4-ethylpiperazine
Conditions | Yield |
---|---|
With trifluoroacetic acid at 20℃; for 0.0833333h; | 94% |
piperazine
chloroethane
A
4-ethylpiperazine
B
1,4-diethylpiperazine
Conditions | Yield |
---|---|
A 20% B 55% |
4-ethyl-1-formylpiperazine
4-ethylpiperazine
Conditions | Yield |
---|---|
With hydrogenchloride |
Conditions | Yield |
---|---|
With ethanol |
4-ethyl-piperazine-1-carboxylic acid ethyl ester
4-ethylpiperazine
Conditions | Yield |
---|---|
With hydrogen bromide; acetic acid | |
With hydrogenchloride |
EtN(CH2CN)2
4-ethylpiperazine
Conditions | Yield |
---|---|
With nickel; platinum; benzene at 44℃; Hydrogenation; |
Conditions | Yield |
---|---|
at 265℃; | |
at 265℃; |
Conditions | Yield |
---|---|
at 250℃; |
4-ethylpiperazine
Conditions | Yield |
---|---|
With palladium on activated charcoal Hydrogenation; |
Conditions | Yield |
---|---|
at 130℃; |
Conditions | Yield |
---|---|
With nickel at 225℃; |
4-ethylpiperazine
Conditions | Yield |
---|---|
With palladium on activated charcoal Hydrogenation; |
4-ethylpiperazine
Conditions | Yield |
---|---|
With sulfur dioxide anschliessend mit wss.KOH; |
4-ethylpiperazine
Conditions | Yield |
---|---|
at 260℃; |
Conditions | Yield |
---|---|
at 260℃; |
Conditions | Yield |
---|---|
at 250℃; |
4-ethylpiperazine
Conditions | Yield |
---|---|
With ammonium chloride at 260℃; |
4-ethylpiperazine
Conditions | Yield |
---|---|
With hydrogenchloride |
propan-1-ol-3-amine
A
morpholine
B
4-ethylpiperazine
C
2-Methylpyrazine
D
ethanol
E
1-amino-2-propene
F
2-Methylaziridine
Conditions | Yield |
---|---|
tungsten(VI) oxide at 400℃; Product distribution; other temperatures; |
(4-ethyl-1-piperazinyl)(phenyl)methanone
4-ethylpiperazine
Conditions | Yield |
---|---|
With hydrogenchloride Heating; |
Conditions | Yield |
---|---|
Stage #1: With hydrogen at 200℃; for 3h; Stage #2: piperazine; ethanol With hydrogen at 200℃; under 7500.75 Torr; for 8h; Product distribution / selectivity; |
Conditions | Yield |
---|---|
With glucose-6-phosphate dehydrogenase; glucose-6-phosphate; Myxococcus stipitatus R-selective imine reductase; NADPH; magnesium chloride In aq. phosphate buffer at 25℃; for 4h; pH=7; Enzymatic reaction; |
Conditions | Yield |
---|---|
With hydrogen In toluene at 200℃; under 37503.8 Torr; Solvent; Reagent/catalyst; Temperature; Pressure; Autoclave; Sealed tube; | A 68.63 g B 164.81 g |
4-ethylpiperazine
ethyl 2-chloro-5-(chlorosulfonyl)nicotinate
Ethyl 2-chloro-5-(4-ethyl-1-piperazinylsulfonyl) nicotinoate
Conditions | Yield |
---|---|
With triethylamine In toluene at 10 - 20℃; for 19.5h; | 100% |
With triethylamine In ethyl acetate at 0 - 22℃; for 1.5h; | |
With triethylamine In ethyl acetate at 0 - 22℃; for 1.5h; |
4-ethylpiperazine
ethyl 4-(1-bromoethyl)benzoic acid
4-(4-ethyl piperazin-1-ylmethyl)-benzoic acid ethyl ester
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 16h; | 100% |
4-ethylpiperazine
Ethyl 4-(bromomethyl)benzoate
4-(4-ethyl piperazin-1-ylmethyl)-benzoic acid ethyl ester
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 16h; | 100% |
In tetrahydrofuran at 20℃; for 16h; |
4-ethylpiperazine
methyl 2-(chloromethyl)-4-(2-methyl-1H-indol-3-yl)-4H-chromene-3-carboxylate
methyl 2-[(4-ethylpiperazin-1-yl)methyl]-4-(2-methyl-1H-indol-3-yl)-4H-chromene-3-carboxylate
Conditions | Yield |
---|---|
In acetonitrile at 25℃; for 20h; | 100% |
4-ethylpiperazine
3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-methyl-2-oxo-7-(phenylsulfonyl)-2,3,4,7-tetrahydro-1H-pyrrolo[3‘,2‘:5,6]pyrido[4,3-d]pyrimidine-8-carbaldehyde
3-(2,6-difluoro-3,5-dimethoxyphenyl)-8-[(4-ethylpiperazin-1-yl)methyl]-1-methyl-7-(phenylsulfonyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3‘,2‘:5,6]pyrido[4,3-d]pyrimidin-2-one
Conditions | Yield |
---|---|
With sodium tris(acetoxy)borohydride; trifluoroacetic acid In dichloromethane at 0℃; for 2h; | 100% |
4-ethylpiperazine
Conditions | Yield |
---|---|
In tetrahydrofuran at 20℃; for 12h; | 100% |
4-ethylpiperazine
N-(4-bromo-2-nitrophenyl)-N-tert-butoxycarbonylcarbamic acid tert-butyl ester
Conditions | Yield |
---|---|
With chloro(2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl)(2′-amino-1,1′-biphenyl-2-yl)-palladium(II); caesium carbonate In toluene at 95 - 105℃; Inert atmosphere; | 100% |
With tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; XPhos In toluene at 110℃; for 8h; Inert atmosphere; | 4.8 g |
4-ethylpiperazine
5-chloro-6-ethoxycarbonylpyridine-3-carboxylic acid
Conditions | Yield |
---|---|
Stage #1: 5-chloro-6-ethoxycarbonylpyridine-3-carboxylic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Stage #2: 4-ethylpiperazine In N,N-dimethyl-formamide at 20℃; | 100% |
Conditions | Yield |
---|---|
In diethyl ether at 20℃; for 5h; | 99.7% |
4-ethylpiperazine
3-methoxyphenyl isocyanate
Conditions | Yield |
---|---|
In diethyl ether at 20℃; for 5h; | 99.7% |
4-ethylpiperazine
1-(3-bromopropoxy)-4-nitrobenzene
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 17h; Reflux; | 99.6% |
4-ethylpiperazine
1-(4-bromobutoxy)-4-nitrobenzene
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile for 17h; Reflux; | 99.5% |
Conditions | Yield |
---|---|
In diethyl ether at 20℃; for 5h; | 99.5% |
Conditions | Yield |
---|---|
In diethyl ether at 20℃; for 5h; | 99.5% |
4-ethylpiperazine
Conditions | Yield |
---|---|
99% |
4-ethylpiperazine
4-(bromomethyl)-3-(trifluoromethyl)benzoic acid methyl ester
Conditions | Yield |
---|---|
With caesium carbonate In N,N-dimethyl-formamide at 80℃; for 3h; | 99% |
4-ethylpiperazine
formaldehyd
1-ethyl-4-methylpiperazine dihydrochloride
Conditions | Yield |
---|---|
Stage #1: 4-ethylpiperazine; formaldehyd With hydrogen In tetrahydrofuran at 120℃; under 3750.38 Torr; for 9h; Autoclave; Stage #2: With hydrogenchloride In water | 99% |
4-ethylpiperazine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 80℃; for 12h; Inert atmosphere; | 99% |
4-ethylpiperazine
2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 70℃; for 5h; | 98.6% |
Stage #1: 4-ethylpiperazine; 2-chloro-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine With sodium t-butanolate In toluene at 10℃; under 75.0075 Torr; for 0.0333333h; Inert atmosphere; Stage #2: With palladium diacetate; triphenylphosphine In toluene at 70℃; under 75.0075 Torr; for 7h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; | 89.12% |
With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate In toluene at 75 - 85℃; for 3h; Large scale; | 88% |
Conditions | Yield |
---|---|
Stage #1: 4-ethylpiperazine With n-butyllithium In tetrahydrofuran at 20℃; for 1h; Inert atmosphere; Cooling with ice; Stage #2: tetramethylorthosilicate In tetrahydrofuran at 0 - 20℃; for 6h; Inert atmosphere; | 98.6% |
Stage #1: 4-ethylpiperazine With n-butyllithium In hexane at 10℃; for 1h; Inert atmosphere; Stage #2: tetramethylorthosilicate In hexane for 17h; Inert atmosphere; |
4-ethylpiperazine
isopropyl trimethoxy silane
Conditions | Yield |
---|---|
Stage #1: 4-ethylpiperazine With n-butyllithium In tetrahydrofuran at 20℃; for 2h; Inert atmosphere; Cooling with ice; Stage #2: isopropyl trimethoxy silane In tetrahydrofuran at 0 - 20℃; for 8h; Inert atmosphere; | 98.4% |
4-ethylpiperazine
6-Chloro-7,8-dihydro-9-oxa-5-aza-benzo[6,7]cyclohepta[1,2-a]naphthalene
Conditions | Yield |
---|---|
at 120 - 130℃; | 98% |
4-ethylpiperazine
6-bromo-8-(4-ethylpiperazin-1-yl)-1,7-naphthyridine
Conditions | Yield |
---|---|
at 100℃; for 0.25h; Neat (no solvent); | 98% |
4-ethylpiperazine
formaldehyd
(E)-7-fluoro-5-(5-(methylthio)-1,3,4-oxadiazol-2-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one
C17H19FN6O2
Conditions | Yield |
---|---|
In ethanol for 0.183333h; Microwave irradiation; | 98% |
4-ethylpiperazine
2-fluoropyridine
1-(5-bromopyridin-2-yl)-4-ethylpiperazine
Conditions | Yield |
---|---|
With potassium carbonate In dimethyl sulfoxide at 120℃; for 2h; Microwave irradiation; | 98% |
4-ethylpiperazine
7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid
enrofloxacin
Conditions | Yield |
---|---|
With nano iron oxide on ZrO2 coated sulfonic acid In water for 0.316667h; Solvent; Temperature; Reagent/catalyst; Reflux; | 97% |
at 150℃; for 0.416667h; Microwave irradiation; | 93% |
With aluminum tri-bromide In ethanol at 75℃; for 4h; Reagent/catalyst; Solvent; Temperature; | 92% |
4-ethylpiperazine
2-(methylthio)-3-nitro-4H-chromen-4-one
2-(4-ethylpiperazin-1-yl)-3-nitro-4H-chromen-4-one
Conditions | Yield |
---|---|
In 1,4-dioxane Reflux; Combinatorial reaction / High throughput screening (HTS); | 97% |
4-ethylpiperazine
1-chloro-7-methyl-3-thiophen-2-yl-isoquinoline
1-(4-ethyl-piperazin-1-yl)-7-methyl-3-thiophen-2-yl-isoquinoline
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 110℃; Inert atmosphere; | 97% |
Conditions | Yield |
---|---|
Stage #1: 4-ethylpiperazine With dichloro(3-chloropyridinyl)(1,3-(diisopropylphenyl)-4,5-bis(dimethylamino)imidazol-2-ylidene)palladium(II); potassium tert-butylate for 0.0333333h; Buchwald-Hartwig Coupling; Inert atmosphere; Schlenk technique; Sealed tube; Stage #2: 3-Chloropyridine In 1,2-dimethoxyethane at 25℃; for 18h; Buchwald-Hartwig Coupling; Inert atmosphere; Schlenk technique; | 97% |
4-ethylpiperazine
1-Phenyl-2-propyn-1-ol
2,2,2-trifluoro-N-(2-iodophenyl)acetamide
2-((4-ethylpiperazin-1-yl)(phenyl)methyl)-1H-indole
Conditions | Yield |
---|---|
With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate In N,N-dimethyl-formamide at 80℃; for 4h; Inert atmosphere; | 96% |
IUPAC Name:1-ethylpiperazine
Molecular Formula:C6H14N2
Molecular Weight:114.188760 g/mol
Appearance:clear, colorless liquid
Melting Point:-60 °C
Boiling Point:157 °C(lit.)
Flash Point:110 °F
density:0.899 g/mL at 25 °C(lit.)
refractive index:n20/D 1.469(lit.)
storage temp.:flammables area
Water Solubility:soluble
Sensitive:Air
BRN:102971
EINECS:226-166-6
Synonyms of N-ethyl Piperazine(5308-25-8):
1-ethyl-piperazin;Piperazine, 1-ethyl-;ETHYLPIPERAZINE-N;LABOTEST-BB LTBB000704;1-ETHYLPIPERAZINE;AKOS BBS-00003610;N-ETHYLPIPERAZINE;NEPRZ;1-Ethylpiperazine
Categories of N-ethyl Piperazine(5308-25-8):
Piperidines,Piperidones,Piperazines;Piperaizine;Piperazines;Building Blocks;Heterocyclic Building Blocks
N-ethyl Piperazine(5308-25-8) is used as an intermediate for veterinary medicine mainly used in the production of ciproflmoxacin ethyl.
N-ethyl Piperazine(5308-25-8) is also used as a raw material for the production of dyes and plant protection agents.
Toxicity Information of N-ethyl Piperazine(5308-25-8):
1.rat LC50 inhalation > 9219mg/m3/4H (9219mg/m3)
SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION International Journal of Toxicology. Vol. 16
2.rat LD50 oral 2158mg/kg (2158mg/kg)
LUNGS, THORAX, OR RESPIRATION: PULMONARY EMBOLI
GASTROINTESTINAL: NAUSEA OR VOMITING
GASTROINTESTINAL: OTHER CHANGES
International Journal of Toxicology. Vol. 16
Safety Information of N-ethyl Piperazine(5308-25-8):
Hazard Codes:Xi
Risk Statements:36/37/38
36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements:26-36
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:Wear suitable protective clothing
RIDADR:UN 1993 3/PG 3
WGK Germany:1
RTECS:TM0815500
F:10-34
HazardClass:3
PackingGroup:III
HS Code:29335995
First Aid Measures of N-ethyl Piperazine(5308-25-8):
Ingestion:Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:Get medical aid immediately. Remove from exposure to fresh air immediately. Do not use mouth-to-mouth respiration if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.
Skin:Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
Eyes:Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed. Extensive irrigation is required (at least 30 minutes).
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