2,3-Difluorobenzyl alcohol

The 2,3-Difluorobenzyl alcohol with CAS registry number of 75853-18-8 is also known as Benzenemethanol,2,3-difluoro-. The IUPAC name is (2,3-Difluorophenyl)methanol. It belongs to product categories of Benzhydrols, Benzyl & Special Alcohols; Aromatic Compound; Miscellaneous; Alcohols; C7 to C8; Oxygen Compounds. In addition, the formula is C₇H₆F₂O and the molecular weight is 144.12. This chemical is a clear colorless to pale brown liquid that may cause inflammation to the skin or other mucous membranes. What's more, it should be sealed in cool and dry place away from oxidants.

Physical properties about 2,3-Difluorobenzyl alcohol are: (1)ACD/LogP: 1.05; (2)# of Rule of 5 Violations: 0; (3)#H bond acceptors: 1; (4)#H bond donors: 1; (5)#Freely Rotating Bonds: 2; (6)Index of Refraction: 1.497; (7)Molar Refractivity: 32.69 cm³; (8)Molar Volume: 111.6 cm³; (9)Surface Tension: 36.8 dyne/cm; (10)Density: 1.29 g/cm³; (11)Flash Point: 93.9 °C; (12)Enthalpy of Vaporization: 45.61 kJ/mol; (13)Boiling Point: 195.2 °C at 760 mmHg; (14)Vapour Pressure: 0.265 mmHg at 25 °C.

Preparation of 2,3-Difluorobenzyl alcohol: it is prepared by reaction of 2,3-Difluorobenzoic acid. The reaction needs reagent B₂H₆ and solvent tetrahydrofuran for 1.5 hours. The yield is about 40%.

Uses of 2,3-Difluorobenzyl alcohol: it is used to produce 1-bromomethyl-2,3-difluoro-benzene. The reaction occurs with reagent PBr₃ and solvent toluene at the temperature of 100 °C for 1 hour. The yield is about 61%.

When you are using this chemical, please be cautious about it. As a chemical, it is irritating to eyes, respiratory system and skin. Besides, there is risk of serious damage to eyes. During using it, wear suitable gloves and eye/face protection. If contact with eyes accidently, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
1. Canonical SMILES: C1=CC(=C(C(=C1)F)F)CO
2. InChI: InChI=1S/C7H6F2O/c8-6-3-1-2-5(4-10)7(6)9/h1-3,10H,4H2
3. InChIKey: JSFGDUIJQWWBGY-UHFFFAOYSA-N