1-Hexadecylamine supplier | CasNO.143-27-1

Name
1-Hexadecylamine
EINECS 205-596-8
CAS No. 143-27-1
Article Data33
CAS DataBase
Density 0,814 g/cm³
Solubility insoluble in water
Melting Point 43-45 °C(lit.)
Formula C₁₆H₃₅N
Boiling Point 321.8 °C at 760 mmHg
Molecular Weight 241.461
Flash Point 140.6 °C
Transport Information UN 3259 8/PG 2
Appearance white low melting crystalline mass or chunks
Safety 26-36/37/39-45
Risk Codes 34
Molecular Structure
Hazard Symbols C
Synonyms Hexadecylamine(8CI);1-Aminohexadecane;1-Hexadecanylamine;1-Hexadecanamine;Alamine 6;Alamine 6D;Amine PB;Armeen 16D;Cetylamine;Monohexadecylamine;NSC8489;Nissan Amine PB;Palmitamine;Palmitylamine;n-Cetylamine;n-Hexadecylamine;
PSA 26.02000
LogP 6.12670

Synthetic route

: 876360-84-8
N-Boc-hexadecylamine

: 143-27-1
hexadecylamine

Conditions

Conditions	Yield
With 3-butyl-l-methyl-1H-imidazol-3-iumtrifloroacetate In 1,4-dioxane; water at 80℃; for 1.5h;	96%

: 66143-67-7
cetyl azide

: 143-27-1
hexadecylamine

Conditions

Conditions	Yield
With tellurium; water at 275℃; for 4h;	91%

: 36653-82-4
1-Hexadecanol

: 143-27-1
hexadecylamine

Conditions

Conditions	Yield
With aluminum oxide; ammonia at 380 - 400℃; under 88260.9 - 95616 Torr;

: 4860-03-1
1-Chlorohexadecan

A: 143-27-1
hexadecylamine

B: 16724-63-3
dihexadecylamine

Conditions

Conditions	Yield
With ethanol; ammonia at 170℃;

: 629-79-8
palmitonitrile

: 143-27-1
hexadecylamine

Conditions

Conditions	Yield
With ethanol; hydrogen; sodium at 120℃; under 14710.2 Torr;
With sodium hydroxide; nickel at 70℃; Hydrogenation;
With kieselguhr; ammonia; nickel at 135℃; Hydrogenation;

: 61020-43-7
N-hexadecyl-phthalimide

: 143-27-1
hexadecylamine

Conditions

Conditions	Yield
With sodium hydroxide; ethanol
With ethanol; hydrazine hydrate anschliessendes Kochen mit konz. HCl;

: 112-82-3
hexadecanyl bromide

: 143-27-1
hexadecylamine

Conditions

Conditions	Yield
With ammonia at 50℃;

: 629-54-9
Palmitamide

: 143-27-1
hexadecylamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride; diethyl ether
With lithium aluminium tetrahydride In tetrahydrofuran for 1h;

: 544-77-4
1-iodohexadecane

: 143-27-1
hexadecylamine

Conditions

Conditions	Yield
With ammonia In ethanol; benzene
Yield given. Multistep reaction;
Multi-step reaction with 2 steps 2: ethanol; NaOH View Scheme

: 17698-04-3
palmitohydroxamic acid

: 143-27-1
hexadecylamine

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran Heating;

: 104944-87-8
Naphthalene-1,8-dicarboxylic acid 1-hexadecylamide 8-phenylamide

A: 143-27-1
hexadecylamine

B: 6914-98-3
2-phenylbenzo[de]isoquinoline-1,3-dione

C: 74240-30-5
2-Hexadecyl-benzo[de]isoquinoline-1,3-dione

D: 62-53-3
aniline

Conditions

Conditions	Yield
at 270℃; for 0.333333h;

...Expand

: C16H35N(1+)*C12H4N4(1-)

A: 143-27-1
hexadecylamine

B: 1518-16-7
7,7',8,8'-tetracyanoquinodimethane

Conditions

Conditions	Yield
In dichloromethane at 25℃; Rate constant;

: 64-17-5
ethanol

: 629-79-8
palmitonitrile

sodium: sodium

: 143-27-1
hexadecylamine

...Expand

: 64-17-5
ethanol

: 4860-03-1
1-Chlorohexadecan

: 7664-41-7
ammonia

A: 143-27-1
hexadecylamine

B: 16724-63-3
dihexadecylamine

Conditions

Conditions	Yield
at 170℃;

...Expand

: 124-30-1
1-aminooctadecane

: 143-27-1
hexadecylamine

Conditions

Conditions	Yield
With cetyltrimethylammonim bromide at 269.84℃; Inert atmosphere;

: 112-67-4
n-hexadecanoyl chloride

: 143-27-1
hexadecylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: ammonia / dichloromethane 2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h View Scheme

: 57-10-3
1-hexadecylcarboxylic acid

: 143-27-1
hexadecylamine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: oxalyl dichloride / benzene / 3 h 2: ammonia / dichloromethane 3: lithium aluminium tetrahydride / tetrahydrofuran / 1 h View Scheme
With D-glucose; pyridoxal 5'-phosphate; glucose dehydrogenase (CDX-901) from Codexis; NADP; isopropylamine; magnesium chloride In n-heptane; dimethyl sulfoxide at 30℃; for 20h; pH=8; Green chemistry; Enzymatic reaction;

: 555-44-2
glyceroltripalmitate

A: 143-27-1
hexadecylamine

B: 16724-63-3
dihexadecylamine

Conditions

Conditions	Yield
With ammonium hydroxide; hydrogen at 220℃; under 41254.1 Torr; for 36h; Autoclave;	A 54 %Chromat. B 19 %Chromat.

: 143-27-1
hexadecylamine

: 506-68-3
bromocyane

: 97226-87-4
hexadecyl cyanamide

Conditions

Conditions	Yield
	100%

: 18871-66-4
N,N-dimethylacetamide dimethyl acetal

: 143-27-1
hexadecylamine

: N'-hexadecyl-N,N-dimethylacetamidine

Conditions

Conditions	Yield
at 60℃; for 0.166667 - 0.333333h; Product distribution / selectivity;	100%

: 143-27-1
hexadecylamine

: 123-08-0
4-hydroxy-benzaldehyde

: 1246401-83-1
C23H39NO

Conditions

Conditions	Yield
at 20℃; for 12h;	100%
In toluene
With acetic acid In ethanol for 3h; Reflux;

: 143-27-1
hexadecylamine

: 100-83-4
meta-hydroxybenzaldehyde

: 1246401-87-5
C23H39NO

Conditions

Conditions	Yield
at 20℃; for 12h;	100%

: 143-27-1
hexadecylamine

: 598-21-0
2-Bromoacetyl bromide

: 1138445-61-0
2-bromo-N-hexadecylethanamide

Conditions

Conditions	Yield
With potassium carbonate In dichloromethane; water at 5 - 20℃; for 4h;	100%
With potassium carbonate In dichloromethane; water at 0 - 20℃; for 16h;	99%

: 143-27-1
hexadecylamine

: 1346422-43-2
(S)-methyl 3-(tert-butoxy)-2-((R)-2-((tert-butoxycarbonyl)amino)-3-((2-hydroxyethyl)thio)propanamido)propanoate

: (2S,5R)-methyl 5-amino-2-(hydroxymethyl)-4,11-dioxo-10-oxa-7-thia-3,12-diazaoctacosan-1-oate

Conditions

Conditions	Yield
Stage #1: (S)-methyl 3-(tert-butoxy)-2-((R)-2-((tert-butoxycarbonyl)amino)-3-((2-hydroxyethyl)thio)propanamido)propanoate With trifluoroacetic acid Stage #2: hexadecylamine	100%

: 143-27-1
hexadecylamine

: 5880-06-8
(7-(carboxymethyl)-1,3,6,8-tetraoxo-3,6,7,8-tetrahydro-1H-benzo[lmn][3,8]phenanthrolin-2-yl)-acetic acid

: C18H10N2O8*2C16H35N

Conditions

Conditions	Yield
In methanol at 20℃;	100%

: 143-27-1
hexadecylamine

: 72925-16-7
(R)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid

: tert-butyl (R)-3-(hexadecylcarbamoyl)pyrrolidine-1-carboxylate

Conditions

Conditions	Yield
With 2,6-dimethylpyridine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 3.5h;	100%
With 2,6-dimethylpyridine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 3.5h;	100%

: 143-27-1
hexadecylamine

: palladium palmitate

: bis(hexadecylamine)palladium(II) palmitate

Conditions

Conditions	Yield
In dichloromethane at 40℃; for 2h;	100%

: 143-27-1
hexadecylamine

: 3375-31-3
palladium diacetate

: bis(hexadecylamine)palladium(II) acetate

Conditions

Conditions	Yield
In dichloromethane at 40℃; for 2h;	100%

: 143-27-1
hexadecylamine

: 107-13-1
acrylonitrile

: 1555-63-1
N-hexadecyl-bis(2-cyanoethyl)amine

Conditions

Conditions	Yield
In methanol at 45℃; for 16h;	99%

: 18871-66-4
N,N-dimethylacetamide dimethyl acetal

: 143-27-1
hexadecylamine

: N'-hexadecyl-N,N-dimethylacetimidamide

Conditions

Conditions	Yield
With dimethyl amine In tetrahydrofuran at 20℃; for 18.25h; Darkness; chemoselective reaction;	99%
With dimethyl amine In tetrahydrofuran for 18h; Darkness;	99%
at 70℃; for 1h;

: 143-27-1
hexadecylamine

: 6914-79-0
1-cyano-cyclopropanecarboxylic acid

: 1266666-37-8
1-cyano-N-hexadecylcyclopropanecarboxamide

Conditions

Conditions	Yield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 4h; Inert atmosphere;	99%

: 143-27-1
hexadecylamine

: 17355-75-8
ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate

: 1428261-49-7
C32H45N3O

Conditions

Conditions	Yield
Stage #1: hexadecylamine With trimethylaluminum In n-heptane; dichloromethane at 20℃; for 1h; Inert atmosphere; Stage #2: ethyl 1,5-diphenyl-1H-pyrazole-3-carboxylate In n-heptane; dichloromethane Reflux; Stage #3: With hydrogenchloride In n-heptane; dichloromethane; water at 40℃; for 0.5h;	99%

: 525-76-8
2-methyl-4-oxo-3,1-benzoxazine

: 143-27-1
hexadecylamine

: 3-hexadecyl-2-methylquinazolin-4(3H)-one

Conditions

Conditions	Yield
Stage #1: 2-methyl-4-oxo-3,1-benzoxazine In ethanol at 20℃; for 0.0833333h; Stage #2: hexadecylamine In ethanol at 100℃; for 6h;	98.1%

: 143-27-1
hexadecylamine

: 57-11-4
stearic acid

: 81126-74-1
N-hexadecyl srearamide

Conditions

Conditions	Yield
With nano sulfated-TiO2 at 115℃; under 760.051 Torr; for 2.5h; Neat (no solvent);	98%

: 143-27-1
hexadecylamine

: 18α-glycyrrhizic acid

: C42H62O16*C16H35N

Conditions

Conditions	Yield
In methanol Reflux;	98%

: 143-27-1
hexadecylamine

: 802294-64-0
propionic acid

: 59453-61-1
N-hexadecylpropanamide

Conditions

Conditions	Yield
With magnesium In toluene at 160℃; for 2h;	98%
Stage #1: hexadecylamine; propionic acid In methanol; water at 20℃; Stage #2: With N-tosylimidazole In N,N-dimethyl-formamide at 100℃; for 1h; Stage #3: With triethylamine In N,N-dimethyl-formamide at 100℃; for 6h;

: 143-27-1
hexadecylamine

: 292638-85-8
acrylic acid methyl ester

: N-hexadecyl-β-aminopropionic acid methyl ester

Conditions

Conditions	Yield
at 60℃; for 6.5h; Michael Addition;	98%
In methanol at 35℃; for 8h; Reflux;

: 143-27-1
hexadecylamine

: C11H14O6

: (3aS,4R,7S,8S,8aR)-N-hexadecyl-2,2-dimethyl-6-oxohexahydro-4,7-methano[1,3]-dioxolo[4–c]oxepin-8-carboxamide

Conditions

Conditions	Yield
Stage #1: C11H14O6 With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.25h; Inert atmosphere; Stage #2: hexadecylamine In dichloromethane; N,N-dimethyl-formamide at 20℃; for 2h; Inert atmosphere;	98%

: 108-30-5
succinic acid anhydride

: 143-27-1
hexadecylamine

: 3384-46-1
4-(hexadecylamino)-4-oxobutanoic acid

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 3h; Inert atmosphere;	98%
In tetrahydrofuran at 40℃;

: 143-27-1
hexadecylamine

: 5222-73-1
3,4-dimethoxy-3-cyclobutene-1,2-dione

: 1428906-20-0
C36H68N2O2

Conditions

Conditions	Yield
In methanol at 20℃; Inert atmosphere;	97.5%

: 143-27-1
hexadecylamine

: 16724-63-3
dihexadecylamine

Conditions

Conditions	Yield
With Co2Rh2/C In toluene at 180℃; under 760.051 Torr; for 18h; Autoclave; Inert atmosphere;	97%
In aluminum nickel; water; benzene	73%
With nickel at 200℃;

: 143-27-1
hexadecylamine

: 58851-58-4
2,4-bis(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide

: 2595-05-3
Diacetone D-glucose

: C26H41O7PS2*C16H35N

Conditions

Conditions	Yield
Stage #1: 2,4-bis(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide; Diacetone D-glucose In benzene at 20℃; for 1h; Inert atmosphere; Stage #2: hexadecylamine In benzene at 20℃; for 1h; Inert atmosphere;	97%

...Expand

: 143-27-1
hexadecylamine

: 100-52-7
benzaldehyde

: 47377-65-1
N-(phenylmethylene)-1-hexadecanamine

Conditions

Conditions	Yield
With 3 A molecular sieve In dichloromethane at 40℃; for 6h; Condensation;	96%
In toluene for 2h; Heating;

: 30169-25-6
3,6-bis-(3,5-dimethyl-pyrazol-1-yl)-1,2,4,5-tetrazine

: 143-27-1
hexadecylamine

A: 67-51-6
3,5-dimethyl-1H-pyrazole

B: [6-(3,5-dimethyl-pyrazol-1-yl)-[1,2,4,5]tetrazin-3-yl]-hexadecyl-amine

Conditions

Conditions	Yield
In acetonitrile at 20 - 25℃; Substitution;	A n/a B 96%

...Expand

: 17084-13-8
potassium hexafluorophosphate

: 143-27-1
hexadecylamine

: (η6-chlorobenzene)(η5-pentamethylcyclopentadienyl)iron hexafluorophosphate

: (η6-hexadecylaminobenzene)(η5-pentamethylcyclopentadienyl)iron hexafluorophosphate

Conditions

Conditions	Yield
In dichloromethane; water the Fe-complex was stirred with the amine in CH2Cl2 under Ar at room temp. for 24 h, then a satd. aq. soln. of KPF4 was added;; the org. layer was separated, dried with MgSO4, concd. and pptd. by mixing with hexane; the crude prod. was recrystd. from MeOH/hexane 1:1; IR and (1)H-NMR spectroscopy;;	96%

...Expand

: 143-27-1
hexadecylamine

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 198971-44-7
2-nitro-N-hexadecylbenzenesulfonamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 23℃; for 1.25h; Large scale reaction;	96%

: 76386-10-2
tetradec-1-en-1-ylsuccinic anhydride

: 143-27-1
hexadecylamine

: C34H65NO3

Conditions

Conditions	Yield
With pyridine at 80℃; for 3h;	96%

1-Hexadecylamine Consensus Reports

Reported in EPA TSCA Inventory.

1-Hexadecylamine Standards and Recommendations

AMINE CONTENT: 215 - 233 mg/g
IODINE VALUE: 2 max (g/100g)
COLOR, APHA: 80 max
C DISTRIBUTION: C18 3% + C16 93% + C14 4% ( Typical)

1-Hexadecylamine Specification

1-Hexadecylamine, with the CAS NO.143-27-1, is also called as 1-Hexadecanylamine;1-Hexadecylamine,straight-chainedC16; Alamine 6; alamine6; alamine6d; Amine 16D; AminePB. 1-Hexadecylamine is derived from the reduction of palm. It is used for producing resin, pesticide and senior detergent.

Physical properties about 1-Hexadecylamine are: (1)ACD/LogP:7.17; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): 4.07; (4)ACD/LogD (pH 7.4): 4.29; (5)ACD/BCF (pH 5.5): 132.70; (6)ACD/BCF (pH 7.4): 220.55; (7)ACD/KOC (pH 5.5): 151.76; (8)ACD/KOC (pH 7.4): 252.23; (9)#H bond acceptors: 1; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 15; (12)Index of Refraction: 1.451; (13)Molar Refractivity:79.71 cm³; (14)Molar Volume: 296.321 cm³; (15)Polarizability: 31.6 10-24cm³; (16)Surface Tension:30.742000579834 dyne/cm; (17)Density: 0.815 g/cm³; (18)Flash Point: 140.556 °C; (19)Enthalpy of Vaporization: 56.363 kJ/mol; (20)Boiling Point: 321.837 °C at 760 mmHg

When you are using 1-Hexadecylamine, please be cautious about it as the following:
1. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;
2. Wear suitable protective clothing, gloves and eye/face protection;
3. In case of accident or if you feel unwell, seek medical advice immediately (show label where possible);

You can still convert the following datas into molecular structure:
(1)InChI=1S/C16H35N/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17/h2-17H2,1H3;
(2)InChIKey=FJLUATLTXUNBOT-UHFFFAOYSA-N;
(3)SmilesC(CCCCCCCC)CCCCCCCN;

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	200mg/kg (200mg/kg)		National Technical Information Service. Vol. AD691-490,

Product Name

1-Hexadecylamine

Synthetic route

1-Hexadecylamine Consensus Reports

1-Hexadecylamine Standards and Recommendations

1-Hexadecylamine Specification

Related Products

Hot Products