Product Name

  • Name

    1,4,5,8-TETRAHYDROXYANTHRAQUINONE

  • EINECS
  • CAS No. 81-60-7
  • Article Data17
  • CAS DataBase
  • Density 1.781g/cm3
  • Solubility
  • Melting Point >274.85°C
  • Formula C14H8 O6
  • Boiling Point 554.8°Cat760mmHg
  • Molecular Weight 272.214
  • Flash Point 303.4°C
  • Transport Information
  • Appearance
  • Safety Moderately toxic by intraperitoneal route. A skin and eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
  • Risk Codes
  • Molecular Structure Molecular Structure of 81-60-7 (1,4,5,8-TETRAHYDROXYANTHRAQUINONE)
  • Hazard Symbols
  • Synonyms Anthraquinone,1,4,5,8-tetrahydroxy- (6CI,7CI,8CI); 1,4,5,8-Tetrahydroxy-9,10-anthracenedione;1,4,5,8-Tetrahydroxy-9,10-anthraquinone; 1,4,5,8-Tetrahydroxyanthraquinone; NSC401144
  • PSA 115.06000
  • LogP 1.28440

Synthetic route

1,4,5,8-tetraacetoxy-9,10-anthraquinone
988-30-7

1,4,5,8-tetraacetoxy-9,10-anthraquinone

1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

Conditions
ConditionsYield
With water; trifluoroacetic acid at 65℃; for 1h;100%
4,8-diamino-1,5-dihydroxyanthraquinone
145-49-3

4,8-diamino-1,5-dihydroxyanthraquinone

A

1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

B

1-amino-4,5,8-trihydroxyanthraquinone
6374-78-3

1-amino-4,5,8-trihydroxyanthraquinone

C

leuco-1,4,5,8-tetrahydroxyanthraquinone
69837-14-5

leuco-1,4,5,8-tetrahydroxyanthraquinone

D

5-Amino-8,9,10-trihydroxy-2,3-dihydro-anthracene-1,4-dione

5-Amino-8,9,10-trihydroxy-2,3-dihydro-anthracene-1,4-dione

Conditions
ConditionsYield
With sodium dithionite In water at 100℃; for 0.666667h;A 2.5%
B 1.3%
C 92%
D 6.4%
...Expand
leuco-1,4,5,8-tetrahydroxyanthraquinone
23478-60-6

leuco-1,4,5,8-tetrahydroxyanthraquinone

1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

Conditions
ConditionsYield
With nitrobenzene for 0.25h; Heating;92%
leuco-4,8-diamino-1,5-dihydroxyanthraquinone

leuco-4,8-diamino-1,5-dihydroxyanthraquinone

A

1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

B

1-amino-4,5,8-trihydroxyanthraquinone
6374-78-3

1-amino-4,5,8-trihydroxyanthraquinone

C

leuco-1,4,5,8-tetrahydroxyanthraquinone
69837-14-5

leuco-1,4,5,8-tetrahydroxyanthraquinone

D

5-Amino-8,9,10-trihydroxy-2,3-dihydro-anthracene-1,4-dione

5-Amino-8,9,10-trihydroxy-2,3-dihydro-anthracene-1,4-dione

Conditions
ConditionsYield
With sodium dithionite In water at 100℃; for 0.666667h;A 3.7%
B 1.4%
C 90%
D 7.1%
With hydrogenchloride at 85 - 90℃; for 2h; Product distribution;A 6.8%
B 22.2%
C 46%
D 16.5%
...Expand
1-amino-4,5,8-trihydroxyanthraquinone
6374-78-3

1-amino-4,5,8-trihydroxyanthraquinone

A

1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

B

leuco-1,4,5,8-tetrahydroxyanthraquinone
69837-14-5

leuco-1,4,5,8-tetrahydroxyanthraquinone

C

5-Amino-8,9,10-trihydroxy-2,3-dihydro-anthracene-1,4-dione

5-Amino-8,9,10-trihydroxy-2,3-dihydro-anthracene-1,4-dione

Conditions
ConditionsYield
With sodium dithionite In water at 100℃; for 0.666667h;A 2.1%
B 88%
C 4.44%
...Expand
4,8-diamino-1,5-dihydroxyanthraquinone-2,6-disulfonate de sodium

4,8-diamino-1,5-dihydroxyanthraquinone-2,6-disulfonate de sodium

A

1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

B

1-amino-4,5,8-trihydroxyanthraquinone
6374-78-3

1-amino-4,5,8-trihydroxyanthraquinone

C

leuco-1,4,5,8-tetrahydroxyanthraquinone
69837-14-5

leuco-1,4,5,8-tetrahydroxyanthraquinone

D

5-Amino-8,9,10-trihydroxy-2,3-dihydro-anthracene-1,4-dione

5-Amino-8,9,10-trihydroxy-2,3-dihydro-anthracene-1,4-dione

Conditions
ConditionsYield
With sodium dithionite In water at 100℃; for 0.666667h;A 2.7%
B 0.2%
C 87%
D 5.1%
With sodium hydroxide at 90 - 100℃; for 0.666667h; Product distribution; NaOH conc.;A 17.4%
B 12.7%
C 8.47%
D 24.9%
...Expand
4,8-diamino-1,5-dihydroxyanthraquinone
145-49-3

4,8-diamino-1,5-dihydroxyanthraquinone

1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

Conditions
ConditionsYield
With sodium hydroxide; sodium dithionite at 100℃; for 1h;80%
With hydrogenchloride at 180℃;
With sodium dithionite; nitrobenzene 1.) 100 deg C; Multistep reaction;
1,4-diamino-5,8-dihydroxy-9,10-anthracenedione
16517-70-7

1,4-diamino-5,8-dihydroxy-9,10-anthracenedione

1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

Conditions
ConditionsYield
With sodium hydroxide In water for 3h; Reflux;75%
1,5-diaminoanthraquinone
129-44-2

1,5-diaminoanthraquinone

1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

Conditions
ConditionsYield
Stage #1: 1,5-diaminoanthraquinone With sodium hydroxide; water for 3h; Heating / reflux;
Stage #2: With sodium hydrogensulfite In water for 3h; Heating / reflux;
Stage #3: With hydrogenchloride In water pH=3;		73%
3,6-dimethoxyphthalic anhydride
14597-12-7

3,6-dimethoxyphthalic anhydride

hydroquinone
123-31-9

hydroquinone

1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

Conditions
ConditionsYield
With aluminium trichloride; sodium chloride
1,8-diamino-4,5-dihydroxyanthraquinone
128-94-9

1,8-diamino-4,5-dihydroxyanthraquinone

1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

Conditions
ConditionsYield
With hydrogenchloride at 180℃;
With sodium hydroxide; sodium disulfite 1.) n-BuOH, 15 min, 2.) n-BuOH, 60 deg C, 30 min; Yield given. Multistep reaction;
1,4,5-trihydroxy-9,10-anthracenedione
2961-04-8

1,4,5-trihydroxy-9,10-anthracenedione

1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

Conditions
ConditionsYield
With manganese(IV) oxide; sulfuric acid
1,4,5,8,10-pentahydroxy-anthrone

1,4,5,8,10-pentahydroxy-anthrone

1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

Conditions
ConditionsYield
With nitrobenzene
1,4,5,8,10-pentahydroxy-anthrone

1,4,5,8,10-pentahydroxy-anthrone

nitrobenzene
98-95-3

nitrobenzene

1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

1,4,5,8-tetraaminoanthraquinone
2475-45-8

1,4,5,8-tetraaminoanthraquinone

1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

Conditions
ConditionsYield
With cis-nitrous acid
leuco-1,4,5,8-tetrahydroxyanthraquinone
69837-14-5

leuco-1,4,5,8-tetrahydroxyanthraquinone

1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

Conditions
ConditionsYield
In nitrobenzene Heating;
leuco-4,8-diamino-1,5-dihydroxyanthraquinone

leuco-4,8-diamino-1,5-dihydroxyanthraquinone

A

1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

B

1-amino-4,5,8-trihydroxyanthraquinone
6374-78-3

1-amino-4,5,8-trihydroxyanthraquinone

Conditions
ConditionsYield
With sodium hydroxide at 85 - 90℃; for 2h; Product distribution;
4.8-dinitro-anthrarufin

4.8-dinitro-anthrarufin

1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

Conditions
ConditionsYield
With sulfuric acid; boric acid
5.8-dichloro-quinizarine

5.8-dichloro-quinizarine

1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

Conditions
ConditionsYield
With calcium hydroxide; water; copper at 250℃;
diazotized 1-amino-4,5,8-trihydroxy-anthraquinone

diazotized 1-amino-4,5,8-trihydroxy-anthraquinone

1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

toluidine Blue

toluidine Blue

1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

Conditions
ConditionsYield
With water; nitric acid
1,8-dihydroxy-9,10-anthracenedione
117-10-2

1,8-dihydroxy-9,10-anthracenedione

dithranol-brown

dithranol-brown

A

1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

B

lead tetraacetate (calculated amount)

lead tetraacetate (calculated amount)

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 76 percent / boric acid, nitric acid, oleum / 25 °C
2: 100 percent / sulfuric acid, iron / 0.5 h / 90 °C
3: 1.) 10percent aq. NaOH, 2.) sodium hydrosulfite / 1.) n-BuOH, 15 min, 2.) n-BuOH, 60 deg C, 30 min
View Scheme
...Expand
1,8-dihydroxy-4,5-dinitro-anthraquinone
81-55-0

1,8-dihydroxy-4,5-dinitro-anthraquinone

A

1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

B

lead tetraacetate (calculated amount)

lead tetraacetate (calculated amount)

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 100 percent / sulfuric acid, iron / 0.5 h / 90 °C
2: 1.) 10percent aq. NaOH, 2.) sodium hydrosulfite / 1.) n-BuOH, 15 min, 2.) n-BuOH, 60 deg C, 30 min
View Scheme
1-amino-4,5,8-trihydroxyanthraquinone
6374-78-3

1-amino-4,5,8-trihydroxyanthraquinone

1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 88 percent / sodium dithionite / H2O / 0.67 h / 100 °C
2: nitrobenzene / Heating
View Scheme
4,8-diamino-1,5-dihydroxyanthraquinone-2,6-disulfonate de sodium

4,8-diamino-1,5-dihydroxyanthraquinone-2,6-disulfonate de sodium

1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 12.7 percent / NaOH, NaS2O8 / 0.67 h / 90 - 100 °C / NaOH conc.
2: 2.1 percent / sodium dithionite / H2O / 0.67 h / 100 °C
View Scheme
Multi-step reaction with 3 steps
1: 12.7 percent / NaOH, NaS2O8 / 0.67 h / 90 - 100 °C / NaOH conc.
2: 88 percent / sodium dithionite / H2O / 0.67 h / 100 °C
3: nitrobenzene / Heating
View Scheme
Multi-step reaction with 2 steps
1: 8.47 percent / NaOH, NaS2O8 / 0.67 h / 90 - 100 °C / NaOH conc.
2: nitrobenzene / Heating
View Scheme
Multi-step reaction with 2 steps
1: 87 percent / sodium dithionite, sodium hydroxyde / H2O / 0.67 h / 90 °C
2: nitrobenzene / Heating
View Scheme
1,5-diamino-4,8-dinitro-anthraquinone
10262-79-0

1,5-diamino-4,8-dinitro-anthraquinone

1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium sulfide
2: nitrous acid
View Scheme
1,8-diamino-4,5-dinitro-anthraquinone
852177-97-0

1,8-diamino-4,5-dinitro-anthraquinone

1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: zinc dust; diluted sulfuric acid
2: nitrous acid
View Scheme
1,8-diazido-anthraquinone
42013-63-8

1,8-diazido-anthraquinone

1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sulfuric acid / 50 °C
2: hydrochloric acid / 180 °C
View Scheme
1,5-diazido-anthraquinone
85192-94-5

1,5-diazido-anthraquinone

1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sulfuric acid
2: hydrochloric acid / 180 °C
View Scheme
1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

aniline
62-53-3

aniline

1,4,5,8-tetraphenylaminoanthraquinone
66181-84-8

1,4,5,8-tetraphenylaminoanthraquinone

Conditions
ConditionsYield
With C24H24Br2ClN3Rh; 1,8-diazabicyclo[5.4.0]undec-7-ene at 120℃; for 10h;93%
1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

1-amino-2-propene
107-11-9

1-amino-2-propene

1,4-bis(2,3-propyleneamino)-5,8-dihydroxy-9,10-anthracenedione
100495-33-8

1,4-bis(2,3-propyleneamino)-5,8-dihydroxy-9,10-anthracenedione

Conditions
ConditionsYield
In ethanol 1.) 60 deg C, 4 h, 2.) 25 deg C, 15 h;90%
((NH2)2(CS)2)2NiCl2*2H2O

((NH2)2(CS)2)2NiCl2*2H2O

1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

(NH2)2(CS)2(C6H2)2(CO)2(OH)3ONiCl(H2O)
135649-20-6

(NH2)2(CS)2(C6H2)2(CO)2(OH)3ONiCl(H2O)

Conditions
ConditionsYield
In ethanol byproducts: HCl, (H2NCS)2; refluxed 3-5 h; concd., filtered, washed (ethanol), dried in vac. over P2O5; elem. anal.;83%
1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

1-dodecylbromide
143-15-7

1-dodecylbromide

1,4,5,8-tetrakis(dodecyloxy)anthraquinone
146519-48-4

1,4,5,8-tetrakis(dodecyloxy)anthraquinone

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 100℃; for 15h;81%
1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

dimethyl sulfate
77-78-1

dimethyl sulfate

1,4,5,8-Tetramethoxy-9,10-anthrachinon
63229-37-8

1,4,5,8-Tetramethoxy-9,10-anthrachinon

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran for 408h; Ambient temperature;76%
With potassium carbonate In acetone
((NH2)2(CS)2)2CoCl2*H2O

((NH2)2(CS)2)2CoCl2*H2O

1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

(NH2)2(CS)2(C6H2)2(CO)2(OH)3OCoCl(H2O)
135649-22-8

(NH2)2(CS)2(C6H2)2(CO)2(OH)3OCoCl(H2O)

Conditions
ConditionsYield
In ethanol byproducts: HCl, (NH2CS)2; refluxed 3-5 h; concd., filtered, washed (ethanol), dried in vac. over P2O5; elem. anal.;76%
((NH2)2(CS)2)2CdCl2
77339-03-8

((NH2)2(CS)2)2CdCl2

1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

(NH2)2(CS)2(C6H2)2(CO)2(OH)3OCd(1+)*Cl(1-) = (NH2)2(CS)2(C6H2)2(CO)2(OH)3OCdCl

(NH2)2(CS)2(C6H2)2(CO)2(OH)3OCd(1+)*Cl(1-) = (NH2)2(CS)2(C6H2)2(CO)2(OH)3OCdCl

Conditions
ConditionsYield
In ethanol byproducts: HCl; refluxed 3-5 h; concd., filtered, washed (ethanol), dried in vac. over P2O5; elem. anal.;73%
(NH2)2(CS)2CuCl2*2H2O

(NH2)2(CS)2CuCl2*2H2O

1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

(NH2)2(CS)2(C6H2)2(CO)2(OH)3OCuCl(H2O)
135649-16-0

(NH2)2(CS)2(C6H2)2(CO)2(OH)3OCuCl(H2O)

Conditions
ConditionsYield
In ethanol byproducts: HCl; refluxed 3-5 h, concd.; filtered, washed (ethanol), dried in vac. over P2O5; elem. anal.;73%
1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

N,N-dimethylethylenediamine
108-00-9

N,N-dimethylethylenediamine

1,4-bis{[2-(dimethylamino)ethyl]amino}-5,8-dihydroxyanthracene-9,10-dione
70476-63-0

1,4-bis{[2-(dimethylamino)ethyl]amino}-5,8-dihydroxyanthracene-9,10-dione

Conditions
ConditionsYield
In ethanol; water for 25h; Reflux; Inert atmosphere;40%
[1-(2-aminoethyl)-3-piperidin-2-yl]methanol
857637-03-7

[1-(2-aminoethyl)-3-piperidin-2-yl]methanol

1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

1,4-bis-{[2-(3-hydroxymethylpiperidine-1-yl)ethyl]amino}-5,8-dihydroxyanthracene-9,10-dione
919487-89-1

1,4-bis-{[2-(3-hydroxymethylpiperidine-1-yl)ethyl]amino}-5,8-dihydroxyanthracene-9,10-dione

Conditions
ConditionsYield
In ethanol at 20℃; for 23h; Heating / reflux;21%
1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

5,6,7,8,8a,9,10,10a-octahydro-anthracene-1,4-diol

5,6,7,8,8a,9,10,10a-octahydro-anthracene-1,4-diol

Conditions
ConditionsYield
With palladium on activated charcoal; acetic acid Hydrogenation;
1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

2-butyl-1,4,5,8-tetrahydroxy-anthraquinone
75313-28-9

2-butyl-1,4,5,8-tetrahydroxy-anthraquinone

Conditions
ConditionsYield
With morpholine; sodium dithionite anschliessend mit Butyraldehyd und Oxidation mit Luft;
1,4,5,8-tetrahydroxy-anthraquinone
81-60-7

1,4,5,8-tetrahydroxy-anthraquinone

leuco-1,4,5,8-tetrahydroxyanthraquinone
69837-14-5

leuco-1,4,5,8-tetrahydroxyanthraquinone

Conditions
ConditionsYield
With sodium dithionite

1,4,5,8-Tetrahydroxyanthraquinone Chemical Properties

Chemical Name: 1,4,5,8-Tetrahydroxyanthraquinone
IUPAC NAME: 1,4,5,8-Tetrahydroxyanthracene-9,10-dione
CAS No.: 81-60-7
EINECS: 201-365-0
Molecular Formula: C14H8O6
Molecular Weight: 272.21 g/mol
Density: 1.781 g/cm3
Flash Point: 303.4 °C
Boiling Point: 554.8 °C at 760 mmHg
Following is the structure of 1,4,5,8-Tetrahydroxyanthraquinone (CAS No.81-60-7):


Product Categories about 1,4,5,8-Tetrahydroxyanthraquinone (CAS No.81-60-7) are Intermediates of Dyes and Pigments
The chemical synonymous of 1,4,5,8-Tetrahydroxyanthraquinone (CAS No.81-60-7) are 1,4,5,8-Tetrahydroxyanthracene-9,10-Dione ; 1,4,5,8-Tetrahydroxyanthraquinone ; Rarechem Aq Bd An29 ; 1,4,5,8-Leucotetraoxyanthraquinone ; 1,4,5,8-Ltoa ; 1,4,5,8-Tetrahydroxy-10-Anthracenedione ; 1,4,5,8-Tetrahydroxy-9,10-Anthacendione ; 1,4,5,8-Tetrahydroxyanthrachinon

1,4,5,8-Tetrahydroxyanthraquinone Toxicity Data With Reference

1.    

skn-rbt 500 mg/24H MLD

     28ZPAK    Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,104.
2.    

eye-rbt 500 mg/24H MLD

     28ZPAK    Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V.,Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha,Czechoslovakia.: 1972,104.
3.    

ipr-rat LD50:2200 mg/kg

     GTPZAB    Gigiena Truda i Professionalnye Zabolevaniia. Labor Hygiene and Occupational Diseases. 21 (12)(1977),27.

1,4,5,8-Tetrahydroxyanthraquinone Safety Profile

Moderately toxic by intraperitoneal route. A skin and eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.

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