Product Name

  • Name

    1-(3-AMINOPROPYL)-2-PYRROLIDINONE

  • EINECS
  • CAS No. 7663-77-6
  • Article Data12
  • CAS DataBase
  • Density 1.06g/cm3
  • Solubility
  • Melting Point
  • Formula C7H14 N2 O
  • Boiling Point 312°Cat760mmHg
  • Molecular Weight 142.201
  • Flash Point 132.4°C
  • Transport Information
  • Appearance Clear Slightly Yellowish Liquid
  • Safety
  • Risk Codes 34
  • Molecular Structure Molecular Structure of 7663-77-6 (1-(3-AMINOPROPYL)-2-PYRROLIDINONE)
  • Hazard Symbols C,Xi
  • Synonyms 1-(3-Aminopropyl)-2-oxopyrrolidine;1-(3-Aminopropyl)-2-pyrrolidinone; 1-(3-Aminopropyl)-2-pyrrolidone;1-(3-Aminopropyl)pyrrolidin-2-one; 3-(2-Oxo-1-pyrrolidinyl)propylamine;Acisoga; N-(3-Aminopropyl)-2-pyrrolidinone; N-(3-Aminopropyl)-2-pyrrolidone;N-(3-Aminopropyl)-g-butyrolactam; NSC 108683; [3-(2-Oxopyrrolidino)propyl]amine
  • PSA 46.33000
  • LogP 0.59580

Synthetic route

DBN
3001-72-7

DBN

1-(3-aminopropyl)-2-pyrrolidone
7663-77-6

1-(3-aminopropyl)-2-pyrrolidone

Conditions
ConditionsYield
With water at 85℃; for 12h;98%
With water at 85℃; for 12h;
With water at 20℃; for 12h;
With water In water-d2 at 27℃; Kinetics;
carbon monoxide
201230-82-2

carbon monoxide

N-allyl-1,3-diaminopropane
34155-45-8

N-allyl-1,3-diaminopropane

A

1-(3-aminopropyl)-2-pyrrolidone
7663-77-6

1-(3-aminopropyl)-2-pyrrolidone

B

octahydropyrrolo[1,2-a]pyrimidine
57672-23-8

octahydropyrrolo[1,2-a]pyrimidine

Conditions
ConditionsYield
With hydrogen; dirhodium tetraacetate In benzene at 80℃; under 20685.9 Torr; for 20h; Product distribution; PPh3 and other ligands;A 90%
B 10%
With dirhodium tetraacetate; hydrogen; triphenylphosphine In benzene at 80℃; under 20685.9 Torr; for 20h;
With dirhodium tetraacetate; hydrogen; tris-(o-tolyl)phosphine In benzene at 80℃; under 20685.9 Torr; for 20h; Product distribution; influence of gas composition, type of ligand;
With dirhodium tetraacetate; tributylphosphine; hydrogen In benzene at 80℃; under 20685.9 Torr; for 20h;
...Expand
acrylonitrile
107-13-1

acrylonitrile

4-amino-n-butyric acid
56-12-2

4-amino-n-butyric acid

1-(3-aminopropyl)-2-pyrrolidone
7663-77-6

1-(3-aminopropyl)-2-pyrrolidone

Conditions
ConditionsYield
With water at 120℃; Hydrieren des Reaktionsgemisches an Raney-Kobalt bei 120grad/200at.;
2-pyrrolidinon
616-45-5

2-pyrrolidinon

3-bromopropylamine hydrochloride
5003-71-4

3-bromopropylamine hydrochloride

1-(3-aminopropyl)-2-pyrrolidone
7663-77-6

1-(3-aminopropyl)-2-pyrrolidone

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide
3-[(prop-2-en-1-yl)amino]propanenitrile
34508-81-1

3-[(prop-2-en-1-yl)amino]propanenitrile

1-(3-aminopropyl)-2-pyrrolidone
7663-77-6

1-(3-aminopropyl)-2-pyrrolidone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 70 percent / LiAlH4
2: H2, P(n-Bu)3, rhodium(II) acetate dimer / benzene / 20 h / 80 °C / 20685.9 Torr
View Scheme
2-[3-(2-Oxo-pyrrolidin-1-yl)-propyl]-isoindole-1,3-dione
84598-48-1

2-[3-(2-Oxo-pyrrolidin-1-yl)-propyl]-isoindole-1,3-dione

1-(3-aminopropyl)-2-pyrrolidone
7663-77-6

1-(3-aminopropyl)-2-pyrrolidone

Conditions
ConditionsYield
With hydrazine hydrate
1-(3-aminopropyl)-2-pyrrolidone
7663-77-6

1-(3-aminopropyl)-2-pyrrolidone

2-([(tert-butoxy)carbonyl]{2-[(4-methoxybenzyl)amino]-2-oxoethyl}amino)acetic acid
194996-03-7

2-([(tert-butoxy)carbonyl]{2-[(4-methoxybenzyl)amino]-2-oxoethyl}amino)acetic acid

[(4-Methoxy-benzylcarbamoyl)-methyl]-{[3-(2-oxo-pyrrolidin-1-yl)-propylcarbamoyl]-methyl}-carbamic acid tert-butyl ester
194996-16-2

[(4-Methoxy-benzylcarbamoyl)-methyl]-{[3-(2-oxo-pyrrolidin-1-yl)-propylcarbamoyl]-methyl}-carbamic acid tert-butyl ester

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 25℃; for 16h; Substitution;100%
With N,N-diethyl-N-isopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate In N,N-dimethyl-formamide at 25℃; for 16h;27%
1-(3-aminopropyl)-2-pyrrolidone
7663-77-6

1-(3-aminopropyl)-2-pyrrolidone

N-((tert-butyloxy)carbonyl)-N'-(2-(4-fluorophenyl)ethyl)iminodiacetic acid monoamide
188625-17-4

N-((tert-butyloxy)carbonyl)-N'-(2-(4-fluorophenyl)ethyl)iminodiacetic acid monoamide

N-((tert-butoxy)carbonyl)-N'-(2-(4-fluorophenyl)ethyl)-N''-(3-(N-pyrrolidin-2-onyl)propyl)iminodiacetic acid diamide
194996-17-3

N-((tert-butoxy)carbonyl)-N'-(2-(4-fluorophenyl)ethyl)-N''-(3-(N-pyrrolidin-2-onyl)propyl)iminodiacetic acid diamide

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 25℃; for 16h; Substitution;100%
With N,N-diethyl-N-isopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate In N,N-dimethyl-formamide at 25℃; for 16h;18%
1-(3-aminopropyl)-2-pyrrolidone
7663-77-6

1-(3-aminopropyl)-2-pyrrolidone

N-((tert-butyloxy)carbonyl)-N'-(2-(4-hydroxyphenyl)ethyl)iminodiacetic acid monoamide
194996-01-5

N-((tert-butyloxy)carbonyl)-N'-(2-(4-hydroxyphenyl)ethyl)iminodiacetic acid monoamide

{[2-(4-Hydroxy-phenyl)-ethylcarbamoyl]-methyl}-{[3-(2-oxo-pyrrolidin-1-yl)-propylcarbamoyl]-methyl}-carbamic acid tert-butyl ester
194996-14-0

{[2-(4-Hydroxy-phenyl)-ethylcarbamoyl]-methyl}-{[3-(2-oxo-pyrrolidin-1-yl)-propylcarbamoyl]-methyl}-carbamic acid tert-butyl ester

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 25℃; for 16h; Substitution;100%
With N,N-diethyl-N-isopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate In N,N-dimethyl-formamide at 25℃; for 16h;9%
1-(3-aminopropyl)-2-pyrrolidone
7663-77-6

1-(3-aminopropyl)-2-pyrrolidone

N-((tert-butyloxy)carbonyl)-N'-(4-(1',4'-dioxolano)piperidino)iminodiacetic acid monoamide
215161-22-1

N-((tert-butyloxy)carbonyl)-N'-(4-(1',4'-dioxolano)piperidino)iminodiacetic acid monoamide

[2-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-2-oxo-ethyl]-{[3-(2-oxo-pyrrolidin-1-yl)-propylcarbamoyl]-methyl}-carbamic acid tert-butyl ester

[2-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-2-oxo-ethyl]-{[3-(2-oxo-pyrrolidin-1-yl)-propylcarbamoyl]-methyl}-carbamic acid tert-butyl ester

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 25℃; for 16h; Substitution;100%
1-(3-aminopropyl)-2-pyrrolidone
7663-77-6

1-(3-aminopropyl)-2-pyrrolidone

4-phenyl-1-butylamine
13214-66-9

4-phenyl-1-butylamine

3-bromomethylbenzoic acid
6515-58-8

3-bromomethylbenzoic acid

C33H39N3O4

C33H39N3O4

Conditions
ConditionsYield
Multistep reaction.;100%
...Expand
1-(3-aminopropyl)-2-pyrrolidone
7663-77-6

1-(3-aminopropyl)-2-pyrrolidone

C7H6BrClN2O
1393598-49-6

C7H6BrClN2O

C14H18N4O2
1393598-31-6

C14H18N4O2

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 85 - 95℃; Inert atmosphere;100%
1-(3-aminopropyl)-2-pyrrolidone
7663-77-6

1-(3-aminopropyl)-2-pyrrolidone

3-(6-(benzyloxy)-9H-purin-9-yl)propanal

3-(6-(benzyloxy)-9H-purin-9-yl)propanal

1-(3-(3-(6-(benzyloxy)-9H-purin-9-yl)propylamino)propyl)pyrrolidin-2-one

1-(3-(3-(6-(benzyloxy)-9H-purin-9-yl)propylamino)propyl)pyrrolidin-2-one

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride In dichloromethane at 20℃; for 4h; Inert atmosphere;100%
1-(3-aminopropyl)-2-pyrrolidone
7663-77-6

1-(3-aminopropyl)-2-pyrrolidone

4-fluoro-3-nitrobenzoyl chloride
400-94-2

4-fluoro-3-nitrobenzoyl chloride

4-fluoro-3-nitro-N-[3-(2-oxo-pyrrolidin-1-yl)-propyl]-benzamide

4-fluoro-3-nitro-N-[3-(2-oxo-pyrrolidin-1-yl)-propyl]-benzamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 23℃; for 1h;98%
carbon disulfide
75-15-0

carbon disulfide

1-(3-aminopropyl)-2-pyrrolidone
7663-77-6

1-(3-aminopropyl)-2-pyrrolidone

N-(3-isothiocyanatopropyl)-γ-butyrolactam
53485-01-1

N-(3-isothiocyanatopropyl)-γ-butyrolactam

Conditions
ConditionsYield
With N-cyclohexylcarbodiimide In tetrahydrofuran at 20℃; for 5h;98%
1-(3-aminopropyl)-2-pyrrolidone
7663-77-6

1-(3-aminopropyl)-2-pyrrolidone

isocyanatodiphenylphosphine oxide
6779-62-0

isocyanatodiphenylphosphine oxide

N-diphenylphosphoryl-N'-[3-(2-oxopyrrolidino)propyl]urea

N-diphenylphosphoryl-N'-[3-(2-oxopyrrolidino)propyl]urea

Conditions
ConditionsYield
In acetonitrile at 20℃; for 1h; Inert atmosphere;97.2%
1-(3-aminopropyl)-2-pyrrolidone
7663-77-6

1-(3-aminopropyl)-2-pyrrolidone

ethyl 2-(1-ethoxyethylidene)hydrazinecarboxylate
51814-82-5, 51814-83-6, 58910-28-4

ethyl 2-(1-ethoxyethylidene)hydrazinecarboxylate

5-methyl-4-[3-(2-oxopyrrolidin-1-yl)propyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

5-methyl-4-[3-(2-oxopyrrolidin-1-yl)propyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Conditions
ConditionsYield
In neat (no solvent) at 160 - 180℃; for 2h;95.6%
1-(3-aminopropyl)-2-pyrrolidone
7663-77-6

1-(3-aminopropyl)-2-pyrrolidone

(1R,2R)-2-[4-(2-Bromo-phenylsulfanyl)-2,3-dichloro-phenyl]-cyclopropanecarboxylic acid

(1R,2R)-2-[4-(2-Bromo-phenylsulfanyl)-2,3-dichloro-phenyl]-cyclopropanecarboxylic acid

(1S,2S)-2-[4-(2-Bromo-phenylsulfanyl)-2,3-dichloro-phenyl]-cyclopropanecarboxylic acid [3-(2-oxo-pyrrolidin-1-yl)-propyl]-amide

(1S,2S)-2-[4-(2-Bromo-phenylsulfanyl)-2,3-dichloro-phenyl]-cyclopropanecarboxylic acid [3-(2-oxo-pyrrolidin-1-yl)-propyl]-amide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃;95%
1-(3-aminopropyl)-2-pyrrolidone
7663-77-6

1-(3-aminopropyl)-2-pyrrolidone

2-formyldimedone
16690-03-2

2-formyldimedone

5,5-dimethyl-2-[3-(2-oxopyrrolidin-1-yl)propylaminomethylene]-1,3-cyclohexanedione

5,5-dimethyl-2-[3-(2-oxopyrrolidin-1-yl)propylaminomethylene]-1,3-cyclohexanedione

Conditions
ConditionsYield
In ethanol for 2h; Heating;95%
1-(3-aminopropyl)-2-pyrrolidone
7663-77-6

1-(3-aminopropyl)-2-pyrrolidone

(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid
1135-24-6

(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid

(E)-3-(4-hydroxy-3-methoxyphenyl)-N-(3-(2-oxopyrrolidin-1-yl)propyl)acrylamide

(E)-3-(4-hydroxy-3-methoxyphenyl)-N-(3-(2-oxopyrrolidin-1-yl)propyl)acrylamide

Conditions
ConditionsYield
at 85℃; for 0.05h; Microwave irradiation;95%
1-(3-aminopropyl)-2-pyrrolidone
7663-77-6

1-(3-aminopropyl)-2-pyrrolidone

iminodiacetic acid
142-73-4

iminodiacetic acid

1-[3-(2-oxo-pyrrolidin-1-yl)-propyl]-piperazine-2,6-dione
1421691-43-1

1-[3-(2-oxo-pyrrolidin-1-yl)-propyl]-piperazine-2,6-dione

Conditions
ConditionsYield
at 85℃; for 0.05h; Microwave irradiation;94%
3-[4-(N-methyl-N-phenylamino)pyrazolo[1,5-a]-1,3,5-triazin-8-yl]propionic acid
652538-76-6

3-[4-(N-methyl-N-phenylamino)pyrazolo[1,5-a]-1,3,5-triazin-8-yl]propionic acid

1-(3-aminopropyl)-2-pyrrolidone
7663-77-6

1-(3-aminopropyl)-2-pyrrolidone

N-[3-(2-oxopyrrolidin-1-yl)propyl]-3-[4-(N-methyl-N-phenylamino)pyrazolo[1,5-a]-1,3,5-triazin-8-yl]propionamide
934524-82-0

N-[3-(2-oxopyrrolidin-1-yl)propyl]-3-[4-(N-methyl-N-phenylamino)pyrazolo[1,5-a]-1,3,5-triazin-8-yl]propionamide

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 24h;93%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;93%
1-(3-aminopropyl)-2-pyrrolidone
7663-77-6

1-(3-aminopropyl)-2-pyrrolidone

4-((2-fluorobenzyl)oxy)-3-methoxybenzaldehyde
423156-68-7

4-((2-fluorobenzyl)oxy)-3-methoxybenzaldehyde

1-{3-[4-(2-Fluoro-benzyloxy)-3-methoxy-benzylamino]-propyl}-pyrrolidin-2-one

1-{3-[4-(2-Fluoro-benzyloxy)-3-methoxy-benzylamino]-propyl}-pyrrolidin-2-one

Conditions
ConditionsYield
Stage #1: 1-(3-aminopropyl)-2-pyrrolidone; 4-((2-fluorobenzyl)oxy)-3-methoxybenzaldehyde With titanium(IV) isopropylate In tetrahydrofuran at 20℃; for 12h;
Stage #2: With sodium tetrahydroborate In tetrahydrofuran; ethanol at 70℃; for 6h;		91.6%
1-(3-aminopropyl)-2-pyrrolidone
7663-77-6

1-(3-aminopropyl)-2-pyrrolidone

N-((tert-butyloxy)carbonyl)-N'-(5-((benzyloxycarbonyl)amino)-5-(methoxycarbonyl)pentyl)iminodiacetic acid monoamide
206867-09-6

N-((tert-butyloxy)carbonyl)-N'-(5-((benzyloxycarbonyl)amino)-5-(methoxycarbonyl)pentyl)iminodiacetic acid monoamide

2-benzyloxycarbonylamino-6-[2-(tert-butoxycarbonyl-{[3-(2-oxo-pyrrolidin-1-yl)-propylcarbamoyl]-methyl}-amino)-acetylamino]-hexanoic acid methyl ester

2-benzyloxycarbonylamino-6-[2-(tert-butoxycarbonyl-{[3-(2-oxo-pyrrolidin-1-yl)-propylcarbamoyl]-methyl}-amino)-acetylamino]-hexanoic acid methyl ester

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 25℃; for 16h; Substitution;91%
1-(3-aminopropyl)-2-pyrrolidone
7663-77-6

1-(3-aminopropyl)-2-pyrrolidone

valinol
16369-05-4

valinol

C21H21ClN3O4Pol

C21H21ClN3O4Pol

C21H21ClN3O4Pol

C21H21ClN3O4Pol

C21H21ClN3O4Pol

C21H21ClN3O4Pol

C21H21ClN3O4Pol

C21H21ClN3O4Pol

C21H21ClN3O4Pol

C21H21ClN3O4Pol

C22H23ClN3O4Pol

C22H23ClN3O4Pol

C22H23ClN3O4Pol

C22H23ClN3O4Pol

C21H22ClN4O4Pol

C21H22ClN4O4Pol

C25H23ClN3O4Pol

C25H23ClN3O4Pol

C25H23ClN3O4Pol

C25H23ClN3O4Pol

C25H23ClN3O4Pol

C25H23ClN3O4Pol

C25H23ClN3O4Pol

C25H23ClN3O4Pol

C25H23ClN3O4Pol

C25H23ClN3O4Pol

C25H23ClN3O4Pol

C25H23ClN3O4Pol

C25H23ClN3O4Pol

C25H23ClN3O4Pol

C25H27ClN5O4Pol

C25H27ClN5O4Pol

C25H27ClN5O4Pol

C25H27ClN5O4Pol

2-Fluoroaniline
348-54-9

2-Fluoroaniline

indan-5-amine
24425-40-9

indan-5-amine

4-methoxy-aniline
104-94-9

4-methoxy-aniline

2,4,6-trimethylaniline
88-05-1

2,4,6-trimethylaniline

6-amino-3,4-benzodioxane
22013-33-8

6-amino-3,4-benzodioxane

N-methylaniline
100-61-8

N-methylaniline

A

1-{3-[9-isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-ylamino]-propyl}-pyrrolidin-2-one

1-{3-[9-isopropyl-6-(4-methoxy-benzylamino)-9H-purin-2-ylamino]-propyl}-pyrrolidin-2-one

B

NG-35

NG-35

C

2-(2-fluorophenylamino)-6-(4-methoxybenzylamino)-9-isopropylpurine

2-(2-fluorophenylamino)-6-(4-methoxybenzylamino)-9-isopropylpurine

D

9-isopropyl-N6-(4-methoxy-benzyl)-N8-(4-methoxy-phenyl)-9H-purine-6,8-diamine

9-isopropyl-N6-(4-methoxy-benzyl)-N8-(4-methoxy-phenyl)-9H-purine-6,8-diamine

E

2-(2,4,6-tri-methylphenylamino)-6-(4-methoxybenzylamino)-9-isopropylpurine

2-(2,4,6-tri-methylphenylamino)-6-(4-methoxybenzylamino)-9-isopropylpurine

F

2-(1,4-benzodioxan-6-amino)-6-(4-methoxybenzylamino)-9-isopropylpurine

2-(1,4-benzodioxan-6-amino)-6-(4-methoxybenzylamino)-9-isopropylpurine

G

2-(indan-5-amino)-6-(4-methoxybenzylamino)-9-isopropylpurine

2-(indan-5-amino)-6-(4-methoxybenzylamino)-9-isopropylpurine

H

2-(N-methylphenylamino)-6-(4-methoxybenzylamino)-9-isopropylpurine

2-(N-methylphenylamino)-6-(4-methoxybenzylamino)-9-isopropylpurine

I

2-(4-methoxyphenylamino)-6-(4-methoxybenzylamino)-9-isopropylpurine

2-(4-methoxyphenylamino)-6-(4-methoxybenzylamino)-9-isopropylpurine

J

N-(4-methoxy-benzyl)-N'-(4-methoxy-phenyl)-pyrazine-2,3-diamine

N-(4-methoxy-benzyl)-N'-(4-methoxy-phenyl)-pyrazine-2,3-diamine

K

N-(4-methoxy-benzyl)-N'-(4-methoxy-phenyl)-pyridazine-3,6-diamine

N-(4-methoxy-benzyl)-N'-(4-methoxy-phenyl)-pyridazine-3,6-diamine

L

N-(4-methoxy-benzyl)-N'-(4-methoxy-phenyl)-pyrazine-2,6-diamine

N-(4-methoxy-benzyl)-N'-(4-methoxy-phenyl)-pyrazine-2,6-diamine

M

N4-(4-methoxy-benzyl)-N2-(4-methoxy-phenyl)-pyrimidine-2,4-diamine

N4-(4-methoxy-benzyl)-N2-(4-methoxy-phenyl)-pyrimidine-2,4-diamine

N

N-(4-methoxy-benzyl)-N'-(4-methoxy-phenyl)-pyrimidine-4,6-diamine

N-(4-methoxy-benzyl)-N'-(4-methoxy-phenyl)-pyrimidine-4,6-diamine

O

N4-(4-methoxy-benzyl)-N2-(4-methoxy-phenyl)-6-methyl-pyrimidine-2,4-diamine

N4-(4-methoxy-benzyl)-N2-(4-methoxy-phenyl)-6-methyl-pyrimidine-2,4-diamine

P

N4-(4-methoxy-benzyl)-N2-(4-methoxy-phenyl)-5-methyl-pyrimidine-2,4-diamine

N4-(4-methoxy-benzyl)-N2-(4-methoxy-phenyl)-5-methyl-pyrimidine-2,4-diamine

Q

N'-(4-methoxy-benzyl)-N''-(4-methoxy-phenyl)-pyrimidine-2,4,6-triamine

N'-(4-methoxy-benzyl)-N''-(4-methoxy-phenyl)-pyrimidine-2,4,6-triamine

R

N4-(4-methoxy-benzyl)-N6-(4-methoxy-phenyl)-quinazoline-4,6-diamine

N4-(4-methoxy-benzyl)-N6-(4-methoxy-phenyl)-quinazoline-4,6-diamine

S

N4-(4-methoxy-benzyl)-N2-(4-methoxy-phenyl)-quinazoline-2,4-diamine

N4-(4-methoxy-benzyl)-N2-(4-methoxy-phenyl)-quinazoline-2,4-diamine

T

N4-(4-methoxy-benzyl)-N7-(4-methoxy-phenyl)-quinazoline-4,7-diamine

N4-(4-methoxy-benzyl)-N7-(4-methoxy-phenyl)-quinazoline-4,7-diamine

U

N4-(4-methoxy-benzyl)-N8-(4-methoxy-phenyl)-quinazoline-4,8-diamine

N4-(4-methoxy-benzyl)-N8-(4-methoxy-phenyl)-quinazoline-4,8-diamine

V

N-(4-methoxy-benzyl)-N'-(4-methoxy-phenyl)-quinoxaline-2,3-diamine

N-(4-methoxy-benzyl)-N'-(4-methoxy-phenyl)-quinoxaline-2,3-diamine

W

N-(4-methoxy-benzyl)-N'-(4-methoxy-phenyl)-phthalazine-1,4-diamine

N-(4-methoxy-benzyl)-N'-(4-methoxy-phenyl)-phthalazine-1,4-diamine

X

N4-(4-methoxy-benzyl)-N5-(4-methoxy-phenyl)-quinazoline-4,5-diamine

N4-(4-methoxy-benzyl)-N5-(4-methoxy-phenyl)-quinazoline-4,5-diamine

Conditions
ConditionsYield
Stage #1: 1-(3-aminopropyl)-2-pyrrolidone; valinol; C21H21ClN3O4Pol; C21H21ClN3O4Pol; C21H21ClN3O4Pol; C21H21ClN3O4Pol; C21H21ClN3O4Pol; C22H23ClN3O4Pol; C22H23ClN3O4Pol; C21H22ClN4O4Pol; C25H23ClN3O4Pol; C25H23ClN3O4Pol; C25H23ClN3O4Pol; C25H23ClN3O4Pol; C25H23ClN3O4Pol; C25H23ClN3O4Pol; C25H23ClN3O4Pol; C25H27ClN5O4Pol; C25H27ClN5O4Pol; 2-Fluoroaniline; indan-5-amine; 4-methoxy-aniline; 2,4,6-trimethylaniline; 6-amino-3,4-benzodioxane; N-methylaniline With potassium tert-butylate; tris-(dibenzylideneacetone)dipalladium(0); 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride In 1,4-dioxane at 80℃; for 12h; Polystyrene; Combinatorial reaction / High throughput screening (HTS);
Stage #2: With dimethylsulfide; trifluoroacetic acid In dichloromethane; water for 2h;		A 90%
B 83%
C 80%
D 85%
E 81%
F 91%
G 88%
H 91%
I 90%
J 86%
K 87%
L 89%
M 90%
N 90%
O 90%
P 91%
Q 82%
R 86%
S 89%
T 89%
U 85%
V 81%
W 84%
X 78%
...Expand
1-(3-aminopropyl)-2-pyrrolidone
7663-77-6

1-(3-aminopropyl)-2-pyrrolidone

methyl 6-amino-2,3-dichloropyrazine-5-carboxylate
1458-18-0

methyl 6-amino-2,3-dichloropyrazine-5-carboxylate

methyl 3-amino-6-chloro-5-((3-(2-oxopyrrolidin-1-yl)propyl)amino)pyrazine-2-carboxylate

methyl 3-amino-6-chloro-5-((3-(2-oxopyrrolidin-1-yl)propyl)amino)pyrazine-2-carboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; Inert atmosphere;91%
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide Inert atmosphere;

1-(3-Aminopropyl)-2-pyrrolidinone Chemical Properties

Molecular Structure:

Molecular Formula: C7H14N2O
Molecular Weight: 142.1989
IUPAC Name: 1-(3-Aminopropyl)pyrrolidin-2-one
Synonyms of 1-(3-Aminopropyl)-2-pyrrolidinone (CAS NO.7663-77-6): 4-21-00-03163 (Beilstein Handbook Reference) ; BRN 0114960 ; EINECS 231-632-7 ; N-(3-Aminopropyl)-2-pyrrolidinone ; NSC 108683 ; 2-Pyrrolidinone, 1-(3-aminopropyl)- ; N-(3-Aminopropyl)pyrrolidin-2-one
CAS NO: 7663-77-6
Classification Code: Miscellaneous Reagents ; Synthetic Intermediates ; Building Blocks ; Heterocyclic Building Blocks ; Pyrrolidines 
Index of Refraction: 1.503
Molar Refractivity: 39.63 cm3
Molar Volume: 134 cm3
Surface Tension: 42.3 dyne/cm
Density: 1.06 g/cm3
Flash Point: 132.4 °C
Enthalpy of Vaporization: 55.29 kJ/mol
Boiling Point: 312 °C at 760 mmHg
Vapour Pressure: 0.000545 mmHg at 25°C

1-(3-Aminopropyl)-2-pyrrolidinone Uses

  1-(3-Aminopropyl)-2-pyrrolidinone (CAS NO.7663-77-6) is used as synthetic intermediate.

1-(3-Aminopropyl)-2-pyrrolidinone Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 320mg/kg (320mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#05698,
mouse LDLo oral 1600mg/kg (1600mg/kg)   Archives of Environmental Contamination and Toxicology. Vol. 14, Pg. 111, 1985.

1-(3-Aminopropyl)-2-pyrrolidinone Safety Profile

Hazard Codes of 1-(3-Aminopropyl)-2-pyrrolidinone (CAS NO.7663-77-6): CorrosiveC,IrritantXi
Risk Statements: 34 
R34: Causes burns.
Safety Statements: 26-27-36/37/39-45 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S27: Take off immediately all contaminated clothing. 
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection. 
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 3267 8/PG 2
WGK Germany: 3
RTECS: UY5739500
F: 9-34
Hazard Note: Irritant

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