(4-Vinylphenyl)methanol supplier

Name
(4-Vinylphenyl)methanol
EINECS
CAS No. 1074-61-9
Article Data48
CAS DataBase
Density 1.039 g/cm³
Solubility
Melting Point
Formula C₉H₁₀O
Boiling Point 247.072 °C at 760 mmHg
Molecular Weight 134.178
Flash Point 115.435 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Benzylalcohol, p-vinyl- (6CI,7CI,8CI);4-Ethenylbenzenemethanol;4-Vinylbenzylalcohol;p-(Hydroxymethyl)styrene;p-Vinylbenzyl alcohol;(4-ethenylphenyl)methanol;benzenemethanol, 4-ethenyl-;
PSA 20.23000
LogP 1.82190

Synthetic route

: 1592-12-7
4-acetoxymethylstyrene

: 1074-61-9
(4-vinyl-phenyl)-methanol

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water for 4h; Reflux;	99%
With water; potassium hydroxide In methanol Reflux;	93%
With potassium hydroxide In methanol; water for 6h; Heating;	81%

: 1592-20-7
4-Vinylbenzyl chloride

: 1074-61-9
(4-vinyl-phenyl)-methanol

Conditions

Conditions	Yield
With sodium hydroxide; tetrabutylammomium bromide; water at 125℃; for 0.333333h;	98%
With cetyltrimethylammonim bromide; sodium hydroxide In water at 125℃; for 0.666667h;	95%
With tetrabutylammomium bromide; sodium hydroxide In water at 125℃; for 2h; Inert atmosphere;	57%

: 1791-26-0
4-vinyl-benzaldehyde

: 1074-61-9
(4-vinyl-phenyl)-methanol

Conditions

Conditions	Yield
With C46H49CoN3P4(2+)*2BF4(1-); hydrogen; potassium hydroxide In ethanol; acetonitrile at 60℃; under 22801.5 Torr; for 24h; Autoclave; Glovebox; chemoselective reaction;	95%
With sodium tetrahydroborate In methanol at 0 - 25℃; for 2h; Inert atmosphere;	92%
With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; tris[3,5-bis(trifluoromethyl)phenyl]-borane In 1,4-dioxane at 25℃; for 12h; Glovebox;	66%

: 10602-04-7
(4-ethynylphenyl)methanol

: 1074-61-9
(4-vinyl-phenyl)-methanol

Conditions

Conditions	Yield
With hydrogen In acetonitrile at 110℃; under 7500.75 Torr; for 15h; chemoselective reaction;	94%
With bis-triphenylphosphine-palladium(II) chloride; tri-n-butyl-tin hydride In tetrahydrofuran at 20℃; Inert atmosphere;

: 1076-96-6
methyl 4-vinylbenzoate

: 1074-61-9
(4-vinyl-phenyl)-methanol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran for 0.166667h; Inert atmosphere; Cooling with ice;	91%

: 873-75-6
4-bromobenzenemethanol

: potassium vinyltrifluoroborate

: 1074-61-9
(4-vinyl-phenyl)-methanol

Conditions

Conditions	Yield
With caesium carbonate; triphenylphosphine; palladium dichloride In tetrahydrofuran; water at 85℃; for 22h; Suzuki-Miyaura reaction;	82%

: 1592-20-7
4-Vinylbenzyl chloride

A: 1074-61-9
(4-vinyl-phenyl)-methanol

B: 115444-35-4
di(4-vinylbenzyl)ether

Conditions

Conditions	Yield
With sodium hydroxide; water In ethanol at 20℃; for 24h;	A 19% B 81%

: 2-(4-vinylbenzyloxy)pinacolborane

: 1074-61-9
(4-vinyl-phenyl)-methanol

Conditions

Conditions	Yield
With methanol at 20℃; for 0.5h; Inert atmosphere;	80%

: 74-85-1
ethene

: 18282-51-4
4-iodo-benzyl alcohol

: 1074-61-9
(4-vinyl-phenyl)-methanol

Conditions

Conditions	Yield
With palladium diacetate; tetra-(n-butyl)ammonium iodide; triethylamine; CyJohnPhos In N,N-dimethyl-formamide; toluene at 120℃; under 11251.1 Torr; for 0.333333h; Mizoroki-Heck coupling;	78%
With palladium diacetate; tetra-(n-butyl)ammonium iodide; triethylamine; johnphos In N,N-dimethyl-formamide; toluene at 120℃; under 11251.1 Torr; for 0.333333h; Heck Reaction;	78%

: 1075-49-6
4-ethenylbenzoic acid

: 1074-61-9
(4-vinyl-phenyl)-methanol

Conditions

Conditions	Yield
With phenylsilane; C34H30CoO6; potassium In tetrahydrofuran at 20℃; for 20h; Inert atmosphere; Schlenk technique; Glovebox;	64%
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at 0 - 20℃;	62%
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at 0 - 20℃; for 1h;	62%
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at 0 - 20℃; for 1h;	62%
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at 0 - 25℃; for 1h; Inert atmosphere;	423 mg

: 2554-06-5
2,4,6,8-tetramethyl-2,4,6,8-tetravinyl-cyclotetrasiloxane

: 873-75-6
4-bromobenzenemethanol

: 1074-61-9
(4-vinyl-phenyl)-methanol

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride; palladium(II) bromide; johnphos In tetrahydrofuran at 50℃; for 14h;	54%

: 53459-40-8
1-(2-chloroethyl)-4-(chloromethyl)benzene

: 1074-61-9
(4-vinyl-phenyl)-methanol

Conditions

Conditions	Yield
With sodium hydroxide; hydroquinone In ethanol

: 253684-21-8
1,1-dibromo-2-(4-methoxycarbonylphenyl)ethene

A: 1074-61-9
(4-vinyl-phenyl)-methanol

B: 117417-08-0
(E)-1-bromo-2-(4-hydroxymethylphenyl)ethene

C: (Z)-1-bromo-2-(4-hydroxymethylphenyl)ethene

Conditions

Conditions	Yield
With lithium aluminium tetrahydride; ethyl acetate In tetrahydrofuran at -40℃; for 12h;

...Expand

: 256449-39-5
4-acetoxymethyl-(1-(R,S)-acetoxyethyl)benzene

: 1074-61-9
(4-vinyl-phenyl)-methanol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: steam / 475 - 500 °C / 25 - 30 Torr / Leiten ueber Silicagel 2: ethanolic KOH; sulfur; hydroquinone View Scheme

: 622-24-2
2-phenylethyl chloride

: 1074-61-9
(4-vinyl-phenyl)-methanol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: HCl, ZnCl2 / CS2 2: aq. NaOH, benzene-1,4-diol / ethanol View Scheme

: 2039-82-9
1-bromo-4-ethenyl-benzene

: 1074-61-9
(4-vinyl-phenyl)-methanol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: magnesium; iodine / tetrahydrofuran / 4.5 h / 0 - 25 °C / Inert atmosphere 1.2: 3 h 2.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 1 h / 0 - 25 °C / Inert atmosphere View Scheme

: 10602-04-7
(4-ethynylphenyl)methanol

A: 1074-61-9
(4-vinyl-phenyl)-methanol

B: 768-59-2
4-ethylbenzyl alcohol

Conditions

Conditions	Yield
With nickel(II) nitrate hexahydrate; hydrogen In acetonitrile at 120℃; under 22502.3 Torr; for 15h; Overall yield = 86 %;

: 1074-61-9
(4-vinyl-phenyl)-methanol

: 1791-26-0
4-vinyl-benzaldehyde

Conditions

Conditions	Yield
With oxalyl dichloride; dimethyl sulfoxide; triethylamine at -60℃; for 0.333333h; Swern oxidation;	100%
With oxalyl dichloride; dimethyl sulfoxide; triethylamine In dichloromethane at -78 - 20℃; Inert atmosphere;	4.2 g
With phosphoric acid In water; toluene at 25℃; under 760.051 Torr; for 24h; pH=3.4; Irradiation; Inert atmosphere; Sealed tube;	63 %Spectr.
Stage #1: (4-vinyl-phenyl)-methanol With Quinuclidine; (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; oxygen; tetrabutylammonium dihydrogen phosphate In 1,2-dichloro-ethane for 0.25h; Molecular sieve; Stage #2: In 1,2-dichloro-ethane for 9h; Molecular sieve; Irradiation;

: 75-21-8
oxirane

: 108-30-5
succinic acid anhydride

: 1074-61-9
(4-vinyl-phenyl)-methanol

poly(ethylene glycol), α-terminated with vinylbenzyloxy group, ω-terminated with 2-carboxylatoethylcarboxy group, potassium salt, Mn 8E3 Da, Mw/Mn 1.08; monomer(s): 4-vinylbenzyl alcohol; ethylene oxide; succinic anhydride: poly(ethylene glycol), α-terminated with vinylbenzyloxy group, ω-terminated with 2-carboxylatoethylcarboxy group, potassium salt, Mn 8E3 Da, Mw/Mn 1.08; monomer(s): 4-vinylbenzyl alcohol; ethylene oxide; succinic anhydride

Conditions

Conditions	Yield
Stage #1: oxirane; (4-vinyl-phenyl)-methanol With potassium enolate of acetone In tetrahydrofuran Stage #2: succinic acid anhydride In tetrahydrofuran	99%

...Expand

: 1074-61-9
(4-vinyl-phenyl)-methanol

: 13368-25-7
1-(bromomethyl)-4-vinylbenzene

Conditions

Conditions	Yield
With phosphorus tribromide In diethyl ether at 0℃; for 2h;	96%
With phosphorus tribromide In diethyl ether at 0 - 20℃; for 2h;	78%
With phosphorus tribromide In diethyl ether at 0 - 20℃; for 2h; Appel Halogenation; Inert atmosphere;

: 75-21-8
oxirane

: 108-30-5
succinic acid anhydride

: 1074-61-9
(4-vinyl-phenyl)-methanol

poly(ethylene glycol), α-terminated with vinylbenzyloxy group, ω-terminated with 2-carboxylatoethylcarboxy group, potassium salt, Mn 4.2E3 Da, Mw/Mn 1.06; monomer(s): 4-vinylbenzyl alcohol; ethylene oxide; succinic anhydride: poly(ethylene glycol), α-terminated with vinylbenzyloxy group, ω-terminated with 2-carboxylatoethylcarboxy group, potassium salt, Mn 4.2E3 Da, Mw/Mn 1.06; monomer(s): 4-vinylbenzyl alcohol; ethylene oxide; succinic anhydride

Conditions

Conditions	Yield
Stage #1: oxirane; (4-vinyl-phenyl)-methanol With potassium enolate of acetone In tetrahydrofuran Stage #2: succinic acid anhydride In tetrahydrofuran	96%

...Expand

: 75-21-8
oxirane

: 108-30-5
succinic acid anhydride

: 1074-61-9
(4-vinyl-phenyl)-methanol

poly(ethylene glycol), α-terminated with vinylbenzyloxy group, ω-terminated with 2-carboxylatoethylcarboxy group, potassium salt, Mn 2.9E3 Da, Mw/Mn 1.07; monomer(s): 4-vinylbenzyl alcohol; ethylene oxide; succinic anhydride: poly(ethylene glycol), α-terminated with vinylbenzyloxy group, ω-terminated with 2-carboxylatoethylcarboxy group, potassium salt, Mn 2.9E3 Da, Mw/Mn 1.07; monomer(s): 4-vinylbenzyl alcohol; ethylene oxide; succinic anhydride

Conditions

Conditions	Yield
Stage #1: oxirane; (4-vinyl-phenyl)-methanol With potassium enolate of acetone In tetrahydrofuran Stage #2: succinic acid anhydride In tetrahydrofuran	95%

...Expand

: 110-87-2
3,4-dihydro-2H-pyran

: 1074-61-9
(4-vinyl-phenyl)-methanol

: 2-[(4-vinylbenzyl)oxy]tetrahydro-2H-pyran

Conditions

Conditions	Yield
With aminosulfonic acid at 20℃; for 24h; Inert atmosphere;	94%

: 626-62-0
1-iodocyclohexane

: 1074-61-9
(4-vinyl-phenyl)-methanol

: C15H20O

Conditions

Conditions	Yield
With copper; sodium carbonate In N,N-dimethyl-formamide at 79.84℃; Catalytic behavior; Heck Reaction; Glovebox;	93%

: 75-21-8
oxirane

: 108-30-5
succinic acid anhydride

: 1074-61-9
(4-vinyl-phenyl)-methanol

poly(ethylene glycol), α-terminated with vinylbenzyloxy group, ω-terminated with 2-carboxylatoethylcarboxy group, potassium salt, Mn 2.1E3 Da, Mw/Mn 1.06; monomer(s): 4-vinylbenzyl alcohol; ethylene oxide; succinic anhydride: poly(ethylene glycol), α-terminated with vinylbenzyloxy group, ω-terminated with 2-carboxylatoethylcarboxy group, potassium salt, Mn 2.1E3 Da, Mw/Mn 1.06; monomer(s): 4-vinylbenzyl alcohol; ethylene oxide; succinic anhydride

Conditions

Conditions	Yield
Stage #1: oxirane; (4-vinyl-phenyl)-methanol With potassium enolate of acetone In tetrahydrofuran Stage #2: succinic acid anhydride In tetrahydrofuran	91%

...Expand

: 1074-61-9
(4-vinyl-phenyl)-methanol

: 2641-34-1
perfluoro-2,5-dimethyl-3,6-dioxanonanoyl fluoride

: 1191466-44-0
C18H9F17O4

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 2h; Inert atmosphere;	91%

: 67-56-1
methanol

: 1074-61-9
(4-vinyl-phenyl)-methanol

: 58310-28-4
(Difluoromethyl)triphenylphosphonium bromide

: (4-(3,3-difluoro-1-methoxypropyl)phenyl)methanol

Conditions

Conditions	Yield
With fac-tris(2-phenylpyridinato-N,C2')iridium(III) at 20℃; for 11h; Schlenk technique; Inert atmosphere; Irradiation;	91%

...Expand

: 1074-61-9
(4-vinyl-phenyl)-methanol

: 2943-42-2
di(4-methyl)phenylthiosulfonate

: (4-(1-(p-tolylthio)-2-tosylethyl)phenyl)methanol

Conditions

Conditions	Yield
With tetrakis(actonitrile)copper(I) hexafluorophosphate; tris(1,10-phenathrolinyl)ruthenium(II) hexafluorophosphate; 2-[4,5-dihydrooxazolin-2'-yl]quinoline; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 12h; Inert atmosphere; Sealed tube; Irradiation;	91%

: 1074-61-9
(4-vinyl-phenyl)-methanol

: 40538-11-2
diphenyl(4-vinylphenyl)phosphine

: 112309-98-5
1,4-bis[4-(vinyl)phenoxy]butane

poly(4-styryldiphenylphosphine-co-[4-vinylbenzyl alcohol]-co-1,4-bis[4-vinylphenoxy]butane); monomer(s): 4-styryldiphenylphosphine; 4-vinylbenzyl alcohol; 1,4-bis(4-vinylphenyl)butane: poly(4-styryldiphenylphosphine-co-[4-vinylbenzyl alcohol]-co-1,4-bis[4-vinylphenoxy]butane); monomer(s): 4-styryldiphenylphosphine; 4-vinylbenzyl alcohol; 1,4-bis(4-vinylphenyl)butane

Conditions

Conditions	Yield
With 2,2'-azobis(isobutyronitrile); sodium chloride; acacia gum In water; chlorobenzene at 85℃; for 20h;	90%

...Expand

: 1074-61-9
(4-vinyl-phenyl)-methanol

: dimethyl 2-((fluoromethyl)(phenyl)-l4-sulfaneylidene)malonate

: 1-((fluoromethoxy)methyl)-4-vinylbenzene

Conditions

Conditions	Yield
Stage #1: (4-vinyl-phenyl)-methanol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 0.5h; Schlenk technique; Inert atmosphere; Stage #2: dimethyl 2-((fluoromethyl)(phenyl)-l4-sulfaneylidene)malonate In N,N-dimethyl-formamide; mineral oil at 20℃; for 12h; Schlenk technique; Inert atmosphere;	90%

: 1074-61-9
(4-vinyl-phenyl)-methanol

: 95-64-7
4-amino-o-xylene

: C17H17N

Conditions

Conditions	Yield
With oxygen In toluene at 90℃; Reagent/catalyst; Sealed tube;	90%

: 75-21-8
oxirane

: 108-30-5
succinic acid anhydride

: 1074-61-9
(4-vinyl-phenyl)-methanol

poly(ethylene glycol), α-terminated with vinylbenzyloxy group, ω-terminated with 2-carboxylatoethylcarboxy group, potassium salt, Mn 5.3E3 Da, Mw/Mn 1.14; monomer(s): 4-vinylbenzyl alcohol; ethylene oxide; succinic anhydride: poly(ethylene glycol), α-terminated with vinylbenzyloxy group, ω-terminated with 2-carboxylatoethylcarboxy group, potassium salt, Mn 5.3E3 Da, Mw/Mn 1.14; monomer(s): 4-vinylbenzyl alcohol; ethylene oxide; succinic anhydride

Conditions

Conditions	Yield
Stage #1: oxirane; (4-vinyl-phenyl)-methanol With Naphthalene anion ( K(1+) is the counterion) Stage #2: succinic acid anhydride	88%

...Expand

: 67-56-1
methanol

: 1074-61-9
(4-vinyl-phenyl)-methanol

: [3-(methoxycarbonyl)pyridinium-1-yloxy](trifluoromethyl)difluoroborate

: [4-(3,3,3-trifluoro-1-methoxypropyl)phenyl]methanol

Conditions

Conditions	Yield
With [copper(I)(2,9-di(4-methoxyphenyl)-1,10-phenanthroline)2] hexafluorophosphate; potassium hydrogencarbonate at 20℃; for 1h; Inert atmosphere; Schlenk technique; Irradiation;	87%

...Expand

: 1074-61-9
(4-vinyl-phenyl)-methanol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 149636-62-4
O-(tert-butyl)dimethylsilyl(4-vinylphenyl)methanol

Conditions

Conditions	Yield
With 1H-imidazole In N,N-dimethyl-formamide for 48h; Inert atmosphere;	86%

: 1074-61-9
(4-vinyl-phenyl)-methanol

: 1-(fluoromethyl)-4-vinylbenzene

Conditions

Conditions	Yield
With potassium 2-(difluoro(trifluoromethoxy)methoxy)-2,2-difluoroacetate; tetramethylammonium fluoride at 150℃; for 5h; Glovebox; Inert atmosphere; Schlenk technique; Sealed tube;	85%
With potassium 2-(difluoro(trifluoromethoxy)methoxy)-2,2-difluoroacetate; tetramethylammonium fluoride at 150℃; for 5h; Schlenk technique; Glovebox; Inert atmosphere;	85%

: 1074-61-9
(4-vinyl-phenyl)-methanol

: 1592-20-7
4-Vinylbenzyl chloride

Conditions

Conditions	Yield
With oxalyl dichloride; Tropone In dichloromethane at 20℃; for 0.25h; Inert atmosphere;	84%

: 1074-61-9
(4-vinyl-phenyl)-methanol

: 70-55-3
toluene-4-sulfonamide

: 1217489-64-9
4-methyl-N-(4-vinylbenzyl)benzenesulfonamide

Conditions

Conditions	Yield
With (bis[(2-diisopropylphosphino)ethyl]amine)Mn(CO)2Br; potassium carbonate In 5,5-dimethyl-1,3-cyclohexadiene at 150℃; for 24h; Sealed tube; chemoselective reaction;	84%

: 1074-61-9
(4-vinyl-phenyl)-methanol

: 74808-10-9
O-(2,3,4,6-Tetra-O-acetyl-α-D-glucopyranosyl)trichloroacetimidate

: 4-vinylbenzyl 2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside

Conditions

Conditions	Yield
With boron trifluoride diethyl etherate In dichloromethane for 0.166667h;	83%

: 1074-61-9
(4-vinyl-phenyl)-methanol

: 2-bromo-1-(4-(hydroxymethyl)phenyl)ethanol

Conditions

Conditions	Yield
With hydrogen bromide; dimethyl sulfoxide In water at 60℃; for 12h;	83%
With water; hydrogen bromide In dimethyl sulfoxide at 60℃; for 12h; Schlenk technique;	83%

: 1074-61-9
(4-vinyl-phenyl)-methanol

: 1075-49-6
4-ethenylbenzoic acid

Conditions

Conditions	Yield
With oxygen at 120℃; for 16h; Green chemistry;	83%

: 1074-61-9
(4-vinyl-phenyl)-methanol

: 5332-73-0
3-methoxypropylamine

: C13H17NO

Conditions

Conditions	Yield
With oxygen In toluene at 90℃; Sealed tube;	82%

(4-Vinylphenyl)methanol Specification

The (4-Vinylphenyl)methanol, with the CAS registry number 1074-61-9, has the systematic name of (4-ethenylphenyl)methanol. It belongs to the product category of API intermediate. And the molecular formula of this chemical is C₉H₁₀O.

The physical properties of (4-Vinylphenyl)methanol are as following: (1)ACD/LogP: 1.52; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.52; (4)ACD/LogD (pH 7.4): 1.52; (5)ACD/BCF (pH 5.5): 8.36; (6)ACD/BCF (pH 7.4): 8.36; (7)ACD/KOC (pH 5.5): 159.11; (8)ACD/KOC (pH 7.4): 159.11; (9)#H bond acceptors: 1; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 20.23 Å²; (13)Index of Refraction: 1.59; (14)Molar Refractivity: 43.62 cm³; (15)Molar Volume: 129.1 cm³; (16)Polarizability: 17.29×10^-24cm³; (17)Surface Tension: 40.4 dyne/cm; (18)Density: 1.038 g/cm³; (19)Flash Point: 115.4 °C; (20)Enthalpy of Vaporization: 51.17 kJ/mol; (21)Boiling Point: 247.1 °C at 760 mmHg; (22)Vapour Pressure: 0.0139 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES: OCc1ccc(C=C)cc1
(2)InChI: InChI=1/C9H10O/c1-2-8-3-5-9(7-10)6-4-8/h2-6,10H,1,7H2
(3)InChIKey: CLECMSNCZUMKLM-UHFFFAOYAH

Product Name

(4-Vinylphenyl)methanol

Synthetic route

(4-Vinylphenyl)methanol Specification

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