-[1,1’-biphenyl]-4-sulfonamide

Conditions

Conditions	Yield
With pyridine at 0 - 20℃;	95%
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;	77%
With triethylamine In dichloromethane at 0 - 20℃;	70%

: 1623-93-4
4-diphenylsulfonyl chloride

: 155252-35-0
4β-amino-4-deoxypodophyllotoxin

: 1365699-73-5
4β-[biphenyl-4-sulfonamido]podophyllotoxin

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 3h;	95%

: C14H21N5O2

: 1623-93-4
4-diphenylsulfonyl chloride

: 1401318-33-9
C26H29N5O4S

Conditions

Conditions	Yield
In dichloromethane Inert atmosphere;	95%

: 2206-94-2
1-acetoxy-1-phenylethene

: 1623-93-4
4-diphenylsulfonyl chloride

: 130188-81-7
2-([1,1′-biphenyl]-4-ylsulfonyl)-1-phenylethan-1-one

Conditions

Conditions	Yield
With fac-Ir(ppy)3 In dichloromethane at 20℃; Inert atmosphere; Irradiation;	95%

: 1623-93-4
4-diphenylsulfonyl chloride

: copper(l) cyanide

: 2920-38-9
4-cyano-1,1'-biphenyl

Conditions

Conditions	Yield
With dichloro bis(acetonitrile) palladium(II); copper acetylacetonate; sodium carbonate In 1,4-dioxane at 130℃; for 24h; Sealed tube; Air;	93%

: 1623-93-4
4-diphenylsulfonyl chloride

: 13033-84-6
D-phenylalanine methyl ester hydrochloride

: methyl ([1,1'-biphenyl]-4-ylsulfonyl)-D-phenylalaninate

Conditions

Conditions	Yield
With pyridine at 130℃; for 0.2h; Microwave irradiation;	93%

: 1623-93-4
4-diphenylsulfonyl chloride

: 824420-41-9
4-(4-bromo-phenyl)-1-nicotinoyl semicarbazide

: biphenyl-4-sulfonic acid (4-bromophenyl)-(5-pyridin-3-yl-[1,3,4]oxadiazol-2-yl)amide

Conditions

Conditions	Yield
With polymer-supported 1,3,2-diazaphosphorinane derivative In acetonitrile at 150℃; for 0.333333h; microwave irradiation;	92%

: 1016265-90-9
benzyl 7-amino-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

: 1623-93-4
4-diphenylsulfonyl chloride

: benzyl-7-([(4-biphenyl)sulfonyl]amino)-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃;	92%

: 88-12-0
1-ethenyl-2-pyrrolidinone

: 1623-93-4
4-diphenylsulfonyl chloride

: 1429936-59-3
(E)-1-(2-(biphenyl-4-ylsulfonyl)vinyl)pyrrolidin-2-one

Conditions

Conditions	Yield
With sodium dihydrogenphosphate; (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate In acetonitrile at 20℃; for 8h; Inert atmosphere; Irradiation;	92%

: 2508-29-4
5-hydroxypentylamine

: 1623-93-4
4-diphenylsulfonyl chloride

: biphenyl-4-sulfonic acid-(5-hydroxypentyl)amide

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 2h;	91%

: 1623-93-4
4-diphenylsulfonyl chloride

: 3081-28-5, 6404-30-4, 16367-71-8, 16874-17-2
D-phenylalanine tert-butyl ester

: 1469273-31-1
C25H27NO4S

Conditions

Conditions	Yield
With dmap; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 3h;	91%

: 1623-93-4
4-diphenylsulfonyl chloride

: 59816-83-0
2-allyl-4-methyl-phenylamine

: C22H21NO2S

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0℃; for 16h;	91%

: 438012-15-8
C9H9Cl2N3OS

: 1623-93-4
4-diphenylsulfonyl chloride

: biphenyl-4-sulfonic acid (3,4-dichloro-phenyl)-(5-methyl-[1,3,4]oxadiazol-2-yl)-amide

Conditions

Conditions	Yield
With polymer-supported 1,3,2-diazaphosphorinane derivative at 150℃; for 0.333333h; microwave irradiation;	90%

: 1623-93-4
4-diphenylsulfonyl chloride

: 660-88-8
5-aminopentanoic acid

: 5-(biphenyl-4-sulfonylamino)pentanoic acid

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 2h;	90%

: 32704-22-6
2-allyl-phenylamine

: 1623-93-4
4-diphenylsulfonyl chloride

: C21H19NO2S

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0℃; for 16h;	90%
With pyridine In chloroform at 0 - 20℃;

: 477983-48-5
2-allyl-5-methylaniline

: 1623-93-4
4-diphenylsulfonyl chloride

: C22H21NO2S

Conditions

Conditions	Yield
With pyridine In dichloromethane at 0℃; for 16h;	90%

: 1623-93-4
4-diphenylsulfonyl chloride

: 211572-59-7
N-benzyl-2-(pyridin-3-ylcarbonyl)hydrazinecarbothioamide

: biphenyl-4-sulfonic acid benzyl-(5-pyridin-3-yl-[1,3,4]thiadiazol-2-yl)-amide

Conditions

Conditions	Yield
With polymer-supported 1,3,2-diazaphosphorinane derivative at 150℃; for 0.333333h; microwave irradiation;	89%

: 13325-10-5
4-Aminobutanol

: 1623-93-4
4-diphenylsulfonyl chloride

: 871113-50-7
biphenyl-4-sulfonic acid-(4-hydroxybutyl)amide

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 2h;	89%
With pyridine In dichloromethane at 20℃; for 2h;

: 1623-93-4
4-diphenylsulfonyl chloride

: 1446-61-3
leelamine

: C32H39NO2S

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 23℃;	89%

: 1623-93-4
4-diphenylsulfonyl chloride

: 3-(4-(aminomethyl)benzyl)-7-ethyl-1H-purine-2,6(3H,7H)-dione trifluoroacetic acid salt

: N-(4-((7-ethyl-2,6-dioxo-1H-purin-3(2H,6H,7H)-yl)methyl)benzyl)-[1,1′-biphenyl]-4-sulfonamide

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 12h;	89%

: 1623-93-4
4-diphenylsulfonyl chloride

: (S)-N-(5,6-dihydroxybenzo[d]thiazol-2-yl)pyrrolidine-2-carboxamide hydrobromide

: (S)-1-([1,1'-biphenyl]-4-ylsulfonyl)-N-(5,6-dihydroxybenzo[d]thiazol-2-yl)pyrrolidine-2-carboxamide

Conditions

Conditions	Yield
With pyridine In acetonitrile for 14h;	89%

(1,1'-Biphenyl)-4-sulphonyl chloride Chemical Properties

Molecular Structure of (1,1'-Biphenyl)-4-sulphonyl chloride (CAS NO.1623-93-4):

IUPAC Name: 4-Phenylbenzenesulfonyl chloride
CAS NO: 1623-93-4
Molecular Formula: C₁₂H₉ClO₂S
Molecular Weight: 252.72
EINECS: 216-609-1
Index of Refraction: 1.595
Surface Tension: 44.4 dyne/cm
Density: 1.32 g/cm³
Flash Point: 180.8 °C
Enthalpy of Vaporization: 59.83 kJ/mol
Boiling Point: 375.3 °C at 760 mmHg
Vapour Pressure: 1.7E-05 mmHg at 25°C
Melting point: 103-108 °C(lit.)
Sensitive Moisture Sensitive
InChI
InChI=1/C12H9ClO2S/c13-16(14,15)12-8-6-11(7-9-12)10-4-2-1-3-5-10/h1-9H
Smiles
S(c1ccc(cc1)c1ccccc1)(=O)(=O)Cl
Product Categories: Phenyls & Phenyl-Het; Sulphonyl Chlorides; Phenyls & Phenyl-Het; Sulphonyl Chlorides; Organic Building Blocks; Sulfonyl Halides; Sulfur Compounds

(1,1'-Biphenyl)-4-sulphonyl chloride Safety Profile

Hazard Codes: Corrosive C
Risk Statements: 14-34
R14 :Reacts violently with water.
R34: causes burns.
Safety Statements: 26-36/37/39-45
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR UN 3261 8/PG 2
WGK Germany: 3
F: 10-21
Hazard Note: Corrosive
HazardClass: 8
PackingGroup: II

(1,1'-Biphenyl)-4-sulphonyl chloride Specification

(1,1'-Biphenyl)-4-sulphonyl chloride , with CAS number of 1623-93-4, can be called (1,1'-Biphenyl)-4-sulphonyl chloride ; [1,1'-biphenyl]-4-sulfonyl chloride ; 1,1'-Biphenyl-4-sulfonyl chloride ; Biphenyl-4-sulfonyl chloride . It is a white crystalline.powder. (1,1'-Biphenyl)-4-sulphonyl chloride (CAS NO.1623-93-4) is used as intermediate in organic synthesis.

Product Name

4-BIPHENYLSULFONYL CHLORIDE

Synthetic route

(1,1'-Biphenyl)-4-sulphonyl chloride Chemical Properties

(1,1'-Biphenyl)-4-sulphonyl chloride Safety Profile

(1,1'-Biphenyl)-4-sulphonyl chloride Specification

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