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Dayang Chem (Hangzhou) Co.,Ltd.

DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

Cladribine Manufacturer/High quality/Best price/In stock

Cas:4291-63-8

Min.Order:1 Kilogram

FOB Price: $3.0

Type:Lab/Research institutions

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Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd

We can provide GMP validation service that complies with SFDA, FDA, WHO and EU EMPA.Excellent registration team could help us easlily to register our products in different countries.If you and your customer are interested in some products or need C

Cladribine injection 10mg/10ml

Cas:4291-63-8

Min.Order:1 Gram

Negotiable

Type:Manufacturers

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Wuhan Fortuna Chemical Co.,Ltd

Cladribine CAS 4291-63-8 Company profile Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distributing th

Cladribine CAS 4291-63-8

Cas:4291-63-8

Min.Order:1 Kilogram

FOB Price: $10.0

Type:Trading Company

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Henan Allgreen Chemical Co.,Ltd

good quality Appearance:white powder Storage:cold storage Package:meet the demand of customer Application:diagnostic reagent Transportation:by sea or by air Port:shanghai

Cladribine

Cas:4291-63-8

Min.Order:0 Metric Ton

Negotiable

Type:Manufacturers

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Xi'an Xszo Chem Co., Ltd.

1. Factory price and high quality must be guaranteed, base on 8 years of production and R&D experience2. Free samples will be provided,ensure specifications and quality are right for customer3. Customers will receive the most professional technical s

Factory Price API 99% Cladribine 4291-63-8 GMP Manufacturer

Cas:4291-63-8

Min.Order:1 Gram

FOB Price: $0.1

Type:Manufacturers

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Shanghai Seasonsgreen Chemical Co.,Ltd

Shanghai Seasonsgreen Chemical is a high-tech research and development, production, sale and custom synthesis set in one high-tech chemical products enterprises. Our sales and marketing division is located in Shanghai, serving international pharmaceu

lower price High quality Cladribine

Cas:4291-63-8

Min.Order:1 Kilogram

FOB Price: $1.0

Type:Manufacturers

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Chemwill Asia Co., Ltd.

Cladribine -- CHemwill

Cas:4291-63-8

Min.Order:1 Metric Ton

FOB Price: $1.0

Type:Manufacturers

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Hubei DiBo chemical co., LTD

Name:Cladribine CAS NO:4291-63-8 Grade:Medical scientific research and export Molecular formula:C10H12ClN5O3 Molecular weight:285.68698 Product Quality 12 years of chemical raw materials Mature operation of the industry System stability D

Cladribine/ CAS:4291-63-8/raw material/ high-quality

Cas:4291-63-8

Min.Order:25 Kilogram

FOB Price: $2.0 / 3.0

Type:Other

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Henan Tianfu Chemical Co., Ltd.

Product Name: Cladribine Synonyms: CDA;CLADRIBINE;CLADRIBINE CDA;LABOTEST-BB LT01147851;2-CHLORO-2'-DEOXYADENOSINE;2CDA;2-CL-DADO;2-chloro-2’-deoxy-adenosin CAS: 4291-63-8 MF: C10H12ClN5O3 MW: 285.69 EINECS: 636-978-6 Product Catego

4291-63-8 Cladribine

Cas:4291-63-8

Min.Order:1 Kilogram

FOB Price: $240.0

Type:Lab/Research institutions

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LIDE PHARMACEUTICALS LIMITED

Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&amp

Cladribine/ LIDE PHARMA- Factory supply / Best price

Cas:4291-63-8

Min.Order:1 Gram

FOB Price: $10.0

Type:Lab/Research institutions

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Hebei Nengqian Chemical Import and Export Co., LTD

Our advantages: 1. All inquiries will be replied within 12 hours. 2. Dedication to quality, supply & service. 3. Strictly on selecting raw materials. 4. Reasonable & competitive price, fast lead time. 5. Sample is available for your eva

Cladribine

Cas:4291-63-8

Min.Order:1 Kilogram

FOB Price: $9.0 / 99.0

Type:Trading Company

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Zhuozhou Wenxi import and Export Co., Ltd

WITH US,YOUR MONEY IN SAFE,YOUR BUSINESS IN SAFE 1)Quick Response Within 12 hours; 2)Quality Guarantee: All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France et

New production CAS 4291-63-8 with best quality

Cas:4291-63-8

Min.Order:1 Kilogram

FOB Price: $139.0 / 210.0

Type:Trading Company

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Henan Sinotech Import&Export Corporation

1.4291-63-8 2.Cladribine 3.Good quality 4.Competitive price 5.Stock available 1.4291-63-8 2.Cladribine 3.Good quality 4.Competitive price 5.Stock available Appearance:powder Storage: Stored in a cool and dry well-closed c

Cladribine 4291-63-8

Cas:4291-63-8

Min.Order:25 Kilogram

FOB Price: $1.0

Type:Other

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HANWAYS CHEMPHARM CO.,LIMITED

Hanways chempharm is a specialized company concentrating on the R&D, production, marketing and technical service of APIs and pharmaceutical intermediates. The marketing department is located in Wuhan. We have two GMP facilities in Hubei Pr

Cladribine API High Quality 99% CAS No 4291-63-8 Cladribine Powder

Cas:4291-63-8

Min.Order:1 Kilogram

FOB Price: $200.0 / 400.0

Type:Trading Company

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Shanghai Upbio Tech Co.,Ltd

1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

Cladribine 4291-63-8

Cas:4291-63-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

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Shanghai Minstar Chemical Co., Ltd

Product Name: Cladribine Synonyms: 2-CHLORO-2'-DEOXYADENOSINE;2CDA;2-CL-DADO;CDA;CLADRIBINE;CLADRIBINE CDA;LABOTEST-BB LT01147851;2-Chloro-6-amino-9-(2-deoxy-b-D-erythro-pentofuranosyl)purine CAS: 4291-63-8 MF: C10H12ClN5O3 MW: 285

CDA

Cas:4291-63-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

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Baoji Guokang Healthchem co.,ltd

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present

Cladribine

Cas:4291-63-8

Min.Order:1 Gram

FOB Price: $230.0 / 250.0

Type:Trading Company

inquiry

Qingdao Beluga Import and Export Co., LTD

Cladribine CAS:4291-63-8 Qingdao Belugas Import and Export Co., Ltd. is a scientific and technological company integrating research and development, production and trade of chemical intermediates, specializing in high quality organic intermediates,

Cladribine CAS:4291-63-8

Cas:4291-63-8

Min.Order:1 Gram

Negotiable

Type:Lab/Research institutions

inquiry

Changchun Artel lmport and Export trade company

Product Detail Minimum Order Qty. 10 Gram Supply Ability 500 Kilograms/Month Storage store in cool, dry, ventilated place 20℃ Delivery Time 3 business days after payment Payment Term TT,western union,Paypal,

Cladiribine CAS NO.: 4291-63-8

Cas:4291-63-8

Min.Order:20 Metric Ton

Negotiable

Type:Trading Company

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Hubei Jiutian Bio-medical Technology Co., Ltd

1,we produce and sell good chemicals around the world. 2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%. 3,our staff consists of highly qualifie

Cladribine CAS4291-63-8

Cas:4291-63-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Henan Wentao Chemical Product Co., Ltd.

Henan Wentao Chemical Product Co.,Ltd is Located in Zhengzhou High-tech Development Zone with import and export license, We passed ISO 9001:2008 as well, Henan Wentao has developed more than 1000 compounds, which are widely used in the fields of prod

Cladribine

Cas:4291-63-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Shandong Hanjiang Chemical Co., Ltd.

Hello, dear friend! I'm Hansen and Allen from China. Welcome to my lookchem mall! The following is a brief introduction of our company's products and services. If you are interested in our products, please contact us by emai

Cladribine

Cas:4291-63-8

Min.Order:1 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Triumph International Development Limilted

Lorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin h

Cladribine

Cas:4291-63-8

Min.Order:100 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

Taizhou Crene Biotechnology co.ltd

Our company provides one-stop services of research - development - production for a variety of special prouducts. Not only do we make effective use of our strong technological strength, but also establish of cooperative relations with several well-

cladribine 4291-63-8

Cas:4291-63-8

Min.Order:100 Milligram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Keyingchem Co.,Ltd

Hangzhou KeyingChem Co., Ltd. exported this product to many countries and regions at best price. If you are looking for the material’s manufacturer or supplier in China, KeyingChem is your best choice. Pls contact with us freely for getting det

Cladribine

Cas:4291-63-8

Min.Order:0 Metric Ton

Negotiable

Type:Lab/Research institutions

inquiry

NewCan Biotech Limited

NewCan Biotech Limited was established in 2021 and is primarily engaged in the research, development, production, and sales of sugars, nucleosides, nucleotides, phosphorylated monomers, as well as next-generation antiviral and antitumor drug intermed

2-?chloro-?2'-?deoxy-Adenosine

Cas:4291-63-8

Min.Order:1 Milligram

Negotiable

Type:Trading Company

inquiry

Hangzhou J&H Chemical Co., Ltd.

J&H CHEM R&D center can offer custom synthesis according to the contract research and development services for the fine chemicals, pharmaceutical, biotechnique and some of the other chemicals. J&H CHEM has some Manufacturing base in Jia

Cladribine

Cas:4291-63-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

Afine Chemicals Limited

Our Services 1. New Molecules R&D 2. Own test center HPLC NMR GC LC-MS 3. API and Intermediates from China reputed manufacturers 4. Documents support COA MOA MSDS DMF open part Our advantages 1. Government awarded company. Top 100 enter

CLADRIBINE

Cas:4291-63-8

Min.Order:0

Negotiable

Type:Lab/Research institutions

inquiry

SHANGHAI T&W PHARMACEUTICAL CO., LTD.

A substitute for perfluorooctanoic acid, mainly used as a surfactant, dispersant, additive, etc Appearance:White solid or Colorless liquid Purity:99.3 % We will ship the goods in a timely manner as required We can provide relevant documents acc

Cladribine

Cas:4291-63-8

Min.Order:4 Kilogram

Negotiable

Type:Lab/Research institutions

inquiry

Hangzhou Fonlynn Health Technology Co., Ltd.

Packing: According to customer requirements Delivery time: In stock or depands Port of shipment: Ningbo/Shanghai/Qingdao OEM/ODM:Welcome Sample:We can offer our existing samples at once Transportation:Express/Sea/Air Port:Ningbo/Shanghai/Qingd

Cladribine

Cas:4291-63-8

Min.Order:0

Negotiable

Type:Trading Company

inquiry

Synthetic route

3-benzyl-1-{2-chloro-9-[2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-purin-6-yl}-2-propylimidazolium iodide

3-benzyl-1-{2-chloro-9-[2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-purin-6-yl}-2-propylimidazolium iodide

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

Conditions
ConditionsYield
With ammonia In methanol at 60℃; for 11h;100%
With ammonia In methanol at 60℃;59%
2-chloro-N6,N6-dibenzoyl-3′,5′-O-dibenzoyl-2′-deoxyadenosine
1448245-68-8

2-chloro-N6,N6-dibenzoyl-3′,5′-O-dibenzoyl-2′-deoxyadenosine

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

Conditions
ConditionsYield
With ammonia In methanol at 0 - 20℃; for 12h;95%
9-(3,5-di-O-benzoyl-2-deoxy-β-D-erythro-pentofuranosyl)-2,6-dichloropurine
500225-62-7

9-(3,5-di-O-benzoyl-2-deoxy-β-D-erythro-pentofuranosyl)-2,6-dichloropurine

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

Conditions
ConditionsYield
With ammonia In methanol; dichloromethane at 80℃; for 7h;94%
6-amino-2-chloro-9-(2'deoxy-3',5'-di-O-acetyl-β-D-erythro-pentofuranosyl)-9H-purine
146196-13-6

6-amino-2-chloro-9-(2'deoxy-3',5'-di-O-acetyl-β-D-erythro-pentofuranosyl)-9H-purine

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

Conditions
ConditionsYield
With sodium carbonate In methanol at 20℃; for 2h; pH=8 - 9;93%
With ammonia In methanol at 0 - 20℃;0.62 g
2-chloro-6-amino-9-[3,5-di-O-(4-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-purine
908006-51-9

2-chloro-6-amino-9-[3,5-di-O-(4-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-purine

2-chloro-6-trimethylsilylamino-9-[3,5-di-O-(4-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-purine
1266098-30-9

2-chloro-6-trimethylsilylamino-9-[3,5-di-O-(4-chlorobenzoyl)-2-deoxy-β-D-ribofuranosyl]-purine

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

Conditions
ConditionsYield
With sodium methylate In methanol at 20 - 30℃; for 6h;90%
2'-deoxyribose 1-phosphate diammonium salt

2'-deoxyribose 1-phosphate diammonium salt

2-chloroadenine
1839-18-5

2-chloroadenine

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

Conditions
ConditionsYield
With magnesium hydroxide; purine nucleoside phosphorylase In water at 45℃;88%
9-(3,5-di-O-acetyl-2-deoxy-β-D-erythro-pentofuranosyl)-2,6-dichloropurine
24638-92-4

9-(3,5-di-O-acetyl-2-deoxy-β-D-erythro-pentofuranosyl)-2,6-dichloropurine

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

Conditions
ConditionsYield
With ammonia In methanol; dichloromethane at 80℃; for 7h;87%
2,6-Dichloro-9-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)-purine
38925-80-3

2,6-Dichloro-9-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)-purine

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

Conditions
ConditionsYield
With ammonia In methanol at 110℃; for 5h; Sealed tube;86%
With ammonia In methanol at 100℃; for 5h;71%
2-chloro-9-[2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-6-(2-pentylimidazol-1-yl)purine
914084-44-9

2-chloro-9-[2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-6-(2-pentylimidazol-1-yl)purine

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

Conditions
ConditionsYield
With ammonia In methanol at 60℃; for 13h;85%
2-chloro-9-[2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-6-(2-propylimidazol-1-yl)purine
914084-41-6

2-chloro-9-[2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-6-(2-propylimidazol-1-yl)purine

methanol
67-56-1

methanol

A

2-chloro-9-(2'deoxy-β-D-erythro-pentofuranosyl)-6-methoxy-9H-purine
146196-07-8

2-chloro-9-(2'deoxy-β-D-erythro-pentofuranosyl)-6-methoxy-9H-purine

B

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

Conditions
ConditionsYield
With ammonia at 40℃; for 15h;A 85%
B n/a
9-(3,5-di-O-benzoyl-2-deoxy-β-D-erythro-pentofuranosyl)-2-chloro-6-O-(2,4,6-triisopropylbenzenesulfonyl)purine
500225-59-2

9-(3,5-di-O-benzoyl-2-deoxy-β-D-erythro-pentofuranosyl)-2-chloro-6-O-(2,4,6-triisopropylbenzenesulfonyl)purine

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

Conditions
ConditionsYield
With ammonia In methanol; dichloromethane at 80℃; for 7h;83%
2,6-dichloro-9-(2-deoxy-3,5-di-p-toluoyl-O-β-D-ribofuranosyl)purine

2,6-dichloro-9-(2-deoxy-3,5-di-p-toluoyl-O-β-D-ribofuranosyl)purine

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

Conditions
ConditionsYield
With ammonia In methanol at 50℃; for 10h;82%
2'-Deoxyguanosine
961-07-9

2'-Deoxyguanosine

2-chloroadenine
1839-18-5

2-chloroadenine

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

Conditions
ConditionsYield
With 1A cells; E. coli BMT 4D In phosphate buffer at 65℃; for 4h; pH=7.5;81%
With purine nucleoside 2’-deoxyribosyltransferase from Trypanosoma brucei immobilized on glutaraldehyde-activated MagReSynAmine microspheres In aq. phosphate buffer at 50℃; for 0.333333h; pH=6; Enzymatic reaction;
2,6-dichloro 2’-deoxyriboside
37390-66-2

2,6-dichloro 2’-deoxyriboside

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

Conditions
ConditionsYield
With ammonium hydroxide In acetonitrile at 20℃; for 24h;79%
2,6-di-chloro-9-(3',5'-di-O-p-methoxybenzoyl-2'-deoxy-D-ribofuranosyl)purine
1384553-30-3

2,6-di-chloro-9-(3',5'-di-O-p-methoxybenzoyl-2'-deoxy-D-ribofuranosyl)purine

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

Conditions
ConditionsYield
With methanol; ammonia In dichloromethane at 80℃;79%
2-chloro-6-heptanoylamido-9-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythero pentofuranosyl)purine

2-chloro-6-heptanoylamido-9-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythero pentofuranosyl)purine

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

Conditions
ConditionsYield
With sodium methylate In methanol at 10 - 50℃; for 1.33333h; Heating / reflux;72%
With sodium methylate In methanol at 20 - 50℃; for 0.333333h;72%
2-chloro-3′,5′-di-O-(t-butyldimethylsilyl)-2′-deoxyadenosine

2-chloro-3′,5′-di-O-(t-butyldimethylsilyl)-2′-deoxyadenosine

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

Conditions
ConditionsYield
With potassium fluoride In methanol at 80℃; for 24h;72%
α-D-2′-deoxyribofuranose-1-O-phosphate bis(cyclohexylammonium) salt
98693-55-1, 102783-28-8

α-D-2′-deoxyribofuranose-1-O-phosphate bis(cyclohexylammonium) salt

2-chloroadenine
1839-18-5

2-chloroadenine

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

Conditions
ConditionsYield
With purine nucleoside phosphorylase; calcium hydroxide at 45℃; for 48h; pH=9.3; Enzymatic reaction;72%
2-chloro-9-[2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-6-(2-pentylimidazol-1-yl)purine
914084-44-9

2-chloro-9-[2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-6-(2-pentylimidazol-1-yl)purine

A

6-amino-2-chloro-9-(2-deoxy-α-D-erythro-pentofuranosyl)purine
5542-92-7

6-amino-2-chloro-9-(2-deoxy-α-D-erythro-pentofuranosyl)purine

B

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

Conditions
ConditionsYield
With ammonia In methanol at 80℃; for 13h;A n/a
B 70%
2-chloroadenine
1839-18-5

2-chloroadenine

7-methyl-2′-deoxyguanosine hydroiodide

7-methyl-2′-deoxyguanosine hydroiodide

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

Conditions
ConditionsYield
With potassium dihydrogenphosphate; Escherichia coli purine nucleoside phosphorylase In aq. buffer at 20℃; for 144h; pH=7.5; Enzymatic reaction;70%
2-chloroadenine
1839-18-5

2-chloroadenine

thymidine
50-89-5

thymidine

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

Conditions
ConditionsYield
Stage #1: thymidine With magnesium(II) chloride hexahydrate; E. coli thymidine phosphorylase In aq. phosphate buffer at 40℃; for 120h; pH=7.20; QAE Sephadex-nPi;
Stage #2: 2-chloroadenine With recombinant E. coli purine nucleoside phosphorylase In aq. phosphate buffer at 40℃; for 96h; pH=8.0; QAE Sephadex-nPi;
59%
With immobilized recombinant Geobacillus stearothermophilus BKM-2194 purine nucleoside phosphorylase II/pyrimidine nucleoside phosphorylase In dimethyl sulfoxide at 75℃; for 4h; pH=7.5; aq. phosphate buffer; Enzymatic reaction;86 %Chromat.
With potassium phosphate; Geobacillus thermoglucosidasius purine nucleoside phosphorylase; Thermus thermophilus pyrimidine nucleoside phosphorylase In water at 70℃; for 1h; pH=7; Enzymatic reaction;
9-(3,5-di-O-benzoyl-2-deoxy-β-D-erythro-pentofuranosyl)-2-chloro-6-O-(6-methylbenzenesulfonyl)purine
500225-60-5

9-(3,5-di-O-benzoyl-2-deoxy-β-D-erythro-pentofuranosyl)-2-chloro-6-O-(6-methylbenzenesulfonyl)purine

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

Conditions
ConditionsYield
With ammonia In methanol; dichloromethane at 80℃; for 7h;43%
2'-deoxyuridine
951-78-0

2'-deoxyuridine

2-chloro-N6-dimethylaminomethyleneadenine

2-chloro-N6-dimethylaminomethyleneadenine

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

Conditions
ConditionsYield
With ammonium hydroxide 1.) EtOH, DMSO, alginate gel-entrapped cells of auxotropHic thymine-dependent strain of E. coli, acetate buffer pH 5.8, 37 deg C, 16 h, 2.) room temperature, overnight; Yield given. Multistep reaction;
2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride
4330-21-6

2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride

2,6-dichloro-7H-purine
5451-40-1

2,6-dichloro-7H-purine

A

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

B

6-amino-2-chloro-7-(2-deoxy-β-D-erythro-pentofuranoyl)-7H-purine

6-amino-2-chloro-7-(2-deoxy-β-D-erythro-pentofuranoyl)-7H-purine

Conditions
ConditionsYield
With ammonia; sodium hydride Yield given. Multistep reaction. Yields of byproduct given;
Stage #1: 2,6-dichloro-7H-purine With sodium hydride In acetonitrile at 20℃; for 1.5h; Inert atmosphere;
Stage #2: 2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride In acetonitrile for 24.5h; Inert atmosphere;
Stage #3: With ammonia In methanol at 100℃; for 6h;
A 0.4 g
B 0.1 g
9-(3,5-di-O-acetyl-2-deoxy-β-D-erythro-pentofuranosyl)-2-chloro-6-O-(2,4,6-triisopropylbenzenesulfonyl)purine
500225-58-1

9-(3,5-di-O-acetyl-2-deoxy-β-D-erythro-pentofuranosyl)-2-chloro-6-O-(2,4,6-triisopropylbenzenesulfonyl)purine

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

Conditions
ConditionsYield
With ammonia In methanol; dichloromethane at 80℃; for 7h;
2-Chloro-9-((2R,3aS,9aR)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-ylamine
136850-20-9

2-Chloro-9-((2R,3aS,9aR)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-ylamine

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

Conditions
ConditionsYield
With ammonium fluoride In methanol Heating;
2'-deoxyribose 1-phosphate diammonium salt

2'-deoxyribose 1-phosphate diammonium salt

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 91 percent / purine nucleoside phosphorylase / H2O / 45 °C
2: 79 percent / aq. NH3 / acetonitrile / 24 h / 20 °C
View Scheme
2,6 dichloropurine
5451-40-1

2,6 dichloropurine

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 95 percent / NH3 / methanol / 24 h / 160 °C
2: 88 percent / purine nucleoside phosphorylase; Mg(OH)2 / H2O / 45 °C
View Scheme
Multi-step reaction with 6 steps
1: SnCl4 / acetonitrile / 20 °C
2: NH3 / methanol / 20 °C
3: pyridine / 20 °C
4: DMAP / acetonitrile / 20 °C
5: (Me3Si)3SiH; AIBN / dioxane / Heating
6: NH4F / methanol / Heating
View Scheme
Multi-step reaction with 3 steps
1: 67 percent / NH3, MeOH / 12 h / 100 °C
2: 75 percent / dimethylformamide / Ambient temperature
3: 2.) aq. NH3 / 1.) EtOH, DMSO, alginate gel-entrapped cells of auxotropHic thymine-dependent strain of E. coli, acetate buffer pH 5.8, 37 deg C, 16 h, 2.) room temperature, overnight
View Scheme
Multi-step reaction with 2 steps
1: 59 percent / 1.) NaH / acetonitrile / 1.) r.t., 30 min; 2.) 15 h
2: 71 percent / ammonia / methanol / 5 h / 100 °C
View Scheme
bis(cyclohexylamine) 3',5'-O-bis(4-chlorobenzoyl)-2-deoxy-α-D-ribosyl-1-phosphate

bis(cyclohexylamine) 3',5'-O-bis(4-chlorobenzoyl)-2-deoxy-α-D-ribosyl-1-phosphate

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 92 percent / NH3 / methanol / 24 h / 20 °C
2: 91 percent / purine nucleoside phosphorylase / H2O / 45 °C
3: 79 percent / aq. NH3 / acetonitrile / 24 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: 92 percent / NH3 / methanol / 24 h / 20 °C
2: 88 percent / purine nucleoside phosphorylase; Mg(OH)2 / H2O / 45 °C
View Scheme
acetic anhydride
108-24-7

acetic anhydride

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

6-amino-2-chloro-9-(2'deoxy-3',5'-di-O-acetyl-β-D-erythro-pentofuranosyl)-9H-purine
146196-13-6

6-amino-2-chloro-9-(2'deoxy-3',5'-di-O-acetyl-β-D-erythro-pentofuranosyl)-9H-purine

Conditions
ConditionsYield
With pyridine for 3h;92%
With pyridine for 2h; Ambient temperature;81%
2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

2-azido-9-(2-deoxy-β-D-erythro-pentofuranosyl)adenine
404839-80-1

2-azido-9-(2-deoxy-β-D-erythro-pentofuranosyl)adenine

Conditions
ConditionsYield
Stage #1: 2-chloro-2'-deoxyadenosine With hydrazine hydrate at 20℃; for 16h;
Stage #2: With acetic acid; sodium nitrite In water for 1h; cooling;
91%
Multi-step reaction with 2 steps
1: H2NNH2*H2O / 20 °C
2: NaNO2; acetic acid / H2O / 0 °C
View Scheme
ethylamine
75-04-7

ethylamine

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

2-ethylamino-2’-deoxyadenosine

2-ethylamino-2’-deoxyadenosine

Conditions
ConditionsYield
In methanol at 130℃; for 24h;90%
2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

tert-butylchlorodiphenylsilane
58479-61-1

tert-butylchlorodiphenylsilane

2-chloro-9-<2-deoxy-5-O-<(1,1-dimethylethyl)diphenylsilyl>-β-D-erythro-pentofuranosyl>-9H-purin-6-amine
156834-09-2

2-chloro-9-<2-deoxy-5-O-<(1,1-dimethylethyl)diphenylsilyl>-β-D-erythro-pentofuranosyl>-9H-purin-6-amine

Conditions
ConditionsYield
With pyridine for 14h;83%
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane
69304-37-6

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

2-Chloro-9-((2R,3aS,9aR)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-ylamine
136850-20-9

2-Chloro-9-((2R,3aS,9aR)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-ylamine

Conditions
ConditionsYield
With pyridine at 5 - 20℃; for 1.5h;83%
2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

N,N-dimethylformamide diethyl diacetal
1188-33-6

N,N-dimethylformamide diethyl diacetal

2-chloro-9-(2'-deoxy-β-D-erythro-pentofuranosyl)-6-<<(dimethylamino)methylidene>amino>-9H-purine
146196-18-1

2-chloro-9-(2'-deoxy-β-D-erythro-pentofuranosyl)-6-<<(dimethylamino)methylidene>amino>-9H-purine

Conditions
ConditionsYield
In N,N-dimethyl-formamide Ambient temperature;82%
allyl alcohol
107-18-6

allyl alcohol

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

2-allyloxy-6-amino-9-[2-deoxy-β-D-erythro-pentofuranosyl]-9H-purine
916755-74-3

2-allyloxy-6-amino-9-[2-deoxy-β-D-erythro-pentofuranosyl]-9H-purine

Conditions
ConditionsYield
With sodium allyloxide at 60℃; for 2h;79%
Stage #1: allyl alcohol With sodium In paraffin oil at 0℃; for 1h; Inert atmosphere;
Stage #2: 2-chloro-2'-deoxyadenosine In paraffin oil at 88℃; for 12h;
62%
tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

5'-O-tert-butyldimethylsilylcladribine
128126-38-5

5'-O-tert-butyldimethylsilylcladribine

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 20h; Inert atmosphere;75%
With 1H-imidazole In pyridine at 20℃;
2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

1-amino-2-propene
107-11-9

1-amino-2-propene

2-allylamino-2’-deoxyadenosine

2-allylamino-2’-deoxyadenosine

Conditions
ConditionsYield
In methanol at 130℃; for 24h;75%
p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

C17H18ClN5O5S

C17H18ClN5O5S

Conditions
ConditionsYield
With pyridine; triethylamine at 0 - 20℃; for 24h;74%
2-chloro-2'-deoxyadenosine
4291-63-8

2-chloro-2'-deoxyadenosine

benzyl alcohol
100-51-6

benzyl alcohol

6-amino-2-benzyloxy-9-(2'-deoxy-β-D-erythro-pentofuranosyl)purine

6-amino-2-benzyloxy-9-(2'-deoxy-β-D-erythro-pentofuranosyl)purine

Conditions
ConditionsYield
Stage #1: benzyl alcohol With sodium In paraffin oil at 80℃; for 0.75h; Inert atmosphere;
Stage #2: 2-chloro-2'-deoxyadenosine With silicon In acetonitrile; paraffin oil at 85℃; for 12h;
71%
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