2-Amino-4-chloropyridine supplier

Name
2-Amino-4-chloropyridine
EINECS -0
CAS No. 19798-80-2
Article Data32
CAS DataBase
Density 1.327 g/cm³
Solubility
Melting Point 126-127 °C
Formula C₅H₅ClN₂
Boiling Point 240.793 °C at 760 mmHg
Molecular Weight 128.561
Flash Point 99.428 °C
Transport Information
Appearance light yellow cryst
Safety 26
Risk Codes 22-36/37/38
Molecular Structure
Hazard Symbols Xi,Xn
Synonyms 4-chloro-1H-pyridin-2-amine;4-Chloro-pyridin-2-ylamine;4-chloro-2-aminopyridine;4-chloropyridin-2-amine;4-Chloro-2-amine-pyridine;2-Amino-4-chloro pyridine/2-Amino-6-chloro pyridine;4-Chloro-2-amine-pyridin;
PSA 38.91000
LogP 1.89840

Synthetic route

: 130721-78-7
tert-butyl (4-chloropyridin-2-yl) carbamate

: 19798-80-2
2-Amino-4-chloropyridine

Conditions

Conditions	Yield
With hydrogenchloride In 1,4-dioxane at 20℃; for 18h;	100%
With hydrogenchloride In 1,4-dioxane at 20℃; for 18h;	99%
With trifluoroacetic acid In dichloromethane at 20℃;	90%
With hydrogen bromide for 2h;	87%
With hydrogen bromide for 2h; Ambient temperature;

: 74405-00-8
2,2-dimethyl-3-(4-chloropyrid-2-yl)-4-oxo-4H-1,3-benzoxazine

: 19798-80-2
2-Amino-4-chloropyridine

Conditions

Conditions	Yield
With hydrogenchloride for 8h; Heating;	95%
With hydrogenchloride Hydrolysis;

: 99586-65-9
4-chloropicolinamide

: 19798-80-2
2-Amino-4-chloropyridine

Conditions

Conditions	Yield
With bromine; potassium hydroxide In water at 90℃; for 2h; Cooling with ice;	84%
With calcium hypochlorite In water at 60 - 80℃; Temperature;	81%
With sodium hydroxide; bromine In water at 80℃; for 1.5h; Hofmann Degradation;	64%

: methyl 4-chloropyridine-2-carboxylate hydrochloride

: 19798-80-2
2-Amino-4-chloropyridine

Conditions

Conditions	Yield
With hydrazine hydrate; sodium nitrite In hydrogenchloride; methanol; water; acetic acid	44%
With hydrazine hydrate; acetic acid; sodium nitrite In hydrogenchloride; methanol; water	37 g (60%)

: 26452-80-2
2,4-dichloropyridine

A: 19798-80-2
2-Amino-4-chloropyridine

B: 14432-12-3
4-Amino-2-chloropyridine

Conditions

Conditions	Yield
With ammonium hydroxide at 170 - 180℃;
With ammonium hydroxide at 180℃;

: 187973-17-7
4-chloro-pyridine-2-carbonyl azide

: 19798-80-2
2-Amino-4-chloropyridine

Conditions

Conditions	Yield
With acetic acid

: N-(4-chloro-2-pyridyl)-1-(2-pyridyl)-1-chloroacetamide

A: 19798-80-2
2-Amino-4-chloropyridine

B: α-chloro-(2-pyridyl)acetic acid

Conditions

Conditions	Yield
With hydrogenchloride at 60℃; for 3h;	A 70 mg B 45 mg

: 1026394-00-2
4-chloro-2-pyridinylisocyanate

: 19798-80-2
2-Amino-4-chloropyridine

Conditions

Conditions	Yield
With hydrogenchloride for 48h; Heating; Yield given;

: 73771-11-6
4-chloropyridine-2-carbohydrazide

: 19798-80-2
2-Amino-4-chloropyridine

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid; sodium nitrite 1.) water, 15 min, 2.) water, heating; Yield given. Multistep reaction;

: 26452-80-2
2,4-dichloropyridine

: ammonium hydroxide

A: 19798-80-2
2-Amino-4-chloropyridine

B: 14432-12-3
4-Amino-2-chloropyridine

Conditions

Conditions	Yield
at 180℃;

...Expand

: C9H13ClN2

: 19798-80-2
2-Amino-4-chloropyridine

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane; chloroform at 70℃;

: 1121-76-2
4-chloropyridine N-oxide

: 19798-80-2
2-Amino-4-chloropyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Ts2O / CHCl3; CH2Cl2 / 0.25 h 2: TFA / CHCl3; CH2Cl2 / 70 °C View Scheme
Multi-step reaction with 2 steps 1: CH2Cl2 / Heating 2: conc. HCl View Scheme
Multi-step reaction with 2 steps 1: 90 percent / CHCl3 / 4 h / Heating 2: 95 percent / conc. HCl / 8 h / Heating View Scheme

: 1124-33-0
4-nitraminopyridine N-oxide

zinc-powder: zinc-powder

: 19798-80-2
2-Amino-4-chloropyridine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 20 percent / 1,2-dichloro-ethane / 12 h / Heating 2: 90 percent / CHCl3 / 4 h / Heating 3: 95 percent / conc. HCl / 8 h / Heating View Scheme
Multi-step reaction with 2 steps 1: 8 percent / 1,2-dichloro-ethane / 12 h / Heating 2: 95 percent / conc. HCl / 8 h / Heating View Scheme

: 5470-22-4
4-chloropicolinic acid

4-chloro-6-oxy-picolinic acid: 4-chloro-6-oxy-picolinic acid

: 19798-80-2
2-Amino-4-chloropyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: diphenylphosphoryl azide, triethylamine / 26 h / Heating 2: 25percent HBr / 2 h / Ambient temperature View Scheme

: 1124-33-0
4-nitraminopyridine N-oxide

: 19798-80-2
2-Amino-4-chloropyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sulfuryl chloride / 110 °C 2: aqueous NH3 / 180 °C View Scheme

: 626-03-9
3-deazauracil

: 19798-80-2
2-Amino-4-chloropyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: phosphoryl chloride / 140 °C 2: aqueous NH3 / 180 °C View Scheme

2-(methylcarboxylate)-4-chloro-pyridine: 2-(methylcarboxylate)-4-chloro-pyridine

: 636-80-6
2-picolinic acid hydrochloride

: methyl 4-chloropyridine-2-carboxylate hydrochloride

: 19798-80-2
2-Amino-4-chloropyridine

Conditions

Conditions	Yield
With thionyl chloride; acetic acid; hydrazine; sodium nitrite In methanol; water

...Expand

: 942947-94-6
5-bromo-4-chloro-pyridin-2-ylamine

: 73183-34-3
bis(pinacol)diborane

A: 19798-80-2
2-Amino-4-chloropyridine

B: 944401-60-9
4-chloro-5-(4,4,5,5-tetramethyl(1,3,2-dioxaborolan-2-yl))-2-pyridylamine

Conditions

Conditions	Yield
With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 In 1,4-dioxane at 115℃; for 6.25h; Heating / reflux;
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In 1,4-dioxane at 115℃; for 6h; Inert atmosphere;
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In 1,4-dioxane at 115℃; for 6h; Inert atmosphere;

...Expand

: 98-98-6
2-Picolinic acid

: 19798-80-2
2-Amino-4-chloropyridine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: sodium bromide; thionyl chloride / chlorobenzene / 20.5 h / 50 - 85 °C 2.1: toluene / 1.5 h / 0 - 15 °C 3.1: ammonium hydroxide / 3 h / 20 °C 4.1: bromine; sodium hydroxide / water / 5 h / 20 - 80 °C 4.2: pH 12 - 13 View Scheme
Multi-step reaction with 4 steps 1.1: thionyl chloride / 72 h / Reflux 2.1: toluene / 1 h / 0 - 5 °C 3.1: water / 0.25 h 3.2: 1 h / 20 °C 4.1: sodium hydroxide; bromine / water / 0.58 h / 0 - 5 °C View Scheme
Multi-step reaction with 2 steps 1.1: sodium bromide / thionyl chloride / Reflux 1.2: 20 °C 2.1: calcium hypochlorite / water / 60 - 80 °C View Scheme
Multi-step reaction with 4 steps 1: thionyl chloride / Heating / reflux 2: lithium hydroxide; water / tetrahydrofuran / 20 °C 3: diphenyl phosphoryl azide; triethylamine / toluene / 3.5 h / 65 - 100 °C 4: trifluoroacetic acid / dichloromethane / 20 °C View Scheme
Multi-step reaction with 3 steps 1: sodium bromide; thionyl chloride / 16 h / Reflux 2: ammonium hydroxide / 18 h / 0 - 20 °C 3: bromine; sodium hydroxide / water / 3.5 h / -10 - 100 °C View Scheme

: 24484-93-3
4-Chloro-pyridine-2-carboxylic acid methyl ester

: 19798-80-2
2-Amino-4-chloropyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: ammonium hydroxide / 3 h / 20 °C 2.1: bromine; sodium hydroxide / water / 5 h / 20 - 80 °C 2.2: pH 12 - 13 View Scheme
Multi-step reaction with 2 steps 1.1: water / 0.25 h 1.2: 1 h / 20 °C 2.1: sodium hydroxide; bromine / water / 0.58 h / 0 - 5 °C View Scheme
Multi-step reaction with 3 steps 1: lithium hydroxide; water / tetrahydrofuran / 20 °C 2: diphenyl phosphoryl azide; triethylamine / toluene / 3.5 h / 65 - 100 °C 3: trifluoroacetic acid / dichloromethane / 20 °C View Scheme

: 5470-22-4
4-chloropicolinic acid

: 19798-80-2
2-Amino-4-chloropyridine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: toluene / 1.5 h / 0 - 15 °C 2.1: ammonium hydroxide / 3 h / 20 °C 3.1: bromine; sodium hydroxide / water / 5 h / 20 - 80 °C 3.2: pH 12 - 13 View Scheme
Multi-step reaction with 2 steps 1.1: thionyl chloride / toluene / 6 h / 80 °C 1.2: 1 h / 20 °C / Cooling with ice 2.1: potassium hydroxide; bromine / water / 2 h / 90 °C / Cooling with ice View Scheme

: 53750-66-6
4-chloro-pyridine-2-carbonyl chloride

: 19798-80-2
2-Amino-4-chloropyridine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: toluene / 1 h / 0 - 5 °C 2.1: water / 0.25 h 2.2: 1 h / 20 °C 3.1: sodium hydroxide; bromine / water / 0.58 h / 0 - 5 °C View Scheme
Multi-step reaction with 2 steps 1: ammonium hydroxide / 18 h / 0 - 20 °C 2: bromine; sodium hydroxide / water / 3.5 h / -10 - 100 °C View Scheme

: 19798-80-2
2-Amino-4-chloropyridine

: 903513-62-2
(2-aminopyridin-4-yl)boronic acid

Conditions

Conditions	Yield
With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium(0); potassium acetate; bis(pinacol)diborane In 1,4-dioxane at 100℃; for 3h; Inert atmosphere;	100%
With potassium acetate; bis(pinacol)diborane; bis(dibenzylideneacetone)-palladium(0); XPhos In 1,4-dioxane at 110℃;

: 19798-80-2
2-Amino-4-chloropyridine

: 126726-62-3
2-isopropenyl-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

: 4-(prop-1-en-2-yl)pyridin-2-amine

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); tricyclohexylphosphine In 1,4-dioxane; water; acetonitrile at 120℃;	100%
With tris-(dibenzylideneacetone)dipalladium(0) In 1,4-dioxane; water; acetonitrile at 90℃; for 12h;

: 19798-80-2
2-Amino-4-chloropyridine

: 2-azido-1-(4-chlorophenyl)-3-(3,5-dimethoxyphenyl)prop-2-en-1-one

: N-(7-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-1-(3,5-dimethoxyphenyl)methanimine

Conditions

Conditions	Yield
In tetrahydrofuran Reflux;	99.9%

: 19798-80-2
2-Amino-4-chloropyridine

: 108-24-7
acetic anhydride

: N-(4-chloropyridin-2-yl)acetamide

Conditions

Conditions	Yield
With triethylamine at 20 - 60℃; for 12h;	99%
With triethylamine at 60℃; for 12h;	99%
With pyridine In dichloromethane at 20℃; for 26h;	75%

: 19798-80-2
2-Amino-4-chloropyridine

: 24484-97-7
N-nitro-2-amino-4-chloropyridine

Conditions

Conditions	Yield
With sulfuric acid; nitric acid at 0 - 5℃; for 78h;	99%
With sulfuric acid; nitric acid at 0 - 20℃; for 0.333333h;	92%
With sulfuric acid; nitric acid at 0℃; for 0.333333h;

: 19798-80-2
2-Amino-4-chloropyridine

: 3282-30-2
pivaloyl chloride

: 188577-70-0
4-chloro-2-trimethylacetamidopyridine

Conditions

Conditions	Yield
With pyridine at 0 - 20℃; for 12h;	99%
With pyridine at 0 - 20℃; for 12h;	99%
With pyridine for 12h; Ambient temperature;	95%

: 19798-80-2
2-Amino-4-chloropyridine

: 1885-14-9
phenyl chloroformate

: 670253-26-6
phenyl N-(4-chloro-2-pyridyl)-N-phenoxycarbonylcarbamate

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 25℃; for 2h;	99%
With triethylamine In tetrahydrofuran at 20℃; for 1.5h;	53.4%

: 19798-80-2
2-Amino-4-chloropyridine

: 124-40-3
dimethyl amine

: 50426-31-8
2-amino-4-(dimethylamino)-pyridine

Conditions

Conditions	Yield
In water at 120℃; Microwave irradiation;	99%
In water at 175℃; for 0.583333h; Microwave;	94%
Stage #1: 2-Amino-4-chloropyridine; dimethyl amine In water at 175℃; for 0.583333h; Microwave irradiation; Stage #2: With ammonium carbonate In water; acetonitrile	94%
In water at 175℃; for 0.583333h; Microwave irradiation;	94%

: 19798-80-2
2-Amino-4-chloropyridine

: 942947-94-6
5-bromo-4-chloro-pyridin-2-ylamine

Conditions

Conditions	Yield
With N-Bromosuccinimide In acetonitrile for 14h;	99%
With N-Bromosuccinimide In acetonitrile at 20℃; for 14h;	99%
With N-Bromosuccinimide In acetonitrile at 20℃;	99%

: 19798-80-2
2-Amino-4-chloropyridine

: 411235-57-9
cyclopropylboronic acid

: 908269-97-6
2-amino-4-(cyclopropyl)pyridine

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; tricyclohexylphosphine In 1,4-dioxane; acetonitrile at 120℃; Inert atmosphere;	99%
With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride In 1,4-dioxane; water at 80℃; for 15h;

: 19798-80-2
2-Amino-4-chloropyridine

: 4-(chlorosulfonyl)benzenesulfonyl fluoride

: 4-(N-(4-chloropyridin-2-yl)sulfamoyl)benzene-1-sulfonyl fluoride

Conditions

Conditions	Yield
With pyridine In chloroform at 20℃; for 48h; chemoselective reaction;	99%

: 19798-80-2
2-Amino-4-chloropyridine

: 1170108-38-9
tert-butyl (azetidin-3-ylmethyl)carbamate hydrochloride

: tert-butyl ((1-(2-aminopyridin-4-yl)azetidin-3-yl)methyl)carbamate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 120℃; for 24h; Sealed tube;	96%
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 120℃; for 24h; Sealed tube;

: 19798-80-2
2-Amino-4-chloropyridine

: 38870-89-2
Methoxyacetyl chloride

: 1262776-53-3
N-(4-chloro-2-pyridyl)-2-methoxyacetamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20 - 25℃; for 0.25h;	96%

: 19798-80-2
2-Amino-4-chloropyridine

: 15687-27-1
ibuprofen

: N-(4-chloro-pyridin-2-yl)-2-(4-isobutyl-phenyl)-propionamide

Conditions

Conditions	Yield
Stage #1: ibuprofen With 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 0.5h; Stage #2: 2-Amino-4-chloropyridine In dichloromethane for 72h; Heating;	95%

: 19798-80-2
2-Amino-4-chloropyridine

: 714274-03-0
ethyl (2E)-3-dimethylamino-2-(1H-indol-3-yl)propenoate

: 7-chloro-3-(1H-indol-3-yl)-4H-pyrido[1,2-a]pyrimidin-4-one

Conditions

Conditions	Yield
With acetic acid for 4h; Heating;	95%

: 19798-80-2
2-Amino-4-chloropyridine

: 1692-25-7
3-pyridylboronic acid

: 865604-20-2
4-(pyridin-3-yl)pyridin-2-amine

Conditions

Conditions	Yield
With potassium phosphate; PdCl2[P(tBu)2(p-Me2NC6H4)]2 In 1,4-dioxane; water at 100℃; Suzuki-Miyaura cross-coupling;	95%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate In acetonitrile at 170℃; Suzuki reaction; Microwave irradiation;	95%

: 19798-80-2
2-Amino-4-chloropyridine

: 16182-04-0
Ethoxycarbonyl isothiocyanate

: 1131410-83-7
ethyl [(4-chloropyridin-2-yl)carbamothioyl]carbamate

Conditions

Conditions	Yield
In 1,4-dioxane at 20℃;	95%
In 1,4-dioxane at 25℃; for 2h;	92.1%
In 1,4-dioxane at 20℃; for 2h;	16.5 g
In 1,4-dioxane at 20℃; for 2h;	8.5 g

: 19798-80-2
2-Amino-4-chloropyridine

: 612-16-8
(2-methoxyphenyl)methanol

: C13H11ClN2O2

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; copper(l) iodide In water at 20℃; for 6h;	95%

: 19798-80-2
2-Amino-4-chloropyridine

: 535-80-8
3-chlorobenzoate

: 901390-17-8
3-chloro-N-(4-chloropyridin-2-yl)benzamide

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;	94%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane

: 19798-80-2
2-Amino-4-chloropyridine

: 111-77-3
2-(2-methoxyethoxy)ethyl alcohol

: 4-(2-(2-methoxyethoxy)ethoxy)pyridin-2-amine

Conditions

Conditions	Yield
Stage #1: 2-(2-methoxyethoxy)ethyl alcohol With sodium hydride In neat (no solvent) for 0.166667h; Inert atmosphere; Cooling with ice; Stage #2: 2-Amino-4-chloropyridine In neat (no solvent) at 120℃; for 16h; Sealed tube;	94%

: 19798-80-2
2-Amino-4-chloropyridine

: 18209-60-4
(N,N-dimethylamino)dimethylchlorosilane

: C9H16ClN3Si

Conditions

Conditions	Yield
Stage #1: 2-Amino-4-chloropyridine With n-butyllithium In hexane at 0 - 20℃; for 12h; Inert atmosphere; Schlenk technique; Stage #2: (N,N-dimethylamino)dimethylchlorosilane In hexane at 0 - 20℃; for 12h; Inert atmosphere; Schlenk technique;	94%

: 19798-80-2
2-Amino-4-chloropyridine

: 119072-55-8, 7188-38-7
tert-butylisonitrile

: 298-12-4
Glyoxilic acid

: 1329425-87-7
C11H14ClN3

Conditions

Conditions	Yield
Stage #1: 2-Amino-4-chloropyridine; Glyoxilic acid With perchloric acid In methanol Groebke-Blackburn-Bienayme reaction; Stage #2: tert-butylisonitrile In methanol at 20℃; for 12h; Groebke-Blackburn-Bienayme reaction; regioselective reaction;	93%

...Expand

: 19798-80-2
2-Amino-4-chloropyridine

: 100-51-6
benzyl alcohol

: N-(4-chloropyridin-2-yl)benzamide

Conditions

Conditions	Yield
With tert.-butylhydroperoxide; copper(l) iodide In water at 20℃; for 6h;	93%

: 19798-80-2
2-Amino-4-chloropyridine

: 22918-01-0
2-bromo-4-chloropyridine

Conditions

Conditions	Yield
Stage #1: 2-Amino-4-chloropyridine With hydrogen bromide; bromine In water at 0℃; for 0.166667h; Stage #2: With sodium nitrite In water at -10 - 20℃; Stage #3: With sodium hydroxide In water at 0℃; pH=> 10;	92%
Stage #1: 2-Amino-4-chloropyridine With hydrogen bromide; bromine In water at 0℃; for 0.166667h; Stage #2: With sodium nitrite In water at -10 - 20℃; Stage #3: With sodium hydroxide In water at 0℃; pH=10;	92%
Stage #1: 2-Amino-4-chloropyridine With hydrogen bromide; bromine In water at -5℃; for 0.333333h; Stage #2: With sodium nitrite In water at -5℃; for 0.5h;	40%

: 19798-80-2
2-Amino-4-chloropyridine

: 135632-53-0
tert-butyl N-(4-piperidinylmethyl)carbamate

: tert-butyl ((1-(2-aminopyridin-4-yl)piperidin-4-yl)methyl)carbamate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 120℃; for 24h; Sealed tube;	92%
With N-ethyl-N,N-diisopropylamine In isopropyl alcohol at 120℃; for 24h; Sealed tube;

: 19798-80-2
2-Amino-4-chloropyridine

: 6630-33-7
ortho-bromobenzaldehyde

: 2-(4-chloropyridin-2-yl)-2H-indazole

Conditions

Conditions	Yield
With choline azide; caesium carbonate at 20℃; for 4h; Green chemistry;	92%

: 4045-30-1
4,4-dimethylpiperidine

: 19798-80-2
2-Amino-4-chloropyridine

: 4-(4,4-dimethylpiperidin-1-yl)pyridin-2-amine

Conditions

Conditions	Yield
In 1-methyl-pyrrolidin-2-one at 200℃; for 0.75h; Microwave irradiation;	92%

: 19798-80-2
2-Amino-4-chloropyridine

: 670253-37-9
4-chloro-5-iodopyridin-2-ylamine

Conditions

Conditions	Yield
With N-iodo-succinimide In N,N-dimethyl-formamide for 43h; regioselective reaction;	90%
With N-iodo-succinimide In N,N-dimethyl-formamide at 40℃;	70%
With N-iodo-succinimide In N,N-dimethyl-formamide at 20℃; for 18h;	62%

2-Amino-4-chloropyridine Specification

The 4-Chloro-pyridin-2-ylamine is an organic compound with the formula C₅H₅ClN₂. The IUPAC name of this chemical is 4-chloropyridin-2-amine. With the CAS registry number 19798-80-2, it is also named as 2-Pyridinamine, 4-chloro-. The product's categories are Pyridine; Blocks; Pyridines; Amines and Anilines; Heterocycles; Pyridines, Pyrimidines, Purines and Pteredines; Heterocyclic Series; Pharmacetical; Pyridine Series; Amines; Nucleotides and Nucleosides; Bases & Related Reagents; Nucleotides; Pharmaceutical Intermediate; Amino-Pyridine Eeries.

Physical properties about 4-Chloro-pyridin-2-ylamine are: (1)ACD/LogP: 1.32; (2)ACD/LogD (pH 5.5): 0.897; (3)ACD/LogD (pH 7.4): 1.308; (4)ACD/BCF (pH 5.5): 2.244; (5)ACD/BCF (pH 7.4): 5.785; (6)ACD/KOC (pH 5.5): 47.149; (7)ACD/KOC (pH 7.4): 121.544; (8)#H bond acceptors: 2; (9)#H bond donors: 2; (10)Polar Surface Area: 38.91 Å²; (11)Index of Refraction: 1.607; (12)Molar Refractivity: 33.475 cm³; (13)Molar Volume: 96.888 cm³; (14)Polarizability: 13.271×10^-24cm³; (15)Surface Tension: 54.396 dyne/cm; (16)Density: 1.327 g/cm³; (17)Flash Point: 99.428 °C; (18)Enthalpy of Vaporization: 47.772 kJ/mol; (19)Boiling Point: 240.793 °C at 760 mmHg; (20)Vapour Pressure: 0.037 mmHg at 25°C.

Preparation: this chemical can be prepared by t-butyl N-(4-chloro-2-pyridinyl)carbamate. This reaction will need reagent 25 percent HBr. The reaction time is 2 hours. The yield is about 87%.

Uses of 4-Chloro-pyridin-2-ylamine: it can be used to produce 4-methoxy-pyridin-2-ylamine at temperature of 140 °C. It will need solvent methanol with reaction time of 7 hours. The yield is about 44%.

When you are using this chemical, please be cautious about it as the following:
It is harmful if swallowed. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Besides, this chemical is irritating to eyes, respiratory system and skin.

You can still convert the following datas into molecular structure:
(1)SMILES: c1cnc(cc1Cl)N
(2)InChI: InChI=1/C5H5ClN2/c6-4-1-2-8-5(7)3-4/h1-3H,(H2,7,8)
(3)InChIKey: RQMWVVBHJMUJNZ-UHFFFAOYAQ
(4)Std. InChI: InChI=1S/C5H5ClN2/c6-4-1-2-8-5(7)3-4/h1-3H,(H2,7,8)
(5)Std. InChIKey: RQMWVVBHJMUJNZ-UHFFFAOYSA-N

Product Name

2-Amino-4-chloropyridine

Synthetic route

2-Amino-4-chloropyridine Specification

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