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Dayang Chem (Hangzhou) Co.,Ltd.

As a leading manufacturer and supplier of chemicals in China, DayangChem not only supply popular chemicals, but also DayangChem's R&D center offer custom synthesis services. DayangChem can provide different quantities of custom synthesis ch

4-CHLORO-2-(TRIFLUOROMETHYL)PYRIMIDINE

Cas:1514-96-1

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

Pharmaceutical Grade CAS 1514-96-1 with competitive price

Cas:1514-96-1

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.In No Less 10 years exporting experience. you can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specializ

Pyrimidine,4-chloro-2-(trifluoromethyl)-

Cas:1514-96-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Pyrimidine,4-chloro-2-(trifluoromethyl)-

Cas:1514-96-1

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Pyrimidine,4-chloro-2-(trifluoromethyl)-

Cas:1514-96-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

4-CHLORO-2-(TRIFLUOROMETHYL)PYRIMIDINE

Cas:1514-96-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Hangzhou Huarong Pharm Co., Ltd.

We Huarong Pharm can provide Customized Synthesis & Process R&D & APIs and intermediates Production & Quality Research & Registration Application, especially our GMP validation service which complies with SFDA, FDA, WHO and EU EMPA. O

4-CHLORO-2-(TRIFLUOROMETHYL)PYRIMIDINE

Cas:1514-96-1

Min.Order:0

Negotiable

Type:Trading Company

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TAIZHOU ZHENYU BIOTECHNOLOGY CO., LTD

Zhenyu biotech exported this product to many countries and regions at best price. if you are looking for the material's manufacturer or supplier in china, zhenyu biotech is your best choice. pls contact with us freely for getting detailed

4-CHLORO-2-(TRIFLUOROMETHYL)PYRIMIDINE

Cas:1514-96-1

Min.Order:1 Kilogram

FOB Price: $2.0

Type:Lab/Research institutions

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KAISA GROUP INC

1.Applied in food field.it can improve the immune system and prolong life. 2.Appliedin cosmetic field.it can improve the skin care. 3.Applied in pharmaceutical field.it can treat various dieases. 4.Our product quality assurance will make our customer

1514-96-1 CAS NO.1514-96-1

Cas:1514-96-1

Min.Order:1 Metric Ton

FOB Price: $7.0 / 8.0

Type:Trading Company

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Win-Win chemical Co.Ltd

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

4-CHLORO-2-(TRIFLUOROMETHYL)PYRIMIDINE Cas no.1514-96-1 98%

Cas:1514-96-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Nanjing Yuance Industry&Trade Co., Ltd.

Product Name 4-hydroxy-1H-pyrazolo(3.4-d)pyrimidine CAS 315-30-0 MF C5H4N4O MW 136.11 EINECS 206-250-9 Product Name 4-hydroxy…

4-Chloro-2-trifluoromethyl-pyrimidine

Cas:1514-96-1

Min.Order:0

Negotiable

Type:Manufacturers

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Kono Chem Co.,Ltd

high purity lowest priceAppearance:solid or liquid Storage:in sealed air resistant place Package:drum and bag Application:for pharma use Transportation:by sea or air Port:Beijing or Guangzhou

4-CHLORO-2-(TRIFLUOROMETHYL)PYRIMIDINE

Cas:1514-96-1

Min.Order:0

Negotiable

Type:Other

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Henan Tianfu Chemical Co., Ltd.

1.Our services:A.Supply sampleB.The packing also can be according the customers` requirmentC.Any inquiries will be replied within 24 hoursD.we provide Commerical Invoice, Packing List, Bill of loading, COA , Health certificate and Origin certificate.

Pyrimidine,4-chloro-2-(trifluoromethyl)-

Cas:1514-96-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Antimex Chemical Limied

Ansciep Chemical is a professional enterprise manufacturing and distributing fine chemicals and speciality chemicals. We have been dedicated to heterocycle compounds and phenyl rings for tens of years. This is our mature product for export. Our quali

Pyrimidine,4-chloro-2-(trifluoromethyl)-

Cas:1514-96-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Guangdong Juda Chemical Industrial Co.,Limited

Appearance:solid or liquid Storage:sealed in cool and dry place Package:As customer's requested Application:Pharma Intermediate Transportation:by courier/air/sea Port:Any port in China

4-Chloro-2-trifluoromethyl-pyrimidine CAS No.1514-96-1

Cas:1514-96-1

Min.Order:0

Negotiable

Type:Trading Company

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Changchun Artel lmport and Export trade company

Supply top quality products with a reasonable price Application:api

1514-96-1

Cas:1514-96-1

Min.Order:0

Negotiable

Type:Trading Company

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Hangzhou Fandachem Co.,Ltd

4-CHLORO-2-(TRIFLUOROMETHYL)PYRIMIDINECASAppearance:white crystalline powder Storage:Store in dry, dark and ventilated place Package:25KG drum Application:intermediate Transportation:by air, by sea, by express

4-CHLORO-2-(TRIFLUOROMETHYL)PYRIMIDINECAS

Cas:1514-96-1

Min.Order:0

Negotiable

Type:Other

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Hangzhou Sartort Biopharma Co., Ltd

Best quality with low priceAppearance:Yellow power Storage:ln stock Package:25kg/Barrel Application:Chemicals Transportation:Express/Sea/Air Port:Shanghai

4-Chloro-2-(trifluoromethyl)pyrimidine

Cas:1514-96-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Henan Kanbei Chemical Co.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

4-CHLORO-2-(TRIFLUOROMETHYL)PYRIMIDINE

Cas:1514-96-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

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Chemlyte Solutions

Stock products, own laboratory Package:Grams, Kilograms Application:For R&D Transportation:According to customer request Port:Shanghai

4-Chloro-2-trifluoromethyl-pyrimidine

Cas:1514-96-1

Min.Order:0

Negotiable

Type:Other

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ZHEJIANG JIUZHOU CHEM CO.,LTD

factory?direct?saleAppearance:White powder Storage:Sealed and preserved Package:200/Kilograms Application:healing drugs Transportation:By sea Port:Shanghai/tianjin

4-CHLORO-2-(TRIFLUOROMETHYL)PYRIMIDINE

Cas:1514-96-1

Min.Order:0

Negotiable

Type:Trading Company

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LEAP CHEM Co., Ltd.

Best Seller, High Quality, Competitive Price, Fast Delivery, Quick ResponseAppearance:powder, or liquid Storage:Stored in room temperature, ventilated place Package:Bottle, barrel, cargo, container, etc. Application:Pharmaceuticals, intermediates, AP

4-Chloro-2-trifluoromethyl-pyrimidine

Cas:1514-96-1

Min.Order:0

Negotiable

Type:Trading Company

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Amadis Chemical Co., Ltd.

1.Professional synthesis laboratory and production base. 2.Strong synthesis team and service team. 3.Professional data management system. 4.We provide the professional test date and product information ,ex. HNMR ,CNMR,FNMR, HPLC/G

4-Chloro-2-trifluoromethyl-pyrimidine

Cas:1514-96-1

Min.Order:10 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Jilin haofei import and export trade Co.,Ltd

Price, service, company and transport advantage: 1. Best service, place of origin China, high quality, and reasonable price. 2. It's customers' right to choose the package (EMS, DHL, FEDEX, UPS). 3. It's customers' right

4-CHLORO-2-(TRIFLUOROMETHYL)PYRIMIDINE CAS NO.1514-96-1

Cas:1514-96-1

Min.Order:0

Negotiable

Type:Trading Company

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Watson International Ltd

Watson International Ltd' has a very strong R&D and technical capacity supported by FCAD's platform. The subsidiaries under FCAD Group have accumulated much know-how of different fine chemical branches. For example, Apnoke Scientific L

4-Chloro-2-trifluoromethyl-pyrimidine

Cas:1514-96-1

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Changzhou Pesan Chemical Co.,Ltd

Strong R&D strength and team We have a R&D team with around 30 R&D personnel.All of our employees have chemical backgrounds and have worked in the chemical industry for many years.Our laboratory can synthesize target products with wei

4-CHLORO-2-(TRIFLUOROMETHYL)PYRIMIDINE

Cas:1514-96-1

Min.Order:0

Negotiable

Type:Other

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Henan Wising Chem Co., Ltd

Henan Wising Chem specializes in sourcing chemicals in China. We are associated with many trusted manufacturers each having different areas of expertise required for meeting the needs of our local as well as overseas buyers. We have access to custom

4-CHLORO-2-(TRIFLUOROMETHYL)PYRIMIDINE

Cas:1514-96-1

Min.Order:10 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Nanjing Zhiyan Pharmaceutical Technology Co. Ltd.

High quality / commercialize;Stable production capacity.Appearance:actual character Storage:Temperature controlled NMT 30℃ Package:As customer request Application:Used for Synthesis API and Research Transportation:Follow the MSDS

4-chloro-2-(trifluoromethyl)pyrimidine

Cas:1514-96-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Wu Han Runder Pharmda Technology Co.,Ltd

799842-07-2 Rosuvastatin intermediate 1.honest and trustworthy company 2.in very competitive price 3.Quality Guarantee Rosuvast…

4-Chloro-2-trifluoromethyl-pyrimidine

Cas:1514-96-1

Min.Order:0

Negotiable

Type:Other

inquiry

Shanghai united Scientific Co.,Ltd.

United Scientific Company Located in Shanghai of China , is a competitive player in the global specialty and fine chemical market. Fenghua has both the expertise and flexibility to produce a wide range of chemicals. Focusing on developing the innovat

Pyrimidine,4-chloro-2-(trifluoromethyl)-

Cas:1514-96-1

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Synthetic route

2-trifluoromethyl-4-hydroxypyrimidine
1546-80-1

2-trifluoromethyl-4-hydroxypyrimidine

4-chloro-2-(trifluoromethyl)pyrimidine
1514-96-1

4-chloro-2-(trifluoromethyl)pyrimidine

Conditions
ConditionsYield
With trichlorophosphate at 100 - 105℃; for 3h;87%
With N,N-dimethyl-aniline; trichlorophosphate for 2h; Heating / reflux;71%
With N,N-dimethyl-formamide; trichlorophosphate at 120℃; for 2h;56%
4-chloro-6-methoxy-2-trifluoromethylpyrimidine

4-chloro-6-methoxy-2-trifluoromethylpyrimidine

4-chloro-2-(trifluoromethyl)pyrimidine
1514-96-1

4-chloro-2-(trifluoromethyl)pyrimidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: palladium 10% on activated carbon; hydrogen; triethylamine / 15 h / 25 - 35 °C / 760.05 Torr
2: hydrogen bromide / 5 h / 60 - 70 °C
3: trichlorophosphate / 3 h / 100 - 105 °C
View Scheme
2-trifluoromethyl-4,6-dihydroxypyrimidine
672-47-9

2-trifluoromethyl-4,6-dihydroxypyrimidine

4-chloro-2-(trifluoromethyl)pyrimidine
1514-96-1

4-chloro-2-(trifluoromethyl)pyrimidine

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: trichlorophosphate; triethylamine / 4 h / 5 - 105 °C
2: methanol / 5 h / 0 - 35 °C
3: palladium 10% on activated carbon; hydrogen; triethylamine / 15 h / 25 - 35 °C / 760.05 Torr
4: hydrogen bromide / 5 h / 60 - 70 °C
5: trichlorophosphate / 3 h / 100 - 105 °C
View Scheme
4,6-dichloro-2-(trifluoromethyl)pyrimidine
705-24-8

4,6-dichloro-2-(trifluoromethyl)pyrimidine

4-chloro-2-(trifluoromethyl)pyrimidine
1514-96-1

4-chloro-2-(trifluoromethyl)pyrimidine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: methanol / 5 h / 0 - 35 °C
2: palladium 10% on activated carbon; hydrogen; triethylamine / 15 h / 25 - 35 °C / 760.05 Torr
3: hydrogen bromide / 5 h / 60 - 70 °C
4: trichlorophosphate / 3 h / 100 - 105 °C
View Scheme
4-chloro-2-(trifluoromethyl)pyrimidine
1514-96-1

4-chloro-2-(trifluoromethyl)pyrimidine

Cyclopentamine
1003-03-8

Cyclopentamine

N-cyclopentyl-2-(trifluoromethyl)pyrimidin-4-amine
917895-57-9

N-cyclopentyl-2-(trifluoromethyl)pyrimidin-4-amine

Conditions
ConditionsYield
In 1,4-dioxane at 0 - 20℃;99%
tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

4-chloro-2-(trifluoromethyl)pyrimidine
1514-96-1

4-chloro-2-(trifluoromethyl)pyrimidine

4-(1-ethoxyvinyl)-2-(trifluoromethyl)pyrimidine

4-(1-ethoxyvinyl)-2-(trifluoromethyl)pyrimidine

Conditions
ConditionsYield
Stage #1: tributyl(1-ethoxyvinyl)stannane; 4-chloro-2-(trifluoromethyl)pyrimidine With bis-triphenylphosphine-palladium(II) chloride In N,N-dimethyl-formamide at 85℃; for 18h; Inert atmosphere;
Stage #2: With potassium fluoride In water; N,N-dimethyl-formamide at 20℃; for 0.166667h; Inert atmosphere;
93%
4-piperidone monohydrochloride monohydrate
40064-34-4

4-piperidone monohydrochloride monohydrate

sodium carbonate
497-19-8

sodium carbonate

4-chloro-2-(trifluoromethyl)pyrimidine
1514-96-1

4-chloro-2-(trifluoromethyl)pyrimidine

1-[2-(Trifluoromethyl)-4-pyrimidinyl]-4-piperidone

1-[2-(Trifluoromethyl)-4-pyrimidinyl]-4-piperidone

Conditions
ConditionsYield
In dichloromethane92%
4-chloro-2-(trifluoromethyl)pyrimidine
1514-96-1

4-chloro-2-(trifluoromethyl)pyrimidine

diethyl malonate
105-53-3

diethyl malonate

ethyl 2-[2-(trifluoromethyl)pyrimidin-4-yl]acetate

ethyl 2-[2-(trifluoromethyl)pyrimidin-4-yl]acetate

Conditions
ConditionsYield
Stage #1: diethyl malonate With sodium hydride In N,N-dimethyl-formamide at -78℃; for 0.166667h;
Stage #2: 4-chloro-2-(trifluoromethyl)pyrimidine In N,N-dimethyl-formamide at 80 - 120℃;
92%
(S)-4-ethylaminomethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester
1048351-33-2

(S)-4-ethylaminomethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

4-chloro-2-(trifluoromethyl)pyrimidine
1514-96-1

4-chloro-2-(trifluoromethyl)pyrimidine

(S)-4-{[ethyl-(2-trifluoromethyl-pyrimidin-4-yl)-amino]-methyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester
1048351-35-4

(S)-4-{[ethyl-(2-trifluoromethyl-pyrimidin-4-yl)-amino]-methyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 180℃; for 0.5h; Microwave irradiation;90%
methanol
67-56-1

methanol

carbon monoxide
201230-82-2

carbon monoxide

4-chloro-2-(trifluoromethyl)pyrimidine
1514-96-1

4-chloro-2-(trifluoromethyl)pyrimidine

methyl 2-(trifluoromethyl)pyrimidine-4-carboxylate
878745-51-8

methyl 2-(trifluoromethyl)pyrimidine-4-carboxylate

Conditions
ConditionsYield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine at 80℃; under 2585.81 Torr; for 16h;88%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine at 80℃; for 16h; Inert atmosphere;88%
With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine at 60℃; under 3102.97 Torr; for 16h;62%
With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine at 60℃; under 3102.97 Torr;
With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine at 60℃; under 3102.97 Torr;
tert-butyl 4-[(2-{[6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate

tert-butyl 4-[(2-{[6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazol-2-yl]amino}pyridin-4-yl)methyl]piperazine-1-carboxylate

4-chloro-2-(trifluoromethyl)pyrimidine
1514-96-1

4-chloro-2-(trifluoromethyl)pyrimidine

tert-butyl 4-{[2-({6-[2-(trifluoromethyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate

tert-butyl 4-{[2-({6-[2-(trifluoromethyl)pyrimidin-4-yl]-1H-benzimidazol-2-yl}amino)pyridin-4-yl]methyl}piperazine-1-carboxylate

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate In 1,4-dioxane; water for 24h; Suzuki Coupling; Reflux;83%
tributyl(1-ethoxyvinyl)stannane
97674-02-7

tributyl(1-ethoxyvinyl)stannane

4-chloro-2-(trifluoromethyl)pyrimidine
1514-96-1

4-chloro-2-(trifluoromethyl)pyrimidine

1-(2-(trifluoromethyl)pyrimidin-4-yl)ethanone
878760-55-5

1-(2-(trifluoromethyl)pyrimidin-4-yl)ethanone

Conditions
ConditionsYield
Stage #1: tributyl(1-ethoxyvinyl)stannane; 4-chloro-2-(trifluoromethyl)pyrimidine With bis-triphenylphosphine-palladium(II) chloride In N,N-dimethyl-formamide at 85℃; Inert atmosphere; Sealed tube;
Stage #2: With potassium fluoride In diethyl ether; N,N-dimethyl-formamide at 20℃;
Stage #3: With hydrogenchloride In water; N,N-dimethyl-formamide; acetone at 60℃; for 2h;
82%
N-phenylpyrrolidine
4096-21-3

N-phenylpyrrolidine

4-chloro-2-(trifluoromethyl)pyrimidine
1514-96-1

4-chloro-2-(trifluoromethyl)pyrimidine

C15H14F3N3

C15H14F3N3

Conditions
ConditionsYield
With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; sodium acetate In N,N-dimethyl acetamide; water at 0℃; Irradiation;72%
N-ethyl-N-[(4-piperidinyl)methyl]acetamide hydrochloride

N-ethyl-N-[(4-piperidinyl)methyl]acetamide hydrochloride

4-chloro-2-(trifluoromethyl)pyrimidine
1514-96-1

4-chloro-2-(trifluoromethyl)pyrimidine

N-ethyl-N-[[1-[2-(trifluoromethyl)-4-pyrimidinyl]-4-piperidinyl]methyl]-acetamide

N-ethyl-N-[[1-[2-(trifluoromethyl)-4-pyrimidinyl]-4-piperidinyl]methyl]-acetamide

Conditions
ConditionsYield
With sodium carbonate In dichloromethane; N,N-dimethyl-formamide67%
(S)-tert-butyl (1-(2-cyano-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)-2,4-dimethylpentan-2-yl)carbamate

(S)-tert-butyl (1-(2-cyano-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)-2,4-dimethylpentan-2-yl)carbamate

4-chloro-2-(trifluoromethyl)pyrimidine
1514-96-1

4-chloro-2-(trifluoromethyl)pyrimidine

(S)-tert-butyl (1-(2-cyano-4-(2-(trifluoromethyl)pyrimidin-4-yl)phenoxy)-2,4-dimethylpentan-2-yl) carbamate

(S)-tert-butyl (1-(2-cyano-4-(2-(trifluoromethyl)pyrimidin-4-yl)phenoxy)-2,4-dimethylpentan-2-yl) carbamate

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; caesium carbonate In 1,4-dioxane; water at 80℃; for 12h; Inert atmosphere;64%
4-amino-phenol
123-30-8

4-amino-phenol

4-chloro-2-(trifluoromethyl)pyrimidine
1514-96-1

4-chloro-2-(trifluoromethyl)pyrimidine

4-{[2-(trifluoromethyl)pyrimidin-4-yl]oxy}aniline
871240-11-8

4-{[2-(trifluoromethyl)pyrimidin-4-yl]oxy}aniline

Conditions
ConditionsYield
Stage #1: 4-amino-phenol With potassium tert-butylate In ISOPROPYLAMIDE at 20℃; for 0.25h;
Stage #2: 4-chloro-2-(trifluoromethyl)pyrimidine In N,N-dimethyl-formamide at 20℃; for 16h;
63%
tert-butyl 3-(4-aminophenoxy)azetidine-1-carboxylate
643087-88-1

tert-butyl 3-(4-aminophenoxy)azetidine-1-carboxylate

4-chloro-2-(trifluoromethyl)pyrimidine
1514-96-1

4-chloro-2-(trifluoromethyl)pyrimidine

tert-butyl 3-(4-(2-(trifluoromethyl)pyrimidin-4-ylamino)phenoxy)azetidine-1-carboxylate

tert-butyl 3-(4-(2-(trifluoromethyl)pyrimidin-4-ylamino)phenoxy)azetidine-1-carboxylate

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In diethylene glycol dimethyl ether at 100℃; Inert atmosphere;58%
2-(3-fluoro-4-methoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane
754226-34-1

2-(3-fluoro-4-methoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

4-chloro-2-(trifluoromethyl)pyrimidine
1514-96-1

4-chloro-2-(trifluoromethyl)pyrimidine

4-(3-fluoro-4-methoxyphenyl)-2-(trifluoromethyl)pyrimidine

4-(3-fluoro-4-methoxyphenyl)-2-(trifluoromethyl)pyrimidine

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; caesium carbonate; potassium bromide In 1,4-dioxane at 80℃; for 1.3h; Inert atmosphere;53%
3-(5-aminopyrazin-2-yl)-6-cyclobutyl-2-fluorophenol

3-(5-aminopyrazin-2-yl)-6-cyclobutyl-2-fluorophenol

4-chloro-2-(trifluoromethyl)pyrimidine
1514-96-1

4-chloro-2-(trifluoromethyl)pyrimidine

5-(4-cyclobutyl-2-fluoro-3-{[2-(trifluoromethyl)pyrimidin-4-yl]oxy}phenyl)pyrazin-2-amine

5-(4-cyclobutyl-2-fluoro-3-{[2-(trifluoromethyl)pyrimidin-4-yl]oxy}phenyl)pyrazin-2-amine

Conditions
ConditionsYield
With caesium carbonate In dimethyl sulfoxide at 80℃; for 1h; Microwave irradiation;52%
With caesium carbonate In dimethyl sulfoxide at 80℃; for 1h; Inert atmosphere; Microwave irradiation;
(S)-tert-butyl (1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)-2,4-dimethylpentan-2-yl)carbamate

(S)-tert-butyl (1-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)-2,4-dimethylpentan-2-yl)carbamate

4-chloro-2-(trifluoromethyl)pyrimidine
1514-96-1

4-chloro-2-(trifluoromethyl)pyrimidine

(S)-tert-butyl(1-(2-chloro-4-(2-(trifluoromethyl)pyrimidin-4-yl)phenoxy)-2,4-dimethylpentan-2-yl) carbamate

(S)-tert-butyl(1-(2-chloro-4-(2-(trifluoromethyl)pyrimidin-4-yl)phenoxy)-2,4-dimethylpentan-2-yl) carbamate

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; caesium carbonate In 1,4-dioxane; water at 80℃; for 12h; Inert atmosphere;52%
(R)-N-(4-cyanophenylethyl)piperidine-3-carboxamide
1595144-12-9

(R)-N-(4-cyanophenylethyl)piperidine-3-carboxamide

4-chloro-2-(trifluoromethyl)pyrimidine
1514-96-1

4-chloro-2-(trifluoromethyl)pyrimidine

(R)-N-(4-cyanophenylethyl)-1-(2-(trifluoromethyl)pyrimidin-6-yl)piperidine-3-carboxamide
1595144-33-4

(R)-N-(4-cyanophenylethyl)-1-(2-(trifluoromethyl)pyrimidin-6-yl)piperidine-3-carboxamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 100℃; for 2h; Sealed tube;50%
4-chloro-2-(trifluoromethyl)pyrimidine
1514-96-1

4-chloro-2-(trifluoromethyl)pyrimidine

tert-butyl 2,8-diazaspiro[4.5]decane-2-carboxylate
336191-17-4

tert-butyl 2,8-diazaspiro[4.5]decane-2-carboxylate

tert-butyl 8-(2-(trifluoromethyl)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-2-carboxylate
1246508-00-8

tert-butyl 8-(2-(trifluoromethyl)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-2-carboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 75℃; for 0.75h; Microwave irradiation;47%
(R)-4-fluoro-N-(1-(5,6,7,8-tetrahydro-1,5-naphthyridin-2-yl)ethyl)benzamide hydrochloride

(R)-4-fluoro-N-(1-(5,6,7,8-tetrahydro-1,5-naphthyridin-2-yl)ethyl)benzamide hydrochloride

4-chloro-2-(trifluoromethyl)pyrimidine
1514-96-1

4-chloro-2-(trifluoromethyl)pyrimidine

trifluoroacetic acid
76-05-1

trifluoroacetic acid

C22H19F4N5O*C2HF3O2

C22H19F4N5O*C2HF3O2

Conditions
ConditionsYield
Stage #1: (R)-4-fluoro-N-(1-(5,6,7,8-tetrahydro-1,5-naphthyridin-2-yl)ethyl)benzamide hydrochloride; 4-chloro-2-(trifluoromethyl)pyrimidine With 2’-(bis(3,5-bis(trifluoromethyl)phenyl)phosphino)-3’,6’-dimethoxy-N2,N2,N6,N6-tetramethyl-[1,1‘-biphenyl]-2,6-diamine; C34H29F12N2O2P*Pd(2+)*C12H10N(1-)*CH3O3S(1-); sodium t-butanolate at 80℃; Inert atmosphere;
Stage #2: trifluoroacetic acid In water; acetonitrile Inert atmosphere;
47%
(S)-tert-butyl (1-(4-bromo-2-methylphenoxy)-2,4-dimethylpentan-2-yl)carbamate

(S)-tert-butyl (1-(4-bromo-2-methylphenoxy)-2,4-dimethylpentan-2-yl)carbamate

4-chloro-2-(trifluoromethyl)pyrimidine
1514-96-1

4-chloro-2-(trifluoromethyl)pyrimidine

(S)-tert-butyl (2,4-dimethyl-1-(2-methyl-4-(2-(trifluoromethyl)pyrimidin-4-yl)phenoxy)pentan-2-yl)carbamate

(S)-tert-butyl (2,4-dimethyl-1-(2-methyl-4-(2-(trifluoromethyl)pyrimidin-4-yl)phenoxy)pentan-2-yl)carbamate

Conditions
ConditionsYield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium bromide In 1,4-dioxane at 80℃; for 1.3h; Inert atmosphere; Microwave irradiation;44%
tert-butyl 3-(4-aminobenzylidene)azetidine-1-carboxylate

tert-butyl 3-(4-aminobenzylidene)azetidine-1-carboxylate

4-chloro-2-(trifluoromethyl)pyrimidine
1514-96-1

4-chloro-2-(trifluoromethyl)pyrimidine

tert-butyl 3-[[4-[[2-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]methylene]azetidine-1-carboxylate

tert-butyl 3-[[4-[[2-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]methylene]azetidine-1-carboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl acetamide at 100℃; for 1h; Inert atmosphere; Microwave irradiation;38%
2-Aminopyrazine
5049-61-6

2-Aminopyrazine

4-chloro-2-(trifluoromethyl)pyrimidine
1514-96-1

4-chloro-2-(trifluoromethyl)pyrimidine

C9H6F3N5

C9H6F3N5

Conditions
ConditionsYield
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 90℃; for 40h; Inert atmosphere;37%
tert-butyl (11bR)-9-amino-1,3,4,6,7,11b-hexahydropyrazino[2,1-a]isoquinoline-2-carboxylate

tert-butyl (11bR)-9-amino-1,3,4,6,7,11b-hexahydropyrazino[2,1-a]isoquinoline-2-carboxylate

4-chloro-2-(trifluoromethyl)pyrimidine
1514-96-1

4-chloro-2-(trifluoromethyl)pyrimidine

tert-butyl (11bR)-9-[[2-(trifluoromethyl)pyrimidin-4-yl]amino]-1,3,4,6,7,11b-hexahydropyrazino[2,1-a]isoquinoline-2-carboxylate

tert-butyl (11bR)-9-[[2-(trifluoromethyl)pyrimidin-4-yl]amino]-1,3,4,6,7,11b-hexahydropyrazino[2,1-a]isoquinoline-2-carboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl acetamide at 100℃;27%
ethanol
64-17-5

ethanol

carbon monoxide
201230-82-2

carbon monoxide

4-chloro-2-(trifluoromethyl)pyrimidine
1514-96-1

4-chloro-2-(trifluoromethyl)pyrimidine

2-trifluoromethylpyrimidine-4-carboxylic acid ethyl ester

2-trifluoromethylpyrimidine-4-carboxylic acid ethyl ester

Conditions
ConditionsYield
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine at 60℃; under 2585.81 Torr; for 16h;25%
C17H21N5O

C17H21N5O

4-chloro-2-(trifluoromethyl)pyrimidine
1514-96-1

4-chloro-2-(trifluoromethyl)pyrimidine

6,6-dimethyl-N-[trans-2-phenylcyclopropyl]-3-{[2-(trifluoromethyl)pyrimidin-4-yl]amino}-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide trifluoroacetate

6,6-dimethyl-N-[trans-2-phenylcyclopropyl]-3-{[2-(trifluoromethyl)pyrimidin-4-yl]amino}-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide trifluoroacetate

Conditions
ConditionsYield
With triethylamine In isopropyl alcohol at 140℃; for 0.333333h; Microwave irradiation;6.4%
3-amino-N-[(1S)-2-(dimethylamino)-1-phenylethyl]-6,6-dimethyl-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide
898044-54-7

3-amino-N-[(1S)-2-(dimethylamino)-1-phenylethyl]-6,6-dimethyl-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide

4-chloro-2-(trifluoromethyl)pyrimidine
1514-96-1

4-chloro-2-(trifluoromethyl)pyrimidine

N-[(1S)-2-(dimethylamino)-1-phenylethyl]-6,6-dimethyl-3-{[2-(trifluoromethyl)pyrimidin-4-yl]amino}-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide trifluoroacetate

N-[(1S)-2-(dimethylamino)-1-phenylethyl]-6,6-dimethyl-3-{[2-(trifluoromethyl)pyrimidin-4-yl]amino}-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide trifluoroacetate

Conditions
ConditionsYield
With triethylamine In isopropyl alcohol at 140℃; for 0.333333h; Microwave irradiation;4%
4-chloro-2-(trifluoromethyl)pyrimidine
1514-96-1

4-chloro-2-(trifluoromethyl)pyrimidine

malonic acid dimethyl ester
108-59-8

malonic acid dimethyl ester

dimethyl 2-trifluoromethyl-4-pyrimidylmalonate
119884-64-9

dimethyl 2-trifluoromethyl-4-pyrimidylmalonate

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide 1.) 2.) 60 deg C, 2 hrs.,;0.3 g
8-fluoro-3-(tri-n-butylstannyl)-7-[2-(triethylsilyloxy)prop-2-yl]imidazo[1,2-a]pyridine
628323-04-6

8-fluoro-3-(tri-n-butylstannyl)-7-[2-(triethylsilyloxy)prop-2-yl]imidazo[1,2-a]pyridine

4-chloro-2-(trifluoromethyl)pyrimidine
1514-96-1

4-chloro-2-(trifluoromethyl)pyrimidine

2-[8-fluoro-3-(2-trifluoromethylpyrimidin-4-yl)imidazo[1,2-a]pyridin-7-yl]propan-2-ol

2-[8-fluoro-3-(2-trifluoromethylpyrimidin-4-yl)imidazo[1,2-a]pyridin-7-yl]propan-2-ol

Conditions
ConditionsYield
Stage #1: 8-fluoro-3-(tri-n-butylstannyl)-7-[2-(triethylsilyloxy)prop-2-yl]imidazo[1,2-a]pyridine; 4-chloro-2-(trifluoromethyl)pyrimidine; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran for 3h; Heating / reflux;
Stage #2: With hydrogenchloride In ethanol; 2-Methylpentane; water; ethyl acetate

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