Product Name

  • Name

    1-Ethylpiperazine

  • EINECS 226-166-6
  • CAS No. 5308-25-8
  • Article Data37
  • CAS DataBase
  • Density 0.895 g/cm3
  • Solubility soluble in water
  • Melting Point -60 °C
  • Formula C6H14 N2
  • Boiling Point 156 °C at 760 mmHg
  • Molecular Weight 114.191
  • Flash Point 53 °C
  • Transport Information UN 1993 3/PG 3
  • Appearance clear colorless to yellow liquid
  • Safety 26-36
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 5308-25-8 (1-Ethylpiperazine)
  • Hazard Symbols IrritantXi
  • Synonyms N-Ethylpiperazin;N-Ethylpiperazine;NSC 60707;
  • PSA 15.27000
  • LogP 0.17820

Synthetic route

C11H22N2O2

C11H22N2O2

4-ethylpiperazine
5308-25-8

4-ethylpiperazine

Conditions
ConditionsYield
With trifluoroacetic acid at 20℃; for 0.0833333h;94%
piperazine
110-85-0

piperazine

chloroethane
75-00-3

chloroethane

A

4-ethylpiperazine
5308-25-8

4-ethylpiperazine

B

1,4-diethylpiperazine
6483-50-7

1,4-diethylpiperazine

Conditions
ConditionsYield
A 20%
B 55%
4-ethyl-1-formylpiperazine
21863-75-2

4-ethyl-1-formylpiperazine

4-ethylpiperazine
5308-25-8

4-ethylpiperazine

Conditions
ConditionsYield
With hydrogenchloride
ethyl bromide
74-96-4

ethyl bromide

piperazine hydrochloride
7542-23-6

piperazine hydrochloride

4-ethylpiperazine
5308-25-8

4-ethylpiperazine

Conditions
ConditionsYield
With ethanol
4-ethyl-piperazine-1-carboxylic acid ethyl ester
98951-41-8

4-ethyl-piperazine-1-carboxylic acid ethyl ester

4-ethylpiperazine
5308-25-8

4-ethylpiperazine

Conditions
ConditionsYield
With hydrogen bromide; acetic acid
With hydrogenchloride
EtN(CH2CN)2
24426-42-4

EtN(CH2CN)2

4-ethylpiperazine
5308-25-8

4-ethylpiperazine

Conditions
ConditionsYield
With nickel; platinum; benzene at 44℃; Hydrogenation;
ethanamine hydrochloride
557-66-4

ethanamine hydrochloride

morpholin hydrochloride
10024-89-2

morpholin hydrochloride

4-ethylpiperazine
5308-25-8

4-ethylpiperazine

Conditions
ConditionsYield
at 265℃;
at 265℃;
diethyl amine hydrochloride
660-68-4

diethyl amine hydrochloride

morpholin hydrochloride
10024-89-2

morpholin hydrochloride

4-ethylpiperazine
5308-25-8

4-ethylpiperazine

Conditions
ConditionsYield
at 250℃;
1-benzyl-4-ethylpiperazine dihydrochloride

1-benzyl-4-ethylpiperazine dihydrochloride

4-ethylpiperazine
5308-25-8

4-ethylpiperazine

Conditions
ConditionsYield
With palladium on activated charcoal Hydrogenation;
bis-(2-chloroethyl)amine hydrochloride
821-48-7

bis-(2-chloroethyl)amine hydrochloride

ethylamine
75-04-7

ethylamine

4-ethylpiperazine
5308-25-8

4-ethylpiperazine

Conditions
ConditionsYield
at 130℃;
ethylamine
75-04-7

ethylamine

2,2'-iminobis[ethanol]
111-42-2

2,2'-iminobis[ethanol]

4-ethylpiperazine
5308-25-8

4-ethylpiperazine

Conditions
ConditionsYield
With nickel at 225℃;
1-ethyl-4-<4-chloro-benzyl>-piperazine dihydrobromide

1-ethyl-4-<4-chloro-benzyl>-piperazine dihydrobromide

4-ethylpiperazine
5308-25-8

4-ethylpiperazine

Conditions
ConditionsYield
With palladium on activated charcoal Hydrogenation;
1-ethyl-4-<4-nitroso-phenyl>-piperazine

1-ethyl-4-<4-nitroso-phenyl>-piperazine

4-ethylpiperazine
5308-25-8

4-ethylpiperazine

Conditions
ConditionsYield
With sulfur dioxide anschliessend mit wss.KOH;
2-<2-diethylamino-ethylamino>-ethanol dihydrochloride

2-<2-diethylamino-ethylamino>-ethanol dihydrochloride

4-ethylpiperazine
5308-25-8

4-ethylpiperazine

Conditions
ConditionsYield
at 260℃;
ethanamine hydrochloride
557-66-4

ethanamine hydrochloride

1-ethyl-piperazine hydrochloride

1-ethyl-piperazine hydrochloride

4-ethylpiperazine
5308-25-8

4-ethylpiperazine

Conditions
ConditionsYield
at 260℃;
diethyl amine hydrochloride
660-68-4

diethyl amine hydrochloride

1-ethyl-piperazine hydrochloride

1-ethyl-piperazine hydrochloride

4-ethylpiperazine
5308-25-8

4-ethylpiperazine

Conditions
ConditionsYield
at 250℃;
ethyl-bis-<2-hydroxy-ethyl>-amine hydrochloride

ethyl-bis-<2-hydroxy-ethyl>-amine hydrochloride

4-ethylpiperazine
5308-25-8

4-ethylpiperazine

Conditions
ConditionsYield
With ammonium chloride at 260℃;
N-ethyl-piperazine-N'-carboxylic acid ethyl ester

N-ethyl-piperazine-N'-carboxylic acid ethyl ester

4-ethylpiperazine
5308-25-8

4-ethylpiperazine

Conditions
ConditionsYield
With hydrogenchloride
propan-1-ol-3-amine
156-87-6

propan-1-ol-3-amine

A

morpholine
110-91-8

morpholine

B

4-ethylpiperazine
5308-25-8

4-ethylpiperazine

C

2-Methylpyrazine
109-08-0

2-Methylpyrazine

D

ethanol
64-17-5

ethanol

E

1-amino-2-propene
107-11-9

1-amino-2-propene

G

propane, methylamine, ethylamine, 2,5-dimethylpyrrole

propane, methylamine, ethylamine, 2,5-dimethylpyrrole

Conditions
ConditionsYield
tungsten(VI) oxide at 400℃; Product distribution; other temperatures;
(4-ethyl-1-piperazinyl)(phenyl)methanone
60787-02-2

(4-ethyl-1-piperazinyl)(phenyl)methanone

4-ethylpiperazine
5308-25-8

4-ethylpiperazine

Conditions
ConditionsYield
With hydrogenchloride Heating;
piperazine
110-85-0

piperazine

Reaxys ID: 11370776

Reaxys ID: 11370776

ethanol
64-17-5

ethanol

A

4-ethylpiperazine
5308-25-8

4-ethylpiperazine

B

1,4-diethylpiperazine
6483-50-7

1,4-diethylpiperazine

Conditions
ConditionsYield
Stage #1: With hydrogen at 200℃; for 3h;
Stage #2: piperazine; ethanol With hydrogen at 200℃; under 7500.75 Torr; for 8h; Product distribution / selectivity;
blonanserin

blonanserin

A

4-ethylpiperazine
5308-25-8

4-ethylpiperazine

B

2-(piperazine-1-yl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

2-(piperazine-1-yl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

C

C21H28FN3

C21H28FN3

D

C23H28FN3O2

C23H28FN3O2

Conditions
ConditionsYield
at 40℃; UV-irradiation;
N-ethylethane-1,2-diamine
110-72-5

N-ethylethane-1,2-diamine

Glyoxal
131543-46-9

Glyoxal

4-ethylpiperazine
5308-25-8

4-ethylpiperazine

Conditions
ConditionsYield
With glucose-6-phosphate dehydrogenase; glucose-6-phosphate; Myxococcus stipitatus R-selective imine reductase; NADPH; magnesium chloride In aq. phosphate buffer at 25℃; for 4h; pH=7; Enzymatic reaction;
2-hydroxy-1-(piperazin-1-yl)ethanone

2-hydroxy-1-(piperazin-1-yl)ethanone

A

4-ethylpiperazine
5308-25-8

4-ethylpiperazine

B

1-(2-hydroxyethyl)piperazine
103-76-4

1-(2-hydroxyethyl)piperazine

Conditions
ConditionsYield
With hydrogen In toluene at 200℃; under 37503.8 Torr; Solvent; Reagent/catalyst; Temperature; Pressure; Autoclave; Sealed tube;A 68.63 g
B 164.81 g
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

ethyl 2-chloro-5-(chlorosulfonyl)nicotinate
334708-07-5

ethyl 2-chloro-5-(chlorosulfonyl)nicotinate

Ethyl 2-chloro-5-(4-ethyl-1-piperazinylsulfonyl) nicotinoate
334708-08-6

Ethyl 2-chloro-5-(4-ethyl-1-piperazinylsulfonyl) nicotinoate

Conditions
ConditionsYield
With triethylamine In toluene at 10 - 20℃; for 19.5h;100%
With triethylamine In ethyl acetate at 0 - 22℃; for 1.5h;
With triethylamine In ethyl acetate at 0 - 22℃; for 1.5h;
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

ethyl 4-(1-bromoethyl)benzoic acid
221279-14-7

ethyl 4-(1-bromoethyl)benzoic acid

4-(4-ethyl piperazin-1-ylmethyl)-benzoic acid ethyl ester
1044872-36-7

4-(4-ethyl piperazin-1-ylmethyl)-benzoic acid ethyl ester

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 16h;100%
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

Ethyl 4-(bromomethyl)benzoate
26496-94-6

Ethyl 4-(bromomethyl)benzoate

4-(4-ethyl piperazin-1-ylmethyl)-benzoic acid ethyl ester
1044872-36-7

4-(4-ethyl piperazin-1-ylmethyl)-benzoic acid ethyl ester

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 16h;100%
In tetrahydrofuran at 20℃; for 16h;
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

methyl 2-(chloromethyl)-4-(2-methyl-1H-indol-3-yl)-4H-chromene-3-carboxylate
1257865-27-2

methyl 2-(chloromethyl)-4-(2-methyl-1H-indol-3-yl)-4H-chromene-3-carboxylate

methyl 2-[(4-ethylpiperazin-1-yl)methyl]-4-(2-methyl-1H-indol-3-yl)-4H-chromene-3-carboxylate
1257865-29-4

methyl 2-[(4-ethylpiperazin-1-yl)methyl]-4-(2-methyl-1H-indol-3-yl)-4H-chromene-3-carboxylate

Conditions
ConditionsYield
In acetonitrile at 25℃; for 20h;100%
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-methyl-2-oxo-7-(phenylsulfonyl)-2,3,4,7-tetrahydro-1H-pyrrolo[3‘,2‘:5,6]pyrido[4,3-d]pyrimidine-8-carbaldehyde
1513859-71-6

3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-methyl-2-oxo-7-(phenylsulfonyl)-2,3,4,7-tetrahydro-1H-pyrrolo[3‘,2‘:5,6]pyrido[4,3-d]pyrimidine-8-carbaldehyde

3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-[(4-ethylpiperazin-1-yl)methyl]-1-methyl-7-(phenylsulfonyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3‘,2‘:5,6]pyrido[4,3-d]pyrimidin-2-one
1513859-72-7

3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-[(4-ethylpiperazin-1-yl)methyl]-1-methyl-7-(phenylsulfonyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3‘,2‘:5,6]pyrido[4,3-d]pyrimidin-2-one

Conditions
ConditionsYield
With sodium tris(acetoxy)borohydride; trifluoroacetic acid In dichloromethane at 0℃; for 2h;100%
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

C18H21ClO

C18H21ClO

1-ethyl-4-[4-(2-tricyclo[3.3.1.13,7]decyl)phenylacetyl]piperazine

1-ethyl-4-[4-(2-tricyclo[3.3.1.13,7]decyl)phenylacetyl]piperazine

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 12h;100%
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

N-(4-bromo-2-nitrophenyl)-N-tert-butoxycarbonylcarbamic acid tert-butyl ester
1228392-59-3

N-(4-bromo-2-nitrophenyl)-N-tert-butoxycarbonylcarbamic acid tert-butyl ester

tert-butyl (4-(4-ethylpiperazin-1-yl)-2-nitrophenyl)carbamate

tert-butyl (4-(4-ethylpiperazin-1-yl)-2-nitrophenyl)carbamate

Conditions
ConditionsYield
With chloro(2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)-palladium(II); caesium carbonate In toluene at 95 - 105℃; Inert atmosphere;100%
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; XPhos In toluene at 110℃; for 8h; Inert atmosphere;4.8 g
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

5-chloro-6-ethoxycarbonylpyridine-3-carboxylic acid
1198475-22-7

5-chloro-6-ethoxycarbonylpyridine-3-carboxylic acid

ethyl 3-chloro-5-(4-ethylpiperazine-1-carbonyl)picolinate

ethyl 3-chloro-5-(4-ethylpiperazine-1-carbonyl)picolinate

Conditions
ConditionsYield
Stage #1: 5-chloro-6-ethoxycarbonylpyridine-3-carboxylic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 0.0833333h;
Stage #2: 4-ethylpiperazine In N,N-dimethyl-formamide at 20℃;
100%
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

4-Methoxyphenyl isocyanate
5416-93-3

4-Methoxyphenyl isocyanate

4-ethyl-N-(4-methoxyphenyl)piperazine-1-carboxamide

4-ethyl-N-(4-methoxyphenyl)piperazine-1-carboxamide

Conditions
ConditionsYield
In diethyl ether at 20℃; for 5h;99.7%
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

3-methoxyphenyl isocyanate
18908-07-1

3-methoxyphenyl isocyanate

4-ethyl-N-(3-methoxyphenyl)piperazine-1-carboxamide

4-ethyl-N-(3-methoxyphenyl)piperazine-1-carboxamide

Conditions
ConditionsYield
In diethyl ether at 20℃; for 5h;99.7%
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

1-(3-bromopropoxy)-4-nitrobenzene
13094-50-3

1-(3-bromopropoxy)-4-nitrobenzene

1-ethyl-4-(3-(4-nitrophenoxy)propyl)piperazine

1-ethyl-4-(3-(4-nitrophenoxy)propyl)piperazine

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 17h; Reflux;99.6%
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

1-(4-bromobutoxy)-4-nitrobenzene
55502-03-9

1-(4-bromobutoxy)-4-nitrobenzene

1-ethyl-4-(4-(4-nitrophenoxy)butyl)piperazine

1-ethyl-4-(4-(4-nitrophenoxy)butyl)piperazine

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 17h; Reflux;99.5%
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

1-fluoro-3-isocyanatobenzene
404-71-7

1-fluoro-3-isocyanatobenzene

4-ethyl-N-(3-fluorophenyl)piperazine-1-carboxamide

4-ethyl-N-(3-fluorophenyl)piperazine-1-carboxamide

Conditions
ConditionsYield
In diethyl ether at 20℃; for 5h;99.5%
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

para-fluorophenyl isocyanate
1195-45-5

para-fluorophenyl isocyanate

4-ethyl-N-(4-fluorophenyl)piperazine-1-carboxamide

4-ethyl-N-(4-fluorophenyl)piperazine-1-carboxamide

Conditions
ConditionsYield
In diethyl ether at 20℃; for 5h;99.5%
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

3-(4-methoxyphenyl)-1-chloromethylisoquinoline

3-(4-methoxyphenyl)-1-chloromethylisoquinoline

3-(4-methoxyphenyl)-(1-(4-ethylpiperazin-1-yl)methyl)isoquinoline

3-(4-methoxyphenyl)-(1-(4-ethylpiperazin-1-yl)methyl)isoquinoline

Conditions
ConditionsYield
99%
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

4-(bromomethyl)-3-(trifluoromethyl)benzoic acid methyl ester
863248-28-6

4-(bromomethyl)-3-(trifluoromethyl)benzoic acid methyl ester

methyl 4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzoate

methyl 4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)benzoate

Conditions
ConditionsYield
With caesium carbonate In N,N-dimethyl-formamide at 80℃; for 3h;99%
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

formaldehyd
50-00-0

formaldehyd

1-ethyl-4-methylpiperazine dihydrochloride
73993-07-4

1-ethyl-4-methylpiperazine dihydrochloride

Conditions
ConditionsYield
Stage #1: 4-ethylpiperazine; formaldehyd With hydrogen In tetrahydrofuran at 120℃; under 3750.38 Torr; for 9h; Autoclave;
Stage #2: With hydrogenchloride In water
99%
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

1-(6-bromopyridin-3-yl)propyl methanesulfonate

1-(6-bromopyridin-3-yl)propyl methanesulfonate

1-(1-(6-bromopyridin-3-yl)propyl)-4-ethylpiperazine

1-(1-(6-bromopyridin-3-yl)propyl)-4-ethylpiperazine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 80℃; for 12h; Inert atmosphere;99%
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
132813-14-0

2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine

blonanserin

blonanserin

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 70℃; for 5h;98.6%
Stage #1: 4-ethylpiperazine; 2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine With sodium t-butanolate In toluene at 10℃; under 75.0075 Torr; for 0.0333333h; Inert atmosphere;
Stage #2: With palladium diacetate; triphenylphosphine In toluene at 70℃; under 75.0075 Torr; for 7h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;
89.12%
With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate In toluene at 75 - 85℃; for 3h; Large scale;88%
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

tetramethylorthosilicate
681-84-5

tetramethylorthosilicate

bis(N-ethyl)piperazinyl dimethoxysilane

bis(N-ethyl)piperazinyl dimethoxysilane

Conditions
ConditionsYield
Stage #1: 4-ethylpiperazine With n-butyllithium In tetrahydrofuran at 20℃; for 1h; Inert atmosphere; Cooling with ice;
Stage #2: tetramethylorthosilicate In tetrahydrofuran at 0 - 20℃; for 6h; Inert atmosphere;
98.6%
Stage #1: 4-ethylpiperazine With n-butyllithium In hexane at 10℃; for 1h; Inert atmosphere;
Stage #2: tetramethylorthosilicate In hexane for 17h; Inert atmosphere;
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

isopropyl trimethoxy silane
14346-37-3

isopropyl trimethoxy silane

ethylpiperazine isopropyl dimethoxy silane

ethylpiperazine isopropyl dimethoxy silane

Conditions
ConditionsYield
Stage #1: 4-ethylpiperazine With n-butyllithium In tetrahydrofuran at 20℃; for 2h; Inert atmosphere; Cooling with ice;
Stage #2: isopropyl trimethoxy silane In tetrahydrofuran at 0 - 20℃; for 8h; Inert atmosphere;
98.4%
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

6-Chloro-7,8-dihydro-9-oxa-5-aza-benzo[6,7]cyclohepta[1,2-a]naphthalene
151080-38-5

6-Chloro-7,8-dihydro-9-oxa-5-aza-benzo[6,7]cyclohepta[1,2-a]naphthalene

6,7-dihydro-8-(4-ethyl-1-piperazinyl)<1>benzoxepino<4,5-c>quinoline

6,7-dihydro-8-(4-ethyl-1-piperazinyl)<1>benzoxepino<4,5-c>quinoline

Conditions
ConditionsYield
at 120 - 130℃;98%
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

6,8-dibromo-1,7-naphthyridine

6,8-dibromo-1,7-naphthyridine

6-bromo-8-(4-ethylpiperazin-1-yl)-1,7-naphthyridine
223553-60-4

6-bromo-8-(4-ethylpiperazin-1-yl)-1,7-naphthyridine

Conditions
ConditionsYield
at 100℃; for 0.25h; Neat (no solvent);98%
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

formaldehyd
50-00-0

formaldehyd

(E)-7-fluoro-5-(5-(methylthio)-1,3,4-oxadiazol-2-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one
1649449-37-5

(E)-7-fluoro-5-(5-(methylthio)-1,3,4-oxadiazol-2-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one

C17H19FN6O2
1649449-58-0

C17H19FN6O2

Conditions
ConditionsYield
In ethanol for 0.183333h; Microwave irradiation;98%
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

2-fluoropyridine
372-48-5

2-fluoropyridine

1-(5-bromopyridin-2-yl)-4-ethylpiperazine
364794-57-0

1-(5-bromopyridin-2-yl)-4-ethylpiperazine

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 120℃; for 2h; Microwave irradiation;98%
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid
86393-33-1

7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid

enrofloxacin
93106-60-6

enrofloxacin

Conditions
ConditionsYield
With nano iron oxide on ZrO2 coated sulfonic acid In water for 0.316667h; Solvent; Temperature; Reagent/catalyst; Reflux;97%
at 150℃; for 0.416667h; Microwave irradiation;93%
With aluminum tri-bromide In ethanol at 75℃; for 4h; Reagent/catalyst; Solvent; Temperature;92%
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

2-(methylthio)-3-nitro-4H-chromen-4-one
1264701-67-8

2-(methylthio)-3-nitro-4H-chromen-4-one

2-(4-ethylpiperazin-1-yl)-3-nitro-4H-chromen-4-one
1264701-87-2

2-(4-ethylpiperazin-1-yl)-3-nitro-4H-chromen-4-one

Conditions
ConditionsYield
In 1,4-dioxane Reflux; Combinatorial reaction / High throughput screening (HTS);97%
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

1-chloro-7-methyl-3-thiophen-2-yl-isoquinoline
1617529-28-8

1-chloro-7-methyl-3-thiophen-2-yl-isoquinoline

1-(4-ethyl-piperazin-1-yl)-7-methyl-3-thiophen-2-yl-isoquinoline
1617529-21-1

1-(4-ethyl-piperazin-1-yl)-7-methyl-3-thiophen-2-yl-isoquinoline

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 110℃; Inert atmosphere;97%
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

3-Chloropyridine
626-60-8

3-Chloropyridine

1-ethyl-4-(pyridin-3-yl)piperazine

1-ethyl-4-(pyridin-3-yl)piperazine

Conditions
ConditionsYield
Stage #1: 4-ethylpiperazine With dichloro(3-chloropyridinyl)(1,3-(diisopropylphenyl)-4,5-bis(dimethylamino)imidazol-2-ylidene)palladium(II); potassium tert-butylate for 0.0333333h; Buchwald-Hartwig Coupling; Inert atmosphere; Schlenk technique; Sealed tube;
Stage #2: 3-Chloropyridine In 1,2-dimethoxyethane at 25℃; for 18h; Buchwald-Hartwig Coupling; Inert atmosphere; Schlenk technique;
97%
4-ethylpiperazine
5308-25-8

4-ethylpiperazine

1-Phenyl-2-propyn-1-ol
4187-87-5

1-Phenyl-2-propyn-1-ol

2,2,2-trifluoro-N-(2-iodophenyl)acetamide
143321-89-5

2,2,2-trifluoro-N-(2-iodophenyl)acetamide

2-((4-ethylpiperazin-1-yl)(phenyl)methyl)-1H-indole
1196834-78-2

2-((4-ethylpiperazin-1-yl)(phenyl)methyl)-1H-indole

Conditions
ConditionsYield
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate In N,N-dimethyl-formamide at 80℃; for 4h; Inert atmosphere;96%

1-Ethylpiperazine Chemical Properties

IUPAC Name:1-ethylpiperazine
Molecular Formula:C6H14N2
Molecular Weight:114.188760 g/mol
Appearance:clear, colorless liquid
Melting Point:-60 °C
Boiling Point:157 °C(lit.)
Flash Point:110 °F
density:0.899 g/mL at 25 °C(lit.)
refractive index:n20/D 1.469(lit.)
storage temp.:flammables area 
Water Solubility:soluble
Sensitive:Air
BRN:102971
EINECS:226-166-6
Synonyms of N-ethyl Piperazine(5308-25-8):
1-ethyl-piperazin;Piperazine, 1-ethyl-;ETHYLPIPERAZINE-N;LABOTEST-BB LTBB000704;1-ETHYLPIPERAZINE;AKOS BBS-00003610;N-ETHYLPIPERAZINE;NEPRZ;1-Ethylpiperazine
Categories of N-ethyl Piperazine(5308-25-8):
Piperidines,Piperidones,Piperazines;Piperaizine;Piperazines;Building Blocks;Heterocyclic Building Blocks

1-Ethylpiperazine Uses

N-ethyl Piperazine(5308-25-8) is used as an intermediate for veterinary medicine mainly used in the production of ciproflmoxacin ethyl.
N-ethyl Piperazine(5308-25-8) is also used as a raw material for the production of dyes and plant protection agents.

1-Ethylpiperazine Toxicity Data With Reference

Toxicity Information of N-ethyl Piperazine(5308-25-8):
1.rat LC50 inhalation > 9219mg/m3/4H (9219mg/m3)
SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION International Journal of Toxicology. Vol. 16
2.rat LD50 oral 2158mg/kg (2158mg/kg)
LUNGS, THORAX, OR RESPIRATION: PULMONARY EMBOLI
GASTROINTESTINAL: NAUSEA OR VOMITING
GASTROINTESTINAL: OTHER CHANGES
International Journal of Toxicology. Vol. 16

1-Ethylpiperazine Safety Profile

Safety Information of N-ethyl Piperazine(5308-25-8):
Hazard Codes:Xi
Risk Statements:36/37/38
36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements:26-36
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:Wear suitable protective clothing
RIDADR:UN 1993 3/PG 3
WGK Germany:1
RTECS:TM0815500
F:10-34
HazardClass:3
PackingGroup:III
HS Code:29335995

1-Ethylpiperazine Specification

First Aid Measures of N-ethyl Piperazine(5308-25-8):
Ingestion:Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:Get medical aid immediately. Remove from exposure to fresh air immediately. Do not use mouth-to-mouth respiration if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
Skin:Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
Eyes:Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed. Extensive irrigation is required (at least 30 minutes).

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