2-Chloro-isonicotinic acid hydrazide supplier

Name
2-Chloro-isonicotinic acid hydrazide
EINECS
CAS No. 58481-04-2
Article Data11
CAS DataBase
Density 1.404 g/cm³
Solubility 2380 mg/L at 25 °C in water
Melting Point
Formula C₆H₆ClN₃O
Boiling Point
Molecular Weight 171.586
Flash Point
Transport Information
Appearance
Safety
Risk Codes
Molecular Structure
Hazard Symbols Xi
Synonyms Isonicotinicacid, 2-chloro-, hydrazide (7CI);2-Chloroisonicotinic acid hydrazide;2-Chloropyridine-4-carboxylic acid hydrazide;NSC 38340;
PSA 68.01000
LogP 1.42970

Synthetic route

: 58481-11-1
methyl 2-chloroisonicotinate

: 58481-04-2
2-chloroisonicotinic acid hydrazide

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol at 90℃; for 4h;	87%
With methanol; hydrazine hydrate
With hydrazine hydrate In ethanol Reflux;

: 6313-54-8
2-chloroisonicotinic acid,

: 58481-04-2
2-chloroisonicotinic acid hydrazide

Conditions

Conditions	Yield
Stage #1: 2-chloroisonicotinic acid, With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In acetonitrile at 20℃; for 2h; Stage #2: With hydrazine In acetonitrile at 0℃; for 0.5h;	57%
Multi-step reaction with 2 steps 1: methanol. HCl 2: methanol; N2H4+H2O View Scheme
With 1,1'-carbonyldiimidazole; hydrazine In tetrahydrofuran at 20℃;

: 54453-93-9
ethyl 2-chloroisonicotinate

: 58481-04-2
2-chloroisonicotinic acid hydrazide

Conditions

Conditions	Yield
With hydrazine hydrate In ethanol for 5h; Reflux;
With hydrazine hydrate In ethanol Reflux;

: 58481-04-2
2-chloroisonicotinic acid hydrazide

: 14527-26-5, 867-44-7
2-methylisothiourea sulphate

: 77314-43-3
2-chloroisonicotinic acid 2-amidinohydrazide

Conditions

Conditions	Yield
With sodium hydroxide for 20h; Ambient temperature;	95%

: 58481-04-2
2-chloroisonicotinic acid hydrazide

: 3-(4-chlorophenyl)-4,6-dimethoxy-7-trichloroacetyl-1H-indole

: N'-(2-chloroisonicotinoyl)-3-(4-chlorophenyl)-4,6-dimethoxy-1H-indole-7-carbohydrazide

Conditions

Conditions	Yield
With triethylamine In acetonitrile for 24h; Reflux;	88%

: 58481-04-2
2-chloroisonicotinic acid hydrazide

: 159634-59-0
2,3-dihydro-3-oxo-spiro[1H-indene-1,4'-piperidine]-1'-carboxylic acid 1,1-dimethylethyl ester

: C24H27ClN4O3

Conditions

Conditions	Yield
With sulfuric acid In ethanol for 5h; Heating / reflux;	70%

: 58481-04-2
2-chloroisonicotinic acid hydrazide

: 1312002-42-8
3-(4-bromophenyl)-4,6-dimethoxy-7-trichloroacetylindole

: 3-(4-bromophenyl)-N'-(2-chloroisonicotinoyl)-4,6-dimethoxy-1H-indole-7-carbohydrazide

Conditions

Conditions	Yield
With triethylamine In acetonitrile for 24h; Reflux;	68%

: 1003-29-8
2-pyrrole aldehyde

: 58481-04-2
2-chloroisonicotinic acid hydrazide

: N'-((1H-pyrrol-2-yl)methylene)-2-chloroisonicotinohydrazide

Conditions

Conditions	Yield
In ethanol for 24h; Reflux;	58%

: 98-03-3
thiophene-2-carbaldehyde

: 58481-04-2
2-chloroisonicotinic acid hydrazide

: 2-chloro-N'-(thiophen-2-ylmethylene)isonicotinohydrazide

Conditions

Conditions	Yield
In ethanol for 24h; Reflux;	53%

: 98-01-1
furfural

: 58481-04-2
2-chloroisonicotinic acid hydrazide

: 2-chloro-N'-(furan-2-ylmethylene)isonicotinohydrazide

Conditions

Conditions	Yield
In ethanol for 24h; Reflux;	52%

: 58481-04-2
2-chloroisonicotinic acid hydrazide

: 70696-29-6
2-chloroisonicotinoyl azide

Conditions

Conditions	Yield
With hydrogenchloride; sodium nitrite

: 58481-04-2
2-chloroisonicotinic acid hydrazide

: 77314-55-7
3-amino-5-(2-chloro-4-pyridyl)-1,2,4-triazole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 95 percent / sodium hydroxide / 20 h / Ambient temperature 2: 53 percent / 14 h / 210 °C / 0.05 Torr View Scheme

: 58481-04-2
2-chloroisonicotinic acid hydrazide

: 77314-66-0
[4-(5-Amino-1H-[1,2,4]triazol-3-yl)-pyridin-2-yl]-ethyl-methyl-amine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 95 percent / sodium hydroxide / 20 h / Ambient temperature 2: H2O / 60 h / 75 °C View Scheme

: 58481-04-2
2-chloroisonicotinic acid hydrazide

: 77314-65-9
[4-(5-Amino-1H-[1,2,4]triazol-3-yl)-pyridin-2-yl]-dimethyl-amine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 95 percent / sodium hydroxide / 20 h / Ambient temperature 2: H2O / 60 h / 75 °C View Scheme

: 58481-04-2
2-chloroisonicotinic acid hydrazide

: 77314-58-0
[4-(5-Amino-1H-[1,2,4]triazol-3-yl)-pyridin-2-yl]-propyl-amine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 95 percent / sodium hydroxide / 20 h / Ambient temperature 2: H2O / 60 h / 75 °C View Scheme

: 58481-04-2
2-chloroisonicotinic acid hydrazide

: 77314-61-5
Allyl-[4-(5-amino-1H-[1,2,4]triazol-3-yl)-pyridin-2-yl]-amine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 95 percent / sodium hydroxide / 20 h / Ambient temperature 2: H2O / 60 h / 75 °C View Scheme

: 58481-04-2
2-chloroisonicotinic acid hydrazide

: 77314-62-6
2-[4-(5-Amino-1H-[1,2,4]triazol-3-yl)-pyridin-2-ylamino]-ethanol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 95 percent / sodium hydroxide / 20 h / Ambient temperature 2: H2O / 60 h / 75 °C View Scheme

: 58481-04-2
2-chloroisonicotinic acid hydrazide

: 77314-68-2
3-(ethylamino)-5-<2-(ethylamino)-4-pyridyl>-1,2,4-triazole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 95 percent / sodium hydroxide / 20 h / Ambient temperature 2: 0.17 percent / H2O / 40 h / 160 °C View Scheme

: 58481-04-2
2-chloroisonicotinic acid hydrazide

: 77314-64-8
[4-(5-Amino-1H-[1,2,4]triazol-3-yl)-pyridin-2-yl]-(2-methoxy-ethyl)-amine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 95 percent / sodium hydroxide / 20 h / Ambient temperature 2: H2O / 60 h / 75 °C View Scheme

: 58481-04-2
2-chloroisonicotinic acid hydrazide

: 77314-59-1
[4-(5-Amino-1H-[1,2,4]triazol-3-yl)-pyridin-2-yl]-hexyl-amine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 95 percent / sodium hydroxide / 20 h / Ambient temperature 2: H2O / 60 h / 75 °C View Scheme

: 58481-04-2
2-chloroisonicotinic acid hydrazide

: 98087-96-8
[4-(5-Amino-1H-[1,2,4]triazol-3-yl)-pyridin-2-yl]-phenyl-amine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 95 percent / sodium hydroxide / 20 h / Ambient temperature 2: 53 percent / 14 h / 210 °C / 0.05 Torr 3: H2O / 15 h / 175 °C View Scheme

: 58481-04-2
2-chloroisonicotinic acid hydrazide

: 77314-71-7
[4-(5-Amino-1H-[1,2,4]triazol-3-yl)-pyridin-2-yl]-benzyl-amine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 95 percent / sodium hydroxide / 20 h / Ambient temperature 2: H2O / 60 h / 75 °C View Scheme

: 58481-04-2
2-chloroisonicotinic acid hydrazide

: 77314-60-4
[4-(5-Amino-1H-[1,2,4]triazol-3-yl)-pyridin-2-yl]-decyl-amine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 95 percent / sodium hydroxide / 20 h / Ambient temperature 2: H2O / 60 h / 75 °C View Scheme

: 58481-04-2
2-chloroisonicotinic acid hydrazide

: 77314-69-3
3-amino-<5-<(2-phenylethyl)amino>-4-pyridyl>-1,2,4-triazole

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 95 percent / sodium hydroxide / 20 h / Ambient temperature 2: 53 percent / 14 h / 210 °C / 0.05 Torr 3: 49 percent / H2O / 15 h / 175 °C View Scheme

: 58481-04-2
2-chloroisonicotinic acid hydrazide

: 77314-73-9
[4-(5-Amino-1H-[1,2,4]triazol-3-yl)-pyridin-2-yl]-(4-methyl-benzyl)-amine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 95 percent / sodium hydroxide / 20 h / Ambient temperature 2: H2O / 60 h / 75 °C View Scheme

: 58481-04-2
2-chloroisonicotinic acid hydrazide

: 98087-97-9
[4-(5-Amino-1H-[1,2,4]triazol-3-yl)-pyridin-2-yl]-(3-phenyl-propyl)-amine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 95 percent / sodium hydroxide / 20 h / Ambient temperature 2: 53 percent / 14 h / 210 °C / 0.05 Torr 3: H2O / 15 h / 175 °C View Scheme

: 58481-04-2
2-chloroisonicotinic acid hydrazide

: 77314-84-2
[4-(5-Amino-1H-[1,2,4]triazol-3-yl)-pyridin-2-yl]-(3,4-dimethyl-benzyl)-amine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 95 percent / sodium hydroxide / 20 h / Ambient temperature 2: H2O / 60 h / 75 °C View Scheme

: 58481-04-2
2-chloroisonicotinic acid hydrazide

: 77314-72-8
3-amino-5-<2-<(p-chlorobenzyl)amino>-4-pyridyl>-1,2,4-triazole

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 95 percent / sodium hydroxide / 20 h / Ambient temperature 2: 43 percent / H2O / 60 h / 75 °C View Scheme

: 58481-04-2
2-chloroisonicotinic acid hydrazide

: [4-(5-Amino-1H-[1,2,4]triazol-3-yl)-pyridin-2-yl]-(4-tert-butyl-benzyl)-amine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 95 percent / sodium hydroxide / 20 h / Ambient temperature 2: H2O / 60 h / 75 °C View Scheme

: 855849-88-6
1'-[trans-3-(4-chlorophenyl)allyl]spiro[indan-1-one-3,4'-piperidine]

: 58481-04-2
2-chloroisonicotinic acid hydrazide

: 2-chloroisonicotinic acid [1'-[trans-3-(4-chlorophenyl)allyl]spiro[indan-1-ylidene-3,4'-piperidine]]hydrazide

Conditions

Conditions	Yield
With sulfuric acid In ethanol for 12h; Heating / reflux;

2-Chloro-isonicotinic acid hydrazide Specification

This chemical is called 2-Chloro-isonicotinic acid hydrazide, and it can also be named as 2-chloropyridine-4-carbohydrazide. With the molecular formula of C₆H₆ClN₃O, its molecular weight is 171.58. The CAS registry number of this chemical is 58481-04-2. Additionally, its product categories are Pyridine Series; Pyridines.

Other characteristics of the 2-Chloro-isonicotinic acid hydrazide can be summarised as followings: (1)ACD/LogP: 0.12; (2)# of Rule of 5 Violations: 0; (3)#H bond acceptors: 4; (4)#H bond donors: 3; (5)#Freely Rotating Bonds: 2; (6)Polar Surface Area: 36.44 Å²; (7)Index of Refraction: 1.599; (8)Molar Refractivity: 41.76 cm³; (9)Molar Volume: 122.1 cm³; (10)Polarizability: 16.55×10^-24cm³; (11)Surface Tension: 59.8 dyne/cm; (12)Density: 1.404 g/cm³.

You can still convert the following datas into molecular structure:
1.SMILES: O=C(c1ccnc(Cl)c1)NN
2.InChI: InChI=1/C6H6ClN3O/c7-5-3-4(1-2-9-5)6(11)10-8/h1-3H,8H2,(H,10,11)
3.InChIKey: MZIIYNBBSHJOLD-UHFFFAOYAR

Product Name

2-Chloro-isonicotinic acid hydrazide

Synthetic route

2-Chloro-isonicotinic acid hydrazide Specification

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