2-Amino-5-methylhexane supplier

Name
2-AMINO-5-METHYLHEXANE
EINECS 248-941-8
CAS No. 28292-43-5
Article Data5
CAS DataBase
Density 0.776 g/cm³
Solubility
Melting Point -19°C (estimate)
Formula C₇H₁₇N
Boiling Point 134.62 °C at 760 mmHg
Molecular Weight 115.219
Flash Point 29.301 °C
Transport Information UN 2734 8/PG 2
Appearance
Safety 26-36/37/39-45
Risk Codes 10-34
Molecular Structure
Hazard Symbols C
Synonyms Pentylamine,1,4-dimethyl- (8CI);1,4-Dimethylpentylamine;5-Methyl-2-hexylamine;NSC 73708;dl-2-Amino-5-methylhexane;
PSA 26.02000
LogP 2.47010

Synthetic route

: 60372-16-9
bis-(1,4-dimethyl-pentylidene)-hydrazine

A: 28292-43-5
2-amino-5-methylhexane

B: 145659-67-2
bis-(1,4-dimethyl-pentyl)-amine

Conditions

Conditions	Yield
With nickel at 190 - 200℃; Hydrogenation;

: 110-12-3
5-Methyl-2-hexanone

: 28292-43-5
2-amino-5-methylhexane

: N-(5-methyl-2-hexyl)phthalimide

: 28292-43-5
2-amino-5-methylhexane

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol hydrazinolysis; Heating;

: 627-59-8
5-methylhexan-2-ol

: 28292-43-5
2-amino-5-methylhexane

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 65 percent / PPh3; diethyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C 2: N2H4*H2O / ethanol / Heating View Scheme

: 646-07-1
4-Methylpentanoic acid

: 28292-43-5
2-amino-5-methylhexane

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: thorium oxide 2: aqueous alcoholic NaOH-solution; hydrazine hydrate 3: nickel / 190 - 200 °C / Hydrogenation View Scheme

: 28292-43-5
2-amino-5-methylhexane

: 98-68-0
4-methoxy-phenyl-sulphonyl chloride

: 4-methoxy-N-(5-methylhexan-2-yl)benzenesulfonamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 12h;	90%

: 28292-43-5
2-amino-5-methylhexane

: 14418-84-9
allylsulfonyl chloride

: N-(5-methylhexan-2-yl)prop-2-ene-1-sulfonamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 3h;	83%

: 28292-43-5
2-amino-5-methylhexane

: 94-36-0
dibenzoyl peroxide

: O-benzoyl-N-(5-methylhexan-2-yl)hydroxylamine

Conditions

Conditions	Yield
Stage #1: dibenzoyl peroxide With caesium carbonate In dichloromethane at 23℃; for 2h; Stage #2: 2-amino-5-methylhexane In dichloromethane at 23℃; for 14h;	82%

: 28292-43-5
2-amino-5-methylhexane

: 145659-67-2
bis-(1,4-dimethyl-pentyl)-amine

Conditions

Conditions	Yield
With chlorohydridocarbonylbis(tricyclohexylphosphine)ruthenium(II) In toluene at 120℃; for 24h; Schlenk technique; Inert atmosphere;	80%

: 28292-43-5
2-amino-5-methylhexane

: 359-06-8
monofluoroacetyl chloride

: N-(1,4-Dimethyl-pentyl)-2-fluoro-acetamide

Conditions

Conditions	Yield
With potassium hydroxide In diethyl ether at 5 - 15℃; for 5h;	75%

: 28292-43-5
2-amino-5-methylhexane

trifluoroacetic anhydride: trifluoroacetic anhydride

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 12h; Inert atmosphere; Cooling with ice;	75%

phthalic anhydride: phthalic anhydride

: 28292-43-5
2-amino-5-methylhexane

: N-(5-methyl-2-hexyl)phthalimide

Conditions

Conditions	Yield
In toluene for 5h; Reflux;	70%

: 28292-43-5
2-amino-5-methylhexane

: 109-63-7
boron trifluoride diethyl etherate

: trifluoro(1,4-dimethylpentylamino)borate

Conditions

Conditions	Yield
In dichloromethane at 0℃; for 1.5h; Inert atmosphere;	63%

: 1120-71-4
1,3-propanesultone

: 28292-43-5
2-amino-5-methylhexane

: 3-(1,4-dimethyl-pentylamino)-1-propanesulfonic acid

Conditions

Conditions	Yield
In acetone; toluene at 20℃; Heating / reflux;	60%

: 28292-43-5
2-amino-5-methylhexane

: 135498-84-9
2-methyl 5-nitrohexane

Conditions

Conditions	Yield
With 3-chloro-benzenecarboperoxoic acid In 1,2-dichloro-ethane at 83℃; for 3h;	59%
With 3-chloro-benzenecarboperoxoic acid In 1,2-dichloro-ethane for 3h; Heating;	59%

: 28292-43-5
2-amino-5-methylhexane

: 100-07-2
4-methoxy-benzoyl chloride

: 4-methoxy-N-(5-methylhexan-2-yl)benzamide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 4h; Inert atmosphere;	55%

: 28292-43-5
2-amino-5-methylhexane

: 93-97-0
benzoic acid anhydride

: 815-57-6
3-Methyl-2,4-pentanedione

A: (R,Z)-3-methyl-4-((5-methylhexan-2-yl)amino)pent-3-en-2-one

B: (S)-N-(5-methylhexan-2-yl)benzamide

C: (S,Z)-3-methyl-4-((5-methylhexan-2-yl)amino)pent-3-en-2-one

Conditions

Conditions	Yield
Stage #1: 2-amino-5-methylhexane; 3-Methyl-2,4-pentanedione With C74H89O4P In diethyl ether at -78 - -5℃; for 20h; Inert atmosphere; Molecular sieve; Resolution of racemate; Stage #2: benzoic acid anhydride With triethylamine In diethyl ether at 20℃; for 0.5h; Inert atmosphere;	A 41% B 46% C n/a

...Expand

: 28292-43-5
2-amino-5-methylhexane

: 1057670-29-7, 57862-43-8
4,7-dihydro-1,3-dimethyl-4-oxo-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid

: 1421702-73-9
4,7-dihydro-1,3-dimethyl-N-(5-methylhexan-2-yl)-4-oxo-1H-pyrazolo[3,4-b]pyridine-5-carboxamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In N,N-dimethyl-formamide at 20℃; for 16.1667h;	25%

: 28292-43-5
2-amino-5-methylhexane

: sodium 1-(5-methyl-2-hexylamino)diazen-1-ium-1,2-diolate

Conditions

Conditions	Yield
Stage #1: 2-amino-5-methylhexane With nitrogen(II) oxide In diethyl ether at -80℃; under 2068.65 Torr; Inert atmosphere; Stage #2: With sodium methylate In methanol for 0.0833333h;	15%

: 28292-43-5
2-amino-5-methylhexane

: 40318-32-9
1-Chloro-3,4-dimethyl-2,6-dinitrobenzene

: 40318-40-9
(3,4-Dimethyl-2,6-dinitro-phenyl)-(1,4-dimethyl-pentyl)-amine

Conditions

Conditions	Yield
In toluene Heating;

: 28292-43-5
2-amino-5-methylhexane

: 4703-53-1, 39978-36-4, 42384-22-5
N-benzyloxycarbonyl-L-leucine hydrazide

: 13532-68-8
L-Leucin-(+)-1,4-dimethylpentylamid

Conditions

Conditions	Yield
(i), (ii) (hydrogenation); Multistep reaction;

: 28292-43-5
2-amino-5-methylhexane

: 64510-61-8
3α-hydroxy-11β-chloroacetoxy-5α-pregnan-20-one

: 64509-79-1
(1,4-Dimethyl-pentylamino)-acetic acid (3R,5S,8S,9S,10S,11S,13S,14S,17S)-17-acetyl-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-11-yl ester

Conditions

Conditions	Yield
With sodium iodide In ethanol for 72h;

: 28292-43-5
2-amino-5-methylhexane

: (1,4-Dimethyl-pentyl)-sulfamic acid

Conditions

Conditions	Yield
With chlorosulfonic acid; triethylamine In chloroform

: 28292-43-5
2-amino-5-methylhexane

: 24110-97-2
(R)-5-methylhexan-2-amine

: 28292-43-5
2-amino-5-methylhexane

: 33263-43-3
4-chloropyridine-3-sulphonamide

: 76254-96-1
4-(1,4-Dimethyl-pentylamino)-pyridine-3-sulfonic acid amide

Conditions

Conditions	Yield
at 80 - 100℃;

: 28292-43-5
2-amino-5-methylhexane

: 75-05-8
acetonitrile

: N-(2-(5-amino-2-methylhexyl))acetamide

Conditions

Conditions	Yield
With tetrafluoroboric acid; methyltrifluoromethyldioxirane; sodium carbonate Yield given. Multistep reaction;

: 28292-43-5
2-amino-5-methylhexane

: 195055-65-3
3-(4-methyl-6-dimethylaminopyridin-3-yl)-2,5-dimethyl-7-chloropyrazolo[1,5-a]pyrimidine

Conditions

Conditions	Yield
In acetonitrile Heating;	44 mg

5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carbonyl chloride: 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carbonyl chloride

: 5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-methyl-1H-pyrazole-3-carboxylic acid (1,4-dimethyl-pentyl)-amide

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 2h;

: 28292-43-5
2-amino-5-methylhexane

: 65224-66-0
2-chloro-6-methyl-5-nitro-3H-pyrimidin-4-one

: 937364-89-1
C12H20N4O3

Conditions

Conditions	Yield
In chloroform Heating;

: 28292-43-5
2-amino-5-methylhexane

: 135921-66-3
Z-2-(2,5-dimethyl hexen-1-yl) 3-nitroimidazo<1,2-a>pyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 59 percent / m-chloroperbenzoic acid / 1,2-dichloro-ethane / 3 h / Heating View Scheme

: 28292-43-5
2-amino-5-methylhexane

: 135921-65-2
E-2-(2,5-dimethyl hexen-1-yl) 3-nitroimidazo<1,2-a>pyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 59 percent / m-chloroperbenzoic acid / 1,2-dichloro-ethane / 3 h / Heating View Scheme

2-Amino-5-methylhexane Chemical Properties

IUPAC Name: (2S)-5-Methylhexan-2-amine
Synonyms: 1,4-Dimethylpentylamine
Molecular Structure of 5-Methyl-2-hexylamine (CAS NO. 28292-43-5) :
Molecular Formula of 5-Methyl-2-hexylamine (CAS NO. 28292-43-5) : C₇H₁₇N
Molecular Weight of 5-Methyl-2-hexylamine (CAS NO. 28292-43-5) : 115.22
CAS NO : 28292-43-5
EINECS : 248-941-8
Mol File: 28292-43-5.mol
Index of Refraction: 1.424
Surface Tension: 25.7 dyne/cm
Density: 0.775 g/cm³
Flash Point: 29.3 °C
Enthalpy of Vaporization: 37.21 kJ/mol
Boiling Point: 134.6 °C at 760 mmHg
Vapour Pressure: 8.02 mmHg at 25°C
BRN : 1731716

2-Amino-5-methylhexane Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	90mg/kg (90mg/kg)	SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Journal of Pharmacology and Experimental Therapeutics. Vol. 103, Pg. 325, 1951.

2-Amino-5-methylhexane Consensus Reports

Reported in EPA TSCA Inventory.

2-Amino-5-methylhexane Safety Profile

Hazard Codes Corrosive C
Risk Statements 10-34
R10:Flammable.
R34: 5-Methyl-2-hexylamine (CAS NO. 28292-43-5) can causes burns.
Safety Statements 26-36/37/39-45
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39: When using 5-Methyl-2-hexylamine (CAS NO. 28292-43-5),wear suitable protective clothing, gloves and eye/face protection.
RIDADR UN 2734 8/PG 2
WGK Germany 3
RTECS SC0875000
HazardClass 3
PackingGroup III

Product Name

2-AMINO-5-METHYLHEXANE

Synthetic route

2-Amino-5-methylhexane Chemical Properties

2-Amino-5-methylhexane Toxicity Data With Reference

2-Amino-5-methylhexane Consensus Reports

2-Amino-5-methylhexane Safety Profile

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