2,3,5-Trimethylpyrazine supplier

Name
Trimethyl-pyrazine
EINECS 238-712-0
CAS No. 14667-55-1
Article Data23
CAS DataBase
Density 0.979 g/cm³
Solubility
Melting Point 156 °C
Formula C₇H₁₀N₂
Boiling Point 173.1 °C at 760 mmHg
Molecular Weight 122.17
Flash Point 54.4 °C
Transport Information UN 1993 3/PG 3
Appearance clear yellow liquid
Safety 16-26-36/37/39
Risk Codes 10-22-36/37/38
Molecular Structure
Hazard Symbols Xn
Synonyms Pyrazine,trimethyl- (6CI,7CI,8CI,9CI);Trimethylpyrazine;2.3.5-trimethyl pyrazine;Trimethyl-pyrazine;
PSA 25.78000
LogP 1.40180

Synthetic route

: 95-89-6
2,5-dimethyl-3-chloropyrazine

: 75-24-1
trimethylaluminum

: 14667-55-1
2,3,5-trimethylpyrazine

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0) In 1,4-dioxane; hexane for 2h; Heating;	64%

: 1147535-04-3
2,3-dimethyl-5-trifluoromethanesulfonyloxypyrazine

: 18815-74-2
zinc methyl bromide

: 14667-55-1
2,3,5-trimethylpyrazine

Conditions

Conditions	Yield
With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) In tetrahydrofuran at 20℃; for 12h; Negishi coupling reaction; Inert atmosphere;	61%

: 1147535-04-3
2,3-dimethyl-5-trifluoromethanesulfonyloxypyrazine

: 544-97-8
dimethyl zinc(II)

: 14667-55-1
2,3,5-trimethylpyrazine

Conditions

Conditions	Yield
With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) In tetrahydrofuran at 20℃; for 12h; Inert atmosphere;	38%

: 123-32-0
2,5-dimethyl-pyrazine

: 917-54-4
methyllithium

: 14667-55-1
2,3,5-trimethylpyrazine

Conditions

Conditions	Yield
With diethyl ether

: 88234-17-7
N-methyl-2,5-dimethylpyrazinium bromide

A: 1124-11-4
Tetramethylpyrazine

B: 14667-55-1
2,3,5-trimethylpyrazine

Conditions

Conditions	Yield
at 275 - 280℃;

: 89940-71-6
2,3,5-trimethylpiperazine

: 14667-55-1
2,3,5-trimethylpyrazine

Conditions

Conditions	Yield
With aluminum oxide; copper oxide-chromium oxide silicon dioxide aluminium oxide catalyst; water; silica gel at 375℃;

: 133129-02-9, 133129-06-3, 149470-70-2
C9H14N2O3

: 14667-55-1
2,3,5-trimethylpyrazine

Conditions

Conditions	Yield
In toluene at 300℃; Yield given;

: 54-17-1, 492-61-5, 492-62-6, 492-66-0, 530-25-6, 530-26-7, 530-27-8, 530-28-9, 552-76-1, 579-36-2, 643-69-6, 655-45-8, 2280-44-6, 3646-73-9, 7282-78-2, 7282-79-3, 7282-80-6, 7282-81-7, 7282-82-8, 7283-02-5, 7283-08-1, 7283-09-2, 7283-10-5, 7283-11-6, 7296-15-3, 7296-64-2, 7322-31-8, 10257-28-0, 12772-65-5, 12773-29-4, 12773-31-8, 12773-32-9, 12773-33-0, 12773-34-1, 19982-85-5, 28538-24-1, 32445-46-8, 32445-47-9, 32445-51-5, 32445-52-6, 34685-56-8, 34685-57-9, 35810-56-1, 39281-65-7, 39281-66-8, 39281-67-9, 39281-68-0, 39281-69-1, 39392-61-5, 39392-62-6, 39392-63-7, 39392-65-9, 39392-66-0, 39392-69-3, 40825-84-1, 40825-86-3, 40825-87-4, 40825-89-6, 42752-07-8, 42789-83-3, 46032-76-2, 54808-89-8, 66069-07-6, 120442-57-1, 120442-58-2, 120442-59-3, 120442-67-3, 131064-91-0, 131064-92-1, 131065-00-4, 131065-01-5, 131348-38-4
D-(+)-Glucose

A: 290-37-9
1,4-pyrazine

B: 109-08-0
2-Methylpyrazine

C: 123-32-0
2,5-dimethyl-pyrazine

D: 5910-89-4
2,3-dimethylpyrazine

E: 108-50-9
2,6-dimethylpyrazine

F: 14667-55-1
2,3,5-trimethylpyrazine

Conditions

Conditions	Yield
With ammonium hydroxide In glycerol for 9h; Product distribution; Heating; also with amino acids;

...Expand

: 78-96-6, 1674-56-2
3-amino-2-propanol

A: 290-37-9
1,4-pyrazine

B: 109-08-0
2-Methylpyrazine

C: 123-32-0
2,5-dimethyl-pyrazine

D: 13360-65-1
2-ethyl-3,6-dimethylpyrazine

E: 14667-55-1
2,3,5-trimethylpyrazine

F: 1-aminoethyl-2-methylaziridine

Conditions

Conditions	Yield
With copper chromite at 180℃; for 0.333333h; Product distribution; var. temp.; other aminoalcohols;

...Expand

: 59-51-8
DL-methionine

A: 290-37-9
1,4-pyrazine

B: 109-08-0
2-Methylpyrazine

C: 123-32-0
2,5-dimethyl-pyrazine

D: 13532-18-8
methyl 3-(methylthio)propionate

E: 14667-55-1
2,3,5-trimethylpyrazine

F: 1-<3-(methylthio)propyl>-2-formylpyrrole

Conditions

Conditions	Yield
With alpha-D-glucopyranose In water at 180℃; for 1h; Product distribution; also with methionine sulfoxide and without glucose;

...Expand

2.5-dimethyl-pyrazine-mono bromomethylate: 2.5-dimethyl-pyrazine-mono bromomethylate

A: 1124-11-4
Tetramethylpyrazine

B: 14667-55-1
2,3,5-trimethylpyrazine

Conditions

Conditions	Yield
at 270 - 280℃;

: 2280-44-6
D-Glucose

: 61-90-5
L-leucine

A: 290-37-9
1,4-pyrazine

B: 109-08-0
2-Methylpyrazine

C: 123-32-0
2,5-dimethyl-pyrazine

D: 5910-89-4
2,3-dimethylpyrazine

E: 108-50-9
2,6-dimethylpyrazine

F: 14667-55-1
2,3,5-trimethylpyrazine

G var. alkyl substituted pyrazines: var. alkyl substituted pyrazines

Conditions

Conditions	Yield
With ammonium hydroxide In glycerol at 120℃; for 4h; Product distribution; var. times, solvents, temp., and ratios of reactants, also without leucine;

...Expand

: 133128-90-2
3-[(Z)-Allylimino]-butan-2-one oxime

: 14667-55-1
2,3,5-trimethylpyrazine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: potassium tert-butoxide / dimethylsulfoxide / 2 h / 50 °C 2: Et3N / CH2Cl2 / 10 - 20 °C 3: toluene / 300 °C View Scheme

: 133128-94-6, 133128-98-0, 149470-69-9
3-{(E)-[(Z)-Propenyl]imino}-butan-2-one oxime

: 14667-55-1
2,3,5-trimethylpyrazine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Et3N / CH2Cl2 / 10 - 20 °C 2: toluene / 300 °C View Scheme

2,3,5-Trimethylpyrazine Chemical Properties

Molecular Structure of 2,3,5-Trimethylpyrazine (CAS NO.14667-55-1):

IUPAC Name: 2,3,5-Trimethylpyrazine
Molecular Formula: C₇H₁₀N₂
Molecular Weight: 122.17
EINECS: 238-712-0
FEMA: 3244
XLogP3: 1
H-Bond Donor: 0
H-Bond Acceptor: 2
Index of Refraction: 1.503
Molar Refractivity: 36.91 cm³
Molar Volume: 124.7 cm³
Surface Tension: 37.4 dyne/cm
Density: 0.979 g/cm³
Flash Point: 54.4 °C
Enthalpy of Vaporization: 39.26 kJ/mol
Boiling Point: 173.1 °C at 760 mmHg
Vapour Pressure: 1.72 mmHg at 25 °C
Appearance: Clear yellow liquid
storage temp.: Flammables area
Canonical SMILES: CC1=CN=C(C(=N1)C)C
InChI: InChI=1S/C7H10N2/c1-5-4-8-6(2)7(3)9-5/h4H,1-3H3
InChIKey: IAEGWXHKWJGQAZ-UHFFFAOYSA-N
Product Categories: Pyrazines; Heterocyclic Compounds; Mono- & Polyalkylpyrazines; pyrazine Flavor; Building Blocks; Heterocyclic Building Blocks; Alphabetical Listings; Flavors and Fragrances; Q-Z; Pyrazine compounds

2,3,5-Trimethylpyrazine Uses

2,3,5-Trimethylpyrazine (CAS NO.14667-55-1) is temporarily allowed in the use of food spices mainly for the preparation of flavor in the cocoa, chocolate and fried nuts.

2,3,5-Trimethylpyrazine Consensus Reports

Reported in EPA TSCA Inventory.

2,3,5-Trimethylpyrazine Safety Profile

Moderately toxic by ingestion. Combustible liquid. When heated to decomposition emits toxic fumes of NO_x.
Safety Information of 2,3,5-Trimethylpyrazine (CAS NO.14667-55-1):
Hazard Codes: Harmful Xn
Risk Statements: 10-22-36/37/38
R10:Flammable.
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 16-26-36/37/39
S16:Keep away from sources of ignition.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: UN 1993 3/PG 3
WGK Germany: 3
RTECS: UQ3907000
HazardClass: 3
PackingGroup: III

2,3,5-Trimethylpyrazine Specification

2,3,5-Trimethylpyrazine (CAS NO.14667-55-1), its Synonyms are 2,3,5-Trimethyl pyrazine ; 2,3,5-Trimethyl pyrazine (natural) ; Pyrazine, trimethyl- ; Trimethylpyrazine ; Pyrazine, 2,3,5-trimethyl- ; Pyrazine,trimethyl- (6CI,7CI,8CI,9CI) .

Product Name

Trimethyl-pyrazine

Synthetic route

2,3,5-Trimethylpyrazine Chemical Properties

2,3,5-Trimethylpyrazine Uses

2,3,5-Trimethylpyrazine Consensus Reports

2,3,5-Trimethylpyrazine Safety Profile

2,3,5-Trimethylpyrazine Specification

Related Products

Hot Products