2-(2-Methoxyphenoxy)ethylamine supplier

Name
2-(2-Methoxyphenoxy)ethylamine
EINECS 606-000-2
CAS No. 1836-62-0
Article Data28
CAS DataBase
Density 1.06 g/cm³
Solubility
Melting Point
Formula C₉H₁₃NO₂
Boiling Point 261.1 °C at 760 mmHg
Molecular Weight 167.208
Flash Point 120.7 °C
Transport Information UN 2735
Appearance Colorless or slightly yellowish liquid
Safety
Risk Codes 22
Molecular Structure
Hazard Symbols Xi
Synonyms Ethylamine,2-(o-methoxyphenoxy)- (7CI,8CI);2-(o-Methoxyphenoxy)ethylamine;Guaiacoxyethylamine;
PSA 44.48000
LogP 1.73300

Synthetic route

: N-[2-(2-methoxyphenoxy)ethyl]acetamide

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

Conditions

Conditions	Yield
With hydrogenchloride for 21h; Reflux;	100%
Stage #1: N-[2-(2-methoxyphenoxy)ethyl]acetamide With hydrogenchloride; water for 4h; Heating / reflux; Stage #2: With sodium hydroxide In water pH=8 - 9;	74.8%

: 64464-07-9
2-[(2-methoxy)phenoxy]ethylamine hydrochloride

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

Conditions

Conditions	Yield
With sodium hydroxide In water at 0℃; pH=12 - 14;	97%

: 26646-63-9
2-[2-(2-methoxyphenoxy)ethyl]-1H-isoindole-1,3(2H)-dione

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

Conditions

Conditions	Yield
With sodium hydroxide In water at 110℃; for 7h;	91.2%
With hydrazine hydrate In water at 20℃; for 5h; Gabriel synthesis;	86%
With hydrazine hydrate; acetic acid In methanol for 4h; Reflux;	86%

: 214778-48-0
2-(2-Methoxy-phenoxy)-ethyl-carbamic acid tert-butyl ester

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

Conditions

Conditions	Yield
Stage #1: 2-(2-Methoxy-phenoxy)-ethyl-carbamic acid tert-butyl ester With hydrogenchloride In 1,4-dioxane for 2h; Heating / reflux; Stage #2: With sodium hydroxide In water; ethyl acetate	90%
With trifluoroacetic acid In dichloromethane	88%

: 183427-87-4
2-(2-methoxyphenoxy)acetamide

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

Conditions

Conditions	Yield
With dimethylsulfide borane complex In tetrahydrofuran at 90℃; for 16h; Inert atmosphere;	88%
With dimethylsulfide borane complex In diethylene glycol dimethyl ether at 90℃; for 18h;	55%
With diethylene glycol dimethyl ether; diborane

: 4463-59-6
2-(methoxyphenoxy)ethylbromide

A: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

B: 3258-70-6
2-(2-methoxyphenoxy)-N-[2-(2-methoxyphenoxy)ethyl]ethanamine

Conditions

Conditions	Yield
With ammonia

: 90-05-1
2-methoxy-phenol

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: aq. NaOH / 7 h / 100 °C 2: dimethylformamide / Heating 3: NH2NH2*H2O / ethanol / Heating View Scheme
Multi-step reaction with 2 steps 1.1: NaOEt / ethanol / 0.5 h / Heating 1.2: 83 percent / KI / ethanol / Heating 2.1: 55 percent / BH3*Me2S / bis-(2-methoxy-ethyl) ether / 18 h / 90 °C View Scheme
Multi-step reaction with 3 steps 1: NaOH / H2O / 100 °C 2: dimethylformamide / 0.5 h 3: hydrazine hydrate / ethanol / 0.75 h / Heating View Scheme

: 4463-59-6
2-(methoxyphenoxy)ethylbromide

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dimethylformamide / Heating 2: NH2NH2*H2O / ethanol / Heating View Scheme
Multi-step reaction with 2 steps 1: dimethylformamide / 0.5 h 2: hydrazine hydrate / ethanol / 0.75 h / Heating View Scheme
Stage #1: 2-(methoxyphenoxy)ethylbromide With 18-crown-6 ether; potassium phtalimide In N,N-dimethyl-formamide at 50℃; for 3h; Gabriel Amine Synthesis; Stage #2: With methylamine In water at 50℃; for 2h; Gabriel Amine Synthesis; Stage #3: With sodium hydroxide In water at 20℃; for 1h; Gabriel Amine Synthesis;
Multi-step reaction with 2 steps 1.1: 18-crown-6 ether / N,N-dimethyl-formamide / 3 h / 50 °C 2.1: methylamine / water / 2 h / 50 °C 2.2: 1 h / 20 °C View Scheme

: 136918-14-4
phthalimide

: 53815-60-4
1-(2-chloroethoxy)-2-methoxybenzene

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

Conditions

Conditions	Yield
With water; sodium hydroxide at 130℃; for 13h;

: 53815-60-4
1-(2-chloroethoxy)-2-methoxybenzene

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: tetrabutylammomium bromide / 180 - 185 °C 2: water; potassium hydroxide / 13 h / 130 °C View Scheme

: 18181-71-0
2-(2-methoxyphenoxy)ethanol

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: thionyl chloride / dichloromethane / 2 h / 0 - 30 °C 2: N,N-dimethyl-formamide / 3 h / 170 °C 3: sodium hydroxide / water / 7 h / 110 °C View Scheme

: 682-76-8
vinyl-phosphonic acid dibutyl ester

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

: dibutyl β-[β'-(2-methoxyphenoxy)ethylamino]ethylphosphonate

Conditions

Conditions	Yield
In ethanol at 60 - 70℃; Addition;	87%

: 27866-06-4
(adamantan-1-ylmethoxy-methyl)-oxirane

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

: 1479050-25-3
1-(adamantan-1-ylmethoxy)-3-{[2-(2-methoxyphenoxy)-ethyl]amino}-2-propanol

Conditions

Conditions	Yield
In isopropyl alcohol Reflux;	87%

: 2461-42-9
3-(1-naphthyloxy)-1,2-epoxypropane

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

: 1479050-16-2
1-((2-(2-methoxyphenoxy)ethyl)amino)-3-(naphthalen-1-yloxy)propan-2-ol

Conditions

Conditions	Yield
In isopropyl alcohol for 5h; Inert atmosphere; Reflux;	86%
In isopropyl alcohol Reflux;	38%

: 141-30-0
3,6-dichlorpyridazine

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

: C13H14ClN3O2

Conditions

Conditions	Yield
In ethanol	84.3%
In ethanol Solvent; Heating; Reflux;	84.3%

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

: 25888-01-1
1,2-dimethyl-5-hydroxy-1H-indole-3-carboxylic acid

: N-[2-(2-methoxyphenoxy)ethyl]-1,2-dimethyl-5-hydroxy-1H-indole-3-carboxamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane; N,N-dimethyl-formamide at 20℃; for 16h;	83.2%

: 1047632-41-6
4-(3-bromopropoxy)-9H-carbazole

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

: 3-((9H-carbazol-4-yl)oxy)-N-(2-(2-methoxyphenoxy)ethyl)propan-1-amine

Conditions

Conditions	Yield
In acetonitrile for 5h; Inert atmosphere; Reflux;	83%
With potassium iodide In acetonitrile for 5h; Reflux; Inert atmosphere;	73%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere;	19%

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

: 1204700-40-2
(S)-5-methoxy-4-(oxiran-2-yl methoxy)-1H-indole

: 1204700-46-8
(2S)-1-(5-methoxy-1H-indol-4-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol

Conditions

Conditions	Yield
In acetonitrile at 80℃;	82%

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

: 1204700-41-3
(R)-5-methoxy-4-(oxiran-2-yl methoxy)-1H-indole

: 1204700-47-9
(2R)-1-(5-methoxy-1H-indol-4-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol

Conditions

Conditions	Yield
In acetonitrile at 80℃;	82%

: 5234-06-0
[(2-naphthalenyloxy)methyl]oxirane

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

: 1-((2-(2-methoxyphenoxy)ethyl)amino)-3-(naphthalen-2-yloxy)propan-2-ol

Conditions

Conditions	Yield
In isopropyl alcohol for 5h; Inert atmosphere; Reflux;	82%

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

: 51997-51-4
4-(2,3-epoxypropoxy)carbazole

: 72956-09-3
carvedilol

Conditions

Conditions	Yield
In isopropyl alcohol for 5h; Inert atmosphere; Reflux;	81%
With N-ethyl-N,N-diisopropylamine In 1,2-dimethoxyethane at 80 - 85℃;	36.26%
With sulfuric acid; potassium carbonate In isopropyl alcohol at 80℃; for 6h;

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

: 144-62-7
oxalic acid

: 51997-51-4
4-(2,3-epoxypropoxy)carbazole

: 72956-09-3
(+/-) 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethyl]amino-2-propanol oxalate

Conditions

Conditions	Yield
Stage #1: 2-(2-methoxy-phenoxy)-ethylamine; 4-(2,3-epoxypropoxy)carbazole In isopropyl alcohol at 70 - 85℃; for 1h; Stage #2: oxalic acid In isopropyl alcohol at 50 - 85℃; for 3h; Heating / reflux;	80.95%

...Expand

: 4698-96-8
2,3-epoxy-1-(4-phenylphenoxy)propane

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

: 1-([1,1'-biphenyl]-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol

Conditions

Conditions	Yield
In isopropyl alcohol for 5h; Inert atmosphere; Reflux;	78%

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

: 144-62-7
oxalic acid

: 72956-09-3
(+/-) 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethyl]amino-2-propanol oxalate

Conditions

Conditions	Yield
Stage #1: 2-(2-methoxy-phenoxy)-ethylamine; 4-(2,3-epoxypropoxy)carbazole In chlorobenzene at 125℃; for 3h; Heating / reflux; Stage #2: oxalic acid In water; chlorobenzene at 60 - 70℃; for 1h; pH=2.5 - 2.7;	77%
Stage #1: 2-(2-methoxy-phenoxy)-ethylamine; 4-(2,3-epoxypropoxy)carbazole In chlorobenzene at 125℃; for 3h; Heating / reflux; Stage #2: oxalic acid In Isopropyl acetate; water at 20 - 50℃; for 3h; pH=2 - 2.5;	74.6%

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

: trans-5-phenyl-1,4-dioxane-2-carboxylic acid

: trans-N-(2-(2-methoxyphenoxy)ethyl)-5-phenyl-1,4-dioxane-2-carboxamide

Conditions

Conditions	Yield
Stage #1: trans-5-phenyl-1,4-dioxane-2-carboxylic acid With chloroformic acid ethyl ester; triethylamine In chloroform at 0℃; for 0.5h; Stage #2: 2-(2-methoxy-phenoxy)-ethylamine In chloroform at 20℃; for 3h;	77%

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

: 1204700-39-9
5-methoxy-4-(oxiran-2-yl methoxy)-1H-indole

: 1204700-45-7
(2RS)-1-(5-methoxy-1H-indol-4-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol

Conditions

Conditions	Yield
In acetonitrile at 80℃;	77%

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

: 1204700-37-7
(S)-7-methoxy-4-(oxiran-2-ylmethoxy)-1H-indole

: 1204700-43-5
(2S)-1-(7-methoxy-1H-indol-4-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)-propan-2-ol

Conditions

Conditions	Yield
In acetonitrile at 80℃;	77%

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

: 90402-61-2
Ethyl 2-<6-chloro-1,3-dimethyl-2,4(1H,3H)-dioxopyrimidine-5-yl>-2-acrylate

: E-ethyl <6-<2-(2-methoxyphenoxy)ethylamino>-1,3-dimethyl-2,4(1H,3H)-dioxo-5-pyrimidinylacrylate>

Conditions

Conditions	Yield
With triethylamine In ethanol for 24h; Ambient temperature;	76%

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

: 244123-12-4
2-(2-(benzyloxy)phenoxy)acetic acid

: 1255188-26-1
2-(2-(benzyloxy)phenoxy)-N-(2-(2-methoxyphenoxy) ethyl)acetamide

Conditions

Conditions	Yield
Stage #1: 2-(2-(benzyloxy)phenoxy)acetic acid With chloroformic acid ethyl ester; triethylamine In chloroform at 0℃; for 0.5h; Stage #2: 2-(2-methoxy-phenoxy)-ethylamine In chloroform at 20℃; for 3h;	76%

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

: 95093-95-1
S-(+)-4-(oxiranylmethoxy)-9H-carbazole

: 95094-00-1, 72956-09-3, 95093-99-5, 107741-96-8
(-)-Carvedilol

Conditions

Conditions	Yield
In isopropyl alcohol for 2h; Reflux; Inert atmosphere;	76%
In isopropyl alcohol for 4h; Reflux;	70%

: 109-09-1
2-chloropyridine

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

: N‑(2‑(2‑methoxyphenoxy)ethyl)‑N‑(pyridin‑2‑yl)pyridin‑2‑amine

Conditions

Conditions	Yield
With triethylamine In methanol at 25℃; for 72h; Inert atmosphere; Schlenk technique;	76%

: 1,2,3,4-tetrahydro-5-(2,3-epoxy-propoxy)-carbazole

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

: 1479050-01-5
1-{[2-(2-methoxyphenoxy)ethyl]amino}-3-(2,3,4,9-tetrahydro-1H-carbazol-6-yloxy)-2-propanol

Conditions

Conditions	Yield
In isopropyl alcohol Reflux;	75%

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

: 3-[3,4-bis(benzyloxy)phenoxy]propylbromide

: 3-[3,4-bis(benzyloxy)phenoxy]-N-[2-(2-methoxyphenoxy)ethyl]propan-1-amine

Conditions

Conditions	Yield
With potassium iodide In acetonitrile for 5h; Reflux; Inert atmosphere;	75%

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

: 120351-75-9
N-[4-(4-Chloro-1-cyano-1-isopropyl-butyl)-phenyl]-acetamide

: 120351-13-5
N-(4-{1-Cyano-1-isopropyl-4-[2-(2-methoxy-phenoxy)-ethylamino]-butyl}-phenyl)-acetamide

Conditions

Conditions	Yield
at 95℃;	74%

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

: 67579-92-4
3-methoxy-4-nitrobenzoic acid chloride

: N-[2-(2-methoxyphenoxy)ethyl]-3-methoxy-4-nitrobenzamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane	74%

: 1836-62-0
2-(2-methoxy-phenoxy)-ethylamine

: cis-3-phenyl-1,4-dioxane-2-carboxylic acid

: cis-N-(2-(2-methoxyphenoxy)ethyl)-3-phenyl-1,4-dioxane-2-carboxamide

Conditions

Conditions	Yield
Stage #1: cis-3-phenyl-1,4-dioxane-2-carboxylic acid With chloroformic acid ethyl ester; triethylamine In chloroform at 0℃; for 0.5h; Stage #2: 2-(2-methoxy-phenoxy)-ethylamine In chloroform at 20℃; for 3h;	74%

2-(2-Methoxyphenoxy)ethylamine Chemical Properties

IUPAC Name: 2-(2-Methoxyphenoxy)ethanamine
Following is the structure of Ethanamine,2-(2-methoxyphenoxy)- (CAS NO.1836-62-0):

Empirical Formula: C₉H₁₃NO₂
Molecular Weight: 167.205
Index of Refraction: 1.518
Molar Refractivity: 47.77 cm³
Molar Volume: 157.6 cm³
Density: 1.06 g/cm³
Flash Point: 120.7 °C
Surface Tension: 37.2 dyne/cm
Enthalpy of Vaporization: 49.88 kJ/mol
Boiling Point: 261.1 °C at 760 mmHg
Vapour Pressure of Ethanamine,2-(2-methoxyphenoxy)- (CAS NO.1836-62-0): 0.0118 mmHg at 25 °C
Product Categories of Ethanamine,2-(2-methoxyphenoxy)- (CAS NO.1836-62-0): Anilines, Aromatic Amines and Nitro Compounds; Amines; (intermediate of carvedilol); Carvedilol Intermediate
Canonical SMILES: COC1=CC=CC=C1OCCN
InChI: InChI=1S/C9H13NO2/c1-11-8-4-2-3-5-9(8)12-7-6-10/h2-5H,6-7,10H2,1H3
InChIKey: CKJRKLKVCHMWLV-UHFFFAOYSA-N

2-(2-Methoxyphenoxy)ethylamine Safety Profile

Hazard Codes: Irritant Xi
RIDADR: UN2735
HazardClass: 8
PackingGroup: III

2-(2-Methoxyphenoxy)ethylamine Specification

Ethanamine,2-(2-methoxyphenoxy)- , its cas register number 1836-62-0. It also can be called 2-(2-Methoxyphenoxy)ethanamin ; and 2-(2-Methoxyphenoxy)ethanamine .

Product Name

2-(2-Methoxyphenoxy)ethylamine

Synthetic route

2-(2-Methoxyphenoxy)ethylamine Chemical Properties

2-(2-Methoxyphenoxy)ethylamine Safety Profile

2-(2-Methoxyphenoxy)ethylamine Specification

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