2,5-Dichloropyridin-3-amine supplier

Name
2,5-Dichloropyridin-3-amine
EINECS
CAS No. 78607-32-6
Article Data8
CAS DataBase
Density 1.498 g/cm³
Solubility
Melting Point 124 °C
Formula C₅H₄Cl₂N₂
Boiling Point 287.009 °C at 760 mmHg
Molecular Weight 163.006
Flash Point 127.379 °C
Transport Information
Appearance
Safety 26-36/37/39-37/39-36
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols Xi
Synonyms 3-Amino-2,5-dichloropyridine;2,5-Dichloropyridin-3-ylamine;
PSA 38.91000
LogP 2.55180

Synthetic route

: 21427-62-3
2,5-dichloro-3-nitropyridine

: 78607-32-6
3-amino-2,5-dichloropyridine

Conditions

Conditions	Yield
With formic acid; triethylamine for 24h; chemoselective reaction;	95%
With hydrogen In tetrahydrofuran; water at 120℃; under 37503.8 Torr; for 15h; chemoselective reaction;	94%
With chlorobis(cyclooctene)rhodium(I) dimer In N,N-dimethyl-formamide at 120℃; for 12h; pH=2.25; Inert atmosphere;	86%

: 90902-83-3
2-bromo-3-amino-5-chloropyridine

: 78607-32-6
3-amino-2,5-dichloropyridine

Conditions

Conditions	Yield
With hydrogenchloride

: 75806-86-9
2-bromo-5-chloro-3-nitropyridine

: 78607-32-6
3-amino-2,5-dichloropyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: iron-turnings; acetic acid 2: aqueous HCl View Scheme

: 5409-39-2
2-amino-5-chloro-3-nitropyridine

: 78607-32-6
3-amino-2,5-dichloropyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: concentrated aqueous hydrochloric acid / -10 °C / anschliessend Behandeln mit wss. Natriumnitrit-Loesung 2: iron-turnings; acetic acid View Scheme

: 21427-61-2
5-chloro-3-nitropyridin-2-ol

: 78607-32-6
3-amino-2,5-dichloropyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: phosphoryl chloride; phosphorus (V)-chloride 2: iron-turnings; acetic acid View Scheme
Multi-step reaction with 3 steps 1: bromine; phosphorus (III)-bromide 2: iron-turnings; acetic acid 3: aqueous HCl View Scheme

: 78607-32-6
3-amino-2,5-dichloropyridine

: C26H35ClN4O3Si

: C31H38Cl2N6O3Si

Conditions

Conditions	Yield
With chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-t-butyl ether adduct; caesium carbonate In tetrahydrofuran at 95℃; for 18h; Inert atmosphere;	100%

: 78607-32-6
3-amino-2,5-dichloropyridine

: 79-04-9
chloroacetyl chloride

: 1256478-40-6
2-chloro-N-(2,5-dichloro-pyridin-3-yl)-acetamide

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; Inert atmosphere;	96%

: 78607-32-6
3-amino-2,5-dichloropyridine

: 535-80-8
3-chlorobenzoate

: 1314530-64-7
2,5-dichloro-N-(3-chloro-phenyl)-nicotinamide

Conditions

Conditions	Yield
In acetonitrile at 20℃;	90%

: 78607-32-6
3-amino-2,5-dichloropyridine

: 75318-43-3
4,5-dichloro-1,2,3-dithiazolium chloride

: 1417816-48-8
(Z)-2,5-dichloro-N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)pyridin-3-amine

Conditions

Conditions	Yield
Stage #1: 3-amino-2,5-dichloropyridine; 4,5-dichloro-1,2,3-dithiazolium chloride In dichloromethane at 20℃; for 1h; Stage #2: With 2,6-dimethylpyridine In dichloromethane at 20℃; for 2h;	82%

: 78607-32-6
3-amino-2,5-dichloropyridine

: 108-67-8
1,3,5-trimethyl-benzene

: 2,5-dichloro-N-mesityl-3-aminopyridine

Conditions

Conditions	Yield
With I,I-bis(acetoxy)iodobenzene at 20℃; regioselective reaction;	82%

: 78607-32-6
3-amino-2,5-dichloropyridine

: 2,5-dichloropyridine-3-sulfonyl chloride

Conditions

Conditions	Yield
Stage #1: 3-amino-2,5-dichloropyridine With tetrafluoroboric acid; thionyl chloride In acetonitrile at 0℃; for 0.166667h; Stage #2: With tert.-butylnitrite In acetonitrile at 0℃; for 1h; Further stages;	81.7%
Stage #1: 3-amino-2,5-dichloropyridine With hydrogenchloride; sodium nitrite In water at 0℃; for 0.666667h; Stage #2: With thionyl chloride; copper(l) chloride In water at 0℃; for 1h; Sandmeyer Reaction;	1.85 g

: 78607-32-6
3-amino-2,5-dichloropyridine

: 635-93-8
5-chlorosalicyclaldehyde

: 96830-44-3
2,8-Dichloro-5-oxa-4,11-diaza-dibenzo[a,d]cycloheptene

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 110 - 120℃; for 4h;	81%

: 78607-32-6
3-amino-2,5-dichloropyridine

: 1761-61-1
5-bromosalicyclaldehyde

: 96830-47-6
8-Bromo-2-chloro-5-oxa-4,11-diaza-dibenzo[a,d]cycloheptene

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 110 - 120℃; for 4h;	81%

: 78607-32-6
3-amino-2,5-dichloropyridine

: 51676-76-7
2,6-dichloro-3,5-dinitrotoluene

: 2,5-dichloro-N-(3-chloro-2-methyl-4,6-dinitrophenyl)pyridin-3-amine

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran; N,N-dimethyl-formamide at 25℃;	78%

: 78607-32-6
3-amino-2,5-dichloropyridine

: 90-02-8
salicylaldehyde

: 96830-45-4
2-Chloro-5-oxa-4,11-diaza-dibenzo[a,d]cycloheptene

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 110 - 120℃; for 4h;	71%

: 78607-32-6
3-amino-2,5-dichloropyridine

: bis(3-amino-5-chloro-2-pyridyl) diselenide

Conditions

Conditions	Yield
With selenium; sodium tetrahydroborate; toluene-4-sulfonic acid at 50℃; for 20h; Inert atmosphere;	66%

: 78607-32-6
3-amino-2,5-dichloropyridine

: 75-36-5
acetyl chloride

: 1256478-46-2
N-(2,5-dichloro-pyridin-3-yl)-acetamide

Conditions

Conditions	Yield
Stage #1: 3-amino-2,5-dichloropyridine; acetyl chloride In dichloromethane at 0℃; Inert atmosphere; Stage #2: With N-ethyl-N,N-diisopropylamine In dichloromethane for 3h; Inert atmosphere;	65%

: 98-98-6
2-Picolinic acid

: 78607-32-6
3-amino-2,5-dichloropyridine

: N-(2,5-dichloropyridin-3-yl)picolinamide

Conditions

Conditions	Yield
With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 70℃; for 12h;	65%

: 78607-32-6
3-amino-2,5-dichloropyridine

: 140-88-5
ethyl acrylate

: 959616-22-9
ethyl (E)-3-(3-amino-5-chloropyridin-2-yl)prop-2-enoate

Conditions

Conditions	Yield
With tetrabutylammomium bromide; palladium diacetate; N-ethyl-N,N-diisopropylamine; 1,4-di(diphenylphosphino)-butane In N,N-dimethyl-formamide at 140℃; for 30h;	52%
With tetrabutylammomium bromide; N-ethyl-N,N-diisopropylamine; palladium diacetate; 1,4-di(diphenylphosphino)-butane In N,N-dimethyl-formamide at 140℃; for 30h; Heck Reaction;
With tetrabutylammomium bromide; palladium diacetate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 140℃; for 30h;

: 78607-32-6
3-amino-2,5-dichloropyridine

: 19810-31-2
Benzyloxyacetyl chloride

: 1227628-86-5
2-(benzyloxy)-N-(2,5-dichloropyridin-3-yl)acetamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 2h;	46%

: 78607-32-6
3-amino-2,5-dichloropyridine

: 62-53-3
aniline

: 6604-46-2
5-chloro-N2-phenylpyridine-2,3-diamine

Conditions

Conditions	Yield
Stage #1: 3-amino-2,5-dichloropyridine; aniline With hydrogen bromide In water; diethylene glycol at 80℃; for 2.5h; Microwave irradiation; Stage #2: With sodium hydrogencarbonate In dichloromethane; water	17%

: 110-91-8
morpholine

: 78607-32-6
3-amino-2,5-dichloropyridine

: 35980-84-8
di-morpholin-4-yl-phosphinic acid 2,5-dichloro-pyridin-3-ylamide

Conditions

Conditions	Yield
(i) PCl5, benzene, (ii) HCO2H, (iii) /BRN= 102549/, Et3N; Multistep reaction;

: 49609-84-9
2-Chloronicotinoyl chloride

: 78607-32-6
3-amino-2,5-dichloropyridine

: 866422-00-6
2-Chloro-N-(2,5-dichloro-pyridin-3-yl)-nicotinamide

Conditions

Conditions	Yield
With pyridine In 1,4-dioxane; cyclohexane Ambient temperature;

: 78607-32-6
3-amino-2,5-dichloropyridine

: 134698-38-7
8-Chloro-5-ethyl-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: pyridine / cyclohexane; dioxane / Ambient temperature 2: xylene / Heating 3: NaH / various solvent(s) / Heating View Scheme

: 78607-32-6
3-amino-2,5-dichloropyridine

: N-(2,5-Dichloro-pyridin-3-yl)-2-ethylamino-nicotinamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: pyridine / cyclohexane; dioxane / Ambient temperature 2: xylene / Heating View Scheme

: 78607-32-6
3-amino-2,5-dichloropyridine

: 133627-14-2
8-Chloro-5-ethyl-10-methyl-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: pyridine / cyclohexane; dioxane / Ambient temperature 2: xylene / Heating 3: NaH / various solvent(s) / Heating 4: 1.) NaH / 1.) DMSO, 2.) DMSO View Scheme

: 78607-32-6
3-amino-2,5-dichloropyridine

: 133627-28-8
8-Chloro-5-ethyl-10-methyl-7-nitro-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: pyridine / cyclohexane; dioxane / Ambient temperature 2: xylene / Heating 3: NaH / various solvent(s) / Heating 4: 1.) NaH / 1.) DMSO, 2.) DMSO 5: nitronium tetrafluoroborate / acetonitrile View Scheme

: 78607-32-6
3-amino-2,5-dichloropyridine

: 135794-93-3
8-Chloro-5-ethyl-10-methyl-2,7-dinitro-5,10-dihydro-4,5,6,10-tetraaza-dibenzo[a,d]cyclohepten-11-one

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: pyridine / cyclohexane; dioxane / Ambient temperature 2: xylene / Heating 3: NaH / various solvent(s) / Heating 4: 1.) NaH / 1.) DMSO, 2.) DMSO 5: nitronium tetrafluoroborate / acetonitrile View Scheme

: 78607-32-6
3-amino-2,5-dichloropyridine

: 96830-57-8
2-Chloro-10,11-dihydro-5-oxa-4,11-diaza-dibenzo[a,d]cycloheptene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 71 percent / NaH / dimethylformamide / 4 h / 110 - 120 °C 2: 87 percent / NaBH4 / ethanol View Scheme

: 78607-32-6
3-amino-2,5-dichloropyridine

: 96830-56-7
2,8-Dichloro-10,11-dihydro-5-oxa-4,11-diaza-dibenzo[a,d]cycloheptene

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 81 percent / NaH / dimethylformamide / 4 h / 110 - 120 °C 2: 99 percent / NaBH4 / ethanol View Scheme

2,5-Dichloropyridin-3-amine Chemical Properties

The Molecular Structure of 2,5-Dichloropyridin-3-amine (CAS NO.78607-32-6) is

Cas Register Number: 78607-32-6
IUPAC Name: 2,5-Dichloropyridin-3-amine
Synonyms: 2,5-Dichloropyridin-3-amine ; 3-Pyridinamine, 2,5-dichloro- ; 3-Amino-2,5-dichloropyridine
Molecular formula: C₅H₄Cl₂N₂
Molecular weight: 163.004660g/mol
Product Categories: pharmacetical;Amines;Pyridines;Pyridine;Nucleotides and Nucleosides;Bases & Related Reagents;Nucleotides;Amino-pyridine series
H bond acceptors: 2
H bond donors: 2
Freely Rotating Bonds: 1
Polar Surface Area: 16.13 Å²
Index of Refraction: 1.622
Molar Refractivity: 38.37 cm³
Molar Volume: 108.8 cm³
Surface Tension: 56.9 dyne/cm
Density: 1.497 g/cm³
Flash Point: 127.4 °C
Enthalpy of Vaporization: 52.62 kJ/mol
Boiling Point: 287 °C at 760 mmHg
Vapour Pressure of 2,5-Dichloropyridin-3-amine (CAS NO.78607-32-6): 0.00255 mmHg at 25°C

2,5-Dichloropyridin-3-amine Uses

2,5-Dichloropyridin-3-amine , whose cas register No. is 78607-32-6, can be used in organic synthesis.

2,5-Dichloropyridin-3-amine Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39-37/39-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S37/39:Wear suitable gloves and eye/face protection.
S36:Wear suitable protective clothing.
HazardClass: IRRITANT

Product Name

2,5-Dichloropyridin-3-amine

Synthetic route

2,5-Dichloropyridin-3-amine Chemical Properties

2,5-Dichloropyridin-3-amine Uses

2,5-Dichloropyridin-3-amine Safety Profile

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