Product Name

  • Name

    1-Benzofuran-5-carbaldehyde

  • EINECS
  • CAS No. 10035-16-2
  • Article Data21
  • CAS DataBase
  • Density 1.238 g/cm3
  • Solubility
  • Melting Point 50.5°C
  • Formula C9H6O2
  • Boiling Point 251.5 °C at 760 mmHg
  • Molecular Weight 146.145
  • Flash Point 110.2 °C
  • Transport Information
  • Appearance Colorless to light yellow liquid
  • Safety 26-36/37/39
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 10035-16-2 (1-Benzofuran-5-carbaldehyde)
  • Hazard Symbols IrritantXi
  • Synonyms 5-Formylbenzofuran;Benzo[b]furan-5-carboxaldehyde;Benzofuran-5-carbaldehyde;5-Benzofurancarboxaldehyde;
  • PSA 30.21000
  • LogP 2.24530

Synthetic route

2,3-dihydro-benzofuran-5-carbaldehyde
55745-70-5

2,3-dihydro-benzofuran-5-carbaldehyde

benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

Conditions
ConditionsYield
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In chlorobenzene at 80℃; for 1h;83%
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In chlorobenzene at 20 - 80℃; for 1h; Inert atmosphere;75%
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In chlorobenzene at 80℃; for 1h;60%
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) In chlorobenzene at 80℃; for 4h; Cooling with ice;55%
benzo[b]furan-5-carbonitrile
79002-39-4

benzo[b]furan-5-carbonitrile

benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

Conditions
ConditionsYield
Stage #1: benzo[b]furan-5-carbonitrile With diisobutylaluminium hydride In n-heptane; dichloromethane at -20 - -15℃; for 0.166667h;
Stage #2: With hydrogenchloride; water In n-heptane; dichloromethane
78%
Stage #1: benzo[b]furan-5-carbonitrile With diisobutylaluminium hydride In n-heptane; dichloromethane at -20 - -15℃; for 0.166667h;
Stage #2: With hydrogenchloride; water In n-heptane; dichloromethane at 20℃;
78%
With diisobutylaluminium hydride In dichloromethane at -15℃; for 0.166667h;
5-bromobenzofuran
23145-07-5

5-bromobenzofuran

N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

Conditions
ConditionsYield
Stage #1: 5-bromobenzofuran With tert.-butyl lithium In diethyl ether; pentane at -78℃; for 2h;
Stage #2: N,N-dimethyl-formamide In diethyl ether; pentane for 1h;
75%
With tert.-butyl lithium In diethyl ether; pentane at -78 - 8℃; for 0.833333h;70%
Stage #1: 5-bromobenzofuran With tert.-butyl lithium In diethyl ether; pentane at -78℃; for 0.333333h;
Stage #2: N,N-dimethyl-formamide In diethyl ether; pentane at -78 - 20℃; for 0.5h; Product distribution / selectivity;
70%
N,N-dimethyl-formamide
68-12-2, 33513-42-7

N,N-dimethyl-formamide

benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

Conditions
ConditionsYield
Stage #1: 5-bromobenzofuran With tert.-butyl lithium In diethyl ether at -78℃; for 0.333333h;
Stage #2: N,N-dimethyl-formamide In diethyl ether at -25 - 20℃; for 3h;
67%
Stage #1: 5-bromobenzofuran With tert.-butyl lithium In diethyl ether at -78℃; for 0.333333h;
Stage #2: N,N-dimethyl-formamide In diethyl ether at -25 - 20℃;
67%
3-ethynyl-4-methoxybenzaldehyde
160625-49-0

3-ethynyl-4-methoxybenzaldehyde

benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

Conditions
ConditionsYield
With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium chloride at 130℃; for 1.5h;58%
3-(prop-1-enyl)-4-(prop-1-enyloxy)benzaldehyde
863659-50-1

3-(prop-1-enyl)-4-(prop-1-enyloxy)benzaldehyde

benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

Conditions
ConditionsYield
With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride In toluene at 90℃; for 3h;50%
4-hydroxy-3-(2-propen-1-yl)benzaldehyde
41052-88-4

4-hydroxy-3-(2-propen-1-yl)benzaldehyde

benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 89 percent / K2CO3 / acetone / 2 h / 60 °C
2: 82 percent / [RuClH(CO)(PPh3)3] / CH2Cl2 / 14 h / 65 °C
3: 50 percent / ((Mes)2C3H5N2)Cl2Ru=CHPh / toluene / 3 h / 90 °C
View Scheme
4-(2-propenyloxy)benzaldehyde
40663-68-1

4-(2-propenyloxy)benzaldehyde

benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 41 percent / 0.17 h / 250 °C / microwave irradiation
2: 89 percent / K2CO3 / acetone / 2 h / 60 °C
3: 82 percent / [RuClH(CO)(PPh3)3] / CH2Cl2 / 14 h / 65 °C
4: 50 percent / ((Mes)2C3H5N2)Cl2Ru=CHPh / toluene / 3 h / 90 °C
View Scheme
3-allyl-4-allyloxybenzaldehyde
136433-45-9

3-allyl-4-allyloxybenzaldehyde

benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 82 percent / [RuClH(CO)(PPh3)3] / CH2Cl2 / 14 h / 65 °C
2: 50 percent / ((Mes)2C3H5N2)Cl2Ru=CHPh / toluene / 3 h / 90 °C
View Scheme
4-hydroxy-benzaldehyde
123-08-0

4-hydroxy-benzaldehyde

n-nonyl halide

n-nonyl halide

benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: K2CO3 / acetone
2: 41 percent / 0.17 h / 250 °C / microwave irradiation
3: 89 percent / K2CO3 / acetone / 2 h / 60 °C
4: 82 percent / [RuClH(CO)(PPh3)3] / CH2Cl2 / 14 h / 65 °C
5: 50 percent / ((Mes)2C3H5N2)Cl2Ru=CHPh / toluene / 3 h / 90 °C
View Scheme
4-bromo-phenol
106-41-2

4-bromo-phenol

isobutyl halide

isobutyl halide

benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) NaH / 1.) DMF, 0 deg C, 2.) DMF
2: polyphosphoric acid / benzene / Heating
3: 1.) t-BuLi / 1.) Et2O, -78 deg C, 2.) Et2O
View Scheme
1-bromo-4-(2,2-diethoxyethoxy)benzene
112598-18-2

1-bromo-4-(2,2-diethoxyethoxy)benzene

benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: polyphosphoric acid / benzene / Heating
2: 1.) t-BuLi / 1.) Et2O, -78 deg C, 2.) Et2O
View Scheme
isovanillin
621-59-0

isovanillin

benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 85 percent / ethyldiisopropylamine / CH2Cl2 / 0.67 h / -78 - 20 °C
2: 88 percent / Pd(PPh3)2Cl2, Et3N / dimethylformamide / 1.5 h / 90 °C
3: 68 percent / K2CO3 / methanol / 8.5 h / Ambient temperature
4: 58 percent / LiCl, HMPA / 1.5 h / 130 °C
View Scheme
4-methoxy-3-[2-(trimethylsilyl)ethynyl]benzaldehyde
160625-48-9

4-methoxy-3-[2-(trimethylsilyl)ethynyl]benzaldehyde

benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 68 percent / K2CO3 / methanol / 8.5 h / Ambient temperature
2: 58 percent / LiCl, HMPA / 1.5 h / 130 °C
View Scheme
4-methoxy-3-trifluoromethanesulfonyloxybenzaldehyde
157790-73-3

4-methoxy-3-trifluoromethanesulfonyloxybenzaldehyde

benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 88 percent / Pd(PPh3)2Cl2, Et3N / dimethylformamide / 1.5 h / 90 °C
2: 68 percent / K2CO3 / methanol / 8.5 h / Ambient temperature
3: 58 percent / LiCl, HMPA / 1.5 h / 130 °C
View Scheme
5-bromobenzofuran
23145-07-5

5-bromobenzofuran

benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

Conditions
ConditionsYield
With hydrogenchloride; iodine; magnesium In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide
5-bromobenzofuran
23145-07-5

5-bromobenzofuran

4-bromo-phenol
106-41-2

4-bromo-phenol

Bromoacetaldehyde diethyl acetal
2032-35-1

Bromoacetaldehyde diethyl acetal

benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

5-hydroxymethylbenzo[b]furan
31823-05-9

5-hydroxymethylbenzo[b]furan

Conditions
ConditionsYield
Stage #1: benzofuran-5-carbaldehyde With sodium tetrahydroborate In methanol Cooling with ice;
Stage #2: With ammonium chloride In methanol Saturated solution;
100%
With sodium tetrahydroborate In methanol at 0℃; for 0.166667h;96%
With 2,2'-bi(1,3,6,2-dioxazaborocane); water at 20℃; for 18h; Inert atmosphere; Sealed tube;86%
benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

benzofuran-5-yl-(3-ethoxy-4-methoxy-phenyl)-methanol
878495-90-0

benzofuran-5-yl-(3-ethoxy-4-methoxy-phenyl)-methanol

Conditions
ConditionsYield
Stage #1: 1-Bromo-3-ethoxy-4-methoxybenzene With n-butyllithium In tetrahydrofuran at -78℃; for 0.333333h;
Stage #2: benzofuran-5-carbaldehyde In tetrahydrofuran at -78℃; for 1h;
Stage #3: With water In isopropyl alcohol
100%
benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

ethyl 2-(bis(2-isopropylphenoxy)phosphoryl)acetate
188945-44-0

ethyl 2-(bis(2-isopropylphenoxy)phosphoryl)acetate

(Z)-ethyl 3-(benzofuran-5-yl)acrylate
1499179-57-5

(Z)-ethyl 3-(benzofuran-5-yl)acrylate

Conditions
ConditionsYield
Stage #1: ethyl 2-[bis(2-isopropylphenoxy)phosphoryl]acetate With N-benzyl-trimethylammonium hydroxide In tetrahydrofuran; methanol at -78℃; Horner-Wadsworth-Emmons Olefination; Inert atmosphere;
Stage #2: benzofuran-5-carbaldehyde In tetrahydrofuran; methanol at -78℃; Horner-Wadsworth-Emmons Olefination; Inert atmosphere; diastereoselective reaction;
96%
benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

ethyl (triphenylphosphoranylidene)acetate
1099-45-2

ethyl (triphenylphosphoranylidene)acetate

C13H12O3

C13H12O3

Conditions
ConditionsYield
In dichloromethane at 40℃; for 20h;96%
benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

benzo[b]furan-5-carbonitrile
79002-39-4

benzo[b]furan-5-carbonitrile

Conditions
ConditionsYield
With ammonium sulfate; sodium carbonate; sulfur In dimethyl sulfoxide at 120℃; for 10h; Sealed tube;96%
benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

4-{4-(methylamino)thieno[3,2-d]pyrimidin-2-yl}benzohydrazide

4-{4-(methylamino)thieno[3,2-d]pyrimidin-2-yl}benzohydrazide

N'-[(benzofuran-5-yl)methylene]-4-{4-(methylamino)thieno[3,2-d]pyrimidin-2-yl}benzohydrazide

N'-[(benzofuran-5-yl)methylene]-4-{4-(methylamino)thieno[3,2-d]pyrimidin-2-yl}benzohydrazide

Conditions
ConditionsYield
With toluene-4-sulfonic acid In ethanol at 120℃; for 1h; Inert atmosphere;93%
benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

methylamine
74-89-5

methylamine

benzofuran-5-yl-N-methylmethanamine
389845-58-3

benzofuran-5-yl-N-methylmethanamine

Conditions
ConditionsYield
Stage #1: benzofuran-5-carbaldehyde; methylamine In methanol; ethanol for 3h;
Stage #2: With sodium tetrahydroborate In methanol at 20℃;
Stage #3: With water In methanol
91%
Stage #1: benzofuran-5-carbaldehyde; methylamine In methanol; water at 0℃; for 0.916667h;
Stage #2: With sodium tetrahydroborate In methanol; water for 0.75h;
benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

benzofuran-5-carbaldehyde oxime
1018038-52-2

benzofuran-5-carbaldehyde oxime

Conditions
ConditionsYield
With hydroxylamine hydrochloride; triethylamine In dichloromethane at 20℃; for 3h;91%
With hydroxylamine hydrochloride; triethylamine In dichloromethane at 20℃; for 12h;
With hydroxylamine hydrochloride; triethylamine In dichloromethane at 20℃; for 3h;4.6 g
With hydroxylamine hydrochloride; triethylamine In dichloromethane at 20℃; for 16h;
BARBITURIC ACID
67-52-7

BARBITURIC ACID

benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

5-(1-benzofuran-5-ylmethylidene)pyrimidine-2,4,6(1H,3H,5H)-trione

5-(1-benzofuran-5-ylmethylidene)pyrimidine-2,4,6(1H,3H,5H)-trione

Conditions
ConditionsYield
In 2-methyl-propan-1-ol for 0.75h; Reflux; Green chemistry;91%
In 2-methyl-propan-1-ol for 0.75h; Reflux;91%
benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

2,3-dibromo-2,3-dihydro-benzofuran-5-carbaldehyde

2,3-dibromo-2,3-dihydro-benzofuran-5-carbaldehyde

Conditions
ConditionsYield
With bromine In chloroform at 20℃; for 1h;90%
benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

(1,3-benzothiazol-2-ylsulfonyl)fluoromethyl n-propyl ketone
1149578-23-3

(1,3-benzothiazol-2-ylsulfonyl)fluoromethyl n-propyl ketone

(Z)-2-fluoro-1-(1-benzofuran-5-yl)-1-hexen-3-one
1184134-88-0

(Z)-2-fluoro-1-(1-benzofuran-5-yl)-1-hexen-3-one

Conditions
ConditionsYield
With 1,8-diazabicyclo[5.4.0]undec-7-ene In tetrahydrofuran; dichloromethane at 0 - 5℃; for 8h; Julia Olefin synthesis; stereoselective reaction;90%
benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

dimethyl 1-(1-diazo-2-oxopropyl)phosphonate
90965-06-3

dimethyl 1-(1-diazo-2-oxopropyl)phosphonate

5-ethynylbenzo[b]furane
1158745-04-0

5-ethynylbenzo[b]furane

Conditions
ConditionsYield
With potassium carbonate In methanol at 20℃; for 12h;90%
benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

Methyltriphenylphosphonium bromide
1779-49-3

Methyltriphenylphosphonium bromide

5-vinyl-1-benzofuran

5-vinyl-1-benzofuran

Conditions
ConditionsYield
Stage #1: Methyltriphenylphosphonium bromide With potassium tert-butylate In tetrahydrofuran at 20℃; for 0.5h; Wittig Olefination; Inert atmosphere;
Stage #2: benzofuran-5-carbaldehyde In tetrahydrofuran at 20℃; for 3h; Wittig Olefination; Inert atmosphere;
86%
benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

5-(difluoromethyl)-7-(3-piperidyl)-[1,2,4]triazolo[1,5-a]pyrimidine hydrochloride

5-(difluoromethyl)-7-(3-piperidyl)-[1,2,4]triazolo[1,5-a]pyrimidine hydrochloride

7-[1-(benzofuran-5-ylmethyl)-3-piperidyl]-5-(difluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidine hydrochloride

7-[1-(benzofuran-5-ylmethyl)-3-piperidyl]-5-(difluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidine hydrochloride

Conditions
ConditionsYield
Stage #1: benzofuran-5-carbaldehyde; 5-(difluoromethyl)-7-(3-piperidyl)-[1,2,4]triazolo[1,5-a]pyrimidine hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 1h; Inert atmosphere;
Stage #2: With sodium tris(acetoxy)borohydride In dichloromethane at 20℃; for 2h; Inert atmosphere;
Stage #3: With hydrogenchloride In diphenylether Inert atmosphere;
86%
benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

4-(trifluoromethyl)phenylmagnesium bromide
402-51-7

4-(trifluoromethyl)phenylmagnesium bromide

benzofuran-5-yl(4-(trifluoromethyl)phenyl)methanol

benzofuran-5-yl(4-(trifluoromethyl)phenyl)methanol

Conditions
ConditionsYield
In tetrahydrofuran at 0℃; for 1h; Inert atmosphere; Schlenk technique;85%
tryptamine
61-54-1

tryptamine

benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

1-benzofuran-5-yl-2,3,4,9-tetrahydro-1H-β-carboline
199678-72-3

1-benzofuran-5-yl-2,3,4,9-tetrahydro-1H-β-carboline

Conditions
ConditionsYield
With trifluoroacetic acid In dichloromethane for 48h;83%
benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

2′-hydroxy-6′-methoxymethoxyacetophenone
78646-28-3

2′-hydroxy-6′-methoxymethoxyacetophenone

(E)-3-Benzofuran-5-yl-1-(2-hydroxy-6-methoxymethoxy-phenyl)-propenone

(E)-3-Benzofuran-5-yl-1-(2-hydroxy-6-methoxymethoxy-phenyl)-propenone

Conditions
ConditionsYield
With potassium hydroxide In ethanol at 20℃;82%
benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

buta-1,3-diene
106-99-0

buta-1,3-diene

phenylboronic acid
98-80-6

phenylboronic acid

(E)-1-(benzofuran-5-yl)-5-phenylpent-3-en-1-ol

(E)-1-(benzofuran-5-yl)-5-phenylpent-3-en-1-ol

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)nickel (0) In tetrahydrofuran; toluene at 20℃; for 6h; Sealed tube; Inert atmosphere; diastereoselective reaction;82%
2-thioxo-4-thiazolidinone
141-84-4

2-thioxo-4-thiazolidinone

benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

(Z)-5-[(benzofuran-5-yl)methylene]-2-thioxothiazolidin-4-one

(Z)-5-[(benzofuran-5-yl)methylene]-2-thioxothiazolidin-4-one

Conditions
ConditionsYield
With ammonium acetate; acetic acid In acetonitrile for 2h; Inert atmosphere; Reflux;81.2%
benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

(2S,4R,5R)-5-amino-2-(bis(4-fluorophenyl)methyl)tetrahydro-2H-pyran-4-ol

(2S,4R,5R)-5-amino-2-(bis(4-fluorophenyl)methyl)tetrahydro-2H-pyran-4-ol

(2S,4R,5R)-5-((benzofuran-5-ylmethyl)amino)-2-(bis(4-fluorophenyl) methyl)tetrahydro-2H-pyran-4-ol

(2S,4R,5R)-5-((benzofuran-5-ylmethyl)amino)-2-(bis(4-fluorophenyl) methyl)tetrahydro-2H-pyran-4-ol

Conditions
ConditionsYield
With sodium cyanoborohydride; acetic acid In methanol; 1,2-dichloro-ethane81%
Stage #1: benzofuran-5-carbaldehyde; (2S,4R,5R)-5-amino-2-(bis(4-fluorophenyl)methyl)tetrahydro-2H-pyran-4-ol With acetic acid In 1,2-dichloro-ethane for 0.5h; Inert atmosphere;
Stage #2: With sodium cyanoborohydride In MeOH; 1,2-dichloro-ethane Inert atmosphere;
81%
benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

1-(7-methoxy-2-(2,4,6-trimethoxyphenyl)benzofuran-5-yl)ethanone

1-(7-methoxy-2-(2,4,6-trimethoxyphenyl)benzofuran-5-yl)ethanone

(E)-3-(benzofuran-5-yl)-1-(7-methoxy-2-(2,4,6-trimethoxyphenyl)benzofuran-5-yl)prop-2-en-1-one

(E)-3-(benzofuran-5-yl)-1-(7-methoxy-2-(2,4,6-trimethoxyphenyl)benzofuran-5-yl)prop-2-en-1-one

Conditions
ConditionsYield
With potassium hydroxide In methanol; water at 20℃; for 24h; Claisen-Schmidt Condensation;79%
benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

(5-methylpyrazine-2-yl)methylamine
132664-85-8

(5-methylpyrazine-2-yl)methylamine

C15H15N3O
1160051-86-4

C15H15N3O

Conditions
ConditionsYield
Stage #1: benzofuran-5-carbaldehyde; (5-methylpyrazine-2-yl)methylamine With sodium acetate; acetic acid In methanol at 20℃; for 0.5h;
Stage #2: With sodium tetrahydroborate In methanol for 0.5h;
Stage #3: With water; sodium hydrogencarbonate In methanol
75%
benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

(8-morpholin-4-yl-2-pyridin-4-yl-imidazo[1,2-b]pyridazin-6-yl)-hydrazine
1313014-23-1

(8-morpholin-4-yl-2-pyridin-4-yl-imidazo[1,2-b]pyridazin-6-yl)-hydrazine

N-benzofuran-5-ylmethylene-N'-(8-morpholin-4-yl-2-pyridin-4-yl-imidazo[1,2-b]pyridazin-6-yl)-hydrazine
1313014-05-9

N-benzofuran-5-ylmethylene-N'-(8-morpholin-4-yl-2-pyridin-4-yl-imidazo[1,2-b]pyridazin-6-yl)-hydrazine

Conditions
ConditionsYield
In ethanol at 20℃;71%
benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

(2RS,3SR)-2,3-dibromo-2,3-dihydrobenzofuran-5-carbaldehyde

(2RS,3SR)-2,3-dibromo-2,3-dihydrobenzofuran-5-carbaldehyde

Conditions
ConditionsYield
With bromine; acetic acid at 100℃; for 0.5h;70%
With bromine In chloroform at 20℃; Cooling;50%
(2S,4R,5R)-5-amino-2-benzhydryltetrahydro-2H-pyran-4-ol
869114-22-7

(2S,4R,5R)-5-amino-2-benzhydryltetrahydro-2H-pyran-4-ol

benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

(2S,4R,5R)-2-benzhydryl-5-((benzofuran-5-ylmethyl)amino)tetrahydro-2H-pyran-4-ol

(2S,4R,5R)-2-benzhydryl-5-((benzofuran-5-ylmethyl)amino)tetrahydro-2H-pyran-4-ol

Conditions
ConditionsYield
Stage #1: (2S,4R,5R)-5-amino-2-benzhydryl-tetrahydropyran-4-ol; benzofuran-5-carbaldehyde With acetic acid In 1,2-dichloro-ethane for 0.5h; Inert atmosphere;
Stage #2: With sodium cyanoborohydride In MeOH; 1,2-dichloro-ethane Inert atmosphere;
69%
cis-(3S,6S)-(6-benzhydryl-tetrahydropyran-3-yl)-amine
869114-39-6

cis-(3S,6S)-(6-benzhydryl-tetrahydropyran-3-yl)-amine

benzofuran-5-carbaldehyde
10035-16-2

benzofuran-5-carbaldehyde

(3S,6S)-6-benzhydryl-N-(benzofuran-5-ylmethyl)tetrahydro-2H-pyran-3-amine

(3S,6S)-6-benzhydryl-N-(benzofuran-5-ylmethyl)tetrahydro-2H-pyran-3-amine

Conditions
ConditionsYield
Stage #1: cis-(3S,6S)-(6-benzhydryl-tetrahydropyran-3-yl)-amine; benzofuran-5-carbaldehyde With acetic acid In 1,2-dichloro-ethane for 0.5h;
Stage #2: With sodium cyanoborohydride In methanol; 1,2-dichloro-ethane
67%
Stage #1: cis-(3S,6S)-(6-benzhydryl-tetrahydropyran-3-yl)-amine; benzofuran-5-carbaldehyde With acetic acid In acetic acid; 1,2-dichloro-ethane for 0.5h; Inert atmosphere;
Stage #2: With sodium cyanoborohydride In MeOH; 1,2-dichloro-ethane Inert atmosphere;
67%

1-Benzofuran-5-carbaldehyde Specification

The 5-Benzofurancarboxaldehyde, with CAS registry number 10035-16-2, belongs to the following product categories: (1)Furan & Benzofuran; (2)API intermediates. It has the systematic name of 1-benzofuran-5-carbaldehyde. This chemical is a kind of colorless to light yellow liquid. And the chemical formula of this chemical is C9H6O2.

Physical properties of 5-Benzofurancarboxaldehyde: (1)ACD/LogP: 2.09; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.09; (4)ACD/LogD (pH 7.4): 2.09; (5)ACD/BCF (pH 5.5): 22.89; (6)ACD/BCF (pH 7.4): 22.89; (7)ACD/KOC (pH 5.5): 327.24; (8)ACD/KOC (pH 7.4): 327.24; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 30.21 Å2; (13)Index of Refraction: 1.651; (14)Molar Refractivity: 43.14 cm3; (15)Molar Volume: 118 cm3; (16)Polarizability: 17.1×10-24cm3; (17)Surface Tension: 47.7 dyne/cm; (18)Enthalpy of Vaporization: 48.89 kJ/mol; (19)Vapour Pressure: 0.0203 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
The 5-Benzofurancarboxaldehyde irritates to eyes, respiratory system and skin. When use it, wear suitable protective clothing, gloves and eye/face protection. If contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: O=Cc2cc1c(occ1)cc2
(2)InChI: InChI=1/C9H6O2/c10-6-7-1-2-9-8(5-7)3-4-11-9/h1-6H
(3)InChIKey: LLLBDLDNTMMZHL-UHFFFAOYAJ
(4)Std. InChI: InChI=1S/C9H6O2/c10-6-7-1-2-9-8(5-7)3-4-11-9/h1-6H
(5)Std. InChIKey: LLLBDLDNTMMZHL-UHFFFAOYSA-N

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