2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride supplier

Name
2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride
EINECS -0
CAS No. 86604-75-3
Article Data17
CAS DataBase
Density
Solubility Soluble in water.
Melting Point 128-131 °C(lit.)
Formula C₉H₁₂ClNO^.HCl
Boiling Point 272.2 °C at 760 mmHg
Molecular Weight 222.114
Flash Point 118.4 °C
Transport Information UN 3261
Appearance White to off White crystalline powder with irritating odour
Safety 26-36/37/39-45
Risk Codes 34
Molecular Structure
Hazard Symbols
Synonyms 2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride
PSA 22.12000
LogP 3.24780

Synthetic route

: 86604-78-6
(4-methoxy-3,5-dimethylpyridin-2-yl)methanol

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

Conditions

Conditions	Yield
With thionyl chloride In dichloromethane at 20℃; for 1h;	100%
With thionyl chloride In dichloromethane at 20℃; for 1h;	100%
With bis(trichloromethyl) carbonate; Triphenylphosphine oxide In toluene at 20 - 60℃; for 6h; Temperature;	98%

: 84006-10-0
(chloromethyl)-4-methoxy-3,5-dimethylpyridine

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In toluene at 15℃; for 0.1h;	94.5%
With hydrogenchloride In ethanol at 20℃; for 1h; Inert atmosphere;	92.6%

: 695-98-7
2,3,5-trimethyl-pyridine

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: 76 percent / 30percent aq. H2O2, HOAc / 23 h / 90 °C 2: HNO3 / Heating 4: 110 °C 5: aq. NaOH / methanol / Heating 6: 90 percent / SOCl2 / CH2Cl2 / 0.5 h / Heating View Scheme

: 86604-79-7
2,3,5-trimethyl-4-nitropyridine N-oxide

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 2: 110 °C 3: aq. NaOH / methanol / Heating 4: 90 percent / SOCl2 / CH2Cl2 / 0.5 h / Heating View Scheme
Multi-step reaction with 4 steps 1: NaOMe / 16 h / 40 °C 2: 2 h / 90 °C 3: 2 N aq. NaOH / 2 h / 80 °C 4: SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C View Scheme

: 74409-42-0
2,3,5-trimethylpyridine 1-oxide

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: HNO3 / Heating 3: 110 °C 4: aq. NaOH / methanol / Heating 5: 90 percent / SOCl2 / CH2Cl2 / 0.5 h / Heating View Scheme
Multi-step reaction with 5 steps 1: 98percent HNO3 / acetic acid / 33 h / 80 °C 2: NaOMe / 16 h / 40 °C 3: 2 h / 90 °C 4: 2 N aq. NaOH / 2 h / 80 °C 5: SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C View Scheme

: 86604-80-0
4-methoxy-2,3,5-trimethylpyridine 1-oxide

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 110 °C 2: aq. NaOH / methanol / Heating 3: 90 percent / SOCl2 / CH2Cl2 / 0.5 h / Heating View Scheme
Multi-step reaction with 3 steps 1: 2 h / 90 °C 2: 2 N aq. NaOH / 2 h / 80 °C 3: SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C View Scheme
Multi-step reaction with 3 steps 1: acetic acid / methanol; toluene 2: sodium hydroxide / methanol 3: thionyl chloride View Scheme
Multi-step reaction with 3 steps 1: Raney nickel / methanol / 6 h / 40 °C 2: trichloroisocyanuric acid / chloroform / 4 h / 50 °C 3: hydrogenchloride / toluene / 0.1 h / 15 °C View Scheme

: 91219-90-8
(4-methoxy-3,5-dimethyl-pyridin-2-yl)methyl acetate

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aq. NaOH / methanol / Heating 2: 90 percent / SOCl2 / CH2Cl2 / 0.5 h / Heating View Scheme
Multi-step reaction with 2 steps 1: 2 N aq. NaOH / 2 h / 80 °C 2: SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C View Scheme
Multi-step reaction with 2 steps 1: sodium hydroxide / methanol 2: thionyl chloride View Scheme

SO2 Cl2: SO2 Cl2

: 86604-78-6
(4-methoxy-3,5-dimethylpyridin-2-yl)methanol

A 2-chloromethyl-5-dimethyl-4-methoxypyridine hydrochloride: 2-chloromethyl-5-dimethyl-4-methoxypyridine hydrochloride

B: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

Conditions

Conditions	Yield
In chloroform

...Expand

: 67-63-0
isopropyl alcohol

: 104916-41-8
3,5-dimethyl-4-methoxy-2-cyanopyridine

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

Conditions

Conditions	Yield
With sodium hydroxide; thionyl chloride; sodium nitrite; aluminum nickel In NH3 -saturated methanol; water; acetic acid

: 96300-88-8
2-Hydroxymethyl-4-methoxy-3,5-dimethylpyridine hydrochloride

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

Conditions

Conditions	Yield
With thionyl chloride In dichloromethane at 15 - 30℃; for 1h;
With thionyl chloride

: 109371-20-2
4-chloro-2,3,5-trimethylpyridine 1-oxide

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: sodium hydroxide 2: acetic acid / methanol; toluene 3: sodium hydroxide / methanol 4: thionyl chloride View Scheme

: 651729-89-4
3-[4-(2-mercapto-5-methoxy-benzimidazole-1-sulfonyl)-phenyl]-propionic acid 2-(toluene-4-sulfonyl)ethyl ester

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

: 651729-90-7
3-[4-(5-methoxy-2-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethylsulfanyl)benzimidazole-1-sulfonyl)-phenyl]-propionic acid 2-(toluene-4-sulfonyl)ethyl ester

Conditions

Conditions	Yield
With potassium carbonate In DMF (N,N-dimethyl-formamide) for 2h;	100%
With potassium carbonate In DMF (N,N-dimethyl-formamide) for 2h;	100%

: 848694-70-2
N-{5-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-yl}-acetamide

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

: 848694-71-3
N-[5-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-chloro-7-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-acetamide

Conditions

Conditions	Yield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 20℃;	100%

: 37052-78-1
2-Mercapto-5-methoxybenzimidazole

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

: 73590-85-9
omeprazole sulfide

Conditions

Conditions	Yield
With tetrabutylammomium bromide; edetate disodium; sodium hydroxide In dichloromethane; water pH=10; pH-value;	100%
With sodium hydroxide at 20℃;	98%
With sodium hydroxide In methanol; water Reflux;	95.2%

: 136918-14-4
phthalimide

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

: 946071-49-4
2-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)isoindoline-1,3-dione

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 16h;	100%

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

: 5-methoxy-1H-imidazo[4,5-b]pyridine-2-thiol

: 113713-24-9
5-methoxy-2-((4-methoxy-3,5-dimethylpyridin-2-yl)methylthio)-1H-imidazo[4,5-b]pyridine

Conditions

Conditions	Yield
With sodium hydroxide In water at 25 - 30℃; Large scale reaction;	98%
With sodium hydroxide In methanol; water at 25 - 30℃; for 0.75h;	88.8%

: tert-butyl 4-(6-Hydroxy-2-methylpyridin-3-yl)piperidine-1-carboxylate

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

: tert-butyl 4-{6-[(4-methoxy-3,5-dimethylpyridin-2-yl)-methoxy]-2-methylpyridin-3-yl}piperidine-1-carboxylate

Conditions

Conditions	Yield
With silver carbonate In toluene at 110℃; for 6h; Darkness;	98%

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

: 92806-76-3
5-tert-butyl-2-mercapto-1H-benzimidazole

: 5-tert-Butyl-2-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethylsulfanyl)-1H-benzoimidazole

Conditions

Conditions	Yield
With sodium hydroxide In methanol Heating;	97%

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

: 110-70-3
N,N`-dimethylethylenediamine

: 1523156-35-5
N,N′‑dimethyl‑N,N′‑bis(4‑methoxy‑3,5‑dimethylpyridine‑2‑ylmethyl)‑1,2 diaminoethane

Conditions

Conditions	Yield
Stage #1: 2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride With potassium carbonate In water at 20℃; for 0.5h; Stage #2: N,N`-dimethylethylenediamine With sodium hydroxide In dichloromethane; water at 20℃; for 60h;	97%
With sodium hydroxide In dichloromethane; water

: 37052-78-1
2-Mercapto-5-methoxybenzimidazole

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

: 73590-85-9
6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole

Conditions

Conditions	Yield
With sodium hydroxide In 1,4-dioxane; water at 80℃; for 1h; Solvent; Temperature;	97%
With sodium hydroxide In methanol; water at 55 - 65℃; for 2h; Large scale;	86%
With sodium hydrogencarbonate In ethanol Reagent/catalyst; Temperature; Solvent; Reflux; Large scale;	85.3%
With sodium hydroxide In ethanol; water Solvent; Reflux; Large scale;	81.1%
With sodium hydroxide In methanol at 50℃; for 4h; Reagent/catalyst; Temperature; Solvent;	34.1 g

: 843615-24-7
4-(2-mercapto-5-methoxy-benzimidazole-1-sulfonyl)-3-methoxy-benzoic acid 2-(toluene-4-sulfonyl)ethyl ester

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

: 651729-67-8
4-methoxy-3-[5-methoxy-2-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethylsulfanyl)-benzimidazole-1-sulfonyl]-benzoic acid 2-(toluene-4-sulfonyl)ethyl ester

Conditions

Conditions	Yield
With potassium carbonate In DMF (N,N-dimethyl-formamide) for 2h;	96%
With potassium carbonate In DMF (N,N-dimethyl-formamide) for 2h;	96%

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

: 37052-78-1
6-methoxy-1H-benzoimidazole-2-thiol

: 73590-58-6
omeprazole

Conditions

Conditions	Yield
Stage #1: 6-methoxy-1H-benzoimidazole-2-thiol With sodium hydroxide In ethanol; water at 70 - 90℃; Stage #2: 2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride With hydrogenchloride In ethanol; water at -10 - 30℃; for 4h; Reflux;	96%

: 129422-96-4
1-(p-toluenesulfonyl)-1,4,7-triazacyclononane

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

: C31H43N5O4S

Conditions

Conditions	Yield
With tetrabutylammomium bromide; sodium carbonate In acetonitrile for 24h; Inert atmosphere; Reflux;	96%
With tetrabutylammomium bromide; sodium carbonate In acetonitrile for 22h; Reflux; Inert atmosphere;	91%

: 37052-78-1
5-methoxy-1,3-dihydro-2H-benzo[d]imidazole-2-thione

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

: 73590-85-9
omeprazole sulfide

Conditions

Conditions	Yield
With sodium carbonate In methanol for 1.5h; Reflux;	95%
In methanol at 70℃; Kinetics;

: 136247-90-0
tert-butyl (3-(methoxymethoxy)phenyl)carbamate

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

: tert-butyl ((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)(3-(methoxymethoxy)phenyl)carbamate

Conditions

Conditions	Yield
Stage #1: tert-butyl (3-(methoxymethoxy)phenyl)carbamate With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 0.5h; Stage #2: 2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride In N,N-dimethyl-formamide at 0 - 20℃; for 12h;	95%

: 97963-62-7
5-(difluoromethoxy)-2-mercapto-1H-benzimidazole

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

: 102625-64-9
pantoprazole sulfide

Conditions

Conditions	Yield
With sodium hydroxide In ethanol at 80℃; for 8h;	94%

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

: 164513-38-6
2-hydroxy-4-methyl-5-bromopyridine

: 2-{[(5-bromo-4-methylpyridin-2-yl)oxy]methyl}-4-methoxy-3,5-dimethylpyridine

Conditions

Conditions	Yield
With silver carbonate In toluene at 110℃; for 6h; Darkness;	94%

: 2-(4-tolylsulfonyl)ethyl 3-{4-[2-mercapto-5-methoxybenzimidazolyl]sulfonyl}-3,5-dimethylphenoxy-2,2-dimethylpropionate

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

: 651729-45-2
2-(4-tolylsulfonyl)ethyl 3-{4-[(5-methoxy-2-{[4-methoxy-3,5-dimethyl(2-pyridyl)]methylthio}benzimidazolyl)sulfonyl]-3,5-dimethylphenoxy}-2,2-dimethylpropionate

Conditions

Conditions	Yield
Stage #1: 2-(4-tolylsulfonyl)ethyl 3-{4-[2-mercapto-5-methoxybenzimidazolyl]sulfonyl}-3,5-dimethylphenoxy-2,2-dimethylpropionate; 2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride With potassium carbonate In DMF (N,N-dimethyl-formamide) for 1.5h; Stage #2: With hydrogenchloride at 0℃;	93%

: 651729-74-7
3-[4-(2-mercapto-5-methoxy-benzimidazole-1-sulfonyl)-phenoxy]-2,2-dimethyl-propionic acid methyl ester

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

: 651729-75-8
3-[4-(5-methoxy-2-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethylsulfanyl)benzimidazole-1-sulfonyl)-phenoxy]-2,2-dimethyl-propionic acid methyl ester

Conditions

Conditions	Yield
With potassium carbonate In DMF (N,N-dimethyl-formamide) for 1h;	93%
With potassium carbonate In DMF (N,N-dimethyl-formamide) for 1h;	93%

: 843615-34-9
2-carbamoylmethoxy-4-[{6-methoxy-2-mercaptobenzimidazolyl}sulfonyl]phenoxyacetamide

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

: 843615-35-0
1-(3,4-dimethoxycarboxamidobenzenesulfonyl)-6-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]thio-1H-benzimidazole

Conditions

Conditions	Yield
With potassium carbonate In DMF (N,N-dimethyl-formamide) for 0.25h;	93%

: 1319671-99-2
C14H18N4OS

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

: 2-[(3,5-dimethyl-4-methoxy-pyridin-2-yl)methylthio]-6-acetylamino-5-(piperidin-1-yl)-1H-benzimidazole

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In ethanol; acetone at 45℃; for 4h;	92%

: 3731-51-9
(2-aminomethylpyridine)

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

: 1-(4-methoxy-3,5-dimethylpyridin-2-yl)-N-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-N-(pyridin-2-ylmethyl)methanamine

Conditions

Conditions	Yield
With tetrabutylammomium bromide; sodium carbonate In acetonitrile at 80℃; for 48h; Inert atmosphere;	92%
With potassium carbonate In acetonitrile for 72h; Inert atmosphere; Reflux;	49%
Inert atmosphere; Reflux;

: 54923-31-8
3-bromo-6-hydroxy-2-methylpyridine

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

: 2-{[(5-bromo-6-methylpyridin-2-yl)oxy]methyl}-4-methoxy-3,5-dimethylpyridine

Conditions

Conditions	Yield
With silver carbonate In toluene at 110℃; for 6h; Darkness;	92%

: 1074-82-4
potassium phtalimide

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

: 946071-49-4
2-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)isoindoline-1,3-dione

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 85℃; Inert atmosphere;	91%

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

: 848694-10-0
2-chloromethyl-3,5-dimethyl-4-methoxypyridine-N-oxide

Conditions

Conditions	Yield
Stage #1: 2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride With sodium hydroxide In chloroform for 0.5h; Stage #2: With 3-chloro-benzenecarboperoxoic acid In chloroform at 55 - 60℃; for 1.5h; Further stages.;	90.4%
Stage #1: 2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride With sodium hydrogencarbonate In chloroform Stage #2: With 3-chloro-benzenecarboperoxoic acid at 5℃; for 2.41667h; Further stages.;	52.47%

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

: 134469-07-1
Benzimidazol-2-thiol

: 73590-87-1
2-[(3,5-dimethyl-4-methoxy-2-pyridinylmethyl)thio]-1H-benzimidazole

Conditions

Conditions	Yield
With sodium hydroxide In ethanol at 68℃; for 4h;	89.5%
With sodium hydroxide In methanol Heating;	84%

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

: 84445-90-9
5-acetamido-benzimidazoline-2-thione

: 117013-90-8
N-[2-(4-Methoxy-3,5-dimethyl-pyridin-2-ylmethylsulfanyl)-1H-benzoimidazol-5-yl]-acetamide

Conditions

Conditions	Yield
With sodium hydroxide In ethanol; water at 90℃; for 1h;	89%

: 651729-82-7
[4-(2-mercapto-6-methoxy-benzimidazole-1-sulfonyl)-phenoxy]acetic acid methyl ester

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

: 651729-83-8
[4-(6-methoxy-2-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethylsulfanyl)benzimidazole-1-sulfonyl)-phenoxy]acetic acid methyl ester

Conditions

Conditions	Yield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 20℃; for 1.25h;	89%
With potassium carbonate In DMF (N,N-dimethyl-formamide) for 1h;	89%

: 17536-00-4
3,5-diisopropylpyrazole

: 86604-75-3
2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride

: 1191928-12-7
2-[(3,5-diisopropyl-1H-pyrazol-1-yl)methyl]-4-methoxy-3,5-dimethylpyridine

Conditions

Conditions	Yield
With tetra(n-butyl)ammonium hydroxide; sodium hydroxide In water; toluene Inert atmosphere; Reflux;	89%
With tetra(n-butyl)ammonium hydroxide; sodium hydroxide In water; toluene

2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride Specification

The 2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride, with the CAS registry number 86604-75-3, has the systematic name of 2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride (1:1). It belongs to the following product categories: Heterocyclic Building Blocks; Halogenated Heterocycles; Pyridines. The molecular formula of this chemical is C₉H₁₂ClNO^.HCl. What's more, it is usually used as intermediate of omeprazole.You should be cautious while dealing with 2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride. It may cause burns. Therefore, you had better take the following instructions: Wear suitable protective clothing, gloves and eye/face protection, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice; In case of accident or if you feel unwell, seek medical advice immediately (show label where possible).

The physical properties of 2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride are as following:
(1)ACD/LogP: 2.19; (2)# of Rule of 5 Violations: 0; (3)#H bond acceptors: 2; (4)#H bond donors: 0; (5)#Freely Rotating Bonds: 2; (6)Polar Surface Area: 22.12 Å²; (7)Flash Point: 118.4 °C; (8)Enthalpy of Vaporization: 48.99 kJ/mol; (9)Boiling Point: 272.2 °C at 760 mmHg; (10)Vapour Pressure: 0.0103 mmHg at 25°C.

Uses of 2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride:
It can react with 4,5,6,7-tetrahydrobenzimidazoline-2-thione to produce 2-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethylsulfanyl)-4,5,6,7-tetrahydro-1H-benzoimidazole. This reaction will need reagent NaOH, and the solvents ethanol and H₂O. The reaction time is 1 hour with temperature of 90°C, and the yield is about 85%.
2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride can react with 4,5,6,7-tetrahydrobenzimidazoline-2-thione to produce 2-(4-methoxy-3,5-dimethyl-pyridin-2-ylmethylsulfanyl)-4,5,6,7-tetrahydro-1H-benzoimidazole

You can still convert the following datas into molecular structure:
(1)SMILES: ClCc1ncc(c(OC)c1C)C.Cl
(2)InChI: InChI=1/C9H12ClNO.ClH/c1-6-5-11-8(4-10)7(2)9(6)12-3;/h5H,4H2,1-3H3;1H
(3)InChIKey: LCJDHJOUOJSJGS-UHFFFAOYAO

Product Name

2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride

Synthetic route

2-Chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride Specification

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