1,2,3,4-Tetrahydroisoquinoline supplier

Name
1,2,3,4-Tetrahydroisoquinoline
EINECS 202-050-0
CAS No. 91-21-4
Article Data200
CAS DataBase
Density 1.006 g/cm³
Solubility 20 G/L in water
Melting Point -25 °C
Formula C₉H₁₁N
Boiling Point 232.5 °C at 760 mmHg
Molecular Weight 133.193
Flash Point 98.9 °C
Transport Information
Appearance clear yellow to brown liquid
Safety 26-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 1,2,3,4-Tetrahydro isoquinoline;1,2,3,4-Tetrahydroleucoline hydrochloride;3,4-dihydro-1H-isoquinoline;1,2,3,4-Tetrahydro-isoquinoline;3,4-dihydro-1H-isoquinoline chloride;Tetrahydroisoquinoline;
PSA 12.03000
LogP 1.66110

1,2,3,4-Tetrahydroisoquinoline Chemical Properties

IUPAC Name: 1,2,3,4-Tetrahydroisoquinoline
Synonyms of Tetrahydroisoquinoline (CAS NO.91-21-4): 1,2,3,4-Tetrahydroisoquinoline ; Tetrahydroisoquinoline ; Isoquinoline, 1,2,3,4-tetrahydro-
CAS NO: 91-21-4
Molecular Formula: C₉H₁₁N
Molecular Weight: 133.19
Molecular Structure:
EINECS: 202-050-0
Boiling Point: 232.5 °C at 760 mmHg
Index of Refraction: 1.544
Molar Refractivity: 41.77 cm³
Molar Volume: 132.2 cm³
Surface Tension: 37 dyne/cm
Density: 1.006 g/cm³
Flash Point: 98.9 °C
Melting Point: -25°C
Enthalpy of Vaporization: 46.92 kJ/mol
Vapour Pressure: 0.0588 mmHg at 25°C
H bond acceptors: 1
H bond donors: 1
Freely Rotating Bonds: 0
Polar Surface Area: 3.24 Å²
Appearance: clear yellow to brown liquid
Product Categories of Tetrahydroisoquinoline (CAS NO.91-21-4): Quinoline&Isoquinoline;Building Blocks;Heterocyclic Building Blocks;Isoquinolines

1,2,3,4-Tetrahydroisoquinoline Uses

Skeleton of Tetrahydroisoquinoline (CAS NO.91-21-4) is commonly encountered in pharmaceutical drugs, notably quaternary ammonium muscle relaxants such as tubocurarine.

1,2,3,4-Tetrahydroisoquinoline Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LDLo	subcutaneous	240mg/kg (240mg/kg)	AUTONOMIC NERVOUS SYSTEM: CENTRAL SYMPATHOLYTIC	"Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948Vol. -, Pg. 244, 1948.

1,2,3,4-Tetrahydroisoquinoline Consensus Reports

Reported in EPA TSCA Inventory.

1,2,3,4-Tetrahydroisoquinoline Safety Profile

Safety Information about Tetrahydroisoquinoline (CAS NO.91-21-4):
Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
WGK Germany: 3
RTECS: NX4900000
Hazard Note Irritant
Poison by intraperitoneal route. When heated to decomposition it emits toxic fumes of NO_x.

1,2,3,4-Tetrahydroisoquinoline Specification

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Will burn if involved in a fire.
Extinguishing Media: Use foam, dry chemical, or carbon dioxide.
Handling: Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Use only in a chemical fume hood.
Storage: Keep away from sources of ignition. Store in a cool, dry place. Store in a tightly closed container. Corrosives area.

Product Name

1,2,3,4-Tetrahydroisoquinoline