2,4-Dichlorobenzotrifluoride supplier

Name
2,4-Dichlorobenzotrifluoride
EINECS 206-278-1
CAS No. 320-60-5
Article Data5
CAS DataBase
Density 1.464 g/cm³
Solubility 8.67mg/L at 25℃
Melting Point -26 °C
Formula C₇H₃Cl₂F₃
Boiling Point 193.2 °C at 760 mmHg
Molecular Weight 215.002
Flash Point 78.1 °C
Transport Information UN 3265 8/PG 2
Appearance colourless clear liquid
Safety 26-27-36/37/39-45
Risk Codes 34
Molecular Structure
Hazard Symbols C,Xi
Synonyms Toluene,2,4-dichloro-a,a,a-trifluoro- (8CI);1,3-Dichloro-4-(trifluoromethyl)benzene;2,4-Dichloro(trifluoromethyl)benzene;2,4-Dichloro-1-(trifluoromethyl)benzene;2,4-Dichloro-a,a,a-trifluorotoluene;2,4-Dichlorobenzotrifluoride;
PSA 0.00000
LogP 4.01220

Synthetic route

: 7664-39-3
hydrogen fluoride

: 13014-18-1
2,4-dichlorobenzotrichloride

: 320-60-5
2,4-dichloro-benzotrifluoride

Conditions

Conditions	Yield
at 140 - 150℃;
at 140 - 150℃;

: 13014-18-1
2,4-dichlorobenzotrichloride

: 320-60-5
2,4-dichloro-benzotrifluoride

Conditions

Conditions	Yield
With hydrogen fluoride at 110℃; under 11251.1 - 12751.3 Torr; Pressure; Temperature;
With hydrogen fluoride at 110℃; under 11251.1 - 12751.3 Torr; Temperature; Pressure;
With hydrogen fluoride at 110℃; under 11251.1 - 12751.3 Torr; Temperature; Pressure; Green chemistry;

: 462-06-6
fluorobenzene

: 320-60-5
2,4-dichloro-benzotrifluoride

: 656803-77-9
2,4-dichloro-1-[dichloro-(4-fluorophenyl)methyl]benzene

Conditions

Conditions	Yield
With aluminum (III) chloride In 1,2-dichloro-ethane at 0 - 5℃; for 5h;	100%
With aluminium trichloride In 1,2-dichloro-ethane at 0℃; for 5h;
With aluminum (III) chloride In 1,2-dichloro-ethane at 0 - 5℃; for 5h;

: 320-60-5
2,4-dichloro-benzotrifluoride

: 5720-05-8
4-methylphenylboronic acid

: 1419798-74-5
3-chloro-4'-methyl-4-(trifluoromethyl)biphenyl

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 80℃; for 6h; Suzuki-Miyaura Coupling; Inert atmosphere;	97%

: 320-60-5
2,4-dichloro-benzotrifluoride

: 17933-03-8
m-tolylboronic acid

: 1419798-73-4
3-chloro-3'-methyl-4-(trifluoromethyl)biphenyl

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 80℃; for 6h; Suzuki-Miyaura Coupling; Inert atmosphere;	95%

: 320-60-5
2,4-dichloro-benzotrifluoride

: 16419-60-6
2-Methylphenylboronic acid

: 1419798-72-3
3'-chloro-2-methyl-4'-(trifluoromethyl)biphenyl

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 80℃; for 6h; Suzuki-Miyaura Coupling; Inert atmosphere;	93%

: 320-60-5
2,4-dichloro-benzotrifluoride

: 60933-65-5
(R)-S-methyl-S-phenylsulfoximine

: C14H11NSOClF3

Conditions

Conditions	Yield
Stage #1: 2,4-dichloro-benzotrifluoride; (R)-S-methyl-S-phenylsulfoximine With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate In toluene at 20℃; for 0.5h; Stage #2: In toluene at 135℃; for 1.5h; microwave irradiation; Further stages.;	92%

: 320-60-5
2,4-dichloro-benzotrifluoride

: 400-70-4
2,4-dichloro-5-nitrobenzotrifluoride

Conditions

Conditions	Yield
With sulfuric acid; potassium nitrate at 15 - 20℃; for 18.5h;	87%
With sulfuric acid; nitric acid
Nitrierung;
Nitrierung;

: 75-77-4
chloro-trimethyl-silane

: 320-60-5
2,4-dichloro-benzotrifluoride

: 871254-70-5
[2,6-dichloro-3-(trifluoromethyl)phenyl]trimethylsilane

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran; hexane at -75℃;	82%

: 124-38-9
carbon dioxide

: 320-60-5
2,4-dichloro-benzotrifluoride

: 25922-41-2
2,6-dichloro-3-(trifluoromethyl)benzoic acid

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran; hexane at -75℃;	75%

: 320-60-5
2,4-dichloro-benzotrifluoride

: 40972-86-9
(2,3-dimethoxyphenyl)boronic acid

: 1419798-79-0
3'-chloro-2,3-dimethoxy-4'-(trifluoromethyl)biphenyl

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 80℃; for 6h; Suzuki-Miyaura Coupling; Inert atmosphere;	74%

: 320-60-5
2,4-dichloro-benzotrifluoride

: 172975-69-8
3,5-dimethylphenyl boronic acid

: 1419798-76-7
3-Chloro-3',5'-dimethyl-4-(trifluoromethyl)biphenyl

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 80℃; for 6h; Suzuki-Miyaura Coupling; Inert atmosphere;	72%

: 320-60-5
2,4-dichloro-benzotrifluoride

: 104-88-1
4-chlorobenzaldehyde

: (4-chlorophenyl)(2,6-dichloro-3-(trifluoromethyl)phenyl)methanol

Conditions

Conditions	Yield
Stage #1: 2,4-dichloro-benzotrifluoride With 2,2,6,6-tetramethylpiperidinyl-lithium; magnesium chloride In tetrahydrofuran at 0℃; for 0.0111111h; Flow reactor; Inert atmosphere; Stage #2: 4-chlorobenzaldehyde In tetrahydrofuran at 25℃; for 0.5h; Flow reactor; Inert atmosphere; regioselective reaction;	69%

: 320-60-5
2,4-dichloro-benzotrifluoride

: 77-78-1
dimethyl sulfate

: 2,4-dichloro-3-methyltrifluoromethylbenzene

Conditions

Conditions	Yield
With lithium diisopropyl amide In tetrahydrofuran at -50℃; for 2h;	64%

: 557-21-1
zinc(II) cyanide

: 320-60-5
2,4-dichloro-benzotrifluoride

: 1092460-79-1
3-chloro-4-(trifluoromethyl)benzonitrile

Conditions

Conditions	Yield
Stage #1: zinc(II) cyanide With aluminum oxide; Ni(xantphos)(o-tolyl)Cl for 1h; Schlenk technique; Inert atmosphere; Sealed tube; Stage #2: 2,4-dichloro-benzotrifluoride In 1-methyl-pyrrolidin-2-one at 20℃; for 24h; Schlenk technique; Inert atmosphere;	63%

: 320-60-5
2,4-dichloro-benzotrifluoride

: 29091-09-6
2,4-dichloro-3,5-dinitro-benzotrifluoride

Conditions

Conditions	Yield
With sulfuric acid; nitric acid In water at 80℃; for 96h;	60%
With sulfuric acid; sulfur trioxide; nitric acid; sodium hydrogencarbonate In water; toluene	166.6 grams (79%)
With sulfuric acid; sulfur trioxide; nitric acid

: 320-60-5
2,4-dichloro-benzotrifluoride

: 5720-05-8
4-methylphenylboronic acid

: 1419798-84-7
4-trifluoromethyl-1,3-bis(4-methylphenyl)-benzene

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 110℃; for 8h; Suzuki-Miyaura Coupling; Inert atmosphere;	60%

: 320-60-5
2,4-dichloro-benzotrifluoride

: 118062-05-8
2,3,4-trimethoxyphenylboronic acid

: 1419798-80-3
3'-chloro-2,3,4-trimethoxy-4'-(trifluoromethyl)biphenyl

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 80℃; for 6h; Suzuki-Miyaura Coupling; Inert atmosphere;	60%

: 320-60-5
2,4-dichloro-benzotrifluoride

: 16419-60-6
2-Methylphenylboronic acid

: 1419798-82-5
4-trifluoromethyl-1,3-bis(2-methylphenyl)-benzene

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 110℃; for 8h; Suzuki-Miyaura Coupling; Inert atmosphere;	57%

: 320-60-5
2,4-dichloro-benzotrifluoride

: 5720-06-9
2-Methoxyphenylboronic acid

: 1419798-78-9
3'-chloro-2-methoxy-4'-(trifluoromethyl)biphenyl

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 80℃; for 6h; Suzuki-Miyaura Coupling; Inert atmosphere;	56%

: 320-60-5
2,4-dichloro-benzotrifluoride

: 63139-21-9
4-ethylphenylboronic acid

: 1419798-77-8
3-chloro-4'-ethyl-4-(trifluoromethyl)biphenyl

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 80℃; for 6h; Suzuki-Miyaura Coupling; Inert atmosphere;	49%

: 320-60-5
2,4-dichloro-benzotrifluoride

: 1765-93-1
4-fluoroboronic acid

: 1419798-85-8
4-trifluoromethyl-1,3-bis(4-fluorophenyl)-benzene

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 110℃; for 8h; Suzuki-Miyaura Coupling; Inert atmosphere;	49%

: 320-60-5
2,4-dichloro-benzotrifluoride

: 3900-89-8
2-Chlorobenzeneboronic acid

: 1419798-81-4
2,3'-dichloro-4'-(trifluoromethyl)biphenyl

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 80℃; for 6h; Suzuki-Miyaura Coupling; Inert atmosphere;	47%

: 320-60-5
2,4-dichloro-benzotrifluoride

: 1765-93-1
4-fluoroboronic acid

: 1214335-06-4
3-chloro-4'-fluoro-4-(trifluoromethyl)biphenyl

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 80℃; for 6h; Suzuki-Miyaura Coupling; Inert atmosphere;	46%

: 320-60-5
2,4-dichloro-benzotrifluoride

: 17933-03-8
m-tolylboronic acid

: 1419798-83-6
4-trifluoromethyl-1,3-bis(3-methylphenyl)-benzene

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 110℃; for 8h; Suzuki-Miyaura Coupling; Inert atmosphere;	39%

: 320-60-5
2,4-dichloro-benzotrifluoride

: 100379-00-8
2,6-dimethylbenzene boronic acid

: 1419798-75-6
3'-chloro-2,6-dimethyl-4'-(trifluoromethyl)biphenyl

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 80℃; for 6h; Suzuki-Miyaura Coupling; Inert atmosphere;	36%

: 320-60-5
2,4-dichloro-benzotrifluoride

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1261805-20-2
3-chloro-4,4'-bis(trifluoromethyl)biphenyl

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 80℃; for 6h; Suzuki-Miyaura Coupling; Inert atmosphere;	35%

: 320-60-5
2,4-dichloro-benzotrifluoride

: 1423-26-3
(meta-(trifluoromethyl)phenyl)boronic acid

: 1261887-61-9
3-chloro-3',4-bis(trifluoromethyl)biphenyl

Conditions

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 80℃; for 6h; Suzuki-Miyaura Coupling; Inert atmosphere;	32%

: 12130-88-0
pentamethylcyclopentadienyltricarbonylrhenium

: 320-60-5
2,4-dichloro-benzotrifluoride

A: 2Re(1+)*2C5(CH3)5(1-)*5CO=[Re2(C5(CH3)5)2(CO)5]

: 847019-92-5
trans-[(η5-C5Me5)Re(CO)2(C6H3ClCF3)Cl

Conditions

Conditions	Yield
In neat (no solvent) Irradiation (UV/VIS); N2 atm., room temp., complex was UV irradiated (λ=350 nm) in neat2,4-dichloro-1-trifluoromethylbenzene for 14 h; solvent was removed in vac., the residue was chromd. on silica gel (Fluka), hexane-CH2Cl2 (2:1); layered a concd. CH2Cl2-soln. with hexane; elem. anal.;	A n/a B 14%

...Expand

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 320-60-5
2,4-dichloro-benzotrifluoride

: 521064-74-4
methyl 5-chloro-2-(trifluoromethyl)benzoate

Conditions

Conditions	Yield
Stage #1: methanol; carbon monoxide; 2,4-dichloro-benzotrifluoride With potassium carbonate at 20℃; for 0.333333h; Stage #2: With dicobalt octacarbonyl for 0.0833333h; regioselective reaction; Further stages;	8.8%

...Expand

: 110-91-8
morpholine

: 320-60-5
2,4-dichloro-benzotrifluoride

A: 4-(3-chloro-4-trifluoromethylphenyl)morpholine

B: 98-56-6
4-chlorobenzotrifluoride

C: 88-16-4
1-chloro-2-(trifluoromethyl)benzene

Conditions

Conditions	Yield
With Adipic acid; N'-phenyloxalyl bishydrazide; copper diacetate; sodium acetate; cetyltrimethylammonim bromide; 2,5-hexanedione; potassium hydroxide In water at 110℃; for 3h; Inert atmosphere;	A 5% B n/a C n/a

...Expand

: 320-60-5
2,4-dichloro-benzotrifluoride

: 393-45-3
1-bromo-2,4-dichloro-5-trifluoromethyl-benzene

Conditions

Conditions	Yield
With antimonypentachloride; bromine anschliessend Behandeln mit Chlor;

2,4-Dichlorobenzotrifluoride Chemical Properties

IUPAC Name of o-Aminotrifluoromethylbenzene (320-60-5): 2,4-dichloro-1-(trifluoromethyl)benzene
Product Categories: Chlorine Compounds;Fluorine Compounds
Molecular Formula: C₇H₃Cl₂F₃
Molecular Weight: 214.99993
Appearance:colourless clear liquid
Surface Tension: 27.4 dyne/cm
Index of Refraction: 1.47
odor: penetrating
BRN: 2098743
Melting Point: -26 °C
Density: 1.464 g/cm³
Flash Point: 78.1 °C
Enthalpy of Vaporization: 41.18 kJ/mol
Boiling Point: 193.2 °C at 760 mmHg
Vapour Pressure: 0.656 mmHg at 25 °C
CAS DataBase Reference:320-60-5(CAS DataBase Reference)
NIST Chemistry Reference:320-60-5(NIST)
EPA Substance Registry System:320-60-5(EPA Substance)
Synonyms of o-Aminotrifluoromethylbenzene (320-60-5):
2,4-dichloro-1-(trifluoromethyl)-benzen;2,4-dichloro-alpha,alpha,alpha-trifluoro-toluen;2,4-Dichlorotrifluoromethylbenzene;1,3-DICHLORO-4-(TRIFLUOROMETHYL)BENZENE;2,4-Dichloro-1-(triflouromethyl)-benzene;2,4-DICHLORO-1-(TRIFLUOROMETHYL)BENZENE;2,4-DCBTF;2,4-DICHLORO-A,A,A-TRIFLUOROTOLUENE; 2,4-Dichlorobenzotrifluoride;2,4-Dichloro-1-(trifluoromethyl)benzene;Benzene, 2,4-dichloro-1-(trifluoromethyl)-;2,4-Dichloro-alpha,alpha,alpha-trifluorotoluene;Toluene, 2,4-dichloro-alpha,alpha,alpha-trifluoro-

2,4-Dichlorobenzotrifluoride Uses

o-Aminotrifluoromethylbenzene (320-60-5) is raw material of madinitramine which is weedicide used in the dry soil.

2,4-Dichlorobenzotrifluoride Production

o-Aminotrifluoromethylbenzene(320-60-5) is synthesized by the method of chloridizing parachlorotoluene.

2,4-Dichlorobenzotrifluoride Safety Profile

Safety Information of o-Aminotrifluoromethylbenzene(320-60-5):
Hazard Codes:C ,Xi
Risk Statements:34
34:Causes burns
Safety Statements:26-27-36/37/39-45
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
27:Take off immediately all contaminated clothing
36/37/39:Wear suitable protective clothing, gloves and eye/face protection
45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
RIDADR:UN 3265 8/PG 2
WGK Germany:2
RTECS:CZ5566877
Hazard Note:Corrosive
TSCA:T
HazardClass:8
PackingGroup:III

Product Name

2,4-Dichlorobenzotrifluoride

Synthetic route

2,4-Dichlorobenzotrifluoride Chemical Properties

2,4-Dichlorobenzotrifluoride Uses

2,4-Dichlorobenzotrifluoride Production

2,4-Dichlorobenzotrifluoride Safety Profile

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