1-(2-Aminoethyl)pyrrolidine supplier

Name
1-(2-Aminoethyl)pyrrolidine
EINECS 230-509-5
CAS No. 7154-73-6
Article Data31
CAS DataBase
Density 0.943 g/cm³
Solubility
Melting Point 219 °C (decomp)
Formula C₆H₁₄N₂
Boiling Point 164.1 °C at 760 mmHg
Molecular Weight 114.191
Flash Point 47.8 °C
Transport Information UN 2734 8/PG 2
Appearance clear colorless to light brown liquid
Safety 16-26-27-36/37/39-45
Risk Codes 10-34
Molecular Structure
Hazard Symbols C
Synonyms Pyrrolidine,1-(2-aminoethyl)- (6CI,7CI,8CI);2-(1-Pyrrolidinyl)ethanamine;2-(Pyrrolidino)ethanamine;2-Pyrrolidinoethyl amine;N-(2-Aminoethyl)pyrrolidine;N-(2'-Aminoethyl)pyrrolidine;N-Aminoethylpyrrolidine;N-[2-(Pyrrolidin-1-yl)ethyl]amine;NSC 73740;Pyrrolidinoethanamine;
PSA 29.26000
LogP 0.67910

Synthetic route

: 109-99-9
tetrahydrofuran

: 107-15-3
ethylenediamine

A: 7154-73-6
1-(2-aminoethyl)pyrrolidine

B: 21408-05-9
1,2-di(pyrrolidin-1-yl)ethane

Conditions

Conditions	Yield
titanium(IV) oxide at 250 - 300℃; Yields of byproduct given;	A 87% B n/a
titanium(IV) oxide at 250 - 300℃; Yield given;	A 87% B n/a

...Expand

: 76277-38-8
2-(2-pyrrolidinylethyl)-1H-isoindole-1,3(2H)-dione

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol for 24h; Reflux;	82%
With hydrogenchloride
With hydrazine hydrate In ethanol at 20℃;

: 123-75-1
pyrrolidine

: 2576-47-8
2-bromoethylamine hydrobromide

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 29134-29-0
N-cyanomethyl pyrrolidine

A: 7154-73-6
1-(2-aminoethyl)pyrrolidine

B: 91689-56-4
Bis<2-(pyrrolidin-1-yl)ethyl>amine

Conditions

Conditions	Yield
With methanol; nickel at 50℃; under 88260.9 Torr; Hydrogenation;

: 110-52-1
1,4-dibromo-butane

: 64-17-5
ethanol

: 107-15-3
ethylenediamine

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

...Expand

: 7250-67-1
1-(2-chloroethyl)pyrrolidine hydrochloride

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

Conditions

Conditions	Yield
With ammonium hydroxide for 0.5h;

: 79315-01-8
N-(2-Pyrrolidin-1-yl-ethyl)-propionamide

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

Conditions

Conditions	Yield
With hydrogenchloride for 16h; Heating; Yield given;

: 110-52-1
1,4-dibromo-butane

ethylenediamine, hydrate: ethylenediamine, hydrate

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

Conditions

Conditions	Yield
With ethanol

: 29134-29-0
N-cyanomethyl pyrrolidine

A: 7154-73-6
1-(2-aminoethyl)pyrrolidine

B other compounds: other compounds

Conditions

Conditions	Yield
With nickel at 85℃; Hydrogenation;

: 5050-41-9
N-(2-chloroethyl)-pyrrolidine

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: toluene 2: aqueous hydrochloric acid View Scheme

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 73331-33-6
Δ2-Cyclopentenylphenylacetyl chloride

: 73330-95-7
N-<2-(1-Pyrrolidinyl)ethyl>-Δ2-cyclopentenylphenylacetamide

Conditions

Conditions	Yield
In benzene for 0.25h; Heating;	100%

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 105-45-3
acetoacetic acid methyl ester

: methyl 3-<(2'-(pyrrolidin-1"-yl)ethyl)amino>but-2-enoate

Conditions

Conditions	Yield
In methanol at 25℃; for 3h;	100%

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 250718-98-0
3-(4-oxo-1-piperidinyl)-benzonitrile

: 887950-85-8
3-[4-[[2-(1-pyrrolidinyl)ethyl]amino]-1-piperidinyl]benzonitrile

Conditions

Conditions	Yield
Stage #1: 1-(2-aminoethyl)pyrrolidine; 3-(4-oxo-1-piperidinyl)-benzonitrile With titanium(IV) isopropylate In dichloromethane at 20℃; Stage #2: With methanol; sodium cyanoborohydride In dichloromethane at 20℃;	100%

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: C23H23NO4

: C29H37N3O4

Conditions

Conditions	Yield
With 2-hydroxypyridin at 50℃; for 14h;	100%

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 945381-57-7
2-carboxymethyl-4-methyl-1H-pyrrole-3-carboxylic acid ethyl ester

: 945381-63-5
4-methyl-2-[(2-pyrrolidin-1-yl-ethylcarbamoyl)-methyl]-1H-pyrrole-3-carboxylic acid ethyl ester

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 20℃; Cooling with ice;	100%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃;	100%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane; N,N-dimethyl-formamide at 20℃; Cooling;

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 24424-99-5
di-tert-butyl dicarbonate

: 942077-76-1
(2-pyrrolidin-1-ylethyl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
In tetrahydrofuran at 0 - 20℃;	100%
In tetrahydrofuran at 20℃; for 10h;	78%
With sodium hydrogencarbonate In tetrahydrofuran; water at 0 - 20℃; for 8h;

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 3,4'-difluoro-4-nitro-biphenyl

: 4'-fluoro-4-nitro-N-(2-(pyrrolidin-1-yl)ethyl)biphenyl-3-amine

Conditions

Conditions	Yield
Stage #1: 1-(2-aminoethyl)pyrrolidine; 3,4'-difluoro-4-nitro-biphenyl In acetonitrile for 0.25h; Stage #2: With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃;	100%

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 1338708-49-8
2,3,4-tris((4-methoxybenzyl)oxy)benzoic acid

: 1338708-50-1
2,3,4-tris((4-methoxybenzyl)oxy)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 1h; Inert atmosphere;	100%

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 3,4-bis(benzyloxy)-2-methoxybenzoic acid

: 1338708-55-6
3,4-bis(benzyloxy)-2-methoxy-N-(2-(pyrrolidin-1-yl)ethyl)benzamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 1h; Inert atmosphere;	100%

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 98-09-9
benzenesulfonyl chloride

: N-(2-(pyrrolidin-1-yl)ethyl)benzenesulfonamide

Conditions

Conditions	Yield
Stage #1: benzenesulfonyl chloride With triethylamine In dichloromethane at 20℃; Stage #2: 1-(2-aminoethyl)pyrrolidine In dichloromethane	100%

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 783366-00-7
Ethyl 9-chloro-5,6-difluoro-3-oxo-3H-pyrido[3,2,1-kl]phenoxazine-2-carboxylate

: C22H18ClF2N3O3

Conditions

Conditions	Yield
With aluminum (III) chloride In tetrahydrofuran at 20℃;	99%
With aluminum (III) chloride In dichloromethane at 20℃; for 1h;

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 1154500-36-3
2,3-bis((4-methoxybenzyl)oxy)benzoic acid

: 1338709-05-9
2,3-bis((4-methoxybenzyl)oxy)-N-(2-(pyrrolidin-1-yl)ethyl)benzamide

Conditions

Conditions	Yield
Stage #1: 2,3-bis((4-methoxybenzyl)oxy)benzoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.5h; Cooling with ice; Stage #2: 1-(2-aminoethyl)pyrrolidine In dichloromethane at 20℃; for 3h; Cooling with ice;	99%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 1h; Inert atmosphere;	99%

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 607-68-1
2,4-dichloroquinazoline

: 76004-35-8
2-chloro-N-<2-(1-pyrrolidinyl)ethyl>-4-quinazolinamine

Conditions

Conditions	Yield
In diethyl ether at 20℃; for 12h;	98%
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 18h;	65%
In diethyl ether for 1.5h;	56%

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 877121-52-3
C26H29NO2SSi

: C32H43N3OSSi

Conditions

Conditions	Yield
With sodium tetrahydroborate; 3 A molecular sieve In dichloromethane	98%

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 1158844-09-7
dimethyl 1-[3-(diethoxyphosphoryl)ethyl]-1H-1,2,3-triazole-4,5-dicarboxylate

: 1378311-20-6
diethyl [2-[4,5-bis[[2-(1-pyrrolidinyl)ethylamino]carbonyl]-1H-1,2,3-triazol-1-yl]ethyl]phosphonate

Conditions

Conditions	Yield
In methanol at 20℃; for 12h;	98%

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 1407156-12-0
C28H30O8

: 1407156-13-1
C34H42N2O7

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 4.5h;	98%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 4.5h; Inert atmosphere;	98%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 4.5h;	98%

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 24277-39-2
N-tert-butoxycarbonyl glutamic acid tert-butyl ester

: C20H37N3O5

Conditions

Conditions	Yield
With HATU In tetrahydrofuran at 20℃; Cooling with ice;	98%

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 49627-27-2
sulindac sulfide

: (Z)-2-(5-fluoro-2-methyl-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)-N-(2-(pyrrolidin-1-yl)ethyl)acetamide

Conditions

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In acetonitrile at 20℃; Inert atmosphere;	98%

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 120085-99-6
2,9‐bis(4-formylphenyl)‐1,10‐phenanthroline

: 2,9-bis{4-[(2-pyrrolidin-1-ylethyl)iminomethyl]phenyl}-1,10-phenanthroline

Conditions

Conditions	Yield
In ethanol for 5h; Reflux;	98%

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 100-52-7
benzaldehyde

: 134-81-6
benzil

: 2,4,5-triphenyl-1-(2-(pyrrolidin-1-yl)ethyl)-1H-imidazole

Conditions

Conditions	Yield
With ammonium acetate In ethanol at 80℃; for 9h; Catalytic behavior; Reagent/catalyst; Solvent; Green chemistry;	98%

...Expand

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 4-chloro-2-(3-methyl-1H-indol-2-yl)quinazoline

: 2-(3-methyl-1H-indol-2-yl)-N-(2-(pyrrolidin-1-yl)ethyl)quinazolin-4-amine

Conditions

Conditions	Yield
With triethylamine In toluene at 80℃; for 6h;	98%

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 42076-04-0
2-methyl-3H-naphtho[1,2-d]imidazole-5,6-dicarboxylic anhydride

: 9-methyl-5-(2-pyrrolidin-1-yl-ethyl)-8H-5,8,10-triaza-cyclopenta[a]phenalene-4,6-dione

Conditions

Conditions	Yield
In ethanol; toluene Heating;	97%

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 2-ethoxycarbonyl-3-(4-methylanilino)quinoxaline

: N-(2-(pyrrolidin-1-yl)ethyl)-3-(p-tolylamino)quinoxaline-2-carboxamide

Conditions

Conditions	Yield
In ethanol at 80℃;	96.7%

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 1338708-44-3
C24H24O6

: 1338708-45-4
3,4-bis((4-methoxybenzyl)oxy)-2-methyl-N-(2-(pyrrolidin-1-yl)ethyl)benzamide

Conditions

Conditions	Yield
Stage #1: C24H24O6 With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 0.5h; Cooling with ice; Stage #2: 1-(2-aminoethyl)pyrrolidine In dichloromethane at 20℃; Cooling with ice;	96%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 1h; Inert atmosphere;	96%

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 4-fluoro-N-(3-oxo-7-(phenylamino)isoindolin-4-yl)benzamide

: N-(3-oxo-7-(phenylamino)isoindolin-4-yl)-4-((2-(pyrrolidin-1-yl)ethyl)amino)benzamide

Conditions

Conditions	Yield
at 160 - 165℃; for 15h; Inert atmosphere; Sealed tube;	96%

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 6089-92-5
(2α,3β)-2,3-bis(acetyloxy)-olean-12-en-28-oic acid

: (2α,3β)-N-(2-pyrrolidin-1-ylethyl)-2,3-diacetyloxy-olean-12-en-28-amide

Conditions

Conditions	Yield
Stage #1: 2α,3β-diacetoxyoleane 12-ene-28-carboxylic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 25℃; for 1h; Stage #2: 1-(2-aminoethyl)pyrrolidine In dichloromethane at 25℃; for 2h;	96%
Stage #1: 2α,3β-diacetoxyoleane 12-ene-28-carboxylic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 25℃; for 1h; Stage #2: 1-(2-aminoethyl)pyrrolidine at 25℃; for 2h;	96%

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: hexakis((4-N'-dichloro(thio)phosphonyl)-N'-methyl-diazobenzene)cyclotriphosphazene

: C120H204N39O6P9S6

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃;	95.7%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃;

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: (2-chloro-3,4-bis((4-methoxybenzyl)oxy)benzoyl)glycine

: C31H36ClN3O6

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 72h;	95.3%

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 61690-44-6
3-acetylaminonaphthalene-1,8-dicarboxylic anhydride

: 69409-03-6
N-[1,3-Dioxo-2-(2-pyrrolidin-1-yl-ethyl)-2,3-dihydro-1H-benzo[de]isoquinolin-5-yl]-acetamide

Conditions

Conditions	Yield
In ethanol for 2h; Ambient temperature;	95%

: 101709-82-4
1-chloro-4-nitro-9H-xanthen-9-one

: 7154-73-6
1-(2-aminoethyl)pyrrolidine

: 869853-04-3
4-nitro-1-(2-pyrrolidin-1-yl-ethylamino)-xanthen-9-one

Conditions

Conditions	Yield
With pyridine Heating;	95%
With pyridine Heating;

1-(2-Aminoethyl)pyrrolidine Chemical Properties

Molecule structure of 1-(2-Aminoethyl)pyrrolidine (CAS NO.7154-73-6):

IUPAC Name: 2-Pyrrolidin-1-ylethanamine
Molecular Weight: 114.18876 [g/mol]
Molecular Formula: C₆H₁₄N₂
Index of Refraction: 1.488
Molar Refractivity: 34.87 cm³
Molar Volume: 121 cm³
Surface Tension: 36.1 dyne/cm
Density: 0.943 g/cm³
Flash Point: 47.8 °C
Enthalpy of Vaporization: 40.07 kJ/mol
Boiling Point: 164.1 °C at 760 mmHg
Vapour Pressure: 1.99 mmHg at 25 °C
Storage temp.: Flammables area
Sensitive: air sensitive
XLogP3: 0.1
H-Bond Donor: 1
H-Bond Acceptor: 2
Rotatable Bond Count: 2
Exact Mass: 114.115698
MonoIsotopic Mass: 114.115698
Topological Polar Surface Area: 29.3
Heavy Atom Count: 8
Complexity: 57.5
Canonical SMILES: C1CCN(C1)CCN
InChI: InChI=1S/C6H14N2/c7-3-6-8-4-1-2-5-8/h1-7H2
InChIKey: WRXNJTBODVGDRY-UHFFFAOYSA-N
EINECS: 230-509-5
Product Categories of 1-(2-Aminoethyl)pyrrolidine (CAS NO.7154-73-6): Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines; Heterocycles; Nitro/Nitriles

1-(2-Aminoethyl)pyrrolidine Safety Profile

Hazard Codes: Corrosive C
Risk Statements: 10-34
R10:Flammable.
R34:Causes burns.
Safety Statements: 16-26-27-36/37/39-45
S16:Keep away from sources of ignition.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S27:Take off immediately all contaminated clothing.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2734 8/PG 2
WGK Germany: 3
F: 9-23
HazardClass: 3
PackingGroup: III

1-(2-Aminoethyl)pyrrolidine Specification

1-(2-Aminoethyl)pyrrolidine (CAS NO.7154-73-6) is also called 2-(1-Pyrrolidinyl)ethylamine ; 2-Pyrrolidinoethyl amine ; N-(2-Aminoethyl)pyrrolidine ; NSC 73740 ; Pyrrolidine, 1-(2-aminoethyl)- ; Pyrrolidinoethanamine ; Pyrrolidinoethylamine ; 1-Pyrrolidineethanamine ; N-(2-Aminoethyl)pyrrolidine . 1-(2-Aminoethyl)pyrrolidine (CAS NO.7154-73-6) is clear colorless to light brpwn liquid.

Product Name

1-(2-Aminoethyl)pyrrolidine

Synthetic route

1-(2-Aminoethyl)pyrrolidine Chemical Properties

1-(2-Aminoethyl)pyrrolidine Safety Profile

1-(2-Aminoethyl)pyrrolidine Specification

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