2,6-Dimethylpiperazine supplier

Name
2,6-Dimethylpiperazine
EINECS 203-588-9
CAS No. 108-49-6
Article Data17
CAS DataBase
Density 0.824 g/cm³
Solubility
Melting Point 108-111 °C(lit.)
Formula C₆H₁₄N₂
Boiling Point 161.1 °C at 760 mmHg
Molecular Weight 114.191
Flash Point 45 °C
Transport Information UN 1325 4.1/PG 2
Appearance White to pale yellow crystalline powder
Safety 26-36-16-7/8
Risk Codes 11-36/37/38
Molecular Structure
Hazard Symbols F,Xi,C
Synonyms 3,5-Dimethylpiperazine;NSC 49197;
PSA 24.06000
LogP 0.61380

Synthetic route

: 55380-34-2
1,4-dinitroso-2,6-dimethylpiperazine

: 108-49-6
2,6-dimethylpiperazine

Conditions

Conditions	Yield
With hydrogenchloride; ammonium sulphamate at 50℃; Rate constant; piperidinium perchlorate, 18h; transnitrosating studies;

: 67774-31-6
N-nitroso-3,5-dimethylpiperazine

: 108-49-6
2,6-dimethylpiperazine

Conditions

Conditions	Yield
With hydrogenchloride; ammonium sulphamate at 50℃; Rate constant;

: C6H13(2)HN2

: 108-49-6
2,6-dimethylpiperazine

Conditions

Conditions	Yield
With water-d2 In water at 34.9℃; Equilibrium constant;

: C6H13(2)HN2

: 108-49-6
2,6-dimethylpiperazine

Conditions

Conditions	Yield
With water-d2 In water at 34.9℃; Equilibrium constant;

: 592-20-1
Acetol acetate

: 7664-41-7
ammonia

: 7732-18-5
water

Raney nickel: Raney nickel

hydrogen: hydrogen

A: 108-49-6
2,6-dimethylpiperazine

B bis-acetoxypropyl-amines: bis-acetoxypropyl-amines

Conditions

Conditions	Yield
at 200℃; 90 at Anfangsdruck bei 25grad;

...Expand

: 56-81-5
glycerol

A: 110-85-0
piperazine

B: 2811-20-3
N-(1-aminomethyl-2-hydroxyethyl)amine

C: 21291-99-6
1,2,3-triaminopropane

D: 109-07-9
(RS)-2-methylpiperazine

E: 107-15-3
ethylenediamine

F: 78-90-0, 10424-38-1
1,2-diaminopropan

G: 108-49-6
2,6-dimethylpiperazine

Conditions

Conditions	Yield
With ammonia; hydrogen; Raney nickel In water at 200℃; under 15001.5 - 150015 Torr; Product distribution / selectivity; Autoclave;

...Expand

: 56-81-5
glycerol

A: 6168-72-5
2-Amino-1-propanol

B: 2811-20-3
N-(1-aminomethyl-2-hydroxyethyl)amine

C: 21291-99-6
1,2,3-triaminopropane

D: 109-07-9
(RS)-2-methylpiperazine

E: 78-90-0, 10424-38-1
1,2-diaminopropan

F: 108-49-6
2,6-dimethylpiperazine

G: 106-55-8
2,5-dimethylpiperazine

Conditions

Conditions	Yield
With ammonia; hydrogen; catalyst precursor whose active composition comprised 13% by weight of Cu, calculated as CuO, 28% by weight of Ni, calculated as NiO, 28% by weight of Co, calculated as CoO and 31% by weight of Zr, calculated as ZrO2 In water at 180℃; under 150015 Torr; for 53h; Product distribution / selectivity;

...Expand

: 56-81-5
glycerol

A: 6168-72-5
2-Amino-1-propanol

B: 2811-20-3
N-(1-aminomethyl-2-hydroxyethyl)amine

C: 21291-99-6
1,2,3-triaminopropane

D: 1122585-40-3
2-aminomethyl-6-methylpiperazine

E: 1122585-41-4
2,5-bis(aminomethyl)piperazine

F: 130861-85-7
2-aminomethylpiperazine

G: 136665-35-5
2-aminomethyl-5-methylpiperazine

H: 109-07-9
(RS)-2-methylpiperazine

I: 78-90-0, 10424-38-1
1,2-diaminopropan

J: 108-49-6
2,6-dimethylpiperazine

K: 106-55-8
2,5-dimethylpiperazine

Conditions

Conditions	Yield
With ammonia; hydrogen; catalyst precursor whose active composition comprised 50% by weight of Ni, calculated as NiO, 18% by weight of Cu, calculated as CuO, 2% by weight of Mo, calculated as MoO3, and 30% by weight or Zr, calculated as ZrO2 In water at 192℃; under 150015 Torr; for 1076h; Product distribution / selectivity;

...Expand

: 50-99-7
D-glucose

A: 110-85-0
piperazine

B: 109-07-9
(RS)-2-methylpiperazine

C: 107-15-3
ethylenediamine

D: 78-90-0, 10424-38-1
1,2-diaminopropan

E: 108-49-6
2,6-dimethylpiperazine

Conditions

Conditions	Yield
Stage #1: D-glucose With hydrogen; calcium oxide In water at 230℃; under 75007.5 - 187519 Torr; for 10h; Autoclave; Inert atmosphere; Stage #2: With ammonia; hydrogen In water at 100 - 200℃; under 15001.5 - 150015 Torr; for 36h; Product distribution / selectivity; Autoclave; Inert atmosphere;

...Expand

: 50-70-4
D-sorbitol

A: 109-07-9
(RS)-2-methylpiperazine

B: 107-15-3
ethylenediamine

C: 78-90-0, 10424-38-1
1,2-diaminopropan

D: 108-49-6
2,6-dimethylpiperazine

Conditions

Conditions	Yield
With ammonia; hydrogen; reduced catalyst comprising 13 wtpercent Cu (calculated as CuO), 28 wtpercent Ni (calculated as NiO), 28 wtpercent Co (calculated as CoO), 31 wtpercent Zr (calculated as ZrO2) In water at 100 - 190℃; under 15001.5 - 150015 Torr; for 36h; Product distribution / selectivity; Autoclave; Inert atmosphere;

...Expand

: 50-70-4
D-sorbitol

A: 110-85-0
piperazine

B: 109-07-9
(RS)-2-methylpiperazine

C: 107-15-3
ethylenediamine

D: 78-90-0, 10424-38-1
1,2-diaminopropan

E: 108-49-6
2,6-dimethylpiperazine

F: 106-55-8
2,5-dimethylpiperazine

Conditions

Conditions	Yield
With ammonia; hydrogen; reduced catalyst comprising 13 wtpercent Cu (calculated as CuO), 28 wtpercent Ni (calculated as NiO), 28 wtpercent Co (calculated as CoO), 31 wtpercent Zr (calculated as ZrO2) In water at 100 - 200℃; under 15001.5 - 150015 Torr; for 36h; Product distribution / selectivity; Autoclave; Inert atmosphere;

...Expand

: 57-55-6
propylene glycol

A: 6168-72-5
2-Amino-1-propanol

B: 78-96-6, 1674-56-2
3-amino-2-propanol

C: 108-49-6
2,6-dimethylpiperazine

D: 106-55-8
2,5-dimethylpiperazine

Conditions

Conditions	Yield
With ammonium hydroxide; hydrogen In water at 179.84℃; under 7500.75 Torr; for 24h; Catalytic behavior; Reagent/catalyst; Autoclave; Inert atmosphere;

...Expand

: 78-90-0, 10424-38-1
1,2-diaminopropan

: 56-81-5
glycerol

A: 108-50-9
2,6-dimethylpyrazine

B: 77164-93-3
2-hydroxymethyl-6-methylpyrazine

C: 108-49-6
2,6-dimethylpiperazine

Conditions

Conditions	Yield
With CuCrimp In water at 375℃; under 760.051 Torr; Kinetics; Catalytic behavior; Reagent/catalyst; Flow reactor;
With Nano-crystalline mixed oxides of ZnO-ZnCr2O4 In water at 375℃; under 760.051 Torr; Kinetics; Reagent/catalyst; Flow reactor; Inert atmosphere;

...Expand

: 57-55-6
propylene glycol

A: 123-32-0
2,5-dimethyl-pyrazine

B: 6168-72-5
2-Amino-1-propanol

C: 14008-30-1
(R)-(-)-2-amino-2-propanol

D: 78-90-0, 10424-38-1
1,2-diaminopropan

E: 108-49-6
2,6-dimethylpiperazine

Conditions

Conditions	Yield
With ammonia; hydrogen at 170 - 375℃; under 60006 Torr; for 50h;
With ammonia; hydrogen at 230 - 375℃; under 60006 Torr; for 50h;
With ammonia; hydrogen at 160 - 375℃; under 30003 Torr; for 50h;
With ammonia; hydrogen at 160 - 375℃; under 45004.5 Torr; for 50h;
With ammonia; hydrogen at 160 - 375℃; under 60006 Torr; for 50h;

...Expand

: 93107-30-3
1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

: 108-49-6
2,6-dimethylpiperazine

: 93107-34-7
PD158804

Conditions

Conditions	Yield
In pyridine Heating;	100%

: 95017-63-3
3-bromo-N,N-bis(4-fluorophenyl)propanamide

: 108-49-6
2,6-dimethylpiperazine

: 3-(3,5-dimethyl-piperazin-1-yl)-N,N-bis-(4-fluoro-phenyl)-propionamide

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 2h;	100%

: 24424-99-5
di-tert-butyl dicarbonate

: 108-49-6
2,6-dimethylpiperazine

: 639068-43-2
1-(1,1-Dimethylethoxycarbonyl)-cis-3,5-dimethylpiperazine

Conditions

Conditions	Yield
dmap In dichloromethane	100%
With triethylamine In dichloromethane at 0 - 20℃; for 12h;	56%
In ethanol; water

: 98-88-4
benzoyl chloride

: 108-49-6
2,6-dimethylpiperazine

: 4143-57-1
(2,6-dimethylpiperazin-1-yl)(phenyl)methanone

Conditions

Conditions	Yield
With n-butyllithium; chloro-trimethyl-silane In tetrahydrofuran	99%

: 98-88-4
benzoyl chloride

: 108-49-6
2,6-dimethylpiperazine

: N-(benzoyl)-cis-2,6-dimethylpiperazine

Conditions

Conditions	Yield
Stage #1: 3,5-dimethylpiperazine With n-butyllithium In tetrahydrofuran at 20℃; for 0.5h; Metallation; Stage #2: With triethylsilyl chloride In tetrahydrofuran at 20℃; for 1h; silylation; Stage #3: benzoyl chloride In tetrahydrofuran at 20℃; for 0.166667h; benzoylation; Further stages.;	99%

: 108-49-6
2,6-dimethylpiperazine

: 55052-28-3
4-chloro-7-azaindole

: 1248587-59-8
4-(3,5-dimethylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridine

Conditions

Conditions	Yield
With RuPhos palladacycle; lithium hexamethyldisilazane; ruphos In tetrahydrofuran at 65℃; for 4h; Inert atmosphere; Sealed vial;	99%

: 2735-73-1
1,3-diacetyl-1,3-dihydro-benzoimidazol-2-one

: 108-49-6
2,6-dimethylpiperazine

: 1-(3,5-Dimethyl-piperazin-1-yl)-ethanone

Conditions

Conditions	Yield
In tetrahydrofuran at 20℃; for 0.3h;	98%

: 1-bromo-2-(4-phenyl-1H-1,2,3-triazol-1-yl)ethane-1-sulfonyl fluoride

: 108-49-6
2,6-dimethylpiperazine

: (E)-2-(3,5-dimethylpiperazin-1-yl)ethene-1-sulfonyl fluoride

Conditions

Conditions	Yield
In 1,4-dioxane at 20℃; stereoselective reaction;	96%

: 1-(2-methoxyphenyl)-3,5-bis(trichloromethyl)triazine

: 108-49-6
2,6-dimethylpiperazine

: 2-(3,5-dimethylpiperazin-1-yl)-4-(2-methoxyphenyl)-6-trichloromethyl[1,3,5]triazine

Conditions

Conditions	Yield
With sodium hydrogencarbonate In DMF (N,N-dimethyl-formamide) at 20℃;	95%

: 108-49-6
2,6-dimethylpiperazine

: 353794-08-8
6,7-difluoro-1-(2-fluoro-4-nitrophenyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

: 7-(dimethyl-piperazin-1-yl)-6-fluoro-1-(2-fluoro-4-nitro-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Conditions

Conditions	Yield
With triethylamine In acetonitrile Heating;	93%

: 1026984-41-7
6,7-Difluoro-4-oxo-1-o-tolyl-1,4-dihydro-quinoline-3-carboxylic acid

: 108-49-6
2,6-dimethylpiperazine

: 7-(3,5-Dimethyl-piperazin-1-yl)-6-fluoro-4-oxo-1-o-tolyl-1,4-dihydro-quinoline-3-carboxylic acid

Conditions

Conditions	Yield
In acetonitrile	92%

: 122-04-3
4-nitro-benzoyl chloride

: 108-49-6
2,6-dimethylpiperazine

: N1-(4-nitrobenzoyl)-2,6-dimethylpiperazine

Conditions

Conditions	Yield
Stage #1: 3,5-dimethylpiperazine With n-butyllithium In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere; Stage #2: With chloro-trimethyl-silane In tetrahydrofuran at 20℃; for 1h; Stage #3: 4-nitro-benzoyl chloride In tetrahydrofuran at 20℃; for 0.166667h;	90%
Stage #1: 3,5-dimethylpiperazine With n-butyllithium In tetrahydrofuran at 20℃; for 0.5h; Inert atmosphere; Stage #2: With chloro-trimethyl-silane In tetrahydrofuran for 1h; Stage #3: 4-nitro-benzoyl chloride In tetrahydrofuran for 0.166667h;	90%

: 75338-42-0
1-ethyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

: 108-49-6
2,6-dimethylpiperazine

: 98079-68-6
7-(3,5-Dimethyl-piperazin-1-yl)-1-ethyl-6,8-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Conditions

Conditions	Yield
With triethylamine In acetonitrile Heating;	89%

: 7144-08-3
Cholesteryl chloroformate

: 108-49-6
2,6-dimethylpiperazine

: 1120327-12-9
cholest-5-en-3-yl 3,5-dimethyl-1-piperazinecarboxylate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;	89%
In dichloromethane at 0 - 20℃;

: 2,6-dichloro-4-cyclopropylpyridine-3,5-dicarbonitrile

: 108-49-6
2,6-dimethylpiperazine

: 2-chloro-4-cyclopropyl-6-(3,5-dimethylpiperazin-1-yl)pyridine-3,5-dicarbonitrile

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 20℃; for 0.0833333h;	89%

: 108-49-6
2,6-dimethylpiperazine

: 778611-64-6
5-bromo-2-chloro-4-methylpyridine

: 1-(5-bromo-4-methylpyridin-2-yl)-3,5-dimethylpiperazine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 100℃; for 16h;	87.3%

: 103995-01-3
6,7-difluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-3-quinoline-carboxylic acid

: 108-49-6
2,6-dimethylpiperazine

: PD 160338

Conditions

Conditions	Yield
In acetonitrile	86%

: 80076-53-5
1-ethyl-6,7-difluoro-8-chloro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

: 108-49-6
2,6-dimethylpiperazine

: 131683-65-3
8-Chloro-7-(3,5-dimethyl-piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 60℃;	85%

: 131684-01-0
1-ethyl-6,7,8-trifluoro-1,4-dihydro-5-hydroxy-4-oxo-3-quinolinecarboxylic acid

: 108-49-6
2,6-dimethylpiperazine

: 131683-88-0
7-(3,5-Dimethyl-piperazin-1-yl)-1-ethyl-6,8-difluoro-5-hydroxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Conditions

Conditions	Yield
With triethylamine In acetonitrile Heating;	85%

: 174358-43-1
6,7-difluoro-4-oxo-1-(propan-2-yl)-1,4-dihydroquinoline-3-carboxylic acid

: 108-49-6
2,6-dimethylpiperazine

: PD 163755

Conditions

Conditions	Yield
In acetonitrile for 17h; Heating;	85%

: uranyl thiocyanate hexahydrate

: 108-49-6
2,6-dimethylpiperazine

: UO2(2+)*2NCS(1-)*0.5(CH3)2C4H8N2*C2H5OH=UO2(NCS)2((CH3)2C4H8N2)0.5(C2H5OH)

Conditions

Conditions	Yield
With ethanol In ethanol a soln. of the ligand in abs. ethanol was added dropwise with constant shaking to an ethanolic soln. of UO2-salt; excess of ether was added to complete pptn., ppt. was filtered under anhyd. conditions, washed with ethanol and ether, dried under vac.; elem. anal.;	85%

: 16454-60-7
neodymium(III) nitrate

: 108-49-6
2,6-dimethylpiperazine

: (Nd(NO3)3(C4H8N2(CH3)2)0.5(CH3OH)2)2

Conditions

Conditions	Yield
With CH3OH In methanol soln. of Nd(NO3)3 in methanol/2,2'-dimethoxypropane was refluxed, cooling to room temp., addn. of a soln. of ligand in methanol with shaking;; ppt. was sepd., washed, filtered and dried; elem. anal.;;	85%

: 75464-75-4
6-bromo-N-(6-methoxy-4-methyl-8-quinolinyl)-hexanamide

: 108-49-6
2,6-dimethylpiperazine

: 83547-07-3
N-(6-Methoxy-4-methyl-8-quinolinyl)-3,5-dimethyl-1-piperazine-hexanamide

Conditions

Conditions	Yield
In benzene for 25h; Heating;	83%
With sodium hydroxide; triethylamine In benzene	5 g (83%)

: 455-15-2
1-(methylsufonyl)-4-fluorobenzene

: 108-49-6
2,6-dimethylpiperazine

: 1095538-53-6
(3R,5S)-3,5-dimethyl-1-[4-(methylsulfonyl)phenyl]piperazine

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 4h;	83%

: 700-16-3
Pentafluoropyridine

: 108-49-6
2,6-dimethylpiperazine

: 3,5-dimethyl-1-(perfluoropyridin-4-yl)piperazine

Conditions

Conditions	Yield
In ethanol at 0℃; for 168h;	82%

: 1026747-59-0
1-(2,4-Dichloro-phenyl)-6,7-difluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

: 108-49-6
2,6-dimethylpiperazine

: 1-(2,4-Dichloro-phenyl)-7-(dimethyl-piperazin-1-yl)-6-fluoro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Conditions

Conditions	Yield
In acetonitrile	81%

: 2905-25-1
o-bromobenzenesulfonyl chloride

: 108-49-6
2,6-dimethylpiperazine

: racemic-1-((2-bromophenyl)sulfonyl)-3,5-dimethylpiperazine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 0.25h; Inert atmosphere;	81%

: 108-49-6
2,6-dimethylpiperazine

: 3-[1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbonyl]-1-methyl-3H-imidazol-1-ium; iodide

: N,N'-bis-[2-carbamoyl-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolinyl]-2,6-dimethylpiperazine

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃;	80%

: 10024-93-8
neodymium trichloride

: 108-49-6
2,6-dimethylpiperazine

: Nd(3+)*3Cl(1-)*C4H8N2(CH3)2*C2H5OH=NdCl3(C4H8N2(CH3)2)(C2H5OH)

Conditions

Conditions	Yield
With ethanol In ethanol shaking of the ligand and metal salt (2:1 molar ratio) in abs. ethanol;; ppt. was washed with ethanol and Et2O, filtered, dried under vac.; elem. anal.;;	80%

: 5819-24-9, 64508-54-9
copper(II) ortho-methylbenzoate

: 108-49-6
2,6-dimethylpiperazine

: [di(ortho-toluato)(2,6-dimethylpiperazine)copper(II)]n

Conditions

Conditions	Yield
In diethyl ether to suspn. of copper salt soln. of base (stoich. amt.) added dropwise after successive intervals of 10 min over a total period of ca. 2.5 h understirring, mixt. stirred for another 2 h; mixt. cooled, ppt. filtered, washed with acetone and diethyl ether, dried in vac.; elem. anal.;	80%

2,6-Dimethylpiperazine Chemical Properties

Molecular Structure of Piperazine, 2,6-dimethyl- (CAS NO.108-49-6):

IUPAC Name: 2,6-dimethylpiperazine
Empirical Formula: C₆H₁₄N₂
Molecular Weight: 114.1888
H bond acceptors: 2
H bond donors: 2
Freely Rotating Bonds: 0
Polar Surface Area: 6.48Å²
Index of Refraction: 1.413
Molar Refractivity: 34.55 cm³
Molar Volume: 138.5 cm³
Surface Tension: 23.3 dyne/cm
Density: 0.824 g/cm³
Flash Point: 45 °C
Enthalpy of Vaporization: 39.77 kJ/mol
Boiling Point: 161.1 °C at 760 mmHg
Vapour Pressure: 2.31 mmHg at 25°C
Melting point 108-111 ºC
EINECS: 203-588-9
Blocks; Piperazines
InChI
InChI=1/C6H14N2/c1-5-3-7-4-6(2)8-5/h5-8H,3-4H2,1-2H3
Smiles
C1NC[C@@H](N[C@@H]1C)C
Product Categories: Pharmaceutical Intermediates; Piperazine series; Piperaizine; Building Blocks; Heterocyclic Building

2,6-Dimethylpiperazine Safety Profile

Hazard Codes: F, Irritant Xi, Corrosive C
Risk Statements: 11-36/37/38
R11:Highly flammable.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36-16-7/8
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S16:Keep away from sources of ignition.
S7:Keep container tightly closed.
S8:Keep container dry.
RIDADR: UN 1325 4.1/PG 2
WGK Germany: 3
F: 3-8-10-34
HazardClass: 4.1
PackingGroup: III

2,6-Dimethylpiperazine Specification

Piperazine, 2,6-dimethyl- , with CAS number of 108-49-6, can be called (2R,6S)-2,6-Dimethylpiperazine ; piperazine, 2,6-dimethyl-, (2R,6S)- ; Piperazine, 2,6-dimethyl-, cis- ; (2,6-cis-Dimethyl)piperazine . It is a white to pale yellow crystalline powder.

Product Name

2,6-Dimethylpiperazine

Synthetic route

2,6-Dimethylpiperazine Chemical Properties

2,6-Dimethylpiperazine Safety Profile

2,6-Dimethylpiperazine Specification

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