Product Name

  • Name

    2-Chloro-4,6-dimethoxy-1,3,5-triazine

  • EINECS 221-541-0
  • CAS No. 3140-73-6
  • Article Data37
  • CAS DataBase
  • Density 1.36 g/cm3
  • Solubility insoluble in water
  • Melting Point 71-74 °C(lit.)
  • Formula C5H6ClN3O2
  • Boiling Point 305.1 °C at 760 mmHg
  • Molecular Weight 175.575
  • Flash Point 138.3 °C
  • Transport Information
  • Appearance white to almost white crystalline powder
  • Safety 26-36/37
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 3140-73-6 (2-Chloro-4,6-dimethoxy-1,3,5-triazine)
  • Hazard Symbols IrritantXi
  • Synonyms s-Triazine,2-chloro-4,6-dimethoxy- (6CI,7CI,8CI);2,4-Dimethoxy-6-chloro-1,3,5-triazine;2,4-Dimethoxy-6-chloro-s-triazine;2-Chloro-4,6-dimethoxy-s-triazine;4,6-Dimethoxy-2-chloro-s-triazine;6-Chloro-2,4-dimethoxy-s-triazine;
  • PSA 57.13000
  • LogP 0.54220

Synthetic route

methanol
67-56-1

methanol

1,3,5-trichloro-2,4,6-triazine
108-77-0

1,3,5-trichloro-2,4,6-triazine

2-chloro-4,6-dimethoxy-1 ,3,5-triazine
3140-73-6

2-chloro-4,6-dimethoxy-1 ,3,5-triazine

Conditions
ConditionsYield
With sodium hydrogencarbonate at 25 - 50℃; for 4h;96%
With sodium hydrogencarbonate In water at 100℃; for 36h; Large scale;89.5%
With sodium hydrogencarbonate at 0 - 50℃; for 4h;86%
2,4-dimethoxy-6-hydroxy-1,3,5-triazine
1075-59-8

2,4-dimethoxy-6-hydroxy-1,3,5-triazine

2-chloro-4,6-dimethoxy-1 ,3,5-triazine
3140-73-6

2-chloro-4,6-dimethoxy-1 ,3,5-triazine

Conditions
ConditionsYield
With N,N-diethylaniline; trichlorophosphate for 3h; Heating;90%
With N,N-diethylaniline; trichlorophosphate for 3h; Reflux;
1,3,5-trichloro-2,4,6-triazine
108-77-0

1,3,5-trichloro-2,4,6-triazine

2-chloro-4,6-dimethoxy-1 ,3,5-triazine
3140-73-6

2-chloro-4,6-dimethoxy-1 ,3,5-triazine

Conditions
ConditionsYield
With sodium hydrogencarbonate In methanol; water89.2%
With potassium hydrogencarbonate In methanol; water88.3%
With potassium hydrogencarbonate In methanol; water; ethyl acetate87.5%
1,3,5-trichloro-2,4,6-triazine
108-77-0

1,3,5-trichloro-2,4,6-triazine

sodium methylate
124-41-4

sodium methylate

A

2,4-Dichloro-6-methoxy-1,3,5-triazine
3638-04-8

2,4-Dichloro-6-methoxy-1,3,5-triazine

B

2-chloro-4,6-dimethoxy-1 ,3,5-triazine
3140-73-6

2-chloro-4,6-dimethoxy-1 ,3,5-triazine

Conditions
ConditionsYield
In methanol; toluene at 0℃; for 2h; Substitution;A 10%
B 82%
...Expand
N-methyl-acetamide
79-16-3

N-methyl-acetamide

2,4-Dichloro-6-methoxy-1,3,5-triazine
3638-04-8

2,4-Dichloro-6-methoxy-1,3,5-triazine

A

2-chloro-4,6-dimethoxy-1 ,3,5-triazine
3140-73-6

2-chloro-4,6-dimethoxy-1 ,3,5-triazine

B

2-acetamido-4,6-dichloro-1,3,5-triazine

2-acetamido-4,6-dichloro-1,3,5-triazine

C

2-(acetamido)-4-chloro-6-methoxy-1,3,5-triazine

2-(acetamido)-4-chloro-6-methoxy-1,3,5-triazine

Conditions
ConditionsYield
Stage #1: N-methyl-acetamide With sodium hydride In tetrahydrofuran at 0 - 50℃; for 0.75h;
Stage #2: 2,4-Dichloro-6-methoxy-1,3,5-triazine In tetrahydrofuran at 0℃; for 2h;		A 31%
B 28%
C 4%
...Expand
methanol
67-56-1

methanol

2,4-Dichloro-6-methoxy-1,3,5-triazine
3638-04-8

2,4-Dichloro-6-methoxy-1,3,5-triazine

2-chloro-4,6-dimethoxy-1 ,3,5-triazine
3140-73-6

2-chloro-4,6-dimethoxy-1 ,3,5-triazine

Conditions
ConditionsYield
With sodium hydrogencarbonate
methanol
67-56-1

methanol

1,3,5-trichloro-2,4,6-triazine
108-77-0

1,3,5-trichloro-2,4,6-triazine

A

2-chloro-4,6-dimethoxy-1 ,3,5-triazine
3140-73-6

2-chloro-4,6-dimethoxy-1 ,3,5-triazine

B

2,4,6-trimethoxy-1,3,5-triazine
877-89-4

2,4,6-trimethoxy-1,3,5-triazine

Conditions
ConditionsYield
With sodium hydrogencarbonate In water; water-d2 at 40℃; Product distribution; influence of reaction conditions (base amount and temperature) on the yield of the products;
...Expand
1,3,5-trichloro-2,4,6-triazine
108-77-0

1,3,5-trichloro-2,4,6-triazine

sodium methylate
124-41-4

sodium methylate

2-chloro-4,6-dimethoxy-1 ,3,5-triazine
3140-73-6

2-chloro-4,6-dimethoxy-1 ,3,5-triazine

Conditions
ConditionsYield
at -30℃; Substitution;
methanol
67-56-1

methanol

1,3,5-trichloro-2,4,6-triazine
108-77-0

1,3,5-trichloro-2,4,6-triazine

NaHCO3 <2 mol>

NaHCO3 <2 mol>

2-chloro-4,6-dimethoxy-1 ,3,5-triazine
3140-73-6

2-chloro-4,6-dimethoxy-1 ,3,5-triazine

...Expand
2-(4-methoxybenzoyloxy)-4,6-dimethoxy-1,3,5-triazine
132353-25-4

2-(4-methoxybenzoyloxy)-4,6-dimethoxy-1,3,5-triazine

2-chloro-4,6-dimethoxy-1 ,3,5-triazine
3140-73-6

2-chloro-4,6-dimethoxy-1 ,3,5-triazine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: palladium diacetate / acetonitrile / 10 h / 50 °C / Inert atmosphere
2: N,N-diethylaniline; trichlorophosphate / 3 h / Reflux
View Scheme

2-Chloro-4,6-dimethoxy-1,3,5-triazine Chemical Properties

IUPAC Name: 2-Chloro-4,6-dimethoxy-1,3,5-triazine
Synonyms of 1,3,5-Triazine,2-chloro-4,6-dimethoxy- (CAS NO.3140-73-6): 2-Chloro-4,6-dimethoxy-1,3,5-triazine
CAS NO: 3140-73-6
Molecular Formula: C5H6ClN3O2
Molecular Weight: 175.573
Molecular Structure:
EINECS: 221-541-0
H bond acceptors: 5
H bond donors: 0
Freely Rotating Bonds: 2
Polar Surface Area: 57.13 Å2
Index of Refraction: 1.512
Molar Refractivity: 38.77 cm3
Molar Volume: 129 cm3
Surface Tension: 47.5 dyne/cm
Density: 1.36 g/cm3
Flash Point: 138.3 °C
Enthalpy of Vaporization: 52.37 kJ/mol
Boiling Point: 305.1 °C at 760 mmHg
Vapour Pressure: 0.00152 mmHg at 25°C
Melting Point: 71-74 °C(lit.)
Water Solubility:  insoluble.
Appearance: white to almost white crystalline powder
Product Categories of 1,3,5-Triazine,2-chloro-4,6-dimethoxy- (CAS NO.3140-73-6): Starting Raw Materials & Intermediates;Miscellaneous;Biochemistry;Coupling Reactions (Peptide Synthesis);Peptide Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Triazines;TriazinesBuilding Blocks

2-Chloro-4,6-dimethoxy-1,3,5-triazine Safety Profile

Hazard Codes: IrritantXi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37: Wear suitable protective clothing and gloves.
WGK Germany: 3

2-Chloro-4,6-dimethoxy-1,3,5-triazine Specification

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. 
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Avoid ingestion and inhalation.
Storage: Store 1,3,5-Triazine,2-chloro-4,6-dimethoxy- (CAS NO.3140-73-6) in a cool, dry place. Store in a tightly closed container.

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