• Name

  2-(4-Aminophenyl)-1H-benzimidazol-5-amine

• EINECS 231-538-6
• CAS No. 7621-86-5
• Article Data21
• CAS DataBase
• Density 1.359 g/cm³
• Solubility
• Melting Point 234.0 to 238.0 °C
• Formula C₁₃H₁₂N₄
• Boiling Point 545.5 °C at 760 mmHg
• Molecular Weight 224.265
• Flash Point 317.6 °C
• Transport Information
• Appearance
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms 2-(4-Aminophenyl)-5-aminobenzimidazole;5(6)-Amino-2-(p-aminophenyl)benzimidazole;5-Amino-2-(4-aminophenyl)benzimidazole;1H-Benzimidazol-5-amine,2-(4-aminophenyl)- (9CI);Benzimidazole, 5(or 6)-amino-2-(p-aminophenyl)-(6CI);Benzimidazole, 5-amino-2-(p-aminophenyl)- (8CI);
• PSA 80.72000
• LogP 3.55670

Synthetic route

1772-39-0

5-nitro-2-(4-nitrophenyl)-1H-benzimidazole

7621-86-5

2-(4-aminophenyl)-5-amino-benzimidazole

Conditions

Conditions	Yield
With sodium sulfide; phosphoric acid In water at 100℃; for 12h; pH=< 1;	96%
With hydrogenchloride; tin(ll) chloride

37632-91-0

2',4',4-trinitrobenzanilide

7621-86-5

2-(4-aminophenyl)-5-amino-benzimidazole

Conditions

Conditions	Yield
With 5%-palladium/activated carbon; hydrogen In ethanol at 80℃; under 60006 Torr; for 5h; Autoclave;	93.5%
With hydrogenchloride; tin(ll) chloride
With hydrogenchloride; tin(ll) chloride
Multi-step reaction with 2 steps 1: hydrogenchloride; iron / 90 - 95 °C 2: 250 °C / im Vakuum View Scheme

60779-50-2

2',4',4-Triaminobenzanilide

7621-86-5

2-(4-aminophenyl)-5-amino-benzimidazole

Conditions

Conditions	Yield
at 250℃; im Vakuum;
at 250℃; im Vakuum;

7647-01-0

hydrogenchloride

37632-91-0

2',4',4-trinitrobenzanilide

SnCl2

SnCl2

7621-86-5

2-(4-aminophenyl)-5-amino-benzimidazole

...Expand

3460-11-5

4-nitrobenzanilide

7621-86-5

2-(4-aminophenyl)-5-amino-benzimidazole

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: sulfuric acid; nitric acid / 5 - 10 °C 3: 250 °C / im Vakuum View Scheme
Multi-step reaction with 3 steps 1: sulfuric acid; nitric acid / 5 - 10 °C 2: hydrogenchloride; iron / 90 - 95 °C 3: 250 °C / im Vakuum View Scheme

555-16-8

4-nitrobenzaldehdye

7621-86-5

2-(4-aminophenyl)-5-amino-benzimidazole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: acetic acid 2: SnCl2; aqueous methanol.HCl View Scheme

99-56-9

4-Nitrophenylene-1,2-diamine

7621-86-5

2-(4-aminophenyl)-5-amino-benzimidazole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: acetic acid 2: SnCl2; aqueous methanol.HCl View Scheme

615-47-4

benzene-1,2,4-triamine dihydrochloride

150-13-0

4-amino-benzoic acid

7621-86-5

2-(4-aminophenyl)-5-amino-benzimidazole

Conditions

Conditions	Yield
With methanesulfonic acid; tin(II) chloride dihdyrate In para-xylene; water for 8.25h; Solvent; Dean-Stark; Reflux; Inert atmosphere;

97-02-9

2,4-Dinitroanilin

7621-86-5

2-(4-aminophenyl)-5-amino-benzimidazole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: Degussa F101 catalyst; hydrogen / ethanol / 2 h / 70 °C / 5171.62 Torr / Autoclave; Inert atmosphere 1.2: 15 °C 2.1: tin(II) chloride dihdyrate; methanesulfonic acid / para-xylene; water / 8.25 h / Dean-Stark; Reflux; Inert atmosphere View Scheme

62-23-7

4-nitro-benzoic acid

97-02-9

2,4-Dinitroanilin

7621-86-5

2-(4-aminophenyl)-5-amino-benzimidazole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: boric acid / toluene / 6 h / Reflux 2: 5%-palladium/activated carbon; hydrogen / ethanol / 5 h / 80 °C / 60006 Torr / Autoclave View Scheme

7621-86-5

2-(4-aminophenyl)-5-amino-benzimidazole

90-02-8

salicylaldehyde

377059-64-8

C27H20N4O2

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 50℃; for 4h; Inert atmosphere;	99%

7621-86-5

2-(4-aminophenyl)-5-amino-benzimidazole

41567-99-1

4-(4'-nitrophenyl)benzoyl chloride

C39H26N6O6

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 24h;	78%

7621-86-5

2-(4-aminophenyl)-5-amino-benzimidazole

96-73-1

2-chloro-5-nitro-benzenesulfonic acid

4'-(5(6)-aminobenzimidazol-2-yl)-4-nitro-2-sulfodiphenylamine

Conditions

Conditions	Yield
With magnesium oxide In N,N-dimethyl acetamide; water at 110 - 140℃; for 15h;

7,7'-methylenebis(2-phenyl-3,1-benzoxazin-4-one)

7621-86-5

2-(4-aminophenyl)-5-amino-benzimidazole

polymer; monomer(s): 7,7\-methylenebis(2-phenyl-3,1-benzoxazin-4-one); 5-amino-2-(4-aminophenyl)benzimidazole

polymer; monomer(s): 7,7\-methylenebis(2-phenyl-3,1-benzoxazin-4-one); 5-amino-2-(4-aminophenyl)benzimidazole

Conditions

Conditions	Yield
With phosphorus pentoxide In various solvent(s) at 20 - 180℃; for 10h;

7621-86-5

2-(4-aminophenyl)-5-amino-benzimidazole

7158-32-9

4,4'-bis(chlorocarbonyl)diphenyl oxide

polymer; monomer(s): 4,4\-bis(chlorocarbonyl)diphenyl oxide; 5-amino-2-(4-aminophenyl)benzimidazole

polymer; monomer(s): 4,4\-bis(chlorocarbonyl)diphenyl oxide; 5-amino-2-(4-aminophenyl)benzimidazole

Conditions

Conditions	Yield
In N,N-dimethyl acetamide at -10 - 20℃;

7621-86-5

2-(4-aminophenyl)-5-amino-benzimidazole

dianhydride of bis(3,4-dicarboxyphenyl)resorcinol ether

polymer; monomer(s): 5,5\-(1,3-phenylenedioxy)bis(1,3-isobenzofurandione); 5-amino-2-(4-aminophenyl)benzimidazole

polymer; monomer(s): 5,5\-(1,3-phenylenedioxy)bis(1,3-isobenzofurandione); 5-amino-2-(4-aminophenyl)benzimidazole

Conditions

Conditions	Yield
Stage #1: 2-(4-aminophenyl)-5-amino-benzimidazole; dianhydride of bis(3,4-dicarboxyphenyl)resorcinol ether In 1-methyl-pyrrolidin-2-one at 20℃; for 8h; Stage #2: With pyridine; acetic anhydride; triethylamine In 1-methyl-pyrrolidin-2-one at 20 - 60℃; for 12h;

7621-86-5

2-(4-aminophenyl)-5-amino-benzimidazole

1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

polymer, prepared by chemical condensation of polyamido acid; monomer(s): 5,5\-hexafluoroisopropylidenebis(1,3-isobenzofurandione); 5-amino-2-(4-aminophenyl)benzimidazole

polymer, prepared by chemical condensation of polyamido acid; monomer(s): 5,5\-hexafluoroisopropylidenebis(1,3-isobenzofurandione); 5-amino-2-(4-aminophenyl)benzimidazole

Conditions

Conditions	Yield
Stage #1: 2-(4-aminophenyl)-5-amino-benzimidazole; 4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride In 1-methyl-pyrrolidin-2-one at 20℃; for 8h; Stage #2: With pyridine; acetic anhydride; triethylamine In 1-methyl-pyrrolidin-2-one at 20 - 60℃; for 12h;

7621-86-5

2-(4-aminophenyl)-5-amino-benzimidazole

1107-00-2

4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride

polymer, prepared by cyclodehydration of polyamido acid in N-methylpyrrolidone and toluene at 170 deg C; monomer(s): 5,5\-hexafluoroisopropylidenebis(1,3-isobenzofurandione); 5-amino-2-(4-aminophenyl)benzimidazole

polymer, prepared by cyclodehydration of polyamido acid in N-methylpyrrolidone and toluene at 170 deg C; monomer(s): 5,5\-hexafluoroisopropylidenebis(1,3-isobenzofurandione); 5-amino-2-(4-aminophenyl)benzimidazole

Conditions

Conditions	Yield
Stage #1: 2-(4-aminophenyl)-5-amino-benzimidazole; 4,4'-(1,1,1,3,3,3-hexafluoroisopropylidene)diphthalic anhydride In 1-methyl-pyrrolidin-2-one at 20℃; for 8h; Stage #2: In 1-methyl-pyrrolidin-2-one; toluene at 170℃;

7621-86-5

2-(4-aminophenyl)-5-amino-benzimidazole

4-amino-4'-(5(6)-aminobenzimidazol-2-yl)-2-sulfodiphenylamine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: MgO / H2O; N,N-dimethyl-acetamide / 15 h / 110 - 140 °C 2: 55 percent / Fe, HCl / H2O View Scheme

2-(4-Aminophenyl)-1H-benzimidazol-5-amine Chemical Properties

2-(4-Aminophenyl)-1H-benzimidazol-5-amine Uses

2-(4-Aminophenyl)-1H-benzimidazol-5-amine Toxicity Data With Reference

2-(4-Aminophenyl)-1H-benzimidazol-5-amine Consensus Reports

2-(4-Aminophenyl)-1H-benzimidazol-5-amine Safety Profile

2-(4-Aminophenyl)-1H-benzimidazol-5-amine Specification