• Name

  (S)-N-(3-Bromo-2-acetoxypropyl)acetamide

• EINECS
• CAS No. 474021-97-1
• Density 1.425g/cm³
• Solubility
• Melting Point
• Formula C7H12 Br N O3
• Boiling Point 387.1°C at 760 mmHg
• Molecular Weight 238.081
• Flash Point 187.9°C
• Transport Information
• Appearance
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms (S)-N-Acetyl-3-bromo-2-acetoxypropylamine
• PSA 55.40000
• LogP 0.84000

Synthetic route

474021-97-1

(S)-N-[2-(acetyloxy)-3-bromopropyl]acetamide

183805-10-9

N-[(2S)oxiranylmethyl]acetamide

Conditions

Conditions	Yield
With potassium carbonate In methanol; acetonitrile at 0 - 20℃;	90%
With potassium carbonate In methanol; acetonitrile at 0 - 20℃;	90%
With potassium carbonate In methanol; acetonitrile at 0 - 20℃;	90%
With potassium carbonate In methanol; acetonitrile at 0 - 20℃;	90%

474021-97-1

(S)-N-[2-(acetyloxy)-3-bromopropyl]acetamide

1203468-38-5

3,5-difluoro-4-[3-(tetrazol-2-yl-pyrrolidin-1-yl)]-phenyl carbamic acid benzyl ester

1203468-33-0

N-((5S)-3-{3,5-difluoro-4-[3-(tetrazol-2-yl)pyrrolidin-1-yl]-phenyl}-2-oxo-5-oxazolidinylmethyl)acetamide

Conditions

Conditions	Yield
Stage #1: 3,5-difluoro-4-[3-(tetrazol-2-yl-pyrrolidin-1-yl)]-phenyl carbamic acid benzyl ester With lithium tert-butoxide In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: (S)-N-[2-(acetyloxy)-3-bromopropyl]acetamide In tetrahydrofuran; methanol; N,N-dimethyl-formamide at 20℃; for 48h;	86%

473871-38-4

isobutyl 4-(1,1-dioxidothiomorpholin-4-yl)-3,5-difluorophenylcarbamate

474021-97-1

(S)-N-[2-(acetyloxy)-3-bromopropyl]acetamide

PNU-288034

Conditions

Conditions	Yield
With lithium tert-butoxide In tetrahydrofuran; methanol; acetonitrile	83%

474021-97-1

(S)-N-[2-(acetyloxy)-3-bromopropyl]acetamide

1202878-56-5

3-Fluoro-4-(3-cyanopyrrolidin-1-yl)phenylcarbamic acid benzyl ester

1202878-52-1

N-{(5S)-3-[3-fluoro-4-(3-cyanopyrrolidin-1-yl)phenyl]-2-oxo-5-oxazolidinylmethyl}acetamide

Conditions

Conditions	Yield
Stage #1: 3-Fluoro-4-(3-cyanopyrrolidin-1-yl)phenylcarbamic acid benzyl ester With lithium tert-butoxide In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: (S)-N-[2-(acetyloxy)-3-bromopropyl]acetamide In tetrahydrofuran; methanol; N,N-dimethyl-formamide at 20℃; for 96h;	63%

474021-97-1

(S)-N-[2-(acetyloxy)-3-bromopropyl]acetamide

1161781-97-0

benzyl [4-(4-cyano-piperidin-1-yl)-3-fluoro-phenyl]-carbamate

928160-67-2

(S)-N-{3-[4-(4-cyano-piperidin-1-yl)-3-fluoro-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide

Conditions

Conditions	Yield
Stage #1: benzyl [4-(4-cyano-piperidin-1-yl)-3-fluoro-phenyl]-carbamate With lithium tert-butoxide In methanol; N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: (S)-N-[2-(acetyloxy)-3-bromopropyl]acetamide In methanol; N,N-dimethyl-formamide at 20℃; for 48h; Product distribution / selectivity;	59%

474021-97-1

(S)-N-[2-(acetyloxy)-3-bromopropyl]acetamide

benzyl 3-fluoro-4-(1-methyl-1H-tetrazole-5yl)-phenyl carbamate

1161795-23-8

N-[[(5S)-3-[3-fluoro-4-(1-methyl-1H-tetrazol-5-yl)-phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide

Conditions

Conditions	Yield
Stage #1: benzyl 3-fluoro-4-(1-methyl-1H-tetrazole-5yl)-phenyl carbamate With lithium tert-butoxide In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 0.5h; Stage #2: (S)-N-[2-(acetyloxy)-3-bromopropyl]acetamide In tetrahydrofuran; methanol; N,N-dimethyl-formamide at 20℃; for 96h; Product distribution / selectivity;

(S)-N-(3-Bromo-2-acetoxypropyl)acetamide Chemical Properties

(S)-N-(3-Bromo-2-acetoxypropyl)acetamide Specification