1-(2-Methoxyphenyl)-2-propylamine supplier

Name
N-desmethylmethoxyphenamine
EINECS
CAS No. 15402-84-3
Article Data16
CAS DataBase
Density 0.99g/cm³
Solubility
Melting Point
Formula C₁₀H₁₅NO
Boiling Point 246.7°C at 760 mmHg
Molecular Weight 165.235
Flash Point 98.1°C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Phenethylamine,o-methoxy-a-methyl- (6CI,7CI,8CI);1-(2-Methoxyphenyl)-2-aminopropane;2-Methoxy(phenylisopropyl)amine;2-Methoxyamphetamine;N-Demethylmethoxyphenamine;N-Desmethylmethoxyphenamine;o-Methoxy(phenylisopropyl)amine;o-Methoxy-a-methylphenethylamine;o-Methoxyamphetamine;
PSA 35.25000
LogP 2.28520

Synthetic route

: 5211-62-1
1-(2-methoxyphenyl)propan-2-one

: 15402-84-3
(d,l)-2-methoxyamphetamine

Conditions

Conditions	Yield
With ammonia; hydrogen In tetrahydrofuran at 120℃; for 15h;	88%
With ammonium formate; palladium on activated charcoal In methanol at 20℃;	75%
With palladium 10% on activated carbon; ammonium formate In methanol; water at 20℃;	65%

: N-(1-(2-methoxyphenyl)propan-2-yl)formamide

: 15402-84-3
(d,l)-2-methoxyamphetamine

Conditions

Conditions	Yield
With hydrogenchloride In 1,4-dioxane; water Reflux;	88%

: 2077-36-3
(E)-1-(2-methoxyphenyl)prop-1-ene

: 15402-84-3
(d,l)-2-methoxyamphetamine

Conditions

Conditions	Yield
With terephthalonitrile; 1,3,5-triphenylbenzene; ammonia In water; acetonitrile Irradiation;	75%
With benzene-1,3-dicarbonitrile; 1,3,5-triphenylbenzene; ammonia In water; acetonitrile for 4h; Irradiation;	75%

: 21906-31-0
1-(2-bromophenyl)propane-2-one

: 540-69-2
ammonium formate

: 15402-84-3
(d,l)-2-methoxyamphetamine

Conditions

Conditions	Yield
at 160 - 190℃; und anschliessend mit wss.HCl;

: 858783-40-1
3-(2-methoxy-phenyl)-2-methyl-propionic acid amide

: 15402-84-3
(d,l)-2-methoxyamphetamine

Conditions

Conditions	Yield
With potassium hydroxide; bromine anschliessend Erwaermen des mit Natriumhydroxid versetzten Reaktionsgemisches;

: 6306-34-9
1-(2-methoxyphenyl)-2-nitropropene

: 15402-84-3
(d,l)-2-methoxyamphetamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride
With lithium aluminium tetrahydride In tetrahydrofuran for 4h; Inert atmosphere; Reflux;

(+-)-2-<2-bromo-propyl>-anisole: (+-)-2-<2-bromo-propyl>-anisole

: 15402-84-3
(d,l)-2-methoxyamphetamine

Conditions

Conditions	Yield
With methanol; ammonia at 110℃;

2-<2-bromo-propenyl>-anisole: 2-<2-bromo-propenyl>-anisole

: 15402-84-3
(d,l)-2-methoxyamphetamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride; diethyl ether

: 135-02-4
ortho-anisaldehyde

: 15402-84-3
(d,l)-2-methoxyamphetamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 2.) p-toluenesulfonic acid 2: 75 percent / m-dicyanobenzene, NH3, 1,3,5-triphenylbenzene / acetonitrile; H2O / 4 h / Irradiation View Scheme
Multi-step reaction with 2 steps 1: ammonium acetate / 2 h / Reflux 2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / Reflux View Scheme
Multi-step reaction with 2 steps 1: ammonium acetate / 2 h / Inert atmosphere; Reflux 2: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / Inert atmosphere; Reflux View Scheme

: 3368-15-8
3-(2-methoxyphenyl)-2-methylacrylic acid

: 15402-84-3
(d,l)-2-methoxyamphetamine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: platinum; acetic acid / Hydrogenation 2: chloroform; sodium hydroxide; aqueous ammonia; thionyl chloride 3: bromine; aqueous KOH-solution / anschliessend Erwaermen des mit Natriumhydroxid versetzten Reaktionsgemisches View Scheme

: 52427-12-0
rac-3-(2-methoxyphenyl)-2-methylpropanoic acid

: 15402-84-3
(d,l)-2-methoxyamphetamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: chloroform; sodium hydroxide; aqueous ammonia; thionyl chloride 2: bromine; aqueous KOH-solution / anschliessend Erwaermen des mit Natriumhydroxid versetzten Reaktionsgemisches View Scheme

: 34322-76-4
1-(2'-methoxyphenyl)-2-nitropropane

: 15402-84-3
(d,l)-2-methoxyamphetamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 3h; Reflux;

: 3698-28-0
2-allylanisole

: 15402-84-3
(d,l)-2-methoxyamphetamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium 2,2,2-trifluoroacetate; iron(III) chloride; palladium(II) trifluoroacetate / acetonitrile; water / 60 °C / Inert atmosphere; Darkness 2: pyridoxal 5'-phosphate; isopropylamine; amine transaminase TA-P2-B01 / aq. phosphate buffer / 24 h / 30 °C / pH 7.5 / Enzymatic reaction View Scheme

: potassium cyanide

: 50-00-0
formaldehyd

: 15402-84-3
(d,l)-2-methoxyamphetamine

: 1161921-16-9
[2-(2-methoxyphenyl)-1-methylethylamino]acetonitrile

Conditions

Conditions	Yield
With hydrogenchloride In water at 0 - 20℃; pH=2 - 3;	91%

...Expand

: 15402-84-3
(d,l)-2-methoxyamphetamine

: 5-iodo-2-methoxyamphetamine

Conditions

Conditions	Yield
With iodine; silver sulfate In ethanol for 17h; Ambient temperature;	83%

: 15402-84-3
(d,l)-2-methoxyamphetamine

: 407-25-0
trifluoroacetic anhydride

: 370884-68-7
(+/-)-N-trifluoroacetyl-1-(2-methoxyphenyl)-2-aminopropane

Conditions

Conditions	Yield
In benzene for 2h; Heating;	67%

: 14371-10-9
(E)-3-phenylpropenal

: 15402-84-3
(d,l)-2-methoxyamphetamine

: [2-(2-methoxy-phenyl)-1-methyl-ethyl]-(3-phenyl-propyl)-amine

Conditions

Conditions	Yield
With platinum Hydrogenation;

: 50-00-0
formaldehyd

: 15402-84-3
(d,l)-2-methoxyamphetamine

: 71861-16-0
[2-(2-methoxy-phenyl)-1-methyl-ethyl]-dimethyl-amine

Conditions

Conditions	Yield
With ethanol; sodium acetate; nickel Hydrogenation;

: 15402-84-3
(d,l)-2-methoxyamphetamine

: 5211-62-1
1-(2-methoxyphenyl)propan-2-one

: 47302-54-5
bis-[2-(2-methoxy-phenyl)-1-methyl-ethyl]-amine

Conditions

Conditions	Yield
With methanol; platinum Hydrogenation; isomer(ic) II;
With methanol; platinum Hydrogenation; isomer(ic) II;

: 15402-84-3
(d,l)-2-methoxyamphetamine

: 87835-14-1
2-(2-Amino-propyl)-phenol

Conditions

Conditions	Yield
With hydrogenchloride at 160℃;

: 15402-84-3
(d,l)-2-methoxyamphetamine

: 622-24-2
2-phenylethyl chloride

: [2-(2-methoxy-phenyl)-1-methyl-ethyl]-phenethyl-amine

Conditions

Conditions	Yield
With ethanol at 120℃;

: 15402-84-3
(d,l)-2-methoxyamphetamine

: 100-52-7
benzaldehyde

: benzylidene-[2-(2-methoxy-phenyl)-1-methyl-ethyl]-amine

Conditions

Conditions	Yield
With ethanol

: 15402-84-3
(d,l)-2-methoxyamphetamine

: 103-72-0
phenyl isothiocyanate

: N-[2-(2-methoxy-phenyl)-1-methyl-ethyl]-N'-phenyl-thiourea

: 15402-84-3
(d,l)-2-methoxyamphetamine

: 98-09-9
benzenesulfonyl chloride

: N-[2-(2-methoxy-phenyl)-1-methyl-ethyl]-benzenesulfonamide

Conditions

Conditions	Yield
With sodium hydroxide

: 15402-84-3
(d,l)-2-methoxyamphetamine

: 108-24-7
acetic anhydride

: 72687-66-2
N-Acetyl-2-methoxyamphenamine

Conditions

Conditions	Yield
With pyridine

: 50-00-0
formaldehyd

: 15402-84-3
(d,l)-2-methoxyamphetamine

: 151-50-8
potassium cyanide

: 108-95-2
phenol

: 1-(4-Hydroxy-phenyl)-2-[2-(2-methoxy-phenyl)-1-methyl-ethylamino]-ethanone

Conditions

Conditions	Yield
(i), (ii) /BRN= 969616/, AlCl3; Multistep reaction;

...Expand

: 15402-84-3
(d,l)-2-methoxyamphetamine

: 141-78-6
ethyl acetate

A: (S)-1-(o-methoxyphenyl)propan-2-amine

B: (R)-1-(o-methoxyphenyl)propan-2-amine

C: (R)-N-[1-(o-methoxyphenyl)propan-2-yl]ethanamide

Conditions

Conditions	Yield
With Candida antarctica lipase B at 28℃; for 8h;

...Expand

: 15402-84-3
(d,l)-2-methoxyamphetamine

: 5211-62-1
1-(2-methoxyphenyl)propan-2-one

: N-[2-(2-methoxyphenyl)-1-methylethyl]-N-[2-(2-methoxyphenyl)-1-methylethylidene]amine

Conditions

Conditions	Yield
In toluene for 6h; Heating;

: 15402-84-3
(d,l)-2-methoxyamphetamine

: 103-79-7
1-phenyl-acetone

: N-[2-(2-methoxyphenyl)-1-methylethyl]-N-[1-methyl-2-phenylethylidene]amine

Conditions

Conditions	Yield
In toluene for 6h; Heating;

: 15402-84-3
(d,l)-2-methoxyamphetamine

: 2-[2-methoxy-5-(3-phenyl-propyl)-phenyl]-1-methyl-ethylamine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 67 percent / benzene / 2 h / Heating 2: 24 percent / TiCl4 / CH2Cl2 / 72 h / 20 °C 3: 99 percent / H2; AcOH; 70percent aq. HClO4 / 10percent Pd/C / 5.5 h / 20 °C / 2327.23 Torr 4: 15percent aq. NaOH / methanol / 2 h / Heating View Scheme

: 15402-84-3
(d,l)-2-methoxyamphetamine

: 2,2,2-trifluoro-N-{2-[2-methoxy-5-(3-phenyl-propyl)-phenyl]-1-methyl-ethyl}-acetamide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 67 percent / benzene / 2 h / Heating 2: 24 percent / TiCl4 / CH2Cl2 / 72 h / 20 °C 3: 99 percent / H2; AcOH; 70percent aq. HClO4 / 10percent Pd/C / 5.5 h / 20 °C / 2327.23 Torr View Scheme

: 15402-84-3
(d,l)-2-methoxyamphetamine

: 370884-70-1
(+/-)-N-trifluoroacetyl-1-[2-methoxy-5-(3-phenyl-1-propionyl)phenyl]-2-aminopropane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 67 percent / benzene / 2 h / Heating 2: 24 percent / TiCl4 / CH2Cl2 / 72 h / 20 °C View Scheme

: 15402-84-3
(d,l)-2-methoxyamphetamine

: 93-30-1
methoxyphenamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: ethanol 2: anschliessend Behandeln mit wss. Methanol View Scheme

: 15402-84-3
(d,l)-2-methoxyamphetamine

: 91553-50-3
ethyl-[2-(2-methoxy-phenyl)-1-methyl-ethyl]-amine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: ethanol 2: anschliessend Behandeln mit wss. Methanol View Scheme

1-(2-Methoxyphenyl)-2-propylamine Specification

The 1-(2-Methoxyphenyl)-2-propylamine with the cas number 15402-84-3 is also called Benzeneethanamine,2-methoxy-a-methyl-. Both the systematic name and IUPAC name are 1-(2-methoxyphenyl)propan-2-amine. Its molecular formula is C₁₀H₁₅NO. This chemical is a kind of organics. It should be stored in dry and cool environment.

The properties of the chemical are: (1)ACD/LogP: 1.72; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.36; (4)ACD/LogD (pH 7.4): -0.76; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 2; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 12.47 Å²; (13)Index of Refraction: 1.518; (14)Molar Refractivity: 50.6 cm³; (15)Molar Volume: 166.8 cm³; (16)Polarizability: 20.06×10^-24cm³; (17)Surface Tension: 35.3 dyne/cm; (18)Enthalpy of Vaporization: 48.38 kJ/mol; (19)Vapour Pressure: 0.0268 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES: O(c1ccccc1CC(N)C)C
(2)InChI: InChI=1/C10H15NO/c1-8(11)7-9-5-3-4-6-10(9)12-2/h3-6,8H,7,11H2,1-2H3
(3)InChIKey: VBAHFEPKESUPDE-UHFFFAOYAE

Product Name

N-desmethylmethoxyphenamine

Synthetic route

1-(2-Methoxyphenyl)-2-propylamine Specification

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