-
Name
3-(tert-butylamino)-1-[(6-chloro-m-tolyl)oxy]propan-2-ol hydrochloride
- EINECS
- CAS No. 15148-80-8
- Density 1.098g/cm3
- Solubility
- Melting Point 220-222°
- Formula C14H22 Cl N O2 . Cl H
- Boiling Point 396.3°Cat760mmHg
- Molecular Weight 308.24392
- Flash Point 193.5°C
- Transport Information
- Appearance
- Safety Poison by ingestion, intraperitoneal, and intravenous routes. Moderately toxic by subcutaneous route. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NOx and Cl−.
- Risk Codes
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Molecular Structure
- Hazard Symbols
- Synonyms 2-Propanol,1-(2-chloro-5-methylphenoxy)-3-[(1,1-dimethylethyl)amino]-, hydrochloride(9CI); 2-Propanol, 1-(tert-butylamino)-3-[(6-chloro-m-tolyl)oxy]-,hydrochloride (8CI); (-)-KL 255; (?à)-Kl 255; 1-(6'-Chloro-3'-methylphenoxy)-3-tert-butylaminopropanol,hydrochloride; 1-(tert-Butylamino)-3-(2-chloro-5-methylphenoxy)-2-propanolhydrochloride; 1-tert-Butylamino-3-(6-chloro-m-tolyloxy)-2-propanolhydrochloride; 3-tert-Butylamino-1-(6-chloro-3-methylphenoxy)propan-2-olhydrochloride; B 1312; Betadran; Betadrenol; Betadrenol hydrochloride;Bupranolol hydrochloride; KL 255; Looser; Panimit; SKF 16805A; dl-Bupranololhydrochloride; dl-KL 255
- PSA 41.49000
- LogP 3.96910
1-(tert-Butylamino)-3-(2-chloro-5-methyl phenoxy)-2-propanol hydro-chloride Chemical Properties
IUPAC Name: 1-(tert-Butylamino)-3-(2-chloro-5-methylphenoxy)propan-2-ol hydrochloride
Synonyms: 1-(tert-Butylamino)-3-(2-chloro-5-methylphenoxy)propan-2-ol hydrochloride (1:1) ; 2-Propanol, 1-(2-chloro-5-methylphenoxy)-3-((1,1-dimethylethyl)amino)-, hydrochloride, (+-)- ; 2-Propanol, 1-(2-chloro-5-methylphenoxy)-3-[(1,1-dimethylethyl)amino]-, hydrochloride (1:1) ; 2-Propanol, 1-tert-butylamino-3-(6-chloro-m-tolyloxy)-, hydrochloride
CAS NO:15148-80-8
Molecular Formula of 1-(tert-Butylamino)-3-(2-chloro-5-methyl phenoxy)-2-propanol hydro-chloride (CAS NO.15148-80-8) : C14H23Cl2NO2
Molecular Weight of 1-(tert-Butylamino)-3-(2-chloro-5-methyl phenoxy)-2-propanol hydro-chloride (CAS NO.15148-80-8) :308.24392
Molecular Structure of 1-(tert-Butylamino)-3-(2-chloro-5-methyl phenoxy)-2-propanol hydro-chloride (CAS NO.15148-80-8) :
EINECS: 239-208-3
Flash Point: 193.5 °C
Enthalpy of Vaporization: 68.19 kJ/mol
Boiling Point: 396.3 °C at 760 mmHg
Vapour Pressure: 5.44E-07 mmHg at 25°C
1-(tert-Butylamino)-3-(2-chloro-5-methyl phenoxy)-2-propanol hydro-chloride Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | oral | 438mg/kg (438mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 75, 1973. |
| mouse | LD50 | intravenous | 39300ug/kg (39.3mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 75, 1973. |
| mouse | LD50 | oral | 329mg/kg (329mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 75, 1973. |
| mouse | LD50 | subcutaneous | 567mg/kg (567mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 75, 1973. |
| rabbit | LD50 | intravenous | 15300ug/kg (15.3mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 75, 1973. |
| rabbit | LD50 | oral | 895mg/kg (895mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 75, 1973. |
| rat | LD50 | intraperitoneal | 96mg/kg (96mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 75, 1973. |
| rat | LD50 | intravenous | 15300ug/kg (15.3mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Yakkyoku. Pharmacy. Vol. 25, Pg. 813, 1974. |
| rat | LD50 | oral | 518mg/kg (518mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 75, 1973. |
| rat | LD50 | subcutaneous | 630mg/kg (630mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 75, 1973. |
1-(tert-Butylamino)-3-(2-chloro-5-methyl phenoxy)-2-propanol hydro-chloride Safety Profile
Poison by ingestion, intraperitoneal, and intravenous routes. Moderately toxic by subcutaneous route. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NOx and Cl−.
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