• Name

  1-(3-Methoxypropyl)-4-piperidinamine

• EINECS 431-950-8
• CAS No. 179474-79-4
• Article Data2
• CAS DataBase
• Density 0.946
• Solubility
• Melting Point
• Formula C₉H₂₀N₂O
• Boiling Point 249℃
• Molecular Weight 172.271
• Flash Point 105℃
• Transport Information
• Appearance
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms 1-(3-Methoxypropyl)-4-piperidinamine;
• PSA 38.49000
• LogP 1.08420

Synthetic route

519147-89-8

1-[3-(methyloxy)propyl]-4-piperidinecarboxamide

179474-79-4

4-amino-1-(3-methoxypropyl)piperidine

Conditions

Conditions	Yield
With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; potassium hydroxide In water; acetonitrile at 5 - 25℃; for 13h;	83%

C22H28N2O

179474-79-4

4-amino-1-(3-methoxypropyl)piperidine

Conditions

Conditions	Yield
With hydrogenchloride In water at 0 - 20℃; pH=1 - 2;	81%

1249604-45-2

ethyl 1-(3-methoxy-propyl)-piperidin-4-carboxylate

179474-79-4

4-amino-1-(3-methoxypropyl)piperidine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: ammonia / methanol / 60 °C 2: potassium hydroxide; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / water; acetonitrile / 13 h / 5 - 25 °C View Scheme

methyl-1-(3-methoxypropyl)piperidine-4-carboxylate

179474-79-4

4-amino-1-(3-methoxypropyl)piperidine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: ammonium hydroxide / 60 °C 2: potassium hydroxide; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / water; acetonitrile / 13 h / 5 - 25 °C View Scheme

13035-19-3

4-aminopiperidine

179474-79-4

4-amino-1-(3-methoxypropyl)piperidine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: boron trifluoride diethyl etherate / toluene / Reflux 2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere 2.2: 3 h / 20 °C 3.1: hydrogenchloride / water / 0 - 20 °C / pH 1 - 2 View Scheme

179474-79-4

4-amino-1-(3-methoxypropyl)piperidine

110-15-6

succinic acid

123654-26-2

4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid

prucalopride succinic acid

Conditions

Conditions	Yield
Stage #1: 4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran for 1.5h; Stage #2: 4-amino-1-(3-methoxypropyl)piperidine In tetrahydrofuran at 45℃; for 4h; Stage #3: succinic acid In ethanol at 20℃; for 2h; Solvent; Reagent/catalyst; Temperature;	94%

...Expand

179474-79-4

4-amino-1-(3-methoxypropyl)piperidine

123654-26-2

4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid

179474-81-8

prucalopride

Conditions

Conditions	Yield
Stage #1: 4-amino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylic acid With 1,1'-carbonyldiimidazole In tetrahydrofuran for 0.416667h; Stage #2: 4-amino-1-(3-methoxypropyl)piperidine In tetrahydrofuran at 45 - 50℃; for 4h;	85%

179474-79-4

4-amino-1-(3-methoxypropyl)piperidine

8-chloro-3-methyl-1,7-naphthyridin-2(1H)-one

C18H26N4O2

Conditions

Conditions	Yield
With Caddick catalyst In 2-methyltetrahydrofuran at 20 - 140℃; for 0.5h; Microwave irradiation;	19%

179474-79-4

4-amino-1-(3-methoxypropyl)piperidine

519147-79-6

5-AMINO-6-CHLORO-2-METHYL-N-{1-[3-(METHOXY)PROPYL]-4-PIPERIDINYL}IMIDAZO[1,2-a]PYRIDINE-8-CARBOXAMIDE

519147-96-7

5-amino-6-chloro-2-ethylimidazo[1,2-a]pyridine-8-carboxylic acid

179474-79-4

4-amino-1-(3-methoxypropyl)piperidine

519148-35-7

5-AMINO-6-CHLORO-2-ETHYL-N-{1-[3-(METHOXY)PROPYL]-4-PIPERIDINYL}IMIDAZO[1,2-a]PYRIDINE-8-CARBOXAMIDE

Conditions

Conditions	Yield
In 5-Amino-N-[(1-butyl-4-piperidinyl)methyl]-6-chloro-2-methylimidazo

179474-79-4

4-amino-1-(3-methoxypropyl)piperidine

519148-01-7

5-amino-6-chloro-2-propylimidazo[1,2-a]pyridine-8-carboxylic acid

519148-03-9

5-amino-6-chloro-2-propyl-N-{1-[3-(methoxy)propyl]-4-piperidinyl}imidazo[1,2-a]pyridine-8-carboxamide

Conditions

Conditions	Yield
In 5-Amino-N-[(1-butyl-4-piperidinyl)methyl]-6-chloro-2-methylimidazo

179474-79-4

4-amino-1-(3-methoxypropyl)piperidine

872171-59-0

3-(3-t-butyl-5-(3-(naphthalen-1-yl)ureido)-1H-pyrazol-1-yl)benzoic acid

1254308-91-2

C34H42N6O3

Conditions

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate

179474-79-4

4-amino-1-(3-methoxypropyl)piperidine

prucalopride succinic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.42 h 1.2: 4 h / 45 - 50 °C 2.1: ethanol / 3 h / 40 °C View Scheme

179474-79-4

4-amino-1-(3-methoxypropyl)piperidine

4-amino-5-chloro-7-aldehyde-2,3-dihydrobenzofuran

179474-81-8

prucalopride

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; calcium carbonate pentahydrate In acetonitrile at 80℃; for 8h;	36.5 g

179474-79-4

4-amino-1-(3-methoxypropyl)piperidine

4-amino-5-chloro-7-hydroxymethyl-2,3-dihydrobenzofuran

179474-81-8

prucalopride

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; zinc(II) iodide In acetonitrile at 70℃; for 5h;	33.6 g

179474-79-4

4-amino-1-(3-methoxypropyl)piperidine

7-(4-((tert-butoxycarbonyi)(phenethyl)amino)piperidin-1-yl)-2-oxo-2H-chromen-4-yl-trifluoromethanesulfonate

C36H50N4O5

Conditions

Conditions	Yield
With triethylamine In 1,4-dioxane Reflux;

1-(3-Methoxypropyl)-4-piperidinamine Chemical Properties

1-(3-Methoxypropyl)-4-piperidinamine Specification