2,2,3,3-Tetrafluorooxetane supplier

Name
2,2,3,3-Tetrafluorooxetane
EINECS
CAS No. 765-63-9
Density 1.482 g/cm³
Solubility
Melting Point
Formula C₃H₂F₄O
Boiling Point -15.774 °C at 760 mmHg
Molecular Weight 130.042
Flash Point -74.22 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 2,2,3,3-TETRAFLUOROOXETANE;2,2,3,3-Tetrafluorooxacyclobutane
PSA 9.23000
LogP 1.24470

Synthetic route

: 116-14-3
polytetrafluoroethylene

: 765-63-9
2,2,3,3-tetrafluorooxetane

Conditions

Conditions	Yield
With paraformaldehyde In hydrogen fluoride

: 50-00-0
formaldehyd

: 75-89-8
2,2,2-trifluoroethanol

: 765-63-9
2,2,3,3-tetrafluorooxetane

Conditions

Conditions	Yield
With hydrogen fluoride

: 116-14-3
polytetrafluoroethylene

: 50-00-0
formaldehyd

: 765-63-9
2,2,3,3-tetrafluorooxetane

Conditions

Conditions	Yield
With hydrogen fluoride; trifluoroacetic acid at 50℃; under 6600.66 Torr; for 12h; Product distribution / selectivity; autoclave;
With 2,2,3,3,3-pentafluoropropyl trifluoroacetic acid ester; hydrogen fluoride at 50℃; under 6600.66 Torr; for 12h; Product distribution / selectivity; autoclave;
With 2,2,2-trifluoroethyl trifluoroacetate; hydrogen fluoride at 50℃; under 6600.66 Torr; for 12h; Product distribution / selectivity; autoclave;
With hydrogen fluoride at 50℃; under 6600.66 Torr; for 12h; Product distribution / selectivity; autoclave;

: 765-63-9
2,2,3,3-tetrafluorooxetane

: 99497-42-4
2,2-difluoro-3-iodopropionyl fluoride

Conditions

Conditions	Yield
With sodium iodide	94%
With sodium iodide In water
With sodium iodide

: 6738-06-3
phenylethynylmagnesium bromide

: 765-63-9
2,2,3,3-tetrafluorooxetane

: 1319010-93-9
3-bromo-2,2-difluoro-1,1-bis(phenylethynyl)propan-1-ol

Conditions

Conditions	Yield
Stage #1: phenylethynylmagnesium bromide; 2,2,3,3-tetrafluorooxetane In tetrahydrofuran at -20 - 20℃; for 20h; Inert atmosphere; Stage #2: With ammonium chloride In tetrahydrofuran; water	91%

: 765-63-9
2,2,3,3-tetrafluorooxetane

: 64-17-5
ethanol

: C5H7F2IO2

Conditions

Conditions	Yield
With sodium iodide In chloroform at 50℃; for 2h; Solvent; Cooling with ice;	90.8%

: 765-63-9
2,2,3,3-tetrafluorooxetane

: 64-17-5
ethanol

: 127-09-3
sodium acetate

: 380-41-6
ethyl 2,2-difluoro-3-hydroxypropanoate

Conditions

Conditions	Yield
Stage #1: 2,2,3,3-tetrafluorooxetane; ethanol; sodium acetate at 45 - 70℃; for 2h; Reflux; Stage #2: With sulfuric acid for 8h; Reflux; Stage #3: With sodium hydrogencarbonate In water	81.8%

...Expand

: 765-63-9
2,2,3,3-tetrafluorooxetane

: 60-29-7
diethyl ether

: 111773-24-1
3-bromo-2,2-difluoropropionic acid ethyl ester

Conditions

Conditions	Yield
With magnesium bromide at 0 - 20℃; for 3h; Inert atmosphere;	81%

: 765-63-9
2,2,3,3-tetrafluorooxetane

: 4039-82-1
Benzyl propargyl ether

: 1319010-73-5
2,2-difluoro-1,1,3-tris(3-benzyloxyprop-1-ynyl)propan-1-ol

Conditions

Conditions	Yield
Stage #1: Benzyl propargyl ether With n-butyllithium In tetrahydrofuran; hexane at -20℃; for 0.25h; Inert atmosphere; Stage #2: 2,2,3,3-tetrafluorooxetane In tetrahydrofuran; hexane at -20℃; for 2h; Inert atmosphere; Stage #3: With ammonium chloride In tetrahydrofuran; hexane; water	78%

: 765-63-9
2,2,3,3-tetrafluorooxetane

: 100-58-3
phenylmagnesium bromide

: 1319010-86-0
3-bromo-2,2-difluoro-1,1-diphenylpropan-1-ol

Conditions

Conditions	Yield
Stage #1: 2,2,3,3-tetrafluorooxetane; phenylmagnesium bromide In tetrahydrofuran at -20 - 20℃; for 20h; Inert atmosphere; Stage #2: With ammonium chloride In tetrahydrofuran; water	78%

: 765-63-9
2,2,3,3-tetrafluorooxetane

: 4294-57-9
para-methylphenylmagnesium bromide

: 1319010-89-3
3-bromo-2,2-difluoro-1,1-bis(4-methylphenyl)propan-1-ol

Conditions

Conditions	Yield
Stage #1: 2,2,3,3-tetrafluorooxetane; para-methylphenylmagnesium bromide In tetrahydrofuran at -20 - 20℃; for 20h; Inert atmosphere; Stage #2: With ammonium chloride In tetrahydrofuran; water	78%

: 765-63-9
2,2,3,3-tetrafluorooxetane

: 1066-54-2
trimethylsilylacetylene

: 1319010-74-6
2,2-difluoro-1,1,3-tris(2-trimethylsilylethynyl)propan-1-ol

Conditions

Conditions	Yield
Stage #1: trimethylsilylacetylene With n-butyllithium In tetrahydrofuran; hexane at -20℃; for 0.25h; Inert atmosphere; Stage #2: 2,2,3,3-tetrafluorooxetane In tetrahydrofuran; hexane at -20℃; for 2h; Inert atmosphere; Stage #3: With ammonium chloride In tetrahydrofuran; hexane; water	78%

: 765-63-9
2,2,3,3-tetrafluorooxetane

: 536-74-3
phenylacetylene

: 1319010-70-2
2,2-difluoro-1,1,3-tris(2-phenylethynyl)propan-1-ol

Conditions

Conditions	Yield
Stage #1: phenylacetylene With n-butyllithium In tetrahydrofuran; hexane at -20℃; for 0.25h; Inert atmosphere; Stage #2: 2,2,3,3-tetrafluorooxetane In tetrahydrofuran; hexane at -20℃; for 2h; Inert atmosphere; Stage #3: With ammonium chloride In tetrahydrofuran; hexane; water	77%

: 109-99-9
tetrahydrofuran

: 765-63-9
2,2,3,3-tetrafluorooxetane

: 1319010-98-4
4-iodobutyl 3-iodo-2,2-difluoropropanoate

Conditions

Conditions	Yield
With magnesium iodide at 0 - 20℃; for 3h; Inert atmosphere;	76%

: 765-63-9
2,2,3,3-tetrafluorooxetane

: 693-02-7
hex-1-yne

: 1319010-76-8
2,2-difluoro-1,1,3-tri(hex-1-ynyl)propan-1-ol

Conditions

Conditions	Yield
Stage #1: hex-1-yne With n-butyllithium In tetrahydrofuran; hexane at -20℃; for 0.25h; Inert atmosphere; Stage #2: 2,2,3,3-tetrafluorooxetane In tetrahydrofuran; hexane at -20℃; for 2h; Inert atmosphere; Stage #3: With ammonium chloride In tetrahydrofuran; hexane; water	73%

: 109-99-9
tetrahydrofuran

: 765-63-9
2,2,3,3-tetrafluorooxetane

: 1319010-96-2
4-bromobutyl 3-bromo-2,2-difluoropropanoate

Conditions

Conditions	Yield
With magnesium bromide at 0 - 20℃; for 3h; Inert atmosphere;	70%

: 765-63-9
2,2,3,3-tetrafluorooxetane

: 13139-86-1
4-methoxyphenyl magnesium bromide

: 1319010-88-2
3-bromo-2,2-difluoro-1,1-bis(4-methoxyphenyl)propan-1-ol

Conditions

Conditions	Yield
Stage #1: 2,2,3,3-tetrafluorooxetane; 4-methoxyphenyl magnesium bromide In tetrahydrofuran at -20 - 20℃; for 20h; Inert atmosphere; Stage #2: With ammonium chloride In tetrahydrofuran; water	69%

: 765-63-9
2,2,3,3-tetrafluorooxetane

: 13735-81-4
1-styrenyloxytrimethylsilane

: 1319011-05-6
5-bromo-4,4-difluoro-1-hydroxy-1-phenylpent-1-en-3-one

Conditions

Conditions	Yield
Stage #1: 1-styrenyloxytrimethylsilane With methyllithium In tetrahydrofuran at -78 - 0℃; for 0.5h; Inert atmosphere; Stage #2: 2,2,3,3-tetrafluorooxetane In tetrahydrofuran at -78 - 20℃; for 2h; Inert atmosphere; Stage #3: With ammonium chloride In tetrahydrofuran; water	66%

: 765-63-9
2,2,3,3-tetrafluorooxetane

: 58518-76-6
((1-(4-chlorophenyl)vinyl)oxy)trimethylsilane

: 1319011-16-9
5-bromo-4,4-difluoro-1-hydroxy-1-(4-chlorophenyl)pent-1-en-3-one

Conditions

Conditions	Yield
Stage #1: ((1-(4-chlorophenyl)vinyl)oxy)trimethylsilane With methyllithium In tetrahydrofuran at -78 - 0℃; for 0.5h; Inert atmosphere; Stage #2: 2,2,3,3-tetrafluorooxetane In tetrahydrofuran at -78 - 20℃; for 2h; Inert atmosphere; Stage #3: With ammonium chloride In tetrahydrofuran; water	65%

: 765-63-9
2,2,3,3-tetrafluorooxetane

: 62889-07-0
trimethyl((1-(thiophen-2-yl)vinyl)oxy)silane

: 1319011-21-6
5-bromo-4,4-difluoro-1-hydroxy-1-(2-thienyl)pent-1-en-3-one

Conditions

Conditions	Yield
Stage #1: trimethyl((1-(thiophen-2-yl)vinyl)oxy)silane With methyllithium In tetrahydrofuran at -78 - 0℃; for 0.5h; Inert atmosphere; Stage #2: 2,2,3,3-tetrafluorooxetane In tetrahydrofuran at -78 - 20℃; for 2h; Inert atmosphere; Stage #3: With ammonium chloride In tetrahydrofuran; water	64%

: 765-63-9
2,2,3,3-tetrafluorooxetane

: 105-53-3
diethyl malonate

: 1319011-24-9
4,4-bis(ethoxycarbonyl)-2,2-difluorobutanamide

Conditions

Conditions	Yield
Stage #1: diethyl malonate With sodium hydride In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere; Stage #2: 2,2,3,3-tetrafluorooxetane In tetrahydrofuran at 0 - 20℃; for 2h; Inert atmosphere; Stage #3: With ammonium chloride In tetrahydrofuran; water	63%

: 765-63-9
2,2,3,3-tetrafluorooxetane

: 2358-54-5
2,2,2-trifluoroethoxyethanol

: 1413922-80-1
C11H14F8O5

Conditions

Conditions	Yield
Stage #1: 2,2,2-trifluoroethoxyethanol With sodium hydride In dichloromethane at 40℃; for 1h; Stage #2: 2,2,3,3-tetrafluorooxetane In diethylene glycol dimethyl ether at 0 - 20℃; for 3h;	62%

: 765-63-9
2,2,3,3-tetrafluorooxetane

: 54731-27-0
1-p-methylphenyl-1-trimethylsiloxyethene

: 1319011-14-7
5-bromo-4,4-difluoro-1-hydroxy-1-(4-methylphenyl)pent-1-en-3-one

Conditions

Conditions	Yield
Stage #1: 1-p-methylphenyl-1-trimethylsiloxyethene With methyllithium In tetrahydrofuran at -78 - 0℃; for 0.5h; Inert atmosphere; Stage #2: 2,2,3,3-tetrafluorooxetane In tetrahydrofuran at -78 - 20℃; for 2h; Inert atmosphere; Stage #3: With ammonium chloride In tetrahydrofuran; water	60%

: 765-63-9
2,2,3,3-tetrafluorooxetane

: 928-51-8
4-Chloro-1-butanol

: 1413922-82-3
C11H18Cl2F2O3

Conditions

Conditions	Yield
Stage #1: 2,2,3,3-tetrafluorooxetane; 4-Chloro-1-butanol In diethylene glycol dimethyl ether at 90 - 100℃; for 32.5h; Stage #2: With sodium carbonate In diethylene glycol dimethyl ether	60%

: 765-63-9
2,2,3,3-tetrafluorooxetane

: 62889-08-1
1-(2-furyl)-1-(trimethylsilyloxy)ethylene

: 1319011-20-5
5-bromo-4,4-difluoro-1-hydroxy-1-(2-furyl)pent-1-en-3-one

Conditions

Conditions	Yield
Stage #1: 1-(2-furyl)-1-(trimethylsilyloxy)ethylene With methyllithium In tetrahydrofuran at -78 - 0℃; for 0.5h; Inert atmosphere; Stage #2: 2,2,3,3-tetrafluorooxetane In tetrahydrofuran at -78 - 20℃; for 2h; Inert atmosphere; Stage #3: With ammonium chloride In tetrahydrofuran; water	59%

: 765-63-9
2,2,3,3-tetrafluorooxetane

: 55991-65-6
[1-(4-methoxyphenyl)vinyloxy]trimethylsilane

: 1319011-12-5
5-bromo-4,4-difluoro-1-hydroxy-1-(4-methoxyphenyl)pent-1-en-3-one

Conditions

Conditions	Yield
Stage #1: [1-(4-methoxyphenyl)vinyloxy]trimethylsilane With methyllithium In tetrahydrofuran at -78 - 0℃; for 0.5h; Inert atmosphere; Stage #2: 2,2,3,3-tetrafluorooxetane In tetrahydrofuran at -78 - 20℃; for 2h; Inert atmosphere; Stage #3: With ammonium chloride In tetrahydrofuran; water	45%

: 765-63-9
2,2,3,3-tetrafluorooxetane

: 58518-77-7
((1-(4-fluorophenyl)vinyl)oxy)trimethylsilane

: 1319011-17-0
5-bromo-4,4-difluoro-1-hydroxy-1-(4-fluorophenyl)pent-1-en-3-one

Conditions

Conditions	Yield
Stage #1: ((1-(4-fluorophenyl)vinyl)oxy)trimethylsilane With methyllithium In tetrahydrofuran at -78 - 0℃; for 0.5h; Inert atmosphere; Stage #2: 2,2,3,3-tetrafluorooxetane In tetrahydrofuran at -78 - 20℃; for 2h; Inert atmosphere; Stage #3: With ammonium chloride In tetrahydrofuran; water	40%

: 765-63-9
2,2,3,3-tetrafluorooxetane

A: 425-82-1
2,2,3,3,4,4-hexafluorooxetane

B: 2,2,3,3,4-pentafluorooxetane

Conditions

Conditions	Yield
With hydrogen fluoride

: 765-63-9
2,2,3,3-tetrafluorooxetane

: 24807-55-4
3-nitro-1,2,4-triazole

: 121076-73-1
methyl 3-(3'-nitro-1',2',4'-triazol-1'-yl)-2,2-difluoropropionate

Conditions

Conditions	Yield
With sodium carbonate In methanol

2,2,3,3-Tetrafluorooxetane Specification

The 2, 2, 3, 3-Tetrafluorooxetane has CAS registry number 765-63-9. This chemical's molecular formula is C₃H₂F₄O and molecular weight is 130.041. What's more, its systematic name is 2, 2, 3, 3-Tetrafluorooxetane.

Physical properties about 2, 2, 3, 3-Tetrafluorooxetane are: (1)ACD/LogP: 0.28; (2)# of Rule of 5 Violations: 0; (3)#H bond acceptors: 1; (4)#H bond donors: 0; (5)#Freely Rotating Bonds: 0; (6)Polar Surface Area: 9.23 Å²; (7)Index of Refraction: 1.294; (8)Molar Refractivity: 16.12 cm³; (9)Molar Volume: 87.751 cm³; (10)Polarizability: 6.39×10^-24 cm³; (11)Surface Tension: 14.067 dyne/cm; (12)Density: 1.482 g/cm³; (13)Flash Point: -74.22 °C; (14)Enthalpy of Vaporization: 22.612 kJ/mol; (15)Boiling Point: -15.774 °C at 760 mmHg; (16)Vapour Pressure: 3066.063 mmHg at 25 °C.

You can still convert the following datas into molecular structure:
(1) SMILES: FC1(F)COC1(F)F
(2) InChI: InChI=1/C3H2F4O/c4-2(5)1-8-3(2,6)7/h1H2
(3) InChIKey: OFWDLJKVZZRPOX-UHFFFAOYAZ

Product Name

2,2,3,3-Tetrafluorooxetane

Synthetic route

2,2,3,3-Tetrafluorooxetane Specification

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