• Name

  2,5-dihydroxybenzenesulphonic acid

• EINECS 201-833-4
• CAS No. 88-46-0
• Article Data24
• CAS DataBase
• Density 1.744 g/cm³
• Solubility
• Melting Point
• Formula C₆H₆O₅S
• Boiling Point
• Molecular Weight 190.177
• Flash Point
• Transport Information
• Appearance
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms 2,5-Dihydroxybenzenesulfonicacid;2,5-Diolbenzenesulfonic acid;2-Sulfohydroquinone;Dobesilic acid;Hydroquinone-2-sulfonic acid;Hydroquinonesulfonic acid;
• PSA 103.21000
• LogP 1.42530

Synthetic route

2,5-bis(acetyloxy)benzenesulfonic acid

88-46-0

dobesilate

Conditions

Conditions	Yield
With water; sodium hydroxide at 40℃; for 2h; Temperature;	91.1%

106-51-4

p-benzoquinone

A

88-46-0

dobesilate

B

123-31-9

hydroquinone

Conditions

Conditions	Yield
With sulfur dioxide In not given 0-80°C;	A 20% B 80%
With SO2 In not given 0-80°C;	A 20% B 80%
With sulphurous acid

106-51-4

p-benzoquinone

7757-83-7

sodium sulfite

A

88-46-0

dobesilate

B

123-31-9

hydroquinone

C

14970-71-9

dithionic acid

Conditions

Conditions	Yield
byproducts: H2SO4; slight amount of Na2S2O6;	A 57% B 3% C n/a
byproducts: H2SO4; slight amount of Na2S2O6;	A 57% B 3% C n/a

...Expand

106-51-4

p-benzoquinone

7757-83-7

sodium sulfite

88-46-0

dobesilate

Conditions

Conditions	Yield
addn. of alkali;	35%
addn. of alkali;	35%

88-42-6

2,5-dichlorobenzenesulfonic acid

88-46-0

dobesilate

Conditions

Conditions	Yield
With sodium hydroxide at 200℃; in einem Kupferkessel;

123-31-9

hydroquinone

88-46-0

dobesilate

Conditions

Conditions	Yield
With sulfuric acid at 50 - 100℃; Kinetik;
With oxygen; sodium sulfite
Darst. durch Sulfurieren;

106-51-4

p-benzoquinone

A

4444-23-9

2,5-dihydroxybenzene-1,4-disulphonic acid

B

88-46-0

dobesilate

Conditions

Conditions	Yield
With sodium sulfite

106-51-4

p-benzoquinone

88-46-0

dobesilate

Conditions

Conditions	Yield
With sodium sulfite

123-31-9

hydroquinone

A

2458-55-1

1,4-bis-sulfooxy-benzene

B

17438-29-8

sulfuric acid mono-(4-hydroxy-phenyl ester)

C

88-46-0

dobesilate

Conditions

Conditions	Yield
With sulfur trioxide In nitromethane-d3 at 20℃; Product distribution; (with 1 equiv. SO3); product distribution between 10 and 10000 min;

...Expand

123-31-9

hydroquinone

A

17438-29-8

sulfuric acid mono-(4-hydroxy-phenyl ester)

B

4444-23-9

2,5-dihydroxybenzene-1,4-disulphonic acid

C

88-46-0

dobesilate

D

81010-88-0

2,5-dihydroxy-benzene-1,3-disulfonic acid

E

2-Hydroxy-5-sulfooxy-benzene-1,3-disulfonic acid

F

2-Hydroxy-5-sulfooxy-benzenesulfonic acid

Conditions

Conditions	Yield
With sulfuric acid In water at 25℃; for 18.8889h; Product distribution; Rate constant; various times, concentrations;

...Expand

7446-11-9

sulfur trioxide

123-31-9

hydroquinone

88-46-0

dobesilate

Conditions

Conditions	Yield
unter einer Glasglocke;

106-51-4

p-benzoquinone

Na2SO3

Na2SO3

88-46-0

dobesilate

106-51-4

p-benzoquinone

Na2SO3

Na2SO3

A

88-46-0

dobesilate

B

β-hydroquinonedisulfonic acid

β-hydroquinonedisulfonic acid

...Expand

7732-18-5

water

106-51-4

p-benzoquinone

SO2

SO2

A

88-46-0

dobesilate

B

123-31-9

hydroquinone

...Expand

1205-91-0

benzene-1,4-diyl diacetate

88-46-0

dobesilate

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: chlorosulfonic acid / 1,2-dichloro-ethane / 2.5 h / 5 - 90 °C 2: sodium hydroxide; water / 2 h / 40 °C View Scheme

211915-06-9

dabigatran etexilate

88-46-0

dobesilate

dabigatran etexilate 2,5-dihydroxybenzenesulfonate

Conditions

Conditions	Yield
In ethyl acetate at 30℃; Solvent; Temperature;	92%

2,5-Dihydroxybenzenesulfonic acid Specification