1-Chloroethyl Isopropyl Carbonate supplier

Name
1-Chloroethyl isopropyl carbonate
EINECS
CAS No. 98298-66-9
Article Data30
CAS DataBase
Density 1.114 g/cm^>3
Solubility
Melting Point
Formula C₆H₁₀ClO₃
Boiling Point 164.31 °C at 760 mmHg
Molecular Weight 166.605
Flash Point 55.181 °C
Transport Information
Appearance Colorless and transparent liquid
Safety 16-36/37/39
Risk Codes 10-34
Molecular Structure
Hazard Symbols
Synonyms 1-(Isopropyloxycarbonyloxy)ethylchloride;Isopropyl 1-chloroethyl carbonate;a-Chloroethyl isopropyl carbonate;
PSA 35.53000
LogP 2.13280

Synthetic route

: 50893-53-3
carbonochloridic acid 1-chloro-ethyl ester

: 67-63-0
isopropyl alcohol

: 98298-66-9
1-(isopropoxycarbonyloxy)ethyl chloride

Conditions

Conditions	Yield
With pyridine at -78 - 25℃;	99%
With pyridine at -78℃;	99%
With pyridine In dichloromethane at -78 - 20℃;	97%

: 50893-53-3
carbonochloridic acid 1-chloro-ethyl ester

: 98298-66-9
1-(isopropoxycarbonyloxy)ethyl chloride

: 75-44-5
phosgene

: 75-07-0
acetaldehyde

: 67-63-0
isopropyl alcohol

: 98298-66-9
1-(isopropoxycarbonyloxy)ethyl chloride

Conditions

Conditions	Yield
Stage #1: phosgene; acetaldehyde Stage #2: isopropyl alcohol With pyridine

...Expand

: 98298-66-9
1-(isopropoxycarbonyloxy)ethyl chloride

: 84089-73-6, 91508-00-8
1-iodoethyl isopropyl carbonate

Conditions

Conditions	Yield
With tetrabutylammomium bromide; sodium iodide; calcium chloride In ethyl acetate for 3h; Reflux;	95%
With sodium iodide In acetonitrile at 50℃; for 6h;	90%
With 18-crown-6 ether; sodium iodide In benzene for 12h; Heating;	85%

: 7-[5,6-difluoro-8-(methylamino)-4-[(3aS,6aS)-5-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-1-yl]-9H-pyrido[2,3-b]indol-3-yl]-4-oxoquinolizine-3-carboxylic acid

: 98298-66-9
1-(isopropoxycarbonyloxy)ethyl chloride

: 1-isopropoxycarbonyloxyethyl 7-[5,6-difluoro-8-(methylamino)-4-[(3aS,6aS)-5-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-1-yl]-9H-pyrido[2,3-b]indol-3-yl]-4-oxoquinolizine-3-carboxylate

Conditions

Conditions	Yield
Stage #1: 7-[5,6-difluoro-8-(methylamino)-4-[(3aS,6aS)-5-methyl-2,3,3a,4,6,6a-hexahydropyrrolo[2,3-c]pyrrol-1-yl]-9H-pyrido[2,3-b]indol-3-yl]-4-oxoquinolizine-3-carboxylic acid With potassium carbonate In dimethyl sulfoxide at 20℃; for 0.5h; Stage #2: 1-(isopropoxycarbonyloxy)ethyl chloride In dimethyl sulfoxide at 20℃; for 15.5h;	90.4%

: 1174039-19-0
(R)-7-[3-tertbutoxycarbonylamino-4-(2,4,5-tri-fluorophenyl)butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine-1-carboxylic acid

: 98298-66-9
1-(isopropoxycarbonyloxy)ethyl chloride

: (R)-7-[3-amino-4-(2,4,5-trifluorophenyl)butyryl]-3-trifluoromethyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-1-carboxylic acid isopropoxycarbonyloxy ethyl ester

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 65℃; for 2h; In a sealed tube;	85.3%

: 98298-66-9
1-(isopropoxycarbonyloxy)ethyl chloride

: 104483-30-9
1-bromoethyl isopropyl carbonate

Conditions

Conditions	Yield
With tetrabutylammomium bromide; hydrogen bromide	82%
With tetrabutylammomium bromide; hydrogen bromide at 85℃; for 6h; Yield given;

: 98298-66-9
1-(isopropoxycarbonyloxy)ethyl chloride

: 60846-23-3
cefotaxime sodium salt

: 1-(isopropoxycarbonyloxy)ethyl 7β-<2-(2-aminothiazol-4-yl)-(Z)-methoxyiminoacetamido>-3-acetoxymethyl-3-cephem-4-carboxylate

Conditions

Conditions	Yield
With tetra(n-butyl)ammonium hydrogensulfate In N,N-dimethyl-formamide at 40 - 45℃; for 18h;	82%

: 98298-66-9
1-(isopropoxycarbonyloxy)ethyl chloride

: Sodium; (6R,7R)-7-{2-(2-amino-thiazol-4-yl)-2-[(Z)-methoxyimino]-acetylamino}-8-oxo-3-vinyl-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate

: 1-(ispropyloxycarbonyloxy)ethyl 7β-<2-(2-aminothiazol-4-yl)-(Z)-methoxyiminoacetamido>-3-vinyl-3-cephem-4-carboxylate

Conditions

Conditions	Yield
With tetra(n-butyl)ammonium hydrogensulfate In N,N-dimethyl-formamide for 18h;	81%

: raltegravir potassium

: 98298-66-9
1-(isopropoxycarbonyloxy)ethyl chloride

: 1538603-91-6
1-((4-((4-fluorobenzyl)carbamoyl)-1-methyl-2-(2-(5-methyl-1,3,4-oxadiazole-2-carboxamido)propan-2-yl)-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)ethyl isopropyl carbonate

Conditions

Conditions	Yield
With 18-crown-6 ether; potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 60℃; for 4h;	74%

: potassium 2-butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]pyrimidin-4-(3H)-one

: 98298-66-9
1-(isopropoxycarbonyloxy)ethyl chloride

: 1-(5-(4'-((2-butyl-5-(2-(dimethylamino)-2-thioxoethyl)-4-methyl-6-oxopyrimidin-1(6H)-yl)methyl)-[1,1'-biphenyl]-2-yl)-2H-tetrazol-2-yl)ethyl isopropyl carbonate

Conditions

Conditions	Yield
With potassium iodide In N,N-dimethyl-formamide at 20℃;	67%

: C12H10ClFN2O2

: 98298-66-9
1-(isopropoxycarbonyloxy)ethyl chloride

: C18H20ClFN2O5

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 3h;	65.9%

: C12H10BrFN2O2

: 98298-66-9
1-(isopropoxycarbonyloxy)ethyl chloride

: C18H20BrFN2O5

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 3h;	63.9%

: 2-[2-methyl-1-[[4-methylsulfonyl-2-(trifluoromethyl)phenyl]methyl]pyrrolo[2,3-b]pyridine-3-yl]acetic acid

: 98298-66-9
1-(isopropoxycarbonyloxy)ethyl chloride

: C25H27F3N2O7S

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 40 - 45℃; for 6h;	62.3%

: C12H11BrN2O2

: 98298-66-9
1-(isopropoxycarbonyloxy)ethyl chloride

: C18H21BrN2O5

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 3h;	61.4%

: C12H10F2N2O2

: 98298-66-9
1-(isopropoxycarbonyloxy)ethyl chloride

: C18H20F2N2O5

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 3h;	61%

: C12H10BrClN2O2

: 98298-66-9
1-(isopropoxycarbonyloxy)ethyl chloride

: C18H20BrClN2O5

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 3h;	60.3%

: (2S)-3-[4-({[4-(aminocarbonyl)-1-piperidinyl]carbonyl}oxy)phenyl]-2-[((2S)-4-methyl-2-{[2-(2-methylphenoxy)acetyl]amino}pentanoyl)amino]propanoic acid

: 98298-66-9
1-(isopropoxycarbonyloxy)ethyl chloride

: 4-((2S)-3-(1-((isopropoxycarbonyl)oxy)ethoxy)-2-((S)-4-methyl-2-(2-(o-tolyloxy)acetamido)pentanamido)-3-oxopropyl)phenyl 4-carbamoylpiperidine-1-carboxylate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 60℃; for 26h;	60%

: C12H10Br2N2O2

: 98298-66-9
1-(isopropoxycarbonyloxy)ethyl chloride

: C18H20Br2N2O5*BrH

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 3h;	58.1%

: C12H10BrClN2O2

: 98298-66-9
1-(isopropoxycarbonyloxy)ethyl chloride

: C18H20BrClN2O5

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 3h;	57.2%

: C12H10BrFN2O2

: 98298-66-9
1-(isopropoxycarbonyloxy)ethyl chloride

: C18H20BrFN2O5

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 3h;	57.1%

: 872329-95-8
1-ethyl-6-oxo-3-phenyl-5-(pyridin-3-ylamino)-1,6-dihydropyridazine-4-carboxylic acid

: 98298-66-9
1-(isopropoxycarbonyloxy)ethyl chloride

: 1-[(isopropoxycarbonyl)oxy]ethyl 1-ethyl-6-oxo-3-phenyl-5-(pyridin-3-ylamino)-1,6-dihydropyridazine-4-carboxylate

Conditions

Conditions	Yield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 60℃; for 3h;	57%

: 98298-66-9
1-(isopropoxycarbonyloxy)ethyl chloride

: ammonium thiocyanate

A: 117972-02-8
isopropyl 1-thiocyanoethylcarbonate

B: 117972-10-8
isopropyl 1-isothiocyanoethylcarbonate

Conditions

Conditions	Yield
With tetrabutyl phosphonium bromide In acetone for 19h; Heating;	A 55% B 45%
With Bu3PBr4 In acetone for 19h; Heating;	A 55% B 45%

...Expand

: C12H10Cl2N2O2

: 98298-66-9
1-(isopropoxycarbonyloxy)ethyl chloride

: C18H20Cl2N2O5

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 3h;	54.9%

: R-1-(1-phenylethyl)-1H-2-fluoro-4-chloroimidazole-5-carboxylic acid

: 98298-66-9
1-(isopropoxycarbonyloxy)ethyl chloride

: C18H20ClFN2O5

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 3h;	54.7%

: O2-sodium 1-[N-(2-hydroxyethyl)-N-ethylamino]diazen-1-ium-1,2-diolate

: 98298-66-9
1-(isopropoxycarbonyloxy)ethyl chloride

: 1538566-36-7
(Z)-3-ethyl-1-hydroxy-7,11-dimethyl-9-oxo-6,8,10-trioxa-3,4,5-triazadodec-4-ene 4-oxide

Conditions

Conditions	Yield
In acetonitrile at 20℃;	53%

: methyl 3-[2-(4-carbamimidoylphenylcarbamoyl)-5-methoxy-4-vinylphenyl]-6-(cyclopropylmethylcarbamoyl)pyridine-2-carboxylate methanesulfonate

: 98298-66-9
1-(isopropoxycarbonyloxy)ethyl chloride

: methyl 6-((cyclopropylmethyl)carbamoyl)-3-(2-((4-(N-(isopropoxycarbonyl)carbamimidoyl)phenyl)carbamoyl)-5-methoxy-4-vinylphenyl)picolinate

Conditions

Conditions	Yield
With N,N'-dicyclohexyl-4-morpholine carboxamidine In N,N-dimethyl-formamide at 80℃; for 5h;	53%

: C12H11ClN2O2

: 98298-66-9
1-(isopropoxycarbonyloxy)ethyl chloride

: C18H21ClN2O5

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 3h;	52.8%

: 874566-95-7
3-{4-[({[4-(difluorophosphonomethyl)-3-chlorophenyl]methyl}[(2-methoxyphenyl)sulfonyl]amino)methyl]phenyl}benzenecarbonitrile

: 98298-66-9
1-(isopropoxycarbonyloxy)ethyl chloride

: [({2-chloro-4-[({[4-(3-cyanophenyl)phenyl]methyl}[(2-methoxyphenyl)sulfonyl]amino)methyl]phenyl}difluoromethyl)(hydroxyphosphoryl)oxy]ethyl(methylethoxy)formate sodium salt

Conditions

Conditions	Yield
Stage #1: 3-{4-[({[4-(difluorophosphonomethyl)-3-chlorophenyl]methyl}[(2-methoxyphenyl)sulfonyl]amino)methyl]phenyl}benzenecarbonitrile; 1-(isopropoxycarbonyloxy)ethyl chloride With caesium carbonate In acetonitrile for 18h; Heating / reflux; Stage #2: With sodium hydrogencarbonate In methanol at 20℃;	51%

: R-1-(1-phenylethyl)-1H-4-fluoroimidazole-5-carboxylic acid

: 98298-66-9
1-(isopropoxycarbonyloxy)ethyl chloride

: C18H21FN2O5

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 3h;	47.3%

: 1266342-72-6
(2R)-2-benzyloxy-3,3-dimethyl-4-(3-phenoxysulfonylpropylsulfonyloxy)butanoic acid

: 98298-66-9
1-(isopropoxycarbonyloxy)ethyl chloride

: 1266342-74-8
1-isopropoxycarbonyloxyethyl(2R)-2-benzyloxy-3,3-dimethyl-4-(3-phenoxysulfonylpropyl sulfonyloxy)butanoate

Conditions

Conditions	Yield
With silver carbonate In toluene at 40℃; for 18h;	47%

1-Chloroethyl Isopropyl Carbonate Chemical Properties

The MF of 1-Chloroethyl Isopropyl Carbonate(98298-66-9): C₆H₁₁ClO₃
The MW of 1-Chloroethyl Isopropyl Carbonate(98298-66-9): 166.6
bp: 70 °C at 15mmHg
Density: 1.113 g/cm³
Flash Point: 55.2 °C
Boiling Point: 164.3 °C at 760 mmHg
Index of Refraction: 1.423
Categories: CARBONATES;(intermediate of cefpodoxime proxetil)
Synonyms: 1-CHLOROETHYL ISOPROPYL CARBONATE;CARBONIC ACID 1-CHLOROETHYL ISOPROPYL ESTER;JCC-1;1-CHLOROETHYL ISOPROPYL CARBONATE (JCC-1)(INTERMEDIATE OF CEFPODOXIME PROXETIL (BANAN));1-chloroethyl isopropyl carbonate (intermediate of cefpodoxime proxetil);1-Chloroethyl Isopropyl Carbonate (JCC-1);1 CHLORO ETHYL ISPPROPYL CARBONATE (CEIC);Carbonic acid, 1-chloroethyl-, 1-methyl-, ethyl ester
The Structure of 1-Chloroethyl Isopropyl Carbonate(98298-66-9):

1-Chloroethyl Isopropyl Carbonate Safety Profile

Risk Statements: 10-34
10: Flammable
34: Causes burns
Safety Statements: 16-36/37/39
16: Keep away from sources of ignition - No smoking
36/37/39: Wear suitable protective clothing, gloves and eye/face protection

Product Name

1-Chloroethyl isopropyl carbonate

Synthetic route

1-Chloroethyl Isopropyl Carbonate Chemical Properties

1-Chloroethyl Isopropyl Carbonate Safety Profile

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