• Name

  2-Ethoxythiazole

• EINECS 239-760-5
• CAS No. 15679-19-3
• Article Data5
• CAS DataBase
• Density 1.146 g/cm³
• Solubility
• Melting Point
• Formula C₅H₇NOS
• Boiling Point 167.9 °C at 760 mmHg
• Molecular Weight 129.183
• Flash Point 55.3 °C
• Transport Information UN 1993 3/PG 3
• Appearance Colorless to light yellow liquid
• Safety 16-26
• Risk Codes 10-36/37/38
• Molecular Structure
• Hazard Symbols Xi
• Synonyms Nizatidine intermediate
• PSA 50.36000
• LogP 1.54180

Synthetic route

3034-53-5

2-bromo-1,3-thiazole

141-52-6

sodium ethanolate

15679-19-3

2-ethoxythiazole

Conditions

Conditions	Yield
In ethanol Heating;	90%
In methanol for 20h; Heating;

625-57-0

O-ethyl thiocarbamate

15679-19-3

2-ethoxythiazole

15679-19-3

2-ethoxythiazole

1086382-60-6

5-bromo-2-ethoxythiazole

Conditions

Conditions	Yield
With N-Bromosuccinimide In N,N-dimethyl-formamide at 20℃; for 3h;	91%

15679-19-3

2-ethoxythiazole

96-36-6, 868-85-9

methyl phosphite

(2-ethoxy-thiazol-5-yl)-phosphonic acid dimethyl ester

Conditions

Conditions	Yield
With manganese triacetate In acetic acid at 80℃; for 3h;	89%

15679-19-3

2-ethoxythiazole

29976-53-2

N-ethoxycarbonyl-4-piperidone

850221-28-2

ethyl 4-(2-ethoxy-1,3-thiazol-5-yl)-4-hydroxypiperidine-1-carboxylate

Conditions

Conditions	Yield
Stage #1: 2-ethoxythiazole With n-butyllithium In tetrahydrofuran at 0℃; for 0.166667h; Stage #2: N-ethoxycarbonyl-4-piperidone In tetrahydrofuran at 0 - 25℃; for 4h;	69%

15679-19-3

2-ethoxythiazole

C22H23NO3

C25H24N2O3S

Conditions

Conditions	Yield
With trifluoroacetic acid In dichloromethane for 4h; Reflux; stereoselective reaction;	68%

15679-19-3

2-ethoxythiazole

1432129-33-3

C5H6ClNO3S2

Conditions

Conditions	Yield
Stage #1: 2-ethoxythiazole With sec.-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere; Stage #2: With sulfur dioxide In tetrahydrofuran; hexane at 20℃; for 3h; Stage #3: With N-chloro-succinimide In tetrahydrofuran; hexane at 20℃; for 1h;	65%

15679-19-3

2-ethoxythiazole

A

6039-97-0

3H-thiazol-2-one

B

90109-73-2

4,5-dihydro-3H,3'H-[4,5']bithiazolyl-2,2'-dione

Conditions

Conditions	Yield
With hydrogenchloride

15679-19-3

2-ethoxythiazole

A

6039-97-0

3H-thiazol-2-one

B

74-85-1

ethene

Conditions

Conditions	Yield
at 314.2 - 405.7℃; Kinetics;

2-Ethoxythiazole Chemical Properties

2-Ethoxythiazole Uses

2-Ethoxythiazole Safety Profile

Safety Information of 2-Ethoxythiazole(15679-19-3):
Hazard Codes:Xi
Risk Statements:10-36/37/38
10:Flammable
36/37/38:Irritating to eyes, respiratory system and skin
Safety Statements:16-26
16:Keep away from sources of ignition-No smoking
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
RIDADR:UN 1993 3/PG 3
WGK Germany:3