2,4-Dichloro-5-nitropyridine supplier

Name
Pyridine,2,4-dichloro-5-nitro-
EINECS -0
CAS No. 4487-56-3
Article Data12
CAS DataBase
Density 1.63 g/cm³
Solubility
Melting Point 42.0 to 46.0 °C
Formula C₅H₂Cl₂N₂O₂
Boiling Point 282.329 °C at 760 mmHg
Molecular Weight 192.989
Flash Point 124.548 °C
Transport Information
Appearance Light yellow needles
Safety 45
Risk Codes 25
Molecular Structure
Hazard Symbols Xi
Synonyms 5-Nitro-2,4-dichloro pyridine;
PSA 58.71000
LogP 2.81980

Synthetic route

: 7321-93-9
4,6-dichloropyridin-3-ylamine

: 4487-56-3
2,4-dichloro-5-nitropyridine

Conditions

Conditions	Yield
With sulfuric acid; dihydrogen peroxide In water at 0 - 25℃; for 18h;	77%

: 850663-54-6
4-chloro-2-hydroxy-5-nitropyridine

: 4487-56-3
2,4-dichloro-5-nitropyridine

Conditions

Conditions	Yield
With trichlorophosphate In toluene for 6h; Heating;	74%
With trichlorophosphate In toluene at 60℃; Heating / reflux;	74%
With trichlorophosphate In toluene at 110℃; for 6h;	72%

: 4-(ethyloxy)-5-nitro-2-pyridinol

: 4487-56-3
2,4-dichloro-5-nitropyridine

Conditions

Conditions	Yield
With trichlorophosphate at 100℃; for 12h;	66%

: 24484-96-6
2-amino-4-chloro-5-nitropyridine

: 4487-56-3
2,4-dichloro-5-nitropyridine

Conditions

Conditions	Yield
With hydrogenchloride; sodium nitrite In water at 0 - 25℃; for 51h;	33%

: 5435-54-1
4-hydroxy-3-nitropyridine

: 4487-56-3
2,4-dichloro-5-nitropyridine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 99 percent / POCl3 / toluene / 16 h / 110 °C 2: 80 percent / potassium t-butoxide; t-BuOOH / tetrahydrofuran; decane; liquid ammonia / 2 h / -35 °C 3: 74 percent / POCl3 / toluene / 6 h / Heating View Scheme
Multi-step reaction with 3 steps 1: trichlorophosphate / toluene / 16 h / 0 - 110 °C / Heating / reflux 2: tert.-butylhydroperoxide; potassium tert-butylate; ammonia / tetrahydrofuran; decane / 3.08 h / -78 - 0 °C 3: trichlorophosphate / toluene / 60 °C / Heating / reflux View Scheme

: 13091-23-1
4-chloro-3-nitropyridine

: 4487-56-3
2,4-dichloro-5-nitropyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 80 percent / potassium t-butoxide; t-BuOOH / tetrahydrofuran; decane; liquid ammonia / 2 h / -35 °C 2: 74 percent / POCl3 / toluene / 6 h / Heating View Scheme
Multi-step reaction with 2 steps 1: tert.-butylhydroperoxide; potassium tert-butylate / decane; N,N-dimethyl-formamide / 2 h / -35 - 5 °C 2: trichlorophosphate / toluene / 6 h / 110 °C View Scheme
Multi-step reaction with 2 steps 1: potassium tert-butylate; tert.-butylhydroperoxide; ammonia / tetrahydrofuran / 1 h / -35 °C 2: trichlorophosphate / toluene / 6 h / 100 °C View Scheme

: 1796-84-5
4-ethoxy-3-nitropyridine

: 4487-56-3
2,4-dichloro-5-nitropyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: potassium tert-butylate; ammonia / tetrahydrofuran / 0.17 h / -78 °C 1.2: 1.33 h / -78 - -40 °C 2.1: trichlorophosphate / 12 h / 100 °C View Scheme

: 88675-24-5
3-aminotetrahydrofuran

: 4487-56-3
2,4-dichloro-5-nitropyridine

: 1612171-86-4
(2-chloro-5-nitropyridin-4-yl)(tetrahydrofuran-3-yl)amine

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran for 2h;	100%
With triethylamine In acetonitrile for 0.166667h; regiospecific reaction;

: 38041-19-9
4-aminotetrahydropyran

: 4487-56-3
2,4-dichloro-5-nitropyridine

: 1612171-89-7
2-chloro-5-nitro-N-(tetrahydro-2H-pyran-4-yl)pyridin-4-amine

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran for 2.16667h;	100%
With N-ethyl-N,N-diisopropylamine In ethanol Inert atmosphere; Autoclave; regioselective reaction;	88%
With triethylamine In acetonitrile for 0.166667h; regiospecific reaction;

: 4487-56-3
2,4-dichloro-5-nitropyridine

: 75-31-0
isopropylamine

: 1612171-75-1
(2-chloro-5-nitropyridin-4-yl)isopropylamine

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 3h; Time; Temperature;	100%
With triethylamine In tetrahydrofuran at 20℃; for 3h;	100%
With triethylamine In tetrahydrofuran at 25℃; for 6h;	99%
In acetonitrile at 40℃; for 12h;	91%
With triethylamine In acetonitrile for 0.166667h; regiospecific reaction;

: 4487-56-3
2,4-dichloro-5-nitropyridine

: 100-46-9
benzylamine

: 1457967-10-0
benzyl-(2-chloro-5-nitro-pyridin-4-yl)-amine

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0℃; for 1h;	100%
With N-ethyl-N,N-diisopropylamine In ethanol Inert atmosphere; Autoclave; regioselective reaction;	95%
With N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 0 - 20℃; for 1h;	88%
With N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 0 - 20℃; for 1h;	88%
With N-ethyl-N,N-diisopropylamine In 1-methyl-pyrrolidin-2-one at 0 - 20℃; for 1h; Inert atmosphere;	88%

: 4487-56-3
2,4-dichloro-5-nitropyridine

: 593-51-1
methylamine hydrochloride

: 1449506-71-1
(2-chloro-5-nitro-pyridin-4-yl)-methyl-amine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0℃; for 0.5h;	99%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 25℃; for 12h; Sealed tube;	62%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0 - 20℃; for 16.5h;

: 4487-56-3
2,4-dichloro-5-nitropyridine

: 771572-43-1
2-methyl-3-(trifluoromethyl)benzylamine

: C14H11ClF3N3O2

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃;	99%

: 4487-56-3
2,4-dichloro-5-nitropyridine

: 2393-23-9
4-methoxy-benzylamine

: 2-chloro-N-(4-methoxybenzyl)-5-nitropyridin-4-amine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0 - 20℃; for 0.5h;	99%

: 67-56-1
methanol

: 4487-56-3
2,4-dichloro-5-nitropyridine

: 607373-84-2
2,4-dimethoxy-5-nitropyridine

Conditions

Conditions	Yield
With sodium at 0 - 40℃; for 4.16h; Inert atmosphere;	98%

: 4487-56-3
2,4-dichloro-5-nitropyridine

: 4892-02-8
Methyl thiosalicylate

: methyl 2-((2-chloro-5-nitropyridin-4-yl)thio)benzoate

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 0 - 25℃; for 2h;	97%
With caesium carbonate In acetonitrile at 0 - 20℃; for 3h;	97%

: 4487-56-3
2,4-dichloro-5-nitropyridine

: methyl 3,6-difluoro-2-hydroxybenzoate

: methyl 2-((2-chloro-5-nitropyridin-4-yl)oxy)-3,6-difluorobenzoate

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile at 0 - 20℃; for 3h;	97%

: 4487-56-3
2,4-dichloro-5-nitropyridine

: 75-04-7
ethylamine

: 607373-89-7
2-chloro-N-ethyl-5-nitro-4-pyridinamine

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran; methanol at 0℃; for 2h;	96%
In tetrahydrofuran; water for 1h;	83%
In tetrahydrofuran at 0℃;	81%
With triethylamine In acetonitrile for 0.166667h; regiospecific reaction;

: 4487-56-3
2,4-dichloro-5-nitropyridine

: 70163-98-3
methyl 3-fluoro-2-hydroxybenzoate

: methyl 2-((2-chloro-5-nitropyridin-4-yl)oxy)-3-fluorobenzoate

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile at 0 - 20℃; for 3h;	96%

: 4487-56-3
2,4-dichloro-5-nitropyridine

: 111359-74-1
4-[(tert-butyldimethylsilyl)oxy]aniline

: 850663-60-4
2-chloro-N-(4-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}phenyl)-5-nitro-4-pyridinamine

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃;	95%

: 4487-56-3
2,4-dichloro-5-nitropyridine

: 4,4-difluoropiperidine hydrochloride

: 2-chloro-4-(4,4-difluoropiperidin-1-yl)-5-nitropyridine

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 18h;	95%

: 4487-56-3
2,4-dichloro-5-nitropyridine

: 1607590-17-9
trans-[4-(cyanomethyl)cyclohexyl]ammonium trifluoroacetate

: 2-[trans-4-[(2-chloro-5-nitropyridin-4-yl)amino]cyclohexyl]acetonitrile

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 20h; Solvent; Temperature;	95%

: 4487-56-3
2,4-dichloro-5-nitropyridine

: 6342-70-7
3-methoxymethylsalicylate

: methyl 2-((2-chloro-5-nitropyridin-4-yl)oxy)-3-methoxybenzoate

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile at 0 - 20℃; for 3h;	95%

: 4487-56-3
2,4-dichloro-5-nitropyridine

: 1456506-97-0
(S)-3-((1r,4S)-4-aminocyclohexyl)-5,5-dimethyl-4-phenyloxazolidin-2-one

: 1456507-32-6
3-((1r,4r)-4-((2-chloro-5-nitropyridin-4-yl)amino)cyclohexyl)-5,5-dimethyl-4-phenyloxazolidin-2-one

Conditions

Conditions	Yield
With triethylamine In acetonitrile at 80℃;	94%

: 4487-56-3
2,4-dichloro-5-nitropyridine

: 52159-67-8
methyl 3-chloro-2-hydroxybenzoate

: methyl 3-chloro-2-((2-chloro-5-nitropyridin-4-yl)oxy)benzoate

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile at 0 - 20℃; for 3h;	94%

: 4487-56-3
2,4-dichloro-5-nitropyridine

: 2516-47-4
cyclopropanemethylamine

: 2-chloro-N-(cyclopropylmethyl)-5-nitropyridin-4-amine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 20.0833h; Cooling with ice;	93%

: 4487-56-3
2,4-dichloro-5-nitropyridine

: 51388-20-6
4-benzyloxyaniline hydrochloride

: 850663-93-3
2-chloro-5-nitro-N-{4-[(phenylmethyl)oxy]phenyl}-4-pyridinamine

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 60℃; for 1h;	92%

: 4487-56-3
2,4-dichloro-5-nitropyridine

: 765-30-0
Cyclopropylamine

: 1449669-34-4
(2-chloro-5-nitro-pyridin-4-yl)cyclopropyl-amine

Conditions

Conditions	Yield
With triethylamine In acetonitrile at 20℃; for 2h; Inert atmosphere;	90%
With triethylamine In acetonitrile for 0.166667h; regiospecific reaction;

: 4487-56-3
2,4-dichloro-5-nitropyridine

: 74-89-5
methylamine

: 1449506-71-1
(2-chloro-5-nitro-pyridin-4-yl)-methyl-amine

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 20℃; for 17.5h;	90%
With triethylamine In tetrahydrofuran at 20℃; for 17.5h;

: 4487-56-3
2,4-dichloro-5-nitropyridine

: 371-40-4
4-fluoroaniline

: 2-chloro-N-(4-fluorophenyl)-5-nitropyridin-4-amine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In ethanol Inert atmosphere; Autoclave; regioselective reaction;	90%

: 4487-56-3
2,4-dichloro-5-nitropyridine

: 175137-46-9
3-amino-5-cyclopropyl-1H-pyrazole

: 907203-92-3
2-chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)-5-nitropyridin-4-amine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0 - 25℃; for 17h;	89%

: 4487-56-3
2,4-dichloro-5-nitropyridine

: 104-94-9
4-methoxy-aniline

: 2-chloro-N-(4-methoxyphenyl)-5-nitropyridin-4-amine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In ethanol Inert atmosphere; Autoclave; regioselective reaction;	89%
With N-ethyl-N,N-diisopropylamine In 1,4-dioxane at 25℃; for 1h;

: 4487-56-3
2,4-dichloro-5-nitropyridine

: 72373-81-0
Methyl 2-fluoro-6-hydroxybenzoate

: methyl 2-((2-chloro-5-nitropyridin-4-yl)oxy)-6-fluorobenzoate

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile at 0 - 20℃; for 3h;	89%

: 89590-22-7
4-Hydroxybenzoxazole

: 4487-56-3
2,4-dichloro-5-nitropyridine

: 4-(2-chloro-5-nitro-pyridin-4-yloxy)-benzooxazole

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide; acetone at 20℃; for 4h;	87.8%

: 3731-51-9
(2-aminomethylpyridine)

: 4487-56-3
2,4-dichloro-5-nitropyridine

: 1610045-56-1
2-chloro-5-nitro-N-(pyridin-2-ylmethyl)pyridin-4-amine

Conditions

Conditions	Yield
With triethylamine In 1-methyl-pyrrolidin-2-one at 25℃; for 1h;	87%
With N-ethyl-N,N-diisopropylamine In ethanol at 0 - 20℃; for 1h;

: 4487-56-3
2,4-dichloro-5-nitropyridine

: 119-36-8
methyl salicylate

: methyl 2-((2-chloro-5-nitropyridin-4-yl)oxy)benzoate

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile at 25℃; for 3h;	87%
With caesium carbonate In acetonitrile at 0 - 20℃; for 3h;	87%

: 4487-56-3
2,4-dichloro-5-nitropyridine

: ethyl (3R)-3-amino-3-[2-bromo-6-(difluoromethoxy)phenyl]propanoate hydrochloride

: ethyl (3R)-3-[2-bromo-6-(difluoromethoxy)phenyl]-3-[(2-chloro-5-nitropyridin-4-yl)amino]propanoate

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 0 - 20℃;	87%

2,4-Dichloro-5-nitropyridine Specification

The 2,4-Dichloro-5-nitropyridine, with the CAS registry number 4487-56-3, is also known as Pyridine, 2,4-dichloro-5-nitro-. This chemical's molecular formula is C₅H₂Cl₂N₂O₂ and molecular weight is 192.99. What's more, its IUPAC name is the same with its product name. When you are dealing with this chemical, you should be very careful. This chemical may cause inflammation to the skin or other mucous membranes.

Physical properties about 2,4-Dichloro-5-nitropyridine are: (1)ACD/LogP: 1.71; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2; (4)ACD/LogD (pH 7.4): 2; (5)ACD/BCF (pH 5.5): 9; (6)ACD/BCF (pH 7.4): 9; (7)ACD/KOC (pH 5.5): 165; (8)ACD/KOC (pH 7.4): 165; (9)#H bond acceptors: 4; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 58.71 Å²; (13)Index of Refraction: 1.603; (14)Molar Refractivity: 40.68 cm³; (15)Molar Volume: 118.4 cm³; (16)Surface Tension: 59.359 dyne/cm; (17)Density: 1.63 g/cm³; (18)Flash Point: 124.548 °C; (19)Enthalpy of Vaporization: 50.025 kJ/mol; (20)Boiling Point: 282.329 °C at 760 mmHg; (21)Vapour Pressure: 0.006 mmHg at 25 °C.

You can still convert the following datas into molecular structure:
(1) SMILES: Clc1cc(Cl)ncc1N(=O)=O
(2) InChI: InChI=1S/C5H2Cl2N2O2/c6-3-1-5(7)8-2-4(3)9(10)11/h1-2H
(3) InChIKey: RZVJQUMDJUUBBF-UHFFFAOYSA-N

Product Name

Pyridine,2,4-dichloro-5-nitro-

Synthetic route

2,4-Dichloro-5-nitropyridine Specification

Related Products

Hot Products