2-Amino-2,3-dimethylbutyramide supplier

Name
2-Amino-2,3-dimethylbutyramide
EINECS
CAS No. 40963-14-2
Article Data10
CAS DataBase
Density 0.983 g/cm³
Solubility
Melting Point
Formula C₆H₁₄N₂O
Boiling Point 242.664 °C at 760 mmHg
Molecular Weight 130.19
Flash Point 100.56 °C
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms 2-Amino-2,3-dimethylbutanamide;2-Methylvalinamide;
PSA 69.11000
LogP 1.24570

Synthetic route

: 13893-53-3
2-amino-2,3-dimethylbutyronitrile

: 40963-14-2
2-amino-2,3-dimethylbutyramide

Conditions

Conditions	Yield
With water In aq. phosphate buffer at 20℃; pH=7; Concentration; pH-value; Temperature; Solvent; Microbiological reaction; Green chemistry; Enzymatic reaction;	97.3%
With ammonium hydroxide; dihydrogen peroxide
With sulfuric acid; water

: 1336-21-6
ammonium hydroxide

: 13893-53-3
2-amino-2,3-dimethylbutyronitrile

: 40963-14-2
2-amino-2,3-dimethylbutyramide

Conditions

Conditions	Yield
With sulfuric acid In ice-acetone
With sulfuric acid In ice-acetone

: dimethyl 5-(1-acetyl-3-methyl-2-imidazolidinyl)pyridine-2,3-dicarboxylate

: 40963-14-2
2-amino-2,3-dimethylbutyramide

: 136592-75-1
5-(1-ACETYL-3-METHYL-2-IMIDAZOLIDINYL)-2-(4-ISOPROPYL-4-METHYL-5-OXO-2-IMIDAZOLIN-2-YL)NICOTINIC ACID AMMONIUM SALT

Conditions

Conditions	Yield
With ammonium chloride; potassium tert-butylate In chloroform; toluene	100%

5-(1,3-dioxolan-2-yl)-2,3-pyridinedicarboxylic anhydride: 5-(1,3-dioxolan-2-yl)-2,3-pyridinedicarboxylic anhydride

: 40963-14-2
2-amino-2,3-dimethylbutyramide

: 2-[(1-CARBAMOYL-1,2-DIMETHYLPROPYL)-CARBAMOYL]-5-(1,3-DIOXOLAN-2-YL)NICOTINIC ACID

Conditions

Conditions	Yield
In tetrahydrofuran	100%

: 40963-14-2
2-amino-2,3-dimethylbutyramide

: 610-14-0
2-nitrobenzyl chloride

: N-(1-Carbamoyl-1,2-dimethyl-propyl)-2-nitro-benzamide

Conditions

Conditions	Yield
With triethylamine In chloroform 1.) 1 h, 2.) reflux, 30 min;	98%

: 40963-14-2
2-amino-2,3-dimethylbutyramide

: 778-90-5
2,5-dinitrobenzoyl chloride

: N-(1-Carbamoyl-1,2-dimethyl-propyl)-2,5-dinitro-benzamide

Conditions

Conditions	Yield
With triethylamine In chloroform 1.) 1 h, 2.) reflux, 30 min;	94%

: 2-methoxycarbonyl-5-methyl-3-pyridinecarboxylic acid

: 40963-14-2
2-amino-2,3-dimethylbutyramide

: 104098-48-8
imazapic

Conditions

Conditions	Yield
With sodium methylate at 120℃; for 1h; Temperature;	90.8%

: 24195-07-1
pyridine-2,3-dicarboxylic acid 2-methyl ester

: 40963-14-2
2-amino-2,3-dimethylbutyramide

: 81334-34-1, 81510-77-2, 81510-78-3
2-[4,5-dihydro-5-methyl-5-(1-methylethyl)-4-oxo-1H-imidazol-2-yl]nicotinic acid

Conditions

Conditions	Yield
With sodium methylate at 120℃; for 1h; Temperature;	90.1%

: 40963-14-2
2-amino-2,3-dimethylbutyramide

: C10H11NO4

: 104098-48-8
imazapic

Conditions

Conditions	Yield
With sodium ethanolate at 110℃; for 1h; Temperature; Reagent/catalyst;	89.2%

: furo[2,3-b]pyridine-5,6-dicarboxylic anhydride

: 40963-14-2
2-amino-2,3-dimethylbutyramide

: 94746-47-1
6-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)furo[2,3-b]pyridine-5-carboxylic acid

Conditions

Conditions	Yield
In tetrahydrofuran	88.6%

: 40963-14-2
2-amino-2,3-dimethylbutyramide

: C10H11NO4

: 81334-34-1, 81510-77-2, 81510-78-3
2-[4,5-dihydro-5-methyl-5-(1-methylethyl)-4-oxo-1H-imidazol-2-yl]nicotinic acid

Conditions

Conditions	Yield
With sodium n-propoxide at 110℃; for 1h;	88.5%

: pyridine-2,3-dicarboxylic acid-2-butyl ester

: 40963-14-2
2-amino-2,3-dimethylbutyramide

: 81334-34-1, 81510-77-2, 81510-78-3
2-[4,5-dihydro-5-methyl-5-(1-methylethyl)-4-oxo-1H-imidazol-2-yl]nicotinic acid

Conditions

Conditions	Yield
With potassium n-butoxide at 110℃; for 1h;	88.2%

: 161522-42-5
2-[(ethyloxy)carbonyl]-3-pyridinecarboxylic acid

: 40963-14-2
2-amino-2,3-dimethylbutyramide

: 81334-34-1, 81510-77-2, 81510-78-3
2-[4,5-dihydro-5-methyl-5-(1-methylethyl)-4-oxo-1H-imidazol-2-yl]nicotinic acid

Conditions

Conditions	Yield
With sodium ethanolate at 110℃; for 1h; Temperature; Reagent/catalyst;	87.3%

: 40963-14-2
2-amino-2,3-dimethylbutyramide

: C12H15NO4

: 104098-48-8
imazapic

Conditions

Conditions	Yield
With potassium n-butoxide at 120℃; for 1h;	87.3%

: 40963-14-2
2-amino-2,3-dimethylbutyramide

: 151603-30-4
2-bromobenzene-1,3-dicarboxylic acid dichloride

: 1276021-20-5
(+/-)-N,N'-bis(2-carbamoyl-3-methylbut-2-yl)-2-bromobenzene-1,3-dicarboxamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 12h;	87%

: 40963-14-2
2-amino-2,3-dimethylbutyramide

A: 4378-19-2, 26287-62-7, 53940-82-2, 53940-83-3
(S)-α-Methylvaline

B: 90376-98-0
(+)-(R)-2-amino-2,3-dimethylbutanamide

Conditions

Conditions	Yield
In water at 37℃; Ochrobactrum anthropi NCIMB 40321;	A 86% B 74%
With water at 37℃; for 72h; aminopeptidase from Mycobacterium neoaurum ATCC 25795;

: 40963-14-2
2-amino-2,3-dimethylbutyramide

: 105151-39-1
diethyl 5-ethyl-2,3-pyridinedicarboxylate

: 81335-77-5
imazethapyr

Conditions

Conditions	Yield
With sodium hydride In toluene at 20℃; for 0.25h;	85.2%

: 40963-14-2
2-amino-2,3-dimethylbutyramide

: 100-52-7
benzaldehyde

: 1016561-97-9
(+/-)-2-N-benzylamino-2,3-dimethylbutanamide

Conditions

Conditions	Yield
With sodium cyanoborohydride; acetic acid In methanol at 20℃; for 48h;	85%

: 21815-91-8
3-chlorobenzo[b]thiophen-2-carbonyl chloride

: 40963-14-2
2-amino-2,3-dimethylbutyramide

: 1039755-43-5
N-(2-carbamoyl-3-methylbut-2-yl)-3-chlorobenzo[b]thiophene-2-carboxamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 24h;	85%

: 40963-14-2
2-amino-2,3-dimethylbutyramide

: 32413-08-4
diethyl quinoline-2,3-dicarboxylate

: 81335-37-7
2-[4,5-dihydro-4-methyl-4-(1-methylethyl)-5-oxo-1H-imidazol-2-Yl]-3-quinolinecarboxylic acid

Conditions

Conditions	Yield
With sodium hydride In toluene at 20℃; for 0.25h;	83.7%

: 110-62-3
pentanal

: 40963-14-2
2-amino-2,3-dimethylbutyramide

: 2-butyl-4-methyl-4-(2-methylethyl)-imidazolidin-5-one

Conditions

Conditions	Yield
In methanol; water	82%

: 40963-14-2
2-amino-2,3-dimethylbutyramide

: 122-01-0
4-chloro-benzoyl chloride

: 40963-06-2
N-(1-Carbamoyl-1,2-dimethyl-propyl)-4-chloro-benzamide

Conditions

Conditions	Yield
With triethylamine In chloroform 1.) 1 h, 2.) reflux, 30 min;	81%

Conditions

Conditions	Yield
With triethylamine In chloroform 1.) 1 h, 2.) reflux, 30 min;	81%
In chloroform Yield given;

2-Picolinic acid: 2-Picolinic acid

: 40963-14-2
2-amino-2,3-dimethylbutyramide

: 898529-74-3
(+/-)-2-{[2-(aminocarbonyl)-3-methylbut-2-yl]aminocarbonyl}pyridine

Conditions

Conditions	Yield
Stage #1: 2-Picolinic acid With chloroformic acid ethyl ester; triethylamine In tetrahydrofuran for 0.5h; Stage #2: 2-amino-2,3-dimethylbutyramide In tetrahydrofuran for 3h;	78%

: 40963-14-2
2-amino-2,3-dimethylbutyramide

: 7154-66-7
2-bromobenzoic acid chloride

: 1276021-17-0
(+/-)-N-(2-carbamoyl-3-methylbut-2-yl)-2-bromobenzenecarboxamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 5h;	77%

: 40963-14-2
2-amino-2,3-dimethylbutyramide

: 105151-39-1
diethyl 5-ethyl-2,3-pyridinedicarboxylate

: 2-[4,5-dihydro-5-methyl-5-(1-methylethyl)-4-oxo-1H-imidazol-2-yl]-5-ethyl nicotinic acid

Conditions

Conditions	Yield
With sodium methylate In toluene for 1h; Heating;	76.5%
With hydrogenchloride; potassium tert-butylate In water; toluene

: 40963-14-2
2-amino-2,3-dimethylbutyramide

: 609-65-4
o-chlorobenzoyl chloride

: N-(1-Carbamoyl-1,2-dimethyl-propyl)-2-chloro-benzamide

Conditions

Conditions	Yield
With triethylamine In chloroform 1.) 1 h, 2.) reflux, 30 min;	75%

: 40963-14-2
2-amino-2,3-dimethylbutyramide

: 933-88-0
ortho-toluoyl chloride

: N-(1-Carbamoyl-1,2-dimethyl-propyl)-2-methyl-benzamide

Conditions

Conditions	Yield
With triethylamine In chloroform 1.) 1 h, 2.) reflux, 30 min;	75%

: 40963-14-2
2-amino-2,3-dimethylbutyramide

: 874-60-2
4-methyl-benzoyl chloride

: 100594-41-0, 97712-44-2
(+/-)-N-(1-carbamoyl-1,2-dimethylpropyl)-p-toluamide

Conditions

Conditions	Yield
With triethylamine In chloroform 1.) 1 h, 2.) reflux, 30 min;	70%
With triethylamine In tetrahydrofuran; water
With triethylamine In tetrahydrofuran; water
With triethylamine In acetone

: 766-39-2
2,3-Dimethylmaleic anhydride

Conditions

Conditions	Yield
With sodium ethanolate; triethylamine In ethanol	69.9%

2-amino-2,3-dimethylbutyramide: 2-amino-2,3-dimethylbutyramide

2,6-difluorobenzoylchloride: 2,6-difluorobenzoylchloride

: N-(1-Carbamoyl-1,2-dimethyl-propyl)-2,6-difluoro-benzamide

Conditions

Conditions	Yield
With triethylamine In chloroform 1.) 1 h, 2.) reflux, 30 min;	68%

2-Amino-2,3-dimethylbutyramide Chemical Properties

Molecular Formula: C₆H₁₄N₂O
Molecular Weight: 130.19g/mol
Freely Rotating Bonds: 3
Polar Surface Area: 69.11 Å²
Index of Refraction: 1.469
Molar Refractivity: 36.871 cm³
Molar Volume: 132.475 cm³ Polarizability: 14.617 ×10^-24cm³
Surface Tension: 36.885 dyne/cm
Density: 0.983 g/cm³
Flash Point: 100.56 °C
Enthalpy of Vaporization: 47.965 kJ/mol
Boiling Point: 242.664 °C at 760 mmHg
Vapour Pressure: 0.034 mmHg at 25°C
The Cas Register Number of 2-Amino-2,3-dimethylbutyramide is 40963-14-2 .The chemical synonyms of 2-Amino-2,3-dimethylbutyramide (CAS No.40963-14-2) are 2-Amino-2,3-dimethyl butyramide ; 2-Amino-2,3-dimethylbutacetamide ; 2-Amino-2,3-dimethylbutanamide ; 2-Amino-2,3-dimethylbutacetamide, >93% ; 2-Amino-2,3-dimethy butyramide .The molecular structure of 2-Amino-2,3-dimethylbutyramide (CAS No.40963-14-2) is.

2-Amino-2,3-dimethylbutyramide Uses

It can be used in organic synthesis.

2-Amino-2,3-dimethylbutyramide Specification

The extinguishing agent of 2-Amino-2,3-dimethylbutyramide (CAS No.40963-14-2) are dry powder, foam, sand, carbon dioxide, water mist.

Product Name

2-Amino-2,3-dimethylbutyramide

Synthetic route

2-Amino-2,3-dimethylbutyramide Chemical Properties

2-Amino-2,3-dimethylbutyramide Uses

2-Amino-2,3-dimethylbutyramide Specification

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