2,4-Difluorobenzoic acid supplier

Name
2,4-Difluorobenzoic acid
EINECS 216-430-9
CAS No. 1583-58-0
Article Data26
CAS DataBase
Density 1.432 g/cm³
Solubility soluble in water
Melting Point 186-190 °C
Formula C₇H₄F₂O₂
Boiling Point 239.5 °C at 760 mmHg
Molecular Weight 158.104
Flash Point 98.6 °C
Transport Information
Appearance white to light yellow crystal powder
Safety 26-37/39
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 2,4-Difluorobenzoic;2,4-Difluorobenzoic acid and the derivatives;2,4-Difluorobenzoicacid;2,4-Difluorobenzoic acid and the derivatives;
PSA 37.30000
LogP 1.66300

Synthetic route

: 651027-06-4
2,4-difluoro-3-(triethylsilyl)benzoic acid

: 1583-58-0
2,4-difluoro-benzoic acid

Conditions

Conditions	Yield
With potassium hydroxide In ethanol; water for 2h; Heating;	98%

: N-(4-cyanophenyl)-2,4-difluorobenzamide

: 1583-58-0
2,4-difluoro-benzoic acid

Conditions

Conditions	Yield
With hydrogenchloride at 80℃; for 18h;	98%

: 2,4-difluoro-6-bromo-isopropylbenzene

: 1583-58-0
2,4-difluoro-benzoic acid

Conditions

Conditions	Yield
With 1,3-Dichloro-2-propanol; boron trifluoride diethyl etherate; water at 50℃; for 1.83333h; Temperature;	97%

: 124-38-9
carbon dioxide

: 2265-93-2
2,4-difluoro-1-iodobenzene

: 1583-58-0
2,4-difluoro-benzoic acid

Conditions

Conditions	Yield
With n-butyllithium In tetrahydrofuran; hexane at -75℃;	92%
Stage #1: 2,4-difluoro-1-iodobenzene With copper In tetrahydrofuran at 25℃; for 0.5h; Stage #2: carbon dioxide In tetrahydrofuran for 24h;	76%

: 3939-09-1
2,4-difluorobenzonitrile

: 1583-58-0
2,4-difluoro-benzoic acid

Conditions

Conditions	Yield
With 1-butyl-3-methylimidazolium hydrogen sulfate; water at 60 - 65℃; for 2.5h; Green chemistry;	92%

: 302912-34-1
2,4-difluoroethynylbenzene

: 1583-58-0
2,4-difluoro-benzoic acid

Conditions

Conditions	Yield
With methyl 3,5-bis((1H-1,2,4-triazol-1-yl)methyl)benzoate; oxygen; sodium acetate; nickel dibromide at 120℃; under 760.051 Torr; for 48h;	92%

: 154257-75-7
2,4-difluoro-3-chlorobenzoic acid

: 1583-58-0
2,4-difluoro-benzoic acid

Conditions

Conditions	Yield
With sodium hydroxide; zinc for 2h; Heating;	91%

: 15226-74-1, 61091-28-9, 61117-58-6
dicobalt octacarbonyl

: 2,4-difluorophenyl 2,3,4,5,6-pentafluorobenzenesulfonate

: 1583-58-0
2,4-difluoro-benzoic acid

Conditions

Conditions	Yield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In 1,4-dioxane; water at 20℃; for 16h; Schlenk technique; Inert atmosphere; chemoselective reaction;	90%

: 64-18-6
formic acid

: 2265-93-2
2,4-difluoro-1-iodobenzene

: 1583-58-0
2,4-difluoro-benzoic acid

Conditions

Conditions	Yield
With palladium diacetate; triethylamine; dicyclohexyl-carbodiimide; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In N,N-dimethyl-formamide at 80℃; for 10h; Inert atmosphere; Sealed tube;	87%

: 364-83-0
2',4'-difluoroacetophenone

: 1583-58-0
2,4-difluoro-benzoic acid

Conditions

Conditions	Yield
With oxygen; manganese (II) acetate tetrahydrate; cobalt(II) diacetate tetrahydrate; acetic acid at 180℃; under 18751.9 Torr; for 1.5h; Reagent/catalyst; Temperature; Green chemistry;	85%
With sodium percarbonate; potassium tert-butylate; sphingosylphosphorylcholine; meta-dinitrobenzene In tert-butyl alcohol at 80℃; for 5h;	23%
With potassium permanganate Oxidation;

: 15226-74-1, 61091-28-9, 61117-58-6
dicobalt octacarbonyl

: 2,4-difluorophenyl trifluoromethanesulfonate

: 1583-58-0
2,4-difluoro-benzoic acid

Conditions

Conditions	Yield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In 1,4-dioxane; water at 20℃; for 16h; Schlenk technique; Inert atmosphere; chemoselective reaction;	82%

: 610-30-0
2,4-dinitrobenzoic acid

: 1583-58-0
2,4-difluoro-benzoic acid

Conditions

Conditions	Yield
With potassium fluoride; cetyltrimethylammonim bromide In N,N-dimethyl-formamide at 120℃; for 7h;	72.4%

: 452-76-6
2,4-difluorotoluene

: 1583-58-0
2,4-difluoro-benzoic acid

Conditions

Conditions	Yield
With potassium permanganate

: 348-57-2
2,4-difluorobromobenzene

: 124-38-9
carbon dioxide

A: 28314-81-0
3-bromo-2,6-difluorobenzoic acid

B: 1583-58-0
2,4-difluoro-benzoic acid

C: 385-00-2
2,6-difluorobenzoic acid

Conditions

Conditions	Yield
With n-butyllithium 1) hexane, Et2O, 2 min, -78 deg C. 2) ether; Yield given. Multistep reaction. Yields of byproduct given;
With n-butyllithium 1) hexane, THF; 2 min, -78 deg C. 2) ether; Yield given. Multistep reaction. Yields of byproduct given;

...Expand

: 456-22-4
4-Fluorobenzoic acid

A: 1201-31-6
2,3,4,5-tetrafluorobenzoic acid

B: 455-86-7
3,4-Difluorobenzoic acid

C: 446-17-3
2,4,5-trifluorobenzoic acid

D: 61079-72-9
2,3,4,-trifluorobenzoic acid

E: 121602-93-5
3,4,5-trifluorobenzoic acid

F: 1583-58-0
2,4-difluoro-benzoic acid

Conditions

Conditions	Yield
With fluorine In sulfuric acid Product distribution; various substrate to fluorine ratios; also in 98percent HCOOH;

...Expand

: 1550-35-2
2,4-difluorobenzaldehyde

A: 367-27-1
2,4-difluorophenol

B: 1583-58-0
2,4-difluoro-benzoic acid

Conditions

Conditions	Yield
With 4-hydroxyacetophenone monooxygenase from P. fluorescens ACB; oxygen; NADPH In phosphate buffer at 30℃; for 1h; pH=8.0; Enzyme kinetics; Baeyer-Villiger oxidation;

: 372-18-9
1,3-Difluorobenzene

: 1583-58-0
2,4-difluoro-benzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: BuLi / hexane; tetrahydrofuran / 0.75 h / -75 °C 1.2: 74 percent / 1,1,2-trichloro-1,2,2-trifluoroethane / tetrahydrofuran; hexane / 0.75 h / -75 °C 2.1: BuLi; 2,2,6,6-tetramethylpiperidine / tetrahydrofuran; hexane / 2 h / -75 °C 2.2: 90 percent / tetrahydrofuran; hexane 3.1: 91 percent / Zn; aq. NaOH / 2 h / Heating View Scheme
Multi-step reaction with 3 steps 1: 89 percent / butyllithium / hexane; tetrahydrofuran / -75 °C 2: 89 percent / sec-butyllithium / cyclohexane; tetrahydrofuran / 0.75 h 3: 98 percent / potassium hydroxide / ethanol; H2O / 2 h / Heating View Scheme
Multi-step reaction with 3 steps 1: 98 percent / sec-BuLi; I2 / tetrahydrofuran; cyclohexane / -75 °C 2: 48 percent / LDA / tetrahydrofuran; hexane / -75 °C 3: 92 percent / BuLi / tetrahydrofuran; hexane / -75 °C View Scheme
Multi-step reaction with 2 steps 2: KMnO4 View Scheme

: 38361-37-4
1-chloro-2,6-difluorobenzene

: 1583-58-0
2,4-difluoro-benzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: BuLi; 2,2,6,6-tetramethylpiperidine / tetrahydrofuran; hexane / 2 h / -75 °C 1.2: 90 percent / tetrahydrofuran; hexane 2.1: 91 percent / Zn; aq. NaOH / 2 h / Heating View Scheme

: 651027-02-0
1-triethylsilyl-2,6-difluorobenzene

: 1583-58-0
2,4-difluoro-benzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 89 percent / sec-butyllithium / cyclohexane; tetrahydrofuran / 0.75 h 2: 98 percent / potassium hydroxide / ethanol; H2O / 2 h / Heating View Scheme

: 13697-89-7
2,6-difluoroiodobenzene

: 1583-58-0
2,4-difluoro-benzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 48 percent / LDA / tetrahydrofuran; hexane / -75 °C 2: 92 percent / BuLi / tetrahydrofuran; hexane / -75 °C View Scheme

: 59-88-1
phenylhydrazine hydrochloride

: 72482-64-5
2,4-difluorobenzoyl chloride

A: 613-94-5
benzoic acid hydrazide

B: 1583-58-0
2,4-difluoro-benzoic acid

Conditions

Conditions	Yield
In pyridine	A 98 g (79%) B n/a

...Expand

: C22H18F2O4

: 1583-58-0
2,4-difluoro-benzoic acid

Conditions

Conditions	Yield
In ethanol; dichloromethane at 25℃; Kinetics;

: 367-27-1
2,4-difluorophenol

: 1583-58-0
2,4-difluoro-benzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 0 - 20 °C 2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate / 1,4-dioxane; water / 16 h / 20 °C / Schlenk technique; Inert atmosphere View Scheme

: 2,4-difluorophenylcarbonylmethylenetriphenylphosphine

: 1583-58-0
2,4-difluoro-benzoic acid

Conditions

Conditions	Yield
With dihydrogen peroxide In tetrahydrofuran at 50℃; for 18h; Inert atmosphere;

: 121-14-2
2,4-dinitrotoluene

: 1583-58-0
2,4-difluoro-benzoic acid

Conditions

Conditions	Yield
Stage #1: 2,4-dinitrotoluene With ammonium chloride In ethanol at 75 - 85℃; for 1.16667h; Stage #2: With manganese(IV) oxide; tetrabutylammomium bromide; dihydrogen peroxide at 40 - 60℃; for 1h; Stage #3: With tetrabutylammomium bromide; sodium fluoride In N,N-dimethyl-formamide at 100 - 115℃; for 5.5h;

: 3,5-dichloro-N-(4-cyanophenyl)-2,4,6-trifluorobenzamide

: 1583-58-0
2,4-difluoro-benzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: N-ethyl-N,N-diisopropylamine; tris[2-phenylpyridinato-C2,N]iridium(III) / acetonitrile / 48 h / 60 °C / Sealed tube; Inert atmosphere; Photolysis 2: hydrogenchloride / 18 h / 80 °C View Scheme

: 3,5-dichloro-2,4,6-trifluorobenzoyl chloride

: 1583-58-0
2,4-difluoro-benzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 20 °C 2: N-ethyl-N,N-diisopropylamine; tris[2-phenylpyridinato-C2,N]iridium(III) / acetonitrile / 48 h / 60 °C / Sealed tube; Inert atmosphere; Photolysis 3: hydrogenchloride / 18 h / 80 °C View Scheme

: 13656-36-5
2,4,6-trifluoro-3,5-dichlorobenzoic acid

: 1583-58-0
2,4-difluoro-benzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: thionyl chloride / 4 h / 70 °C 2: N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 20 °C 3: N-ethyl-N,N-diisopropylamine; tris[2-phenylpyridinato-C2,N]iridium(III) / acetonitrile / 48 h / 60 °C / Sealed tube; Inert atmosphere; Photolysis 4: hydrogenchloride / 18 h / 80 °C View Scheme

: 1583-58-0
2,4-difluoro-benzoic acid

: 72482-64-5
2,4-difluorobenzoyl chloride

Conditions

Conditions	Yield
With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 0 - 20℃; for 3h; Inert atmosphere; Cooling with ice;	100%
Stage #1: 2,4-difluoro-benzoic acid With N,N-dimethyl-formamide In dichloromethane at 0℃; for 0.0833333h; Stage #2: With oxalyl dichloride In dichloromethane at 20℃; for 12h;	100%
With thionyl chloride Heating;	96%

: 1583-58-0
2,4-difluoro-benzoic acid

: 2,4-difluoro-5-iodobenzoic acid

Conditions

Conditions	Yield
With N-iodo-succinimide; sulfuric acid at 0℃; for 4h;	100%
With N-iodo-succinimide; trifluorormethanesulfonic acid at 5 - 50℃; for 1.5h; Product distribution / selectivity;	100%
With N-Iodosuccinamide; sulfuric acid at 0 - 5℃; for 5h;	94%

: 869489-00-9
(2S,4S)-2-(3,3-difluoropyrrolidine-1-carbonyl)-4-piperazin-1-ylpyrrolidine-1-carboxylic acid tert-butyl ester

: 1583-58-0
2,4-difluoro-benzoic acid

: (2S,4S)-4-[4-(2,4-difluorobenzoyl)piperazin-1-yl]-2-(3,3-difluoropyrrolidine-1-carbonyl)pyrrolidine-1-carboxylic acid tert-butyl ester

Conditions

Conditions	Yield
Stage #1: (2S,4S)-2-(3,3-difluoropyrrolidine-1-carbonyl)-4-piperazin-1-ylpyrrolidine-1-carboxylic acid tert-butyl ester; 2,4-difluoro-benzoic acid With O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; Stage #2: With sodium hydrogencarbonate In dichloromethane; water	100%

: 1583-58-0
2,4-difluoro-benzoic acid

: 153775-33-8
2,4-difluoro-5-nitro-benzoic acid

Conditions

Conditions	Yield
With sulfuric acid; nitric acid at 0 - 20℃; for 16.5h;	98%
With sulfuric acid; nitric acid In water at 20 - 50℃; for 3.5h;	98%
With sulfuric acid; nitric acid at 0 - 20℃; for 16.5h;	98%

: 24313-88-0
3,4,5-Trimethoxyaniline

: 1583-58-0
2,4-difluoro-benzoic acid

: 2,4-difluoro-N-(3,4,5-trimethoxyphenyl)benzamide

Conditions

Conditions	Yield
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 2h;	98%

: 1583-58-0
2,4-difluoro-benzoic acid

: 106614-28-2
methyl 2,4-difluorobenzoate

Conditions

Conditions	Yield
With thionyl chloride In methanol	97%
Multi-step reaction with 2 steps 1: thionyl chloride; sulfuric acid / 0.2 h / Inert atmosphere; Reflux 2: triethylamine / dichloromethane / 0 °C / Inert atmosphere View Scheme

: 1583-58-0
2,4-difluoro-benzoic acid

: 345-29-9
4-fluorosalicylic acid

Conditions

Conditions	Yield
With 1,3-dimethyl-2-imidazolidinone; sodium hydroxide at 130℃; for 4h;	95.1%
With sodium hydroxide In dimethyl sulfoxide at 130℃; for 8h;	90%
With 1,3-dimethyl-2-imidazolidinone; sodium hydroxide at 135℃; for 4h;	68%
With 1,3-dimethyl-2-imidazolidinone; sodium hydroxide at 135℃; for 6h;	67.52%
With sodium hydroxide In 1-methyl-pyrrolidin-2-one at 150℃; for 1h;

: 14268-66-7
benzo[1,3]dioxolo-5-ylamine

: 1583-58-0
2,4-difluoro-benzoic acid

: N-(benzo[d][1,3]dioxol-5-yl)-2,4-difluorobenzamide

Conditions

Conditions	Yield
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 2h;	93%

: 104-94-9
4-methoxy-aniline

: 1583-58-0
2,4-difluoro-benzoic acid

: 2,4-difluoro-N-(4-methoxyphenyl)benzamide

Conditions

Conditions	Yield
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 2h;	93%

: 1583-58-0
2,4-difluoro-benzoic acid

: 372-20-3
3-fluorophenol

Conditions

Conditions	Yield
With water; sodium carbonate In 5,5-dimethyl-1,3-cyclohexadiene at 170 - 175℃; for 15h; Sealed tube;	92.8%

: 6315-89-5
3,4-dimethoxyaniline

: 1583-58-0
2,4-difluoro-benzoic acid

: N-(3,4-dimethoxyphenyl)-2,4-difluorobenzamide

Conditions

Conditions	Yield
With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 2h;	91%

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 1583-58-0
2,4-difluoro-benzoic acid

: (S)-methyl 2-(2,4-difluorobenzamido)-4-methylpentanoate

Conditions

Conditions	Yield
With pyridine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 0 - 20℃; for 5h; Inert atmosphere;	90%

: europium(III) hydroxide

: 1583-58-0
2,4-difluoro-benzoic acid

: C21H13EuF6O8

Conditions

Conditions	Yield
In methanol; acetone at 60℃; for 1h;	89%

: 75-65-0
tert-butyl alcohol

: 1583-58-0
2,4-difluoro-benzoic acid

: 500353-15-1
tert-butyl 2,4-difluorobenzoate

Conditions

Conditions	Yield
With dmap; di-tert-butyl dicarbonate for 48h;	86%
With dmap; di-tert-butyl dicarbonate at 20℃; for 24h;	84%
With dmap; di-tert-butyl dicarbonate In dichloromethane at 20℃; for 24h;	84%

: 64-17-5
ethanol

: 1583-58-0
2,4-difluoro-benzoic acid

: 108928-00-3
ethyl 2,4-di-fluorobenzoate

Conditions

Conditions	Yield
With sulfuric acid for 3h; Heating;	85%
With hydrogenchloride at 80℃; for 24.25h;	76%
Stage #1: ethanol; 2,4-difluoro-benzoic acid With hydrogenchloride for 5.33333h; Heating / reflux; Stage #2: With sodium hydroxide In diethyl ether; water
With hydrogenchloride
With sulfuric acid Heating;

: 22445-41-6
3,5-dimethylphenyl iodide

: 1583-58-0
2,4-difluoro-benzoic acid

: 1344681-47-5
3,5-difluoro-3',5'-dimethyl-1,1'-biphenyl

Conditions

Conditions	Yield
With palladium diacetate; acetic acid; silver carbonate at 130℃; for 16h; regioselective reaction;	85%

: 5-(3-fluoro-4-methoxyphenyl)-1H-pyrazole-3-carbohydrazide

: 1583-58-0
2,4-difluoro-benzoic acid

: 2-(5-(3-fluoro-4-methoxyphenyl)-1H-pyrazol-3-yl)-5-(2,4-difluorophenyl)-1,3,4-oxadiazole

Conditions

Conditions	Yield
With trichlorophosphate Reflux;	85%

: 924-99-2, 1117-37-9, 114894-59-6
ethyl 3-(dimethylamino)acrylate

: 1583-58-0
2,4-difluoro-benzoic acid

: (Z)-ethyl 2-(2,4-difluorobenzoyl)-3-(dimethylamino)acrylate

Conditions

Conditions	Yield
Stage #1: 2,4-difluoro-benzoic acid With thionyl chloride at 80℃; for 2h; Stage #2: ethyl 3-(dimethylamino)acrylate With triethylamine In toluene at 90℃; for 12h;	85%

: 24424-99-5
di-tert-butyl dicarbonate

: 75-65-0
tert-butyl alcohol

: 1583-58-0
2,4-difluoro-benzoic acid

: 500353-15-1
tert-butyl 2,4-difluorobenzoate

Conditions

Conditions	Yield
dmap In dichloromethane at 20℃; for 24h;	84%

...Expand

: 24424-99-5
di-tert-butyl dicarbonate

: 1583-58-0
2,4-difluoro-benzoic acid

: 500353-15-1
tert-butyl 2,4-difluorobenzoate

Conditions

Conditions	Yield
With dmap In dichloromethane; tert-butyl alcohol at 20℃; for 24h;	84%
dmap In tert-butyl alcohol at 40℃; for 18h;	81%

2,4-Difluorobenzoic acid Specification

The IUPAC name of this chemical is 2,4-difluorobenzoic acid. With the CAS registry number 1583-58-0, it is also named as Benzoic acid, 2,4-difluoro-. The product's categories are Fluorin-contained Benzoic Acid Series; Fine Chemical & Intermediates; Blocks; Carboxes; Fluoro Compounds; API intermediates; Miscellaneous; Acids & Esters; Fluorine Compounds; Fluorobenzoic acids; Carbonyl Compounds; Carboxylic Acids. It is white to light yellow crystal powder which is soluble in water and stable under normal temperature and pressure. Additionally, this chemical should be sealed in the container and stored in the cool and dry place.

The other characteristics of this product can be summarized as: (1)ACD/LogP: 2.07; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.17; (4)ACD/LogD (pH 7.4): -1.04; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1.85; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 2; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 1; (12)Index of Refraction: 1.512; (13)Molar Refractivity: 33.17 cm³; (14)Molar Volume: 110.3 cm³; (15)Polarizability: 13.14×10^-24 cm³; (16)Surface Tension: 43.6 dyne/cm; (17)Enthalpy of Vaporization: 50.34 kJ/mol; (18)Vapour Pressure: 0.0218 mmHg at 25°C; (19)Rotatable Bond Count: 1; (20)Exact Mass: 158.017936; (21)MonoIsotopic Mass: 158.017936; (22)Topological Polar Surface Area: 37.3; (23)Heavy Atom Count: 11; (24)Complexity: 161.

Uses of 2,4-Difluorobenzoic acid: It is used as intermediate of pharmaceutical and liquid crystal. And it also can react with ethanol to get 2,4-difluoro-benzoic acid ethyl ester. This reaction needs reagent conc. H₂SO₄ by heating. The reaction time is 3 hours. The yield is 85%.

When you are using this chemical, please be cautious about it as the following:
It is irritating to eyes, respiratory system and skin. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable gloves and eye/face protection.

People can use the following data to convert to the molecule structure.
1. SMILES:O=C(O)c1ccc(F)cc1F
2. InChI:InChI=1/C7H4F2O2/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3H,(H,10,11)
3. InChIKey:NJYBIFYEWYWYAN-UHFFFAOYAW

Product Name

2,4-Difluorobenzoic acid

Synthetic route

2,4-Difluorobenzoic acid Specification

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