2-Amino-5-bromobenzoic acid supplier

Name
2-Amino-5-bromobenzoic acid
EINECS 227-338-3
CAS No. 5794-88-7
Article Data63
CAS DataBase
Density 1.793 g/cm³
Solubility
Melting Point 213-215 °C(lit.)
Formula C₇H₆BrNO₂
Boiling Point 342.4 °C at 760 mmHg
Molecular Weight 216.034
Flash Point 160.9 °C
Transport Information UN 2811 6.1/PG 3
Appearance slight yellow to white powder
Safety 26-36/37-36/37/39
Risk Codes 22-36/37/38
Molecular Structure
Hazard Symbols Xn, Xi
Synonyms 5-Bromoanthranilic acid;Anthranilic acid, 5-bromo-;Benzoic acid, 2-amino-5-bromo-;
PSA 63.32000
LogP 2.31070

Synthetic route

: 118-92-3
anthranilic acid

: 5794-88-7
5-Bromo-2-aminobenzoic acid

Conditions

Conditions	Yield
With 1-butyl-3-methylimidazolium tribromide at 25℃; for 0.666667h;	98%
Stage #1: anthranilic acid With bromine In tetrachloromethane at 10 - 20℃; for 4h; Stage #2: With potassium carbonate In water	98%
With [bmim]Br3 In dichloromethane at 20℃; for 0.666667h;	95%

: 52727-57-8
5-bromo-2-aminobenzoic acid methyl ester

: 5794-88-7
5-Bromo-2-aminobenzoic acid

Conditions

Conditions	Yield
Stage #1: 5-bromo-2-aminobenzoic acid methyl ester With water; sodium hydroxide In tetrahydrofuran; ethanol at 20℃; for 12h; Stage #2: With hydrogenchloride In water pH=4;	97%
With water; sodium hydroxide In tetrahydrofuran; ethanol at 20℃; for 12h;	97%
With water; sodium hydroxide In tetrahydrofuran at 60℃; Inert atmosphere; Sealed tube;	72%

: 87-48-9
5-Bromo-1H-indole-2,3-dione

: 5794-88-7
5-Bromo-2-aminobenzoic acid

Conditions

Conditions	Yield
With dihydrogen peroxide; sodium hydroxide In water at 80℃; for 1h;	96%
Ring cleavage; oxidation;
With dihydrogen peroxide; sodium hydroxide In water
Stage #1: 5-Bromo-1H-indole-2,3-dione With sodium hydroxide at 80℃; Stage #2: With dihydrogen peroxide at 80℃; for 1.25h;

: 84-40-2
5,5'-dibromo-1H,1'H-[2,2']biindolylidene-3,3'-dione

: 5794-88-7
5-Bromo-2-aminobenzoic acid

Conditions

Conditions	Yield
Stage #1: 5,5'-dibromo-1H,1'H-[2,2']biindolylidene-3,3'-dione With bromamine B; sodium hydroxide; palladium dichloride In water; acetonitrile at 60℃; for 3.66667h; pH=12; Stage #2: In water Acidic conditions;	95%

: 6950-43-2
5-bromo-2-nitrobenzoic acid

: 5794-88-7
5-Bromo-2-aminobenzoic acid

Conditions

Conditions	Yield
With polymer-supported formate; magnesium In methanol at 20℃; for 2.5h;	94%
With ammoniummethyl polystyrene resin formate; palladium on activated charcoal In methanol at 20℃; for 5h;	93%
With aminomethyl polystyrene resin formic acid salt; zinc In methanol at 20℃; for 2.5h;	93%
With hydrogenchloride; tin

: 10075-50-0
5-bromo-1H-indole

: 5794-88-7
5-Bromo-2-aminobenzoic acid

Conditions

Conditions	Yield
Stage #1: 5-bromo-1H-indole With bromamine B; sodium hydroxide; palladium dichloride In water; acetonitrile at 60℃; for 3.66667h; pH=12; Stage #2: In water Acidic conditions;	94%
With ruthenium trichloride; osmium(VIII) oxide; bromamine B; sodium hydroxide In water; acetonitrile at 39.84℃; for 5.5h;	94%

: 38985-79-4
5-bromo-N-acetylanthranilic acid

: 5794-88-7
5-Bromo-2-aminobenzoic acid

Conditions

Conditions	Yield
With water; sodium hydroxide for 4h; Reflux;	93%

: 19165-25-4
2-methyl-6-bromo-4H-3,1-benzoxazine-4-one

: 118-92-3
anthranilic acid

A: 5794-88-7
5-Bromo-2-aminobenzoic acid

B: 89-52-1
o-acetylamino-benzoic acid

Conditions

Conditions	Yield
In benzene for 6h; Heating;	A 45% B 42%

...Expand

: 19165-25-4
2-methyl-6-bromo-4H-3,1-benzoxazine-4-one

A: 5794-88-7
5-Bromo-2-aminobenzoic acid

B: 89-52-1
o-acetylamino-benzoic acid

Conditions

Conditions	Yield
With anthranilic acid In benzene for 6h; Heating;	A 45% B 42%

: 19165-25-4
2-methyl-6-bromo-4H-3,1-benzoxazine-4-one

: 95-54-5
1,2-diamino-benzene

A: 34801-09-7
N-(2-aminophenyl)acetamide

B: 5794-88-7
5-Bromo-2-aminobenzoic acid

C: 2-Acetylamino-N-(2-amino-phenyl)-5-bromo-benzamide

Conditions

Conditions	Yield
In benzene for 6h; Heating;	A 28% B 32% C 36%

...Expand

: 112253-72-2
2-azido-5-bromobenzoic acid

A: 5-bromo-2-oxo-3H-azepine-3-carboxylic acid

B: 5-bromo-2,1-benzisoxazole-3(1H)-one

C: 5794-88-7
5-Bromo-2-aminobenzoic acid

Conditions

Conditions	Yield
With potassium carbonate In 1,4-dioxane; water at 25℃; for 3h; UV-irradiation;	A 18% B 34% C 10%

...Expand

: 118-92-3
anthranilic acid

A: 20776-51-6
2-amino-3-bromo benzoic acid

B: 5794-88-7
5-Bromo-2-aminobenzoic acid

Conditions

Conditions	Yield
With N-Bromosuccinimide at 25℃; for 0.025h; Solid phase reaction; bromination;	A 25% B 25%
With sodium perborate; ammonium heptamolybdate; potassium bromide In acetic acid at 20℃; for 2h; Bromination;
With dihydrogen peroxide; ammonium bromide; acetic acid at 20℃; for 3h;

: 6950-43-2
5-bromo-2-nitrobenzoic acid

A: 5,5'-dibromo-2,2'-azo-di-benzoic acid

B: 5794-88-7
5-Bromo-2-aminobenzoic acid

Conditions

Conditions	Yield
With ethanol; sulfuric acid; zinc

: 24106-05-6
4'-bromo-2'-methylacetanilide

: 5794-88-7
5-Bromo-2-aminobenzoic acid

Conditions

Conditions	Yield
With potassium permanganate; water Verseifen des Produkts mit konz. Salzsaeure;
Multi-step reaction with 2 steps 1: potassium permanganate; magnesium sulfate / water / 5.5 h / Reflux 2: sodium hydroxide; water / 4 h / Reflux View Scheme

: 859333-44-1
N,N'-(2,2,2-trichloro-ethylidene)-di-anthranilic acid

A: 64-19-7
acetic acid

B: 5794-88-7
5-Bromo-2-aminobenzoic acid

Conditions

Conditions	Yield
With bromine

: 5775-33-7
N-chlorodiethylamine

: 118-92-3
anthranilic acid

: 5794-88-7
5-Bromo-2-aminobenzoic acid

Conditions

Conditions	Yield
With acetic acid; potassium bromide

: 67-56-1
methanol

: 87-48-9
5-Bromo-1H-indole-2,3-dione

A: 5794-88-7
5-Bromo-2-aminobenzoic acid

B: 52727-57-8
5-bromo-2-aminobenzoic acid methyl ester

Conditions

Conditions	Yield
With dihydrogen peroxide; sodium methylate 1.) 0-10 deg C 2.) room temperature, 30 min; Yield given. Multistep reaction;

...Expand

: 122082-08-0
2-benzyl-4-oxo-1,2,3-benzotriazin-2-ium-1-olate

: 5794-88-7
5-Bromo-2-aminobenzoic acid

Conditions

Conditions	Yield
With hydrogen bromide In acetic acid

: 7647-01-0
hydrogenchloride

: 4692-98-2
5-bromoisatoic anhydride

A: 15719-64-9, 15719-76-3, 97762-63-5
methylammonium carbonate

B: 5794-88-7
5-Bromo-2-aminobenzoic acid

...Expand

: 7726-95-6
bromine

: 118-92-3
anthranilic acid

: 64-19-7
acetic acid

: 5794-88-7
5-Bromo-2-aminobenzoic acid

...Expand

bromoisatoic acid anhydride: bromoisatoic acid anhydride

: 5794-88-7
5-Bromo-2-aminobenzoic acid

Conditions

Conditions	Yield
With hydrogenchloride

<β.β.β-trichloro-ethyliden>-anthranilic acid: <β.β.β-trichloro-ethyliden>-anthranilic acid

A: 64-19-7
acetic acid

B: 5794-88-7
5-Bromo-2-aminobenzoic acid

Conditions

Conditions	Yield
With bromine

: 7726-95-6
bromine

: 118-92-3
anthranilic acid

: 64-19-7
acetic acid

A: 5794-88-7
5-Bromo-2-aminobenzoic acid

B: 609-85-8
2-amino-3,5-dibromobenzoic acid

...Expand

: 7647-01-0
hydrogenchloride

: 6950-43-2
5-bromo-2-nitrobenzoic acid

tin: tin

A: 118-92-3
anthranilic acid

B: 5794-88-7
5-Bromo-2-aminobenzoic acid

...Expand

: 859333-44-1
N,N'-(2,2,2-trichloro-ethylidene)-di-anthranilic acid

: 7726-95-6
bromine

: 64-19-7
acetic acid

: 5794-88-7
5-Bromo-2-aminobenzoic acid

...Expand

: 5,5'-dibromo-2,2'-(2,2,2-trichloro-ethylidenediamino)-di-benzoic acid

: 7732-18-5
water

A: 75-87-6
chloral

B: 5794-88-7
5-Bromo-2-aminobenzoic acid

...Expand

: 122100-61-2
o-nitrobenzaldehyde benzylhydrazone

: 5794-88-7
5-Bromo-2-aminobenzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 82 percent / iodosobenzene diacetate / CH2Cl2 / 4 h 2: 25percent HBr / acetic acid View Scheme

: 120-66-1
N-(2-methylphenyl)acetamide

: 5794-88-7
5-Bromo-2-aminobenzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrochloric acid; alcohol; water; KBr; KBrO3 2: water; potassium permanganate / Verseifen des Produkts mit konz. Salzsaeure View Scheme

: 13292-87-0
dimethyl sulfide borane

: 5794-88-7
5-Bromo-2-aminobenzoic acid

: 20712-12-3
(2-amino-5-bromophenyl)methanol

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran	100%

: 5794-88-7
5-Bromo-2-aminobenzoic acid

: 20712-12-3
(2-amino-5-bromophenyl)methanol

Conditions

Conditions	Yield
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; Inert atmosphere;	100%
Stage #1: 5-Bromo-2-aminobenzoic acid With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 2h; Stage #2: With water; sodium hydroxide In tetrahydrofuran	100%
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 2h;	100%

: 2524-67-6
4-morpholino-4-yl-phenylamine

: 122-51-0
orthoformic acid triethyl ester

: 5794-88-7
5-Bromo-2-aminobenzoic acid

: 6-bromo-3-(4-morpholinophenyl)quinazolin-4(3H)-one

Conditions

Conditions	Yield
at 110℃;	100%

...Expand

: 79-30-1
isobutyryl chloride

: 5794-88-7
5-Bromo-2-aminobenzoic acid

: 761458-01-9
6-bromo-2-isopropyl-4H-3,1-benzoxazin-4-one

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 2h; Product distribution / selectivity;	99%
Stage #1: isobutyryl chloride; 5-Bromo-2-aminobenzoic acid With triethylamine In dichloromethane at 0 - 20℃; for 15h; Stage #2: With acetic anhydride at 55℃; for 3h; Product distribution / selectivity;	99%
Stage #1: isobutyryl chloride; 5-Bromo-2-aminobenzoic acid With triethylamine In dichloromethane at 20℃; Stage #2: With acetic anhydride In dichloromethane at 50℃; Further stages.;
Stage #1: isobutyryl chloride; 5-Bromo-2-aminobenzoic acid With pyridine for 2h; Stage #2: With acetic anhydride for 1h; Heating;

: 62-53-3
aniline

: 5794-88-7
5-Bromo-2-aminobenzoic acid

: 82827-16-5
2-amino-5-bromo-N-phenylbenzamide

Conditions

Conditions	Yield
Stage #1: 5-Bromo-2-aminobenzoic acid With thionyl chloride In toluene at 130℃; for 2h; Stage #2: aniline In tetrahydrofuran at 0 - 90℃; for 4h;	99%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;

: 75-04-7
ethylamine

: 5794-88-7
5-Bromo-2-aminobenzoic acid

: 1263377-68-9
2-amino-5-bromo-N-ethylbenzamide

Conditions

Conditions	Yield
Stage #1: 5-Bromo-2-aminobenzoic acid With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 0℃; for 0.166667h; Inert atmosphere; Stage #2: ethylamine In tetrahydrofuran; N,N-dimethyl-formamide at 20℃;	99%
Stage #1: 5-Bromo-2-aminobenzoic acid With triethylamine; HATU In N,N-dimethyl-formamide at 0℃; for 0.166667h; Inert atmosphere; Stage #2: ethylamine In tetrahydrofuran; N,N-dimethyl-formamide at 0 - 20℃;	85%
Stage #1: 5-Bromo-2-aminobenzoic acid With triethylamine; HATU In N,N-dimethyl-formamide at 0℃; for 0.166667h; Inert atmosphere; Stage #2: ethylamine In tetrahydrofuran; N,N-dimethyl-formamide at 0 - 20℃;	85%

: 106-31-0
butanoic acid anhydride

: 5794-88-7
5-Bromo-2-aminobenzoic acid

: 6-Bromo-2-propyl-benzo[d][1,3]oxazin-4-one

Conditions

Conditions	Yield
for 1h; Heating;	98%

: 32315-10-9
bis(trichloromethyl) carbonate

: 5794-88-7
5-Bromo-2-aminobenzoic acid

: 4692-98-2
5-bromoisatoic anhydride

Conditions

Conditions	Yield
With pyridine In dichloromethane; acetonitrile at 50 - 55℃; for 2h;	98%
In tetrahydrofuran at 70℃; for 2h;	97%
In tetrahydrofuran for 4h; Reflux;	96%

: 21615-34-9
2-Methoxybenzoyl chloride

: 5794-88-7
5-Bromo-2-aminobenzoic acid

: 693820-77-8
6-bromo-2-(2-methoxyphenyl)-4H-3,1-benzoxazin-4-one

Conditions

Conditions	Yield
Stage #1: 2-Methoxybenzoyl chloride; 5-Bromo-2-aminobenzoic acid With triethylamine In 1,1-dichloroethane at 20℃; for 16h; Stage #2: With sulfuric acid; acetic anhydride In 1,1-dichloroethane at 55℃; for 5h; Product distribution / selectivity;	98%
Stage #1: 2-Methoxybenzoyl chloride; 5-Bromo-2-aminobenzoic acid With triethylamine In dichloromethane at 10 - 20℃; for 3h; Stage #2: With oxalyl dichloride In dichloromethane for 2h; Stage #3: With acetic anhydride In dichloromethane at 50℃; for 1h; Product distribution / selectivity;	69%
Stage #1: 2-Methoxybenzoyl chloride; 5-Bromo-2-aminobenzoic acid With triethylamine In dichloromethane at 20℃; Stage #2: With acetic anhydride In dichloromethane at 50℃; Further stages.;

: 5794-88-7
5-Bromo-2-aminobenzoic acid

: 609-85-8
2-amino-3,5-dibromobenzoic acid

Conditions

Conditions	Yield
With bromine In tetrachloromethane at 20℃; Cooling with ice;	98%

: 186581-53-3, 908094-01-9
diazomethane

: 5794-88-7
5-Bromo-2-aminobenzoic acid

: 52727-57-8
5-bromo-2-aminobenzoic acid methyl ester

Conditions

Conditions	Yield
In 2-methyltetrahydrofuran; diethyl ether at 20℃; for 0.358333h; Flow reactor;	98%

: 98-88-4
benzoyl chloride

: 5794-88-7
5-Bromo-2-aminobenzoic acid

: 66387-70-0
6-bromo-2-phenyl-4H-benzo[2,3-d]-1,3-oxazin-4-one

Conditions

Conditions	Yield
at 140℃; for 3h;	97%
at 140℃; for 3h;	97%
	97%

: 72482-64-5
2,4-difluorobenzoyl chloride

: 5794-88-7
5-Bromo-2-aminobenzoic acid

: 875270-49-8
6-bromo-2-(2,4-difluorophenyl)-4H-benzo[d] [1,3]oxazin-4-one

Conditions

Conditions	Yield
With triethylamine In chloroform at 20℃; for 2h;	97%
Stage #1: 2,4-difluorobenzoyl chloride; 5-Bromo-2-aminobenzoic acid With triethylamine In chloroform at 20℃; for 2h; Stage #2: With acetic anhydride at 50℃; for 2h;	97%
Stage #1: 2,4-difluorobenzoyl chloride; 5-Bromo-2-aminobenzoic acid With triethylamine In dichloromethane at 20℃; for 12h; Stage #2: With acetic anhydride at 50℃; for 2h;	85%

: 119-56-2
(4-chlorophenyl)phenylmethanol

: 5794-88-7
5-Bromo-2-aminobenzoic acid

: 5-bromo-2-{[(4-chlorophenyl)(phenyl)methyl]amino}benzoic acid

Conditions

Conditions	Yield
With Co(hfac)2·xH2O; sodium 3-(diphenylphosphanyl)benzenesulfonate In water at 120℃; for 16h; Sealed tube;	97%

: 108-24-7
acetic anhydride

: 5794-88-7
5-Bromo-2-aminobenzoic acid

: 19165-25-4
2-methyl-6-bromo-4H-3,1-benzoxazine-4-one

Conditions

Conditions	Yield
at 150℃; for 3h;	96%
for 2h; Heating;	88.2%
at 100℃; for 2h;	85%

: 541-41-3
chloroformic acid ethyl ester

: 5794-88-7
5-Bromo-2-aminobenzoic acid

: 116991-07-2
6-bromo-2-ethoxy-(4H)-3,1-benzoxazine-4-one

Conditions

Conditions	Yield
With pyridine at 0℃; for 1h;	96%

: 3473-63-0
formamidine acetic acid

: 5794-88-7
5-Bromo-2-aminobenzoic acid

: 32084-59-6
6-bromo-4-hydroxyquinazoline

Conditions

Conditions	Yield
at 150 - 160℃; for 0.833333h;	96%
at 150 - 160℃; for 0.833333h;	96%
at 150 - 160℃; for 0.833333h;	94%

: 122-51-0
orthoformic acid triethyl ester

: 5794-88-7
5-Bromo-2-aminobenzoic acid

: 449185-77-7
6-bromo-4H-3,1-benzoxazin-4-one

Conditions

Conditions	Yield
at 140℃; for 4h;	96%
at 140℃; for 4h;	71%

: 36239-09-5
ethyl chlorocarbonylacetate

: 5794-88-7
5-Bromo-2-aminobenzoic acid

: 113117-47-8
2-carboxy-4-bromomalonanilic acid ethyl ester

Conditions

Conditions	Yield
With triethylamine In acetone Ambient temperature;	95%
With triethylamine In dichloromethane

: 79-04-9
chloroacetyl chloride

: 5794-88-7
5-Bromo-2-aminobenzoic acid

: 155104-20-4
N-chloroacetyl-5-bromoanthranilic acid

Conditions

Conditions	Yield
In 1,4-dioxane; N,N-dimethyl-formamide for 1.5h;	95%
With pyridine In benzene for 5h; Heating;	72%
In 1,4-dioxane; N,N-dimethyl-formamide at 20℃; Cooling with ice;

: chloro-formamidine hydrochloride

: 5794-88-7
5-Bromo-2-aminobenzoic acid

: 2-amino-4-hydroxy-6-bromoquinazoline

Conditions

Conditions	Yield
Stage #1: chloro-formamidine hydrochloride; 5-Bromo-2-aminobenzoic acid In sulfolane; dimethylsulfone at 165℃; for 0.5h; Stage #2: With ammonia; water In sulfolane; dimethylsulfone pH=7 - 8; Product distribution / selectivity;	95%
Stage #1: chloro-formamidine hydrochloride; 5-Bromo-2-aminobenzoic acid In sulfolane; dimethylsulfone at 165℃; for 0.5h; Stage #2: With ammonia; water In sulfolane; dimethylsulfone pH=7 - 8; Product distribution / selectivity;	95%

: 5794-88-7
5-Bromo-2-aminobenzoic acid

: 100540-90-7
bis(2-hydroxycarbonyl-4-bromophenyl) disulfide

Conditions

Conditions	Yield
Stage #1: 5-Bromo-2-aminobenzoic acid With hydrogenchloride; sodium hydroxide; sodium nitrite In water at 0 - 5℃; for 1h; Stage #2: With potassium acetate; potassium ethyl xanthogenate; potassium carbonate In water at 80℃; for 2h; Cooling; Stage #3: With dihydrogen peroxide In water at 20℃;	95%
Multi-step reaction with 2 steps 1.1: NaNO2; NaOH; aq. HCl / 1 h / 0 - 5 °C 1.2: EtOC(S)SK / H2O / 2 h / 20 - 80 °C 2.1: aq. H2O2 / 20 °C View Scheme

: 77287-34-4, 77287-35-5, 60100-09-6
formamide

: 5794-88-7
5-Bromo-2-aminobenzoic acid

: 32084-59-6
6-bromo-4-hydroxyquinazoline

Conditions

Conditions	Yield
at 165℃; for 6h;	95%
at 165℃; for 6h;	95%
for 5h; Reflux;	80%

: 123-39-7
N-Methylformamide

: 5794-88-7
5-Bromo-2-aminobenzoic acid

: 57573-59-8
6-bromo-3-N-methylquinazoline-4(3H)-one

Conditions

Conditions	Yield
Stage #1: N-Methylformamide; 5-Bromo-2-aminobenzoic acid at 180℃; for 12h; Stage #2: With water	95%
In N,N-dimethyl-formamide at 180℃; for 12h;	95%
at 180℃; for 12h;	95%
for 6.5h; Sealed tube; Reflux;	63%

: 5794-88-7
5-Bromo-2-aminobenzoic acid

: 74189-16-5
2-amino-5-bromobenzoic acid hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In water at 20℃; for 24h;	95%
With hydrogenchloride In water at 20℃; for 24h;	95%
With hydrogenchloride In water for 8h;

: 16182-04-0
Ethoxycarbonyl isothiocyanate

: 5794-88-7
5-Bromo-2-aminobenzoic acid

: 1189797-80-5
5-bromo-2-({[(ethoxycarbonyl)amino]carbonothioyl}-amino)-benzoic acid

Conditions

Conditions	Yield
In acetonitrile at 80℃; for 5h;	95%
In acetonitrile at 80℃; for 5h;	95%

2-Amino-5-bromobenzoic acid Specification

The CAS register number of 2-Amino-5-bromobenzoic acid is 5794-88-7. It also can be called as 5-Bromoanthranilic acid and the IUPAC name about this chemical is 2-amino-5-bromobenzoic acid. The molecular formula about this chemical is C₇H₆BrNO₂and the molecular weight is 216.03. It belongs to the following product categories which include Fine Chemical & Intermediates; Amino Acids and Derivatives; Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts; Carboxylic Acids; Phenyls & Phenyl-Het; Benzoic acid; Organic acids; Acids & Esters; Anilines, Amides & Amines; Bromine Compounds; Carboxylic Acids; Phenyls & Phenyl-Het; Benzoic acid series and so on. This chemical can be used as organic intermediates.

Physical properties about 2-Amino-5-bromobenzoic acid are: (1)ACD/LogP: 2.37; (2)ACD/LogD (pH 5.5): 1.02; (3)ACD/LogD (pH 7.4): -0.52; (4)ACD/BCF (pH 5.5): 1.66; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 20.64; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 3; (9)#H bond donors: 3; (10)#Freely Rotating Bonds: 2; (11)Polar Surface Area: 29.54Å²; (12)Index of Refraction: 1.672; (13)Molar Refractivity: 45.1 cm³; (14)Molar Volume: 120.4 cm³; (15)Polarizability: 17.88x10^-24cm³; (16)Surface Tension: 67.9 dyne/cm; (17)Enthalpy of Vaporization: 61.86 kJ/mol; (18)Boiling Point: 342.4 °C at 760 mmHg; (19)Vapour Pressure: 2.91E-05 mmHg at 25°C.

This chemical can be produced by the bromide of Anthranilic acid.

Preparation: this chemical can be prepared by 2-amino-benzoic acid. This reaction will need reagent bromine.

Uses of 2-Amino-5-bromobenzoic acid: it can be used to produce 6-bromo-3H-quinazolin-4-one with formamide at temperature of 180 ℃.

When you are using this chemical, please be cautious about it as the following:
This chemical is harmful if swallowed. It is irritating to eyes, respiratory system and skin. When you are using it, wear suitable protective clothing, gloves and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: Brc1cc(C(=O)O)c(N)cc1
(2)InChI: InChI=1/C7H6BrNO2/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H,9H2,(H,10,11)
(3)InChIKey: CUKXRHLWPSBCTI-UHFFFAOYAQ
(4)Std. InChI: InChI=1S/C7H6BrNO2/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H,9H2,(H,10,11)
(5)Std. InChIKey: CUKXRHLWPSBCTI-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
rat	LD	oral	> 500mg/kg (500mg/kg)		National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 12, 1953.

Product Name

2-Amino-5-bromobenzoic acid

Synthetic route

2-Amino-5-bromobenzoic acid Specification

Related Products

Hot Products